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马克斯·舍勒与王阳明思想中先天的价值与感受

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齐鲁学刊 2021年第4期 14-26页

作者：卢盈华华东师范大学思勉人文高等研究院哲学系上海200241

在以王阳明为代表的儒家心学中,本心既主观又客观,既内在又超越;天理既客观又主观,既超越又内在。牟宗三的阐发亦基于此种理解。为了更好地说明秩序如何内在于个人体验中,有必要参照现象学的洞见。舍勒展示了情感与价值如何是先天的。... 详细信息

在以王阳明为代表的儒家心学中,本心既主观又客观,既内在又超越;天理既客观又主观,既超越又内在。牟宗三的阐发亦基于此种理解。为了更好地说明秩序如何内在于个人体验中,有必要参照现象学的洞见。舍勒展示了情感与价值如何是先天的。价值级序在偏好行为中被给予,而价值呈现于价值级序中,在价值感受中被给予。透过心的本原活动,价值与感受相互预设并建立彼此。由此,有序的感受与无序的感受得到了区分。与舍勒思想类似,儒家心学肯定了这样的意向性结构:一方面是与天理对应的价值观(级序)与精神价值,一方面是与本心良知对应的爱、偏好、价值感受。一些王阳明的术语,如心、意、良知、物,及其与四句教的关联,在此视域启发下,亦将得到更清晰的初步阐明。

关键词：舍勒王阳明价值感受先天

微胶囊固定化培养重组盘基网柄菌提高人类可溶性Fas配体的表达

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高校化学工程学报 2007年第6期21卷 989-996页

作者：徐宝多徐志南何宁王颖陈杰李清彪卢英华厦门大学化学工程与生物工程系福建厦门361005 浙江大学化学工程与生物工程系浙江杭州310027

首先研究了应用于液芯羧甲基纤维素钠-海藻酸钙(CMC-ALG)微胶囊制备中的各种化学组分对重组盘基网柄菌生长的影响,然后考察不同组分浓度制备而成的各种CMC-ALG微胶囊内重组盘基网柄菌的生长情况,从而得到较适的微胶囊制备的组分配比(CMC... 详细信息

首先研究了应用于液芯羧甲基纤维素钠-海藻酸钙(CMC-ALG)微胶囊制备中的各种化学组分对重组盘基网柄菌生长的影响,然后考察不同组分浓度制备而成的各种CMC-ALG微胶囊内重组盘基网柄菌的生长情况,从而得到较适的微胶囊制备的组分配比(CMC12g·L-1,SA8g·L-1,CaCl2100g·L-1)。结果表明,在以上较适条件下制备的微胶囊内重组盘基网柄菌的生长得到了极大的改善,最大的细胞密度比游离培养时提高了4倍,达到了8.0×107mL-1;相应的人类可溶性Fas配体(FasL)的表达水平也提高了1.5倍,达到了315μg·L-1。最后,开展了微胶囊化重组盘基网柄菌的二次重复发酵FasL的研究,结果表明,经过二次重复批次培养,最大细胞密度可达到1.24×108mL-1,为游离培养的8～10倍,而且FasL的表达水平还能维持高水平(280μg·L-1),为游离培养时的2倍。

关键词： CMC-ALG微胶囊微囊化培养盘基网柄菌人类可溶性Fas配体

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时空守恒元解元方法求解模拟移动床数学模型

厦门大学学报（自然科学版） 2012年第6期51卷 1054-1059页

作者：姚传义李青青卢英华厦门大学化学化工学院福建厦门361005

构建了一种简单的时空守恒元解元(CE/SE)方法用于求解模拟移动床色谱模型方程.首先将该方法用于具有分析解的间歇色谱过程,模拟结果表明该方法的计算精度明显优于直线法.然后将其用于模拟果糖葡萄糖分离过程,并与文献中的方法进行了比较... 详细信息

构建了一种简单的时空守恒元解元(CE/SE)方法用于求解模拟移动床色谱模型方程.首先将该方法用于具有分析解的间歇色谱过程,模拟结果表明该方法的计算精度明显优于直线法.然后将其用于模拟果糖葡萄糖分离过程,并与文献中的方法进行了比较,结果显示CE/SE法计算效率优于直线法和小波配置法,并且构建的CE/SE法比文献中CE/SE法具有更高的计算效率和精度.

