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Emerging electrochemical sensors for life healthcare

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Engineered Regeneration 2021年第1期2卷 175-181页

作者： Huihui lu Bingfang He bingbing Gao School of Pharmaceutical Sciences Nanjing Tech UniversityNanjing 211816China

As electrochemical sensors possess unique potential properties that are strongly related to their high sensitiv-ity,selectivity and cycling stability,making it extensively used in versatile fields of biosensing,electrochemical analysis and drug ***,recent evidence demonstrates that electrochemical technology provides a promising platform for life healthcare by biocompatibility of mimicking human tissue to report electrical signals,potentially enabling timely disorder prediction through non-invasive real time and simultaneous health *** review focuses on the comprehensive set of advances in the field of electrochemical devices for life healthcare,including fabrication,analytical performance,and their multiple applications in clinical settings are deliberated.

关键词： Biosensor Electrochemical sensor Wearable electronics Healthcare

甘露糖对6个人非小细胞肺癌细胞系放射敏感性影响

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中华放射肿瘤学杂志 2020年第7期29卷 558-562页

作者：葛红罗辉刘康栋贾雪超聂文娜张琪琪鲁冰冰杨冉王楠宋帅焦瑞迪郑州大学附属肿瘤医院肿瘤放疗科 450008 中美荷美尔肿瘤研究院郑州450003

目的探讨甘露糖对6个人非小细胞肺癌细胞系放射敏感性的影响及其可能机制。方法采用Western blot检测磷酸甘露糖异构酶在6个肺癌细胞系中的表达。利用MTT法观察甘露糖对肺癌细胞系的增殖抑制作用;分别给予对照组、甘露糖组0、2、4、6、8... 详细信息

目的探讨甘露糖对6个人非小细胞肺癌细胞系放射敏感性的影响及其可能机制。方法采用Western blot检测磷酸甘露糖异构酶在6个肺癌细胞系中的表达。利用MTT法观察甘露糖对肺癌细胞系的增殖抑制作用;分别给予对照组、甘露糖组0、2、4、6、8、10 Gy照射,采用平板克隆形成实验检测甘露糖对6个肺癌细胞放射敏感性的影响;流式细胞术检测对照组、甘露糖组、照射组及联合组细胞的凋亡情况。结果6个肺癌细胞系中磷酸甘露糖异构酶表达量各不相同,其中A549细胞表达量最高,H460细胞表达量最低。11.1 mmol/L甘露糖对A549、H460细胞系抑制作用相同,随着甘露糖浓度增加,对H460细胞系抑制作用更显著。采用11.1 mmol/L的甘露糖可明显增加H460细胞系放射敏感性及细胞凋亡率,而对A549细胞系放射敏感性和凋亡率影响不大。结论在磷酸甘露糖异构酶高表达的6个肺癌细胞系中,甘露糖可增强部分肿瘤细胞的放射敏感性。

关键词：甘露糖非小细胞肺癌细胞系放射敏感性

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溢流下拉法成型砖尖流料稳定性控制与研究

中国建材科技 2024年第S1期33卷 71-74页

作者：何志锋刘琎杨智李拓陆兵兵虹阳显示(咸阳)科技有限公司陕西咸阳712000 彩虹显示器件股份有限公司陕西咸阳712000

溢流下拉法是基板玻璃制造的主流成型技术,成型品质一方面受到自身生产特点、工艺状态、质量控制、作业规范等影响,另一方面受到玻璃黏温特性、设备条件变化的影响。溢流砖的砖尖流料稳定受控,是保证成型品质稳定的基础。本文通过对溢... 详细信息

