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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming lu Xinyan Li Kai Shu department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of Graduate Student Chongqing Medical UniversityChongqingChina department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin lu Jianzhong Hu Yong Cao Chengjun Li department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu lu Jianlin Shi department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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基于特征间几何约束的指针仪表读数识别方法

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沈阳理工大学学报 2025年第1期44卷 1-8页

作者：刘昶卢景峰刘青沈阳理工大学信息科学与工程学院沈阳110159 闪捷信息科技有限公司杭州311121

在指针式仪表示值监控系统中,倾斜拍摄仪表图像时会导致识别结果出现偏差,为此提出一种基于仪表特征间几何约束的识别方法。首先利用一幅平铺于仪表上表面的平面标定板图像实现相机参数标定,生成仪表在标定平面上的虚拟图像;然后利用表... 详细信息

在指针式仪表示值监控系统中,倾斜拍摄仪表图像时会导致识别结果出现偏差,为此提出一种基于仪表特征间几何约束的识别方法。首先利用一幅平铺于仪表上表面的平面标定板图像实现相机参数标定,生成仪表在标定平面上的虚拟图像;然后利用表壳上表面、刻度平面、指针平面与虚拟像平面间的平行关系,确定表壳圆的圆心、仪表刻度圆心、指针转轴中心特征间的透视投影约束关系,利用图像的极坐标变换和离散傅里叶变换提取仪表刻度圆心的最优位置及起始刻度线的角度,利用Hough变换的投票原理估计指针的转动角度;最后利用角度法实现仪表读数的解算。以某型号指针式温度计为测试对象进行实验验证,识别结果的平均误差为0.23℃,最大误差为0.7℃,本文方法能够准确识别仪表读数且识别精度优于人工读数。

关键词：指针式仪表透视投影约束相机标定离散傅里叶变换

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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Polymer Translocation

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Chinese Journal of Polymer Science 2023年第5期41卷 683-698,I0007页

作者： lu-Wei lu Zhen-Hua Wang An-chang Shi Yu-Yuan lu Li-Jia An State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China department of Physics and Astronomy McMaster UniversityHamiltonOntario L8S4M1Canada

The translocation of a polymer through a pore that is much smaller than its size is a fundamental and actively researched topic in polymer *** understanding of the principles governing polymer translocation provides important guidance for various practical applications,such as the separation and purification of polymers,nanopore-based single-molecule deoxyribonucleic acid/ribonucleic acid(DNA/RNA)sequencing,transmembrane transport of DNA or RNA,and infection of bacterial cells by *** past several decades have seen great progresses on the study of polymer *** we present an overview of theoretical,experimental,and simulational stduies on polymer translocation,focusing on the roles played by several important factors,including initial polymer conformations,external fields,polymer topology and architectures,and confinement *** highlight the physical mechanisms of different types of polymer translocations,and the main controversies about the basic rules of translocation *** compare and contrast the behaviors of force-induced versus flow-induced translocations and the effects of unknotted versus knotted ***,we mention several opportunities and challenges in the study of polymer translocation.

关键词： Polymer translocation Knotted polymers Translocation time Critical flux

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Possible Mechanism Associated with Herbicidal Activity of Soybean Meal Hydrolysate (SMH)

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Agricultural Sciences in China 2010年第6期9卷 854-860页

作者： YANG Jian lu chang-yi School of Applied Chemistry and Biotechnology Shenzhen Polytechnic Shenzhen 518055 P.R.China Environmental Science Research Center Xiamen University Xiamen 361005 P.R. China

Soybean meal hydrolyzate （SMH） has been proposed for use as a natural preemergence ***,the mechanism by which SMH exerts its herbicidal activity remains *** this paper,the herbicidal activities of SMH against perennial ryegrass （Lolium perenne L.） under non-sterile and sterile conditions were evaluated and the relationship between the molecular weight of the ultrafiltration （UF） fractions of SMH and their herbicidal activities were ***,the ammonia content changes of the media of SMH treatments 7 d after incubation were also *** results showed that SMH inhibited the radicle growth of germinating *** seeds in a dose-dependent manner under non-sterile ***,SMH in the concentrations investigated increased the radicle length and shoot length by 14-17% and 11-15% respectively under sterile *** ammonia contents in the SMH media at all treatments increased greatly from less than 0.01 mg L-1 to up to 11.86-41.37 mg L-1 after 7 d incubation under non-sterile ***,ammonia content did not change under sterile condition,proposing that the herbicidal activity might be caused by the free ammonia released from SMH by microbial *** was no difference on the perennial ryegrass radicle inhibition among the UF fractions of SMH on an equivalent N *** could be concluded that SMH exerted its herbicidal activity through the free ammonia released under non-sterile condition instead of by specific peptide（s） in SMH.

关键词： soybean meal hydrolysate herbicidal active mechanism ammonia

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Current Oscillation and dc-Voltage-Controlled Chaotic Dynamics in Semiconductor Superlattices

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Communications in Theoretical Physics 2006年第2期45卷 363-368页

作者： WANG chang lu Jing-Tao State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology the Chinese Academy of Sciences Shanghai 200050 China

We report a detailed theoretical study of current oscillation and de-voltage-controlled chaotic dynamics in doped GaAs/AlAs resonant tunneling superlattices under crossed electric and magnetic fields. When the superlattice is biased at the negative differential velocity region, current self-oscillation is observed with proper doping concentration. The current oscillation mode and oscillation frequency can be affected by the dc voltage bias, doping density, and magnetic field. When an ac electric field with fixed amplitude and frequency is also applied to the system, different nonlinear properties show up in the external circuit with the change of dc voltage bias. We carefully study these nonlinear properties with different chaos-detecting methods.

关键词： semiconductor superlattices current oscillation chaotic dynamics

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Data-driven parity-time-symmetric vector rogue wave solutions of multi-component nonlinear Schrödinger equation

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Chinese Physics B 2022年第6期31卷 137-144页

作者： Li-Jun chang Yi-Fan Mo Li-Ming Ling de-lu Zeng School of Mathematics South China University of TechnologyGuangzhou 510640China

Rogue waves are a class of nonlinear waves with extreme amplitudes,which usually appear suddenly and disappear without any ***,the parity-time(PT)-symmetric vector rogue waves(RWs)of multi-component nonlinear Schrödinger equation(n-NLSE)are usually derived by the methods of integrable *** this paper,we utilize the multi-stage physics-informed neural networks(MS-PINNs)algorithm to derive the data-driven symmetric vector RWs solution of coupled NLS system in elliptic and X-shapes domains with nonzero boundary *** results of the experiment show that the multi-stage physics-informed neural networks are quite feasible and effective for multi-component nonlinear physical systems in the above domains and boundary conditions.

关键词： nonlinear Schrödinger equation vector rogue waves deep learning numerical simulations

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