关键词：时空守恒元解元方法模拟移动床数学模型

Deep insight of unique phase transition behaviors and mechanism in Zr_(2)Co-H isotope system with ultra-low equilibrium pressure

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Rare Metals 2024年第1期43卷 212-224页

作者： Yang Liu Pan-Pan Zhou Xue-Zhang Xiao Jia-Cheng Qi Jia-Peng Bi Tiao ying Xing-Wen Feng Yan Shi Wen-hua luo Li-Xin Chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Institute of Materials China Academy of Engineering PhysicsMianyang 621907China Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Hangzhou 310013China

Efficient capture,safe storage and release of tritium from the international thermonuclear experimental reactor(ITER) reaction exhaust gas is a perplexing problem,and the development of an efficient tritium-getter material with ultra-low hydrogenation equilibrium pressure is considered as a reliable *** this work,Zr_(2)Co alloy was selected as a tritium-getter material and prepared through induction levitation *** performance test results show that Zr_(2)Co exhibits an ultra-low hydrogenation equilibrium pressure of 3.22 × 10^(-6) Pa at 25℃ and excellent hydriding kinetics under a low hydrogen pressure of 0.005 ***,unique phase transition behaviors were presented in Zr_(2)Co-H ***,Zr_(2)CoH_(5) formed by Zr_(2)Co hydrogenated at room temperature is initially decomposed into ZrH_(2) and ZrCoH_(3) at200 ℃.With the temperature increasing to 350 ℃,ZrCoH_(3)is dehydrogenated to ZrCo,and then ZrCo further reacts with ZrH_(2) at 650 ℃ to reform Zr_(2)Co and *** the staged phase transition pathways during dehydrogenation,the decomposition of Zr_(2)CoH_(5) occurs preferentially,which is well accordance with both the smallest reaction energy barrier and the maximum reaction spontaneity that are determined respectively from kinetics activation energy and thermodynamics Gibbs free ***,first principles calculation results indicate that the stronger binding of hydrogen in interstitial environments of ZrCoH_(3)and ZrH_(2) triggers the hydrogen-stabilized phase transformation of Zr_(2)CoH_(5).The unique phase transition mechanisms in Zr_(2)Co-H system can shed light on the further exploration and regulation of analogous staged phase transition of hydrogen storage materials.

关键词： Zr_(2)Co alloy Tritium-getter materials Ultralow equilibrium hydrogen pressure Phase transition mechanism

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen huang Fan-ying Meng Lin-Zhu lu Qian-Qian Guo Chang-Jun Lv Nian-hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

Multidisciplinary management of ulcerative colitis complicated by immune checkpoint inhibitor-associated colitis with life-threatening gastrointestinal hemorrhage:A case report

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2329-2336页

作者： Na Hong Bo Wang Hang-Cheng Zhou Zheng-Xiang Wu hua-ying Fang Geng-Qing Song Yue Yu Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Department of Gastroenterology and Hepatology Metro Health Medical CenterCase Western Reserve UniversityClevelandOH 44109United States

BACKGROUND Programmed cell death 1(PD-1)inhibitors are immune checkpoint inhibitors(ICI)that have demonstrated significant efficacy in treating various advanced malignant *** most patients tolerate treatment well,several adverse drug reactions,such as fatigue,myelosuppression,and ICI-associated colitis,have been *** SUMMARY This case involved a 57-year-old male patient with ulcerative colitis complicated by hepatocarcinoma who underwent treatment with tirelizumab(a PD-1 inhibitor)for six *** treatment led to repeated life-threatening lower gastrointestinal *** patient received infliximab,vedolizumab,and other salvage procedures but ultimately required subtotal colectomy due to uncontrollable massive lower gastrointestinal ***,postoperative gastrointestinal bleeding has stopped,the patient’s stool has turned yellow,and his full blood cell count has returned to *** This case highlights the necessity of early identification,timely and adequate treatment of ICI-related colitis,and rapid escalation to achieve the goal of improving prognosis.