溢流下拉法是基板玻璃制造的主流成型技术,成型品质一方面受到自身生产特点、工艺状态、质量控制、作业规范等影响,另一方面受到玻璃黏温特性、设备条件变化的影响。溢流砖的砖尖流料稳定受控,是保证成型品质稳定的基础。本文通过对溢流下拉法成型砖尖“大小料”不良现象的分析,从铂金挡板结构设计、砖尖黏温控制、导流板析晶预防控制等角度进行探讨和研究,为成型关键设备的设计改进和“大小料”预防控制提供思路,有利于成型品质的长期稳定。

关键词：基板玻璃成型品质导流板析晶

The effect of protic ionic liquids incorporation on CO_(2) separation performance of Pebax-based membranes

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Chinese Journal of Chemical Engineering 2022年第3期35卷 169-176页

作者： Haiyan Jiang lu Bai bingbing Yang Shaojuan Zeng Haifeng Dong Xiangping Zhang CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex SystemsBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516003China

The separation of carbon dioxide(CO_(2))is of great importance for environment protection and gas resource *** ionic liquids(ILs)-based gas separation membrane provides a new chance for efficient CO_(2)separation,while high permeability and selectivity of membranes is a great *** this study,the influence of two protic ILs with different anion([TMGH][Im]and[TMGH][PhO])on the CO_(2)separation performance of the prepared ILs/Pebax blended membranes were systematically investigated at different *** results showed the CO_(2)permeability exhibits the rising trend for ILs/Pebax blended membranes with the increment of IL ***,the[TMGH][Im]with low viscosity and high CO_(2)absorption capacity leads to the blended membranes showing better CO_(2)permeability and ideal CO_(2)selectivity than that of membranes with[TMGH][PhO]at high IL ***,with operating temperature increasing,the gas permeability of 20%(mass)[TMGH][Im]/Pebax blended membrane increases due to the decreasing viscosity of IL and the rising chain mobility of ***,the gas selectivity shows decreasing trend because CO_(2)absorption capacity obviously decreased at higher temperature.

关键词： CO_(2) Protic ionic liquids Membranes Pebax

Multi-key FHE without ciphertext-expansion in two-server model

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Frontiers of Computer Science 2022年第1期16卷 165-172页

作者： bingbing JIANG Department of Computer Science and Technology Nanjing UniversityNanjing210023China

López-Alt et al.(STOC12)put forward a primitive called multi-key fully homomorphic encryption(MKFHE),in which each involved party encrypts their own data using keys that are independently and randomly chosen whereby arbitrary computations can be performed on these encrypted data by a final ***,several superior schemes based on the standard assumption(LWE)were *** of these schemes were constructed by expanding a fresh GSW-ciphertext or BGV-ciphertext under a single key to a new same-type ciphertext of the same message under a combination of associated parties’***,the new ciphertext’s size grew more or less linearly with an increase in the number of *** this paper,we proposed a novel and simple scheme of MKFHE based on LWE without increasing the size of the ciphertext in the two non-collusion server *** other words,each party first independently shares their own data between two servers and each server only needs a one-round communication with another to construct a ciphertext of the same plaintext under a sum of associated parties’*** new ciphertext under multiple keys has the same size as that of the original one with only one-round communication between two *** communication complexity is O(kmlogq)-bit,where k is the number of input ciphertexts involved,m is the size of a GSW-ciphertext and q is a *** conclusion,we proved that our scheme is CPA-secure against semi-honest adversaries.

关键词： multi-key FHE secret sharing secure computation

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支承门式墩施工支架的既有线桥梁可靠性分析

山西建筑 2025年第1期51卷 138-143页

作者：张兵兵中铁十二局集团有限公司山西太原030024

针对支承门式墩施工支架的既有线桥梁可靠性分析研究相对不足的问题,研究结合实际工程实例,建立了一种针对门式墩施工对上跨既有线桥梁进行可靠性分析的计算方法。该方法首先计算初步设计的施工支架对既有桥梁的作用力;然后对既有桥梁... 详细信息

