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RB-DEM Modeling and Simulation of Non-Persisting Rough Open Joints Based on the IFS-Enhanced Method

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 337-359页

作者： Hangtian Song Xudong Chen chun Zhu Qian Yin Wei Wang Qingxiang Meng Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China Research Institute of Geotechnical Engineering Hohai UniversityNanjing210098China School of Earth Sciences and Engineering Hohai UniversityNanjing210098China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou221116China

When the geological environment of rock masses is disturbed,numerous non-persisting open joints can appear within *** is crucial to investigate the effect of open joints on the mechanical properties of rock ***,it has been challenging to generate realistic open joints in traditional experimental tests and numerical *** paper presents a novel solution to solve the *** utilizing the stochastic distribution of joints and an enhanced-fractal interpolation system(IFS)method,rough curves with any orientation can be *** Douglas-Peucker algorithm is then applied to simplify these curves by removing unnecessary points while preserving their fundamental ***,open joints are created by connecting points that move to both sides of rough curves based on the aperture *** modeling is performed to construct the final mesh ***,the RB-DEM method is applied to transform the mesh model into a discrete element model containing geometric information about these open ***,this study explores the impacts of rough open joint orientation,aperture,and number on rock fracture *** method provides a realistic and effective approach for modeling and simulating these non-persisting open joints.

关键词： Non-persisting rough open joints stochastic distribution of joints enhanced-IFS method RB-DEM

Potential and prospects in molecular orbital level micro-electric field for low energy consumption water purification

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National Science Open 2024年第3期 194-233页

作者： Lai Lyu Yumeng Wang Chao lu Fan Li Wenrui Cao Yingtao Sun chun Hu Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou University

Conventional water purification technologies struggle to simultaneously address purification efficiency and energy *** orbital level surface micro-electric field（MEF）-driven water purification is an original and innovative concept conceived and developed by our group in recent *** core idea involves creating electron-rich and electron-poor micro-areas on the nanomaterial surface,which drive pollutants or H2O molecules to provide electrons in the electron-poor micro-areas while other environmental factors（such as H2O2and O2） obtain electrons in the electron-rich *** process effectively utilizes the internal energy contained within wastewater and emerging contaminants（ECs）.Centered on this core,this review systematically examines the discovery,construction,and characteristics of MEF and MEF-like systems and summarizes their application *** challenges,bottlenecks,and future development directions of MEF technology are also analyzed and *** of MEFs can facilitate the development of low-consumption,high-efficiency water purification technologies.

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Hemichorea in patients with temporal lobe infarcts: Two case reports

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World Journal of Clinical Cases 2024年第4期12卷 806-813页

作者： Xu-Dong Wang Xing Li chun-Lian Pan Department of Neurology Puren Hospital Affiliated to Wuhan University of Science and TechnologyWuhan 430081Hubei ProvinceChina School of Medicine Wuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina

BACKGROUND Hemichorea and other hyperkinetic movement disorders are uncommon present-ations of stroke and are usually secondary to deep infarctions affecting the basal ganglia and ***,temporal ischemic lesions causing hemichorea are *** report the cases of two patients with acute ischemic temporal lobe infarct strokes that presented as *** SUMMARY Patient 1:An 82-year-old woman presented with a 1-mo history of involuntary movement of the left extremity,which was consistent with *** diffusion-weighted imaging(DWI)revealed an acute ischemic stroke that predominantly affected the right temporal cortex,and magnetic resonance angiography of the head showed significant stenosis of the right middle cerebral artery(MCA).Treatment with 2.5 mg of olanzapine per day was *** she was discharged from the hospital,her symptoms appeared to have improved compared with those previously ***-seven days after the first admission,she was readmitted due to acute ischemic *** tomogra-phy perfusion showed marked hypoperfusion in the right MCA *** emergency transfemoral cerebral angiogram was performed and showed severe stenosis in the M1 segment of the right *** percutaneous transluminal angioplasty was successfully performed,abnormal movements or other neuro-logic problems did not *** 2:A 76-year-old man was admitted to our hospital for a 7-d history of right-upper-sided involuntary *** showed an acute patchy ischemic stroke in the left temporal lobe without basal ganglia *** diffusion tensor imaging confirmed fewer white matter fiber tracts on the left side than on the opposite *** with 2.5 mg of olanzapine per day improved his condition,and he was *** When acute hemichorea suddenly appears,temporal cortical ischemic stroke should be considered a possible *** addition,hemichorea may be a sign of impending cerebral infarcti