关键词： Ulcerative colitis Hepatocarcinoma Immune checkpoint inhibitor-associated colitis Colectomy Case report

First total synthesis,antitumor evaluation and target identification of mornaphthoate E:A new tubulin inhibitor template acting on PI3K/Akt signaling pathway

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2177-2193页

作者： Peipei Shan Tao Ye ying-De Tang Hui Song Chao Wang Kongkai Zhu Feifei Yang Shi-Lei Zhang Pei-Wen Su Shuanhu Gao hua Zhang Institute of Translational Medicine the Affiliated Hospital of Qingdao UniversityCollege of MedicineQingdao UniversityQingdao 266021China School of Biological Science and Technology University of JinanJinan 250022China Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinan 250012China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215127China School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China

Mornaphthoate E(MPE)is a prenylated naphthoic acid methyl ester isolated from the roots of a famous Chinese medicinal plant Morinda officinalis and shows remarkable cytotoxicity against several human tumor cell *** the current project,the first total synthesis of(±)-MPE was achieved in seven steps and 5.6%overall *** the in vitro anti-tumor activity of MPE was first assessed for both enantiomers in two breast cancer cells,with the levoisomer exerting slightly better *** in vivo anti-tumor effect was further verified by applying the racemate in an orthotopic autograft mouse ***,MPE exerted promising anti-metastasis activity both in vitro and in vivo and showed no obvious toxicity on mice at the therapeutic *** investigations demonstrated that MPE acted as a tubulin polymerization stabilizer and disturbed the dynamic equilibrium of microtubules via regulating PI3K/Akt *** conclusion,our work has provided a new chemical template for the future design and development of next-generation tubulin-targeting chemotherapies.

关键词： Mornaphthoate E Tubulin inhibitor Antitumor Anti-metastasis Breast cancer PI3K/Akt

人胰岛素原密码子的优化及其在毕赤酵母中的表达

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厦门大学学报（自然科学版） 2012年第1期51卷 101-106页

作者：史莹飞敬科举凌雪萍卢英华厦门大学化学化工学院福建厦门361005

依据毕赤酵母偏好密码子,设计合成长效人胰岛素原(human proinsulin,HPI)基因序列,所合成的HPI基因全长为200bp,并在其N端添加信号肽(EEAEAEAEPK)以提高目的蛋白表达.将改造后基因克隆到pPIC9K载体中,构建分泌表达型载体pPIC9K-HPI,转... 详细信息

依据毕赤酵母偏好密码子,设计合成长效人胰岛素原(human proinsulin,HPI)基因序列,所合成的HPI基因全长为200bp,并在其N端添加信号肽(EEAEAEAEPK)以提高目的蛋白表达.将改造后基因克隆到pPIC9K载体中,构建分泌表达型载体pPIC9K-HPI,转化到毕赤酵母(Pichia pastoris)GS115中.用遗传霉素G418梯度筛选获得高拷贝菌株,在甲醇诱导下表达分子质量为7.87ku的HPI,利用金属螯合层析纯化蛋白质,胰蛋白酶酶切后利用人胰岛素试剂盒测得生物活性,HPI摇瓶最高产量可达35.4mg/L.该研究为获得大量长效胰岛素基因工程产品奠定研究基础.

关键词：胰岛素原基因改造高拷贝毕赤酵母

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“冶容诲淫”之逻辑分析

阿坝师范高等专科学校学报 2008年第3期25卷 83-86页

作者：卢盈华郑州大学公共管理学院河南郑州450000

"冶容诲淫"语出《周易.系辞上》。如今许多人认为古训已丧失其作用,女性尤其认为"冶容诲淫"不合情理,为自己妖媚之装扮寻求理论支撑。不通逻辑者,但凭直觉之聪明,觉此命题为谬论;通逻辑者,又误解了命题本义。本文以事实依据及人性分析... 详细信息

"冶容诲淫"语出《周易.系辞上》。如今许多人认为古训已丧失其作用,女性尤其认为"冶容诲淫"不合情理,为自己妖媚之装扮寻求理论支撑。不通逻辑者,但凭直觉之聪明,觉此命题为谬论;通逻辑者,又误解了命题本义。本文以事实依据及人性分析为基础,从逻辑学以及伦理学的角度论证这句古训的合理性与合情性。

关键词：冶容诲淫欲望人性