针对支承门式墩施工支架的既有线桥梁可靠性分析研究相对不足的问题,研究结合实际工程实例,建立了一种针对门式墩施工对上跨既有线桥梁进行可靠性分析的计算方法。该方法首先计算初步设计的施工支架对既有桥梁的作用力;然后对既有桥梁进行实体建模分析,主梁采用八节点六面体线性减缩积分单元(C3D8R),预应力筋采用两节点线性三维桁架单元(T3D2),并将预应力钢筋以嵌入(Embed)方式置于混凝土模型内部,网格尺寸设定为1 cm,严格依照图纸进行精细装配;此外,通过模拟降温过程以施加预应力筋的预应力;然后对混凝土的强度、变形以及开裂情况进行可靠性分析。基于分析结果对初步设计的支架结构提供了针对性的改进建议。实际工程应用显示:采用这种方法进行计算,能够切实保证门式墩施工过程的安全性,同时确保既有桥梁在施工阶段的可靠性。

关键词：桥梁工程门式墩施工技术仿真分析上跨既有桥梁

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrendluding male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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吸附剂在低温返修产品中解吸能力的研究

低温与特气 2024年第3期42卷 21-24页

作者：尤振宇雷体平李秀梅陆兵兵南通中集能源装备有限公司江苏南通226300

低温容器使用的分子筛是13X和5A两种分子筛的混合物,它们是低温产品在役期间保证真空质量的重要部件。但吸附剂的吸附是物理吸附,在特定条件下会解吸出原先吸附的气体,从而影响容器的真空度和低温绝热性能,尤其是容器遇到意外情况,导致... 详细信息

低温容器使用的分子筛是13X和5A两种分子筛的混合物,它们是低温产品在役期间保证真空质量的重要部件。但吸附剂的吸附是物理吸附,在特定条件下会解吸出原先吸附的气体,从而影响容器的真空度和低温绝热性能,尤其是容器遇到意外情况,导致真空损失需要返修,如何保证返修后的真空质量,对吸附剂的处理至关重要。在设计工装、模拟真空的条件下,测试不同温度的解吸量,找到合适的处置方案,提高真空效率,为返修产品的真空质量提供有力的保证。

关键词：分子筛解吸性能低温绝热容器真空度

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长臂猿感染H9N2亚型禽流感病毒病例报告

野生动物学报 2024年第4期45卷 873-880页

作者：冯华娟吴俊仪曹佳媛尤宗耀杨露阙腾程黄宁廖小英农汝黄泽琳陆兵兵李宁莉莫亚生南宁市动物园南宁530003 澳门城市大学数据科学学院中国澳门999078 右江民族医学院百色533000 广西壮族自治区陆生野生动物救护研究与疫源疫病监测中心南宁530009 柳州市动物园管理处柳州545005 梧州市动物园梧州543002

2022年1月,某动物园同一馆舍内饲养的6只长臂猿(Nomascus spp.)先后出现流清涕、咳嗽的症状。采集患病长臂猿鼻拭子共6份,利用高通量测序法对样本进行病原筛查,结果显示:2份样本呈AIV阳性,序列组装结果与H9N2亚型禽流感病毒的相似性最高... 详细信息

2022年1月,某动物园同一馆舍内饲养的6只长臂猿(Nomascus spp.)先后出现流清涕、咳嗽的症状。采集患病长臂猿鼻拭子共6份,利用高通量测序法对样本进行病原筛查,结果显示:2份样本呈AIV阳性,序列组装结果与H9N2亚型禽流感病毒的相似性最高;采用qPCR法对2份阳性样本进行H1~H16基因和N1~N9基因检测验证,发现5号样本H9 Ct值为31.35、N2 Ct值为36.16,6号样本H9 Ct值为27.46、N2 Ct值为29.57,均为阳性。给予患病长臂猿化痰止咳、消炎和控制继发感染等综合治疗,同时加强饲养环境消毒,患病长臂猿很快康复。

关键词：长臂猿 H9N2 禽流感病毒高通量测序 qPCR

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