关键词： Acute ischemic stroke Temporal ischemic stroke Movement disorders Cortical hemichorea Case report

Unraveling the incompatibility mechanism of ethylene carbonate-based electrolytes in sodium metal anodes

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Journal of Energy Chemistry 2024年第7期94卷 560-567页

作者： Daomin Qin Fangyuan Cheng Meilian Cao Feiyang Yan Qian Wang chun Fang Jiantao Han State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074HubeiChina

Ethylene carbonate(EC)is widely used in lithium-ion batteries due to its optimal overall performance with satisfactory conductivity,relatively stable solid electrolyte interphase(SEI),and wide electrochemical *** is also the most widely used electrolyte solvent in sodium ion ***,compared to lithium metal,sodium metal(Na)shows higher activity and reacts violently with EC-based electrolyte(NaPF_(6)as solute),which leads to the failure of sodium metal batteries(SMBs).Herein,we reveal the electrochemical instability mechanism of EC on sodium metal battery,and find that the com-bination of EC and NaPF_(6) is electrically reduced in sodium metal anode during charging,resulting in the reduction of the first coulombic efficiency,and the continuous consumption of electrolyte leads to the cell *** address the above issues,an additive modified linear carbonate-based electrolyte is provided as a substitute for EC based ***,ethyl methyl carbonate(EMC)and dimethyl carbon-ate(DMC)as solvents and fluoroethylene carbonate(FEC)as SEI-forming additive have been identified as the optimal solvent for NaFP_(6)based electrolyte and used in Na_(4)Fe_(3)(PO_(4))_(2)(P_(2)O_(7))/Na *** batter-ies exhibit excellent capacity retention rate of about 80%over 1000 cycles at a cut-off voltage of 4.3 V.

关键词： Na metal batteries Ethylene carbonate decomposition Na_(4)Fe_(3)(PO_(4))_(2)(P_(2)O_(7))cathode Interface engineering Ethylene carbonate-free electrolyte

Mechanism of local solidification time variations with melt rate during vacuum arc remelting process of 8Cr4Mo4V high-strength steel

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Journal of Iron and Steel Research(International) 2024年第2期31卷 377-388页

作者： Tao Pan Hong-chun Zhu Zhou-hua Jiang Hua-bing Li Rui Zhang Hao Feng School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

A 2D axisymmetric numerical model was established to investigate the variations of molten pool with different melt rates during the vacuum arc remelting of 8Cr4Mo4V high-strength steel,and the ingot growth was simulated by dynamic mesh *** results show that as the ingot grows,the molten pool profile changes from shallow and flat to V-shaped,and both the molten pool depth and the mushy width ***,the variation of both the molten pool shape and the mushy width melt rate is clarified by the thermal equilibrium *** melt rate increases,both the molten pool depth and the mushy width *** is caused by the increment in sensible heat stored in the ingot due to the limitation of the cooling capacity of the *** nonlinear increment in sensible heat leads to a nonlinear increase in the mushy *** addition,as melt rate increases,the local solidification time(LST)of ingot decreases obviously at first and then *** melt rate is controlled in a suitable range,LST is the lowest and the secondary dendrite arm spacing of the ingot is the smallest,which can effectively improve the compactness degree of 8Cr4Mo4V high-strength steel.

关键词： 8Cr4Mo4V high-strength steel Vacuum arc remelting process Melt rate Molten pool Local solidification time

Prediction model on hydrolysis kinetics of phthalate monoester:A density functional theory study

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Journal of Environmental Sciences 2024年第1期135卷 51-58页

作者： Tong Xu Jingwen Chen Deming Xia Weihao Tang Jiansheng Cui chun Liu Shuangjiang Li College of Environmental Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050000China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and ManagementInstitute of Eco-environmental and Soil SciencesGuangdong Academy of SciencesGuangzhou 510650China

