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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1479-1499页

作者： Xuan-Zeng Pei min Cai Da-Wei Jiang Song-Hai Chen Qing-Qing Wang Hui-min lu Yi-Fan lu Department of Hepatological Surgery The First Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Our study investigated the role of FAM53B in regulating macrophage M2 polarization and its potential mechanisms in promoting pancreatic ductal adenocarcinoma(PDAC)*** To further investigate the role of FAM53B in regulating macrophage M2 polarization and its potential mechanism in promoting PDAC *** goal is to determine how FAM53B affects macrophage M2 polarization and to define its underlying mechanism in PDAC *** Cell culture and various experiments,including protein analysis,immunohisto-chemistry,and animal model experiments,were *** compared FAM53B expression between PDAC tissues and healthy tissues and assessed the correlation of FAM53B expression with clinical *** study analyzed the role of FAM53B in macrophage M2 polarization in vitro by examining the expression of relevant ***,we used a murine model to study the role of FAM53B in PDAC metastasis and analyzed the potential underlying *** Our research showed that there was a significant increase in FAM53B levels in PDAC tissues,which was linked to adverse tumor *** findings indicated that FAM53B can enhance macrophage M2 polarization,leading to increased anti-inflammatory factor *** results from the mouse model further supported the role of FAM53B in PDAC metastasis,as blocking FAM53B prevented tumor cell invasion and *** FAM53B promotes PDAC metastasis by regulating macrophage M2 *** discovery could lead to the development of new strategies for treating *** example,interfering with the FAM53B signaling pathway may prevent cancer *** research findings also provide important information for expanding our understanding of PDAC pathogenesis.

关键词： FAM53B Pancreatic ductal adenocarcinoma Tumor metastasis Macrophage polarization

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Efficacy and safety of Yiqi Peiyuan granules for improving the short-term prognosis of patients with acute kidney injury:A multicenter,double-blind,placebo-controlled,randomized trial

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Journal of Integrative Medicine 2024年第3期22卷 279-285页

作者： Jia-jia Wu Tian-yi Zhang Ying-hui Qi min-yan Zhu Yan Fang Chao-jun Qi Li-ou Cao Ji-fang lu Bo-han lu lu-min Tang Jian-xiao Shen Shan Mou Department of Nephrology Molecular Cell Lab for Kidney DiseaseShanghai Peritoneal Dialysis Research CenterUremia Diagnosis and Treatment CenterRenji Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200127China Department of Nephrology Shanghai Pudong New Area Punan HospitalShanghai 200125China Department of Nephrology Ningbo Hangzhou Bay HospitalNingbo 315336Zhejiang ProvinceChina

Background:Yiqi Peiyuan(YQPY)prescription,a composite prescription of traditional Chinese medicine,has been used to prevent or delay the continued deterioration of renal function after acute kidney injury(AKI)in some institutions and has shown considerable ***:This is the first randomized controlled trial to assess efficacy and safety of YQPY for improving short-term prognosis in adult patients with ***,setting,participants and interventions:This is a prospective,double-blind,multicenter,randomized,and placebo-controlled clinical trial.A total of 144 enrolled participants were randomly allocated to two groups according to a randomization ***,caregivers and investigators assessing the outcomes were blinded to group *** in the YQPY group received 36 g YQPY granules twice a day for 28 *** in the placebo group received a placebo in the same dose as the YQPY *** outcome measures:The primary outcome was the change in the estimated glomerular filtration rate(eGFR)between baseline and after 4 and 24 weeks of *** secondary outcomes were the change of serum creatinine(Scr)level between baseline and after treatment,and the incidence of endpoint events,defined as eGFR increasing by more than 25%above baseline,eGFR>75 mL/min per1.73 m2or the composite endpoint,which was defined as the sum of patients meeting either of the above ***:Data from a total of 114 patients(59 in the YQPY group and 55 in the control group)were *** mean changes in eGFR and Scr in weeks 4 and 24 had no difference between the two *** further subgroup analysis(22 in the YQPY group and 31 in the control group),the mean change in eGFR after treatment for 4 weeks was 27.39 mL/min per 1.73 m2in the YQPY group and 5.78 mL/min per1.73 m2in the placebo group,and the mean difference between groups was 21.61 mL/min per 1.73 m2(P<0.001).Thirteen(59.1%)patients in the YQPY group and 5(16.1%)in the placebo g

关键词： Chinese herbal medicine Randomized controlled trial Acute kidney injury Renal function

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Different timing for abdominal paracentesis catheter placement and drainage in severe acute pancreatitis complicated by intraabdominal fluid accumulation

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 134-142页

作者： Rui Chen Hua-Qiang Chen Rui-Die Li Hui-min lu Department of General Surgery Chengdu Sixth People’s HospitalChengdu 610058Sichuan ProvinceChina West China Center of Exellence for Pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest ChinaDivision of Pancreatic SurgeryDepartment of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina HospitalSichuan University

