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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang di lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Coordinated motion of molecular motors on DNA chains with branch topology

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Acta Mechanica Sinica 2021年第10期37卷 1580-1588,I0004页

作者： di lu Bin Chen Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Hangzhou310027China

Toward understanding the macroscopic mechanical behaviors of responsive deoxyribonucleic acid(DNA)hydrogels integrated with DNA motors,here we construct the state map for the translocation process of a single C-terminal translocase domain(FtsKC)on a single DNA chain at the molecular level and then investigate the movement of single or multiple FtsKC motors on DNA chains with varied branch *** studies indicate that multiple FtsKC motors can have coordinated motion,which is mainly due to the force responsive behavior of individual FtsKC *** further suggest the potential application of motors of FtsKC,together with DNA chains of specific branch topology,to serve as strain sensors in hydrogels.

关键词： DNA Molecular motor Coordinated motion Branch topology Strain sensor

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Tuning mechanical behaviors of highly entangled hydrogels with the random distribution of mobile entanglements

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 277-294页

作者： Jinlong LIU di lu Bin CHEN Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Beijing System Design Institute of Electro-Mechanic Engineering Beijing 100854China Intelligent Robotic Research Center Zhejiang LaboratoryHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Hangzhou 311100China

Highly entangled hydrogels exhibit excellent mechanical properties,including high toughness,high stretchability,and low *** considering the evolution of randomly distributed entanglements within the polymer network upon mechanical stretches,we develop a constitutive theory to describe the large stretch behaviors of these *** the theory,we utilize a representative volume element(RVE)in the shape of a cube,within which there exists an averaged chain segment along each edge and a mobile entanglement at each *** employing an explicit method,we decouple the elasticity of the hydrogels from the sliding motion of their entanglements,and derive the stress-stretch relations for these *** present theoretical analysis is in agreement with experiment,and highlights the significant influence of the entanglement distribution within the hydrogels on their *** also implement the present developed constitutive theory into a commercial finite element software,and the subsequent simulations demonstrate that the exact distribution of entanglements strongly affects the mechanical behaviors of the structures of these ***,the present theory provides valuable insights into the deformation mechanism of highly entangled hydrogels,and can aid in the design of these hydrogels with enhanced performance.

关键词： highly entangled hydrogel constitutive theory entanglement gamma distribution

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Carbon-based materials for photodynamic therapy: A mini-review

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 310-323页

作者： di lu Ran Tao Zheng Wang School of Pharmaceutical Science & Technology Tianjin Key Laboratory for Modem Drug Delivery & High EfficiencyCollaborative Innovation Center of Chemical Science and Engineering (Tianjin)Tianjin UniversityTianjin 300072China

Carbon-based materials have been extensively applied in photodynamic therapy owing to the unique optical characteristics,good biocompatibility and tunable systematic *** mini-review mainly focuses on the recent application of carbon-based materials including graphene,carbon nanotube,fullerene,corannulene,carbon dot and mesoporous carbon *** carbon-based materials can perform not only as photosensitizers,but also effective carriers for photosensitizers in photodynamic therapy,and its combined treatment.

关键词： photodynamic therapy carbon-based materials graphene carbon nanotube fullerene corannulene carbon dot mesoporous carbon nanoparticle

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Iron-based biochar as efficient persulfate activation catalyst for emerging pollutants removal:A review

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Chinese Chemical Letters 2023年第11期34卷 74-81页

作者： Jinjie lu Qinwei lu lu di Yi Zhou Yanbo Zhou State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China School of Carbon Neutrality Future Technology East China University of Science and TechnologyShanghai 200237China

In recent years,biochar(BC)as a low-cost,easily available biomass product,is widely applied in sulfate radical-based advanced oxidation processes(SR-AOPs)for emerging pollutants ***,a state-of-art review of iron-based biochar catalysts is currently available in SR-AOPs application.A general summary of the development of biochar and the catalytic properties of biochar is ***,the synthetic strategies of different types of iron-based biochar catalysts are ***,the theoretical calculation to interpret the interaction between biochar and iron species is discussed to explore the activation *** the regeneration methods of biochar-based catalyst are *** unresolved challenges of the existent biochar-based SR-AOPs are pointed out,and the outlooks of future research directions are proposed.

关键词： Biochar Persulfate Emerging pollutants

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Adaptive controller design for uncertain singular systems with actuator failure

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Journal of Control and Decision 2022年第1期9卷 129-138页

作者： di lu Dongmei Yang Department of College of Sciences University of Northeastern UniversityShenyangLiaoningPeople’s Republic of China

In this paper,the problem of model reference adaptive controller design with actuator failure is solved for a series of uncertain singular *** research on partial actuator failure is relatively mature and it is necessary to solve the problem of how to guarantee the system performance when the actuator fails *** this reason,we treat the system with actuator failure as a switching system with two subsystems and then solve the stability analysis problem of the error switching *** emphasis is to design the adaptive controller by some sufficient linear matrices inequalities(LMIs)conditions and obtain the global stability criterion of the error switching system through the resident time ***,the proposed method is applied to HiMAT aircraft to illustrate the feasibility and effectiveness of this kind of problem.