As primary degradation products of phthalate esters,phthalate monoesters(MPEs)have been widely detected in various aquatic environments and drawn growing toxicological *** kinetics that is of importance for assessing environmental persistence of chemicals remain elusive for ***,kinetics of base-catalyzed and neutral hydrolysis for 18 MPEs with different leaving groups was investigated by density functional theory *** indicate that MPEs with leaving groups having p Kaof<10 prefer dissociative transition *** are more persistent than their parents,and their hydrolysis half-lives were calculated to vary from 3.4 min to 79.2 years(p H=7–9).A quantitative structure-activity relationship model was developed for predicting the hydrolysis kinetics *** was found that p Kaof the leaving groups and electronegativity of the MPEs are key factors determining the hydrolysis *** work may lay a theoretical foundation for better understanding the chemical process that governs MPE persistence in aquatic environments.

关键词： Phthalate monoesters Phthalate esters Hydrolysis Density functional theory Quantitative structure-activity relationship

Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3205-3217页

作者： Bing-Chen Zhang chun-Mei Lai Bang-Yue luo Jing-Wei Shao Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Researchthe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523058China College of Materials and Chemical Engineering MinjiangUniversityFuzhou350108China

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)***,combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted ***,based on a universal triterpene template and the anticancer active agent ursolic acid(UA),a cytomembrane-coated biomimetic delivery nanoplatform(UR@M)prepared by the selfassembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma(HCC)***@M showed enhanced tumor accumulation in vivo with homologous tumor targeting,and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target *** activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway,which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of *** strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor ***,the UA-templated strategy“killed three birds with one stone”by establishing a self-assembly nanosystem,inducing tumor cell death,and promoting synergistic immunostimulation for HCC treatment.

关键词： Ursolic acid Self-assembly Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy Immunotherapy

Understanding the molecular crossroads in acute liver failure:A pathway to new therapies

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World Journal of Gastroenterology 2024年第23期30卷 2931-2933页

作者： chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education National Taiwan University HospitalTaipei 100225Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404333Taiwan

In this editorial we comment on the article published in a recent issue of the World Journal of *** liver failure(ALF)is a critical condition characterized by rapid hepatocellular injury and organ dysfunction,and it often necessitates liver transplant to ensure patient *** research has eluci-dated the involvement of distinct cell death pathways,namely ferroptosis and pyroptosis,in the pathogenesis of *** is driven by iron-dependent lipid peroxidation,whereas pyroptosis is an inflammatory form of cell death;both pathways contribute to hepatocyte death and exacerbate tissue *** comprehensive review explores the interplay between ferroptosis and pyroptosis in ALF,highlighting the role of key regulators such as silent information regulator sirtuin *** from clinical and preclinical studies provide valuable perspectives on the dysregulation of cell death pathways in ALF and the therapeutic potential of targeting these *** across multiple disciplines is essential for translating the experimental insights into effective treatments for this life-threatening condition.

关键词： Silent information regulator sirtuin 1 Ferroptosis Pyroptosis P53/glutathione peroxidase 4/gasdermin D Acute liver failure

Effects of different moxibustion durations on lumbar disk herniation:a clinical study

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Frontiers of Nursing 2024年第1期11卷 47-56页

作者： Bin Chen Ting Yang chun-Qin Zhu Department of Nursing Affiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsu 210004China

Objective:To explore the best duration of moxibustion on lumbar disk herniation(LDH).Methods:A total of 88 patients were randomly divided into control group and 15-min,30-min,and 45-min moxibustion *** control group was treated with conventional therapy,while the other 3 groups were intervened with different moxibustion *** back pain,dysfunction,lumbar function,and effective rates were evaluated before,in the first week and second week of ***:In low back pain,compared with the control group,the score of the 15-min group had no significant difference,but it was significantly lower in the 30-min and 45-min *** dysfunction and lumbar function,compared with the control group,the scores of the 15-min,30-min,and 45-min groups were significantly higher,and the scores of the 30-min and 45-min groups were significantly higher,but there was no significant difference between the 30-min and 45-min *** effective rates,there was no significant difference between the control group and 15-min group;the effective rates of the 30-min and 45-min groups were significantly higher than those of the control ***:Moxibustion has good therapeutic effect on LDH with specific moxibustion time.

关键词： duration of moxibustion lumbar disc herniation moxibustion