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Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 475-492页

作者： Hong-mei Wu Yuan-Yuan Huang Yu-Qiu Xu Wei-Lai Xiang Chang Yang Ru-Yuan Liu Di Li Xue-Feng Guo Zheng-Bao Zhang chun-Hua Bei Sheng-Kui Tan Xiao-Nian Zhu Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health Guilin Medical UniversityGuilin 541199Guangxi Zhuang Autonomous RegionChina

BACKGROUND B56εis a regulatory subunit of the serine/threonine protein phosphatase 2A,which is abnormally expressed in tumors and regulates various tumor cell *** present,the application of B56εin pan-cancer lacks a comprehensive analysis,and its role and mechanism in hepatocellular carcinoma(HCC)are still *** Cancer Genome Atlas,Genotype-Tissue Expression,Gene Expression Profiling Interactive Analysis,and Tumor Immune Estimation Resource databases were used to analyze B56εexpression,prognostic mutations,somatic copy number alterations,and tumor immune characteristics in 33 *** relationships between B56εexpression levels and drug sensitivity,immuno-therapy,immune checkpoints,and human leukocyte antigen(HLA)-related genes were further *** Set Enrichment Analysis(GSEA)was performed to reveal the role of B56εin *** Cell Counting Kit-8,plate cloning,wound healing,and transwell assays were conducted to assess the effects of B56εinterference on the malignant behavior of HCC *** In most tumors,B56εexpression was upregulated,and high B56εexpression was a risk factor for adrenocortical cancer,HCC,pancreatic adenocarcinoma,and pheochromocytoma and paraganglioma(all P<0.05).B56εexpression levels were correlated with a variety of immune cells,such as T helper 17 cells,B cells,and *** was a positive correlation between B56εexpression levels with immune checkpoint genes and HLA-related genes(all P<0.05).The expression of B56εwas negatively correlated with the sensitivity of most chemotherapy drugs,but a small number showed a positive correlation(all P<0.05).GSEA analysis showed that B56εexpression was related to the cancer pathway,p53 downstream pathway,and interleukin-mediated signaling in *** of B56εexpression in HCC cells inhibited the proliferation,migration,and invasion capacity of tumor *** Tip:The expression of protein phosphatase 2A(PP2A)subunit B56εis up-regulated in most tumors,and its high

关键词： B56ε Prognosis Tumor microenvironment Immune infiltration Immunotherapy Hepatocellular carcinoma

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不同煤种在热解过程中氮的释放特性试验

煤炭学报 2007年第1期32卷 77-80页

作者：杨冬徐鸿路春美王永征华北电力大学电站设备状态监测与控制教育部重点实验室山东大学能源与动力工程学院山东济南250063

试验研究了烟煤、贫煤及其混煤在管式炉热解过程中氮的析出特性,探讨了煤质特性、运行参数对氮析出特性的影响.试验结果表明:随煤化程度加深,氮的热解释放速率及最终释放百分比明显降低;加热速率越大,煤中氮的热解释放率越高;加热终温越... 详细信息

试验研究了烟煤、贫煤及其混煤在管式炉热解过程中氮的析出特性,探讨了煤质特性、运行参数对氮析出特性的影响.试验结果表明:随煤化程度加深,氮的热解释放速率及最终释放百分比明显降低;加热速率越大,煤中氮的热解释放率越高;加热终温越高,氮的热解释放百分比越大;颗粒愈粗,氮的热解释放时间延长.混煤中氮的析出与单煤也有一定的相似性;随着混煤中含氮量的增加,热解过程中氮的析出率基本上保持线性增长.

关键词：煤热解氮释放特性

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鲁迅晚期杂文的一种思维向度和言说方式

福建师范大学学报（哲学社会科学版） 2011年第6期 62-67页

作者：鲁春梅迟伟红东北财经大学新闻传播学院辽宁大连116023

鲁迅晚期杂文与上海生活经验有很大关联,上海这个特定的文化空间,不但提供给鲁迅观察社会世相的一扇窗口,同时也影响着杂文创作的思维方式与言说策略。鲁迅晚期杂文往往在都市文化与租界体验的文化语境之中展开,解剖国民劣根性在租界社... 详细信息

鲁迅晚期杂文与上海生活经验有很大关联,上海这个特定的文化空间,不但提供给鲁迅观察社会世相的一扇窗口,同时也影响着杂文创作的思维方式与言说策略。鲁迅晚期杂文往往在都市文化与租界体验的文化语境之中展开,解剖国民劣根性在租界社会的变异,批判沪上文人对金钱物质的依赖,挖掘知识分子流氓人格在洋场文化中的发酵与扩大。鲁迅还通过"剪贴"与"备考"的方式,缩微出一个真实的言论环境,使得晚期杂文具有一种对话感与互动性。

关键词：鲁迅晚期杂文思维向度言说方式

The effect of mydriatic eyedrops on cerebral oxygenation and cerebral blood volume in preterm infants

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The effect of mydriatic eyedrops on cerebral oxygenation and...