关键词： Singular systems actuator failure adaptive controller design state feedback tracking control

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Preparation and Properties of Superhydrophobic ZnO Nanorod-based Nanocomposite on the Surface of Stainless Steel Mesh

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Journal of Bionic Engineering 2023年第3期20卷 910-922页

作者： Shunuo Bian Junhua Xu Lihua Yu di lu School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212003China

Bionic superhydrophobic coating has extremely broad application prospects and practical value. It is based on two important conditions, one is the construction of micro–nano structure, the other is the material with low surface energy. How to stabilize the micro–nano structure has become the focus of researches. In this work, a layer of Zn film is deposited on the stainless steel mesh with sturdy micron structure by RF magnetron sputtering. The solid micron structure of the stainless steel mesh itself, combined with the method of thermal oxidation, the surface of the stainless steel mesh is thus formed into a nanorod like ZnO nano structure, and then modified with perfluorodecyltriethoxysilane (PFDS) for low surface energy. The maximum contact angle of the superhydrophobic sample is 154.8°, and the minimum sliding angle is 2°, and it also has excellent corrosion resistance, thermal stability, self-cleaning, anti-aging and anti-icing properties, which provides a design idea for the preparation of superhydrophobic coatings.

关键词： Superhydrophobic Corrosion resistance Self-cleaning Magnetron sputtering

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Engineering strontium aluminate sacrificial layers for fabricating monocrystalline complex oxide freestanding membranes

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The Innovation 2024年第4期5卷 23-24页

作者： di lu School of Microelectronics University of Science and Technology of ChinaHefei 230026China

There was a long history of releasing various monocrystalline semiconductor structures from their hosting substrates to form“freestanding”structures,in order to change the substrates and for other special *** release was achieved by breaking the bonds between the film and the substrate,through methods such as forming interfacial gas bubbles(“smart-cut”technology for fabricating semiconductor-on-insulator wafers)or chemical etching(selectively etching epitaxial AlAs underlayer for fabricating GaAs-on-silicon photonic devices).The exfoliation of layered van der Waals materials in recent decades also produced another class of freestanding monocrystalline materials—twodimensional(2D)*** addition to changeable substrates,being freestanding also allowed unique methods to manipulate the 2D materials;for example,transferring them on flexible substrates and directly stretching them controls the strain in their lattice,as well as their strain-dependent physical properties.

关键词： free stretching fabricating

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设计师卢迪作品之二合一花瓶

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家具与室内装饰 2021年第6期28卷 140-141页

作者：卢迪北京师范大学未来设计学院广东珠海519087

二合一花瓶设计说明:这是一款花瓶的设计。在插入植物的一刻,植物本身化为了花瓶的“装饰”。两者融为一体,浑然天成。二合一花瓶在它行使承载与展示各式植物的功能性的同时,花瓶的美与植物的美合二为一,将两者融合成一件艺术品,本设计... 详细信息

二合一花瓶设计说明:这是一款花瓶的设计。在插入植物的一刻,植物本身化为了花瓶的“装饰”。两者融为一体,浑然天成。二合一花瓶在它行使承载与展示各式植物的功能性的同时,花瓶的美与植物的美合二为一,将两者融合成一件艺术品,本设计强调环境与事物和谐共处的理念,其倡导理念重新塑造了花瓶与花朵两者之间相互依托的关系,引人深思。

关键词：二合一设计说明和谐共处合二为一重新塑造浑然天成花瓶相互依托

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Targeting tumor-associated macrophages to synergize tumor immunotherapy

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Signal Transduction and Targeted Therapy 2021年第3期6卷 795-806页

作者： Xiaonan Xiang Jianguo Wang di lu Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouChina NHC Key Laboratory of Combined Multi-organ Transplantation Key Laboratory of the Diagnosis and Treatment of Organ TransplantationCAMSHangzhouChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

The current treatment strategies in advanced malignancies remain ***,immunotherapies have raised hope for a successful control of these advanced diseases,but their therapeutic responses are suboptimal and vary considerably among ***-associated macrophages(TAMs)are a major component of the tumor microenvironment(TME)and are often correlated with poor prognosis and therapy resistance,including ***,a deeper understanding of the complex roles of TAMs in immunotherapy regulation could provide new insight into the ***,targeting of TAMs is an emerging field of interest due to the hope that these strategies will synergize with current *** this review,we summarize recent studies investigating the involvement of TAMs in immune checkpoint inhibition,tumor vaccines and adoptive cell transfer therapies,and discuss the therapeutic potential of targeting TAMs as an adjuvant therapy in tumor immunotherapies.

关键词： immunotherapy involvement diseases

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