The FAST all sky HI survey(FASHI):The first release of catalog

2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： LIU lu XU Su-hua ZHANG Peng KONG Yan-ting lu chun-mei CHENG Guo-qiang Department of Neonatology Children's Hospital of Fudan University Key Laboratory of Neonatal Disease Ministry of Health Children's Hospital of Fudan University

Background: To evaluate the changes of cerebral oxygenation and cerebral blood volume of premature infants during and after instillation of mydriatic eyedrops for retinopathy of prematurity(ROP) ***: 24 premature infants with 32 retinopathy of prematurity screenings were recruited prospectively in neonatal intensive care unit(NICU) of Children’s Hospital of Fudan University. Cerebral tissue oxygenation index(cTOI), cerebral tissue hemoglobin index(cTHI) were continuously measured from 30 min before to 30 min after instillation of mydriatic eyedrops utilizing near infrared spectroscopy(NIRS). Pulse rate, oxygen arterial saturation(SaO2) were synchronously recorded by the monitor during the course of the study. Result: The study found no significant difference in the effect of mydriatic drops on cerebral oxygenation and cerebral blood volume. Cerebral tissue oxygenation index had a slight decreasing trend after instillation of mydriatic eyedrops, and gradually recovered to baseline level before examinations start. Cerebral tissue hemoglobin index presented a consistent decrease first then steady trend in the whole *** The study found there were slight trend changes in cerebral oxygenation and cerebral blood volume during and after instillation of mydriatic eyedrops, which provide new insight into the related researches about the effect of mydriatic eyedrops on cerebral hemodynamics.

关键词： Brain hemodynamics Hypoxia Mydriatics Near-infrared spectroscopy Retinopathy of prematurity

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 112-133页

作者： Chuan-Peng Zhang Ming Zhu Peng Jiang Cheng Cheng Jing Wang Jie Wang Jin-Long Xu Xiao-Lan Liu Nai-Ping Yu Lei Qian Haiyang Yu mei Ai Yingjie Jing Chen Xu Ziming Liu Xin Guan chun Sun Qingliang Yang Menglin Huang Qiaoli Hao FAST Collaboration Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China National Astronomical Observatories Chinese Academy of Sciences(CAS)Beijing 100101China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

The FAST All Sky HI survey(FASHI)was designed to cover the entire sky observable by the Five-hundred-meter Aperture Spherical radio Telescope(FAST),spanning approximately 22000 square degrees of declination between-14°and+66°,and in the frequency range of 1050-1450 MHz,with the expectation of eventually detecting more than 100000 HI *** August 2020 and June 2023,FASHI had covered more than 7600 square degrees,which is approximately 35%of the total sky observable by *** has a median detection sensitivity of around 0.76 m Jy beam-1and a spectral line velocity resolution of~6.4 km s-1at a frequency of~1.4 *** of now,a total of 41741 extragalactic HI sources have been detected in the frequency range 1305.5-1419.5 MHz,corresponding to a redshift limit of z■*** cross-matching FASHI sources with the Siena Galaxy Atlas(SGA)and the Sloan Digital Sky Survey(SDSS)catalogs,we found that 16972(40.7%)sources have spectroscopic redshifts and 10975(26.3%)sources have only photometric *** of the remaining 13794(33.0%)HI sources are located in the direction of the Galactic plane,making their optical counterparts difficult to identify due to high extinction or high contamination of Galactic stellar *** on current survey results,the FASHI survey is an unprecedented blind extragalactic H I *** has higher spectral and spatial resolution and broader coverage than the Arecibo Legacy Fast ALFA Survey(ALFALFA).When completed,FASHI will provide the largest extragalactic HI catalog and an objective view of HI content and large-scale structure in the local universe.

关键词： surveys redshifts galaxies telescope radio lines HI line

Single-center retrospective study of the diagnostic value of doubleballoon enteroscopy in Meckel’s diverticulum with bleeding

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1043-1054页

作者： Tian He Chao Yang Jing Wang Ji-Sheng Zhong Ai-Hua Li Ya-Jing Yin Li-Ling luo chun-mei Rao Nian-Fen Mao Qiang Guo Zan Zuo Wen Zhang Ping Wan Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceThe Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Medicine Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina School of Medicine Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina Department of Gastroenterology Qujing Hospital of Traditional Chinese MedicineQujing 655000Yunnan ProvinceChina Department of Gastroenterology Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina

BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract ***,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula *** To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with *** The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of ***(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 *** incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)was30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before *** endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal u

关键词： Meckel’s diverticulum with bleeding Double-balloon colonoscopy 99mTc-pertechnetate scanning Capsule endoscopy Ectopic gastric mucosa

去甲氧柔红霉素或柔红霉素联合阿糖胞苷治疗急性髓系白血病患者的安全性分析

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中国临床药理学杂志 2024年第15期40卷 2265-2268页

作者：陈春红徐鲁杰刘璐任美娟张潇丹闫美兴中国海洋大学医药学院山东青岛266003 青岛市妇女儿童医院药学部山东青岛266034

目的分析去甲氧柔红霉素或柔红霉素联合阿糖胞苷治疗急性髓系白血病患者的安全性。方法检索中国生物医学数据库、中国期刊全文数据库、中文科技期刊全文数据库、万方数据库、Embase、PubMed、Cochrane Library,收集去甲氧柔红霉素联合... 详细信息

目的分析去甲氧柔红霉素或柔红霉素联合阿糖胞苷治疗急性髓系白血病患者的安全性。方法检索中国生物医学数据库、中国期刊全文数据库、中文科技期刊全文数据库、万方数据库、Embase、PubMed、Cochrane Library,收集去甲氧柔红霉素联合阿糖胞苷(试验组)和柔红霉素联合阿糖胞苷(对照组)的随机对照试验(RCT),检索时间为2014-01-01—2024-02-23。用RevMan 5.4软件对所纳入文献的药物不良反应进行Meta分析、敏感性分析和发表偏倚分析。结果Meta分析总共纳入11篇RCT,共计1818例患者,其中,试验组912例、对照组906例。Meta分析结果显示,试验组和对照组的总药物不良反应发生率分别为22.9%(56例/245例)和42.9%(105例/245例),在统计学上差异有统计学意义[相对危险度(RR)=0.53,95%置信区间(CI)=0.41~0.69,P0.05)。敏感性分析结果显示,所得分析结果稳定可靠;发表偏倚分析结果显示,本研究存在发表偏倚的可能性较小。结论去甲氧柔红霉素联合阿糖胞苷在治疗急性髓系白血病患者的总药物不良反应发生率显著低于柔红霉素联合阿糖胞苷,故前者的安全性较好。

关键词：去甲氧柔红霉素柔红霉素阿糖胞苷急性髓系白血病安全性

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融合肤色模型与小波变换的人脸检测算法

西安电子科技大学学报 2007年第6期34卷 864-868页

作者：郝琳波牛海军卢春梅西安电子科技大学计算机学院陕西西安710071

针对目前人脸检测误检率高的问题,提出了一种融合肤色模型与小波变换的新算法.该算法采用肤色模型确定人脸的可能位置,然后分别对人眼和嘴巴进行检测,最终确定人脸位置.其中眼睛位置在小波变换后根据几何位置进行检测,嘴巴位置采用Fishe... 详细信息

针对目前人脸检测误检率高的问题,提出了一种融合肤色模型与小波变换的新算法.该算法采用肤色模型确定人脸的可能位置,然后分别对人眼和嘴巴进行检测,最终确定人脸位置.其中眼睛位置在小波变换后根据几何位置进行检测,嘴巴位置采用Fisher分类器检测.这一新算法实现了在复杂背景中单人脸快速、准确定位.与传统的YCbCr肤色模型检测算法相比,新算法将颜色空间与小波变换、Fisher分类相结合,提高了检测精度.实验表明,该算法的正确检测率为91%,误检率仅为2%.

关键词：人脸检测 Fisher分类器 YCbCr模型小波变换

O_2/CO_2气氛下木醋调质石灰石再燃/先进再燃脱硝性能研究

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燃料化学学报 2013年第2期41卷 228-234页

作者：刘洪涛韩奎华路春美李辉山东大学能源与动力工程学院山东济南250061

在O2/CO2气氛下利用沉降炉脱硝实验台,对木醋调质石灰石和醋酸钙的再燃/先进再燃脱硝特性以及氨气的选择性非催化还原脱硝特性进行了研究。结果表明,木醋调质石灰石和醋酸钙的再燃脱硝效率随温度的升高先提高后降低,1 323 K时获得最高... 详细信息

在O2/CO2气氛下利用沉降炉脱硝实验台,对木醋调质石灰石和醋酸钙的再燃/先进再燃脱硝特性以及氨气的选择性非催化还原脱硝特性进行了研究。结果表明,木醋调质石灰石和醋酸钙的再燃脱硝效率随温度的升高先提高后降低,1 323 K时获得最高脱硝效率分别为82.70%和78.52%;再燃脱硝氧浓度不宜过高,合适的再燃比为14%～17%,停留时间为0.8 s。氨气选择性非催化还原脱硝在1 173 K时获得最高脱硝效率为95.41%,温度窗口为1 142～1 335 K;随着氧浓度的增大,脱硝效率不断降低,反应适宜的氨氮比为1.5,停留时间为1.2 s。按氨氮比0.75向再燃区喷入氨气可显著提高木醋调质石灰石和醋酸钙的再燃脱硝效率,同时脱硝反应适宜的温度区间也得到显著拓宽,1 323 K时两者获得的先进再燃脱硝效率分别为93.49%和92.79%。

关键词： O2 CO2 木醋液醋酸钙先进再燃 NO 选择性非催化还原