BACKGROUND Non-surgical methods such as percutaneous drainage are crucial for the treatment of patients with severe acute pancreatitis(SAP).However,there is still an ongoing debate regarding the optimal timing for abdominal paracentesis catheter place-ment and *** To explore the influence of different timing for abdominal paracentesis catheter placement and drainage in SAP complicated by intra-abdominal fluid *** Using a retrospective approach,184 cases of SAP complicated by intra-abdominal fluid accumulation were enrolled and categorized into three groups based on the timing of catheter placement:group A(catheter placement within 2 d of symptom onset,n=89),group B(catheter placement between days 3 and 5 after symptom onset,n=55),and group C(catheter placement between days 6 and 7 after symptom onset,n=40).The differences in progression rate,mortality rate,and the number of cases with organ dysfunction were compared among the three *** The progression rate of group A was significantly lower than those in groups B and groups C(2.25%vs 21.82%and 32.50%,P0.05).At postoperative day 3,the levels of C-reactive protein(55.41±19.32 mg/L vs 82.25±20.41 mg/L and 88.65±19.14 mg/L,P<0.05),procalcitonin(1.36±0.51 ng/mL vs 3.20±0.97 ng/mL and 3.41±0.98 ng/mL,P<0.05),tumor necrosis factor-alpha(15.12±6.63 pg/L vs 22.26±9.96 pg/L and 23.39±9.12 pg/L,P<0.05),interleukin-6(332.14±90.16 ng/L vs 412.20±88.50 ng/L and 420.08±87.65ng/L,P<0.05),interleukin-8(415.54±68.43 ng/L vs 505.80±66.90 ng/L and 510.43±68.23ng/L,P<0.05)and serum amyloid A(270.06±78.49 mg/L vs 344.41±81.96 mg/L and 350.60±80.42 mg/L,P<0.05)were significantly lower in group A compared to those in groups B and group *** length of hospit

关键词： Abdominal paracentesis catheter drainage Timing Severe acute pancreatitis Intra-abdominal fluid Application value

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Brightening heavily doped upconversion nanoparticles by tuning characteristics of core-shell structures

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Journal of Rare Earths 2024年第5期42卷 947-954,I0005页

作者： Yangyang Niu Zhihao Bao Yuqin Gao Mengchao Guo Jingyao Liu Jinjun Shao min lu Ze Yuan Xiaoji Xie School of Flexible Electronics(Future Technologies)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing211816China

Heavily doped upconversion nanoparticles(UCNPs)potentially have exceptional photon upconversion abilities that are promising for diverse applications,such as lasing and super-resolution ***,heavily doped UCNPs typically can only offer mediocre upconversion luminescence intensity,and there still lacks general guidelines for the design and synthesis of heavily doped ***,in order to boost the upconversion luminescence of heavily doped UCNPs,we studied the influence of characteristics of the core-shell structure on heavily doped UCNPs'upconversion *** find that some empirical guidelines derived from conventional UCNPs are not suitable for heavily doped *** NaYbF_(4):Tm@NaYF_(4) core-shell UCNPs with a high concentration of Yb_(3+)as a representative,our studies reveal that a rather thick inert NaYF4 shell is needed to protect the UCNPs from surface quenching,and the upconversion luminescence may undergo the cooperative sensitization process,which should be due to the highly concentrated Yb~(3+)*** addition,the upconversion luminescence of heavily doped NaYbF4:Tm UCNPs exhibits no obvious dependence on the type of inert ***,our results show that confining both Yb~(3+)and Tm~(3+)dopants in a thin layer(known as theδ-doping strategy)does not work well in the heavily doped ***,we propose a NaYbF_(4):Tm@NaYbF_(4)@NaYF_(4) core-shell-shell structure to enhance the luminescence of heavily doped UCNPs,by weakening the dissipation of excitation energy and strengthening the *** findings should be helpful to establish general design principles for developing the brightest possible UCNPs that can meet the requirements of various applications.

关键词： luminescence Upconversion Nanomaterials Rare earths Lanthanide doping

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Sarcopenia adversely impacts clinical outcomes in patients undergoing pancreaticoduodenectomy: A systematic review and meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1857-1870页

作者： Qi-Hui Zhang Jin-Dong Ma Yan-min lu Run-Nan Zhang Zhong-Hua Zhao Ya-Tong Li Qiang-Pu Chen Department of Clinical Nutrition Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina

BACKGROUND Sarcopenia is a syndrome marked by a gradual and widespread reduction in skeletal muscle mass and strength,as well as a decline in functional ability,which is associated with malnutrition,hormonal changes,chronic inflammation,distur-bance of intestinal flora,and exercise *** is a com-monly employed clinical intervention for conditions such as pancreatic head cancer,ampulla of Vater cancer,and cholangiocarcinoma,among others,with a notably high rate of postoperative *** is frequent in patients undergoing ***,data regarding the effects of sarcopenia in patients undergoing pancreaticoduodenectomy(PD)are both limited and *** PubMed,Cochrane Library,Web of Science,and Embase databases were screened for studies published from the time of database inception to June 2023 that described the effects of sarcopenia on the outcomes and complications of *** researchers independently assessed the quality of the data extracted from the studies that met the inclusion ***-analysis using RevMan 5.3.5 and Stata 14.0 software was *** and funnel plots were used,respectively,to demonstrate the outcomes of the sarcopenia group vs the non-sarcopenia group after PD and to evaluate potential publication *** Sixteen studies encompassing 2381 patients were included in the *** patients in the sarcopenia group(n=833)had higher overall postoperative complication rates[odds ratio(OR)=3.42,95%confidence interval(CI):1.95-5.99,P<0.0001],higher Clavien-Dindo class≥III major complication rates(OR=1.41,95%CI:1.04-1.90,P=0.03),higher bacteremia rates(OR=4.46,95%CI:1.42-13.98,P=0.01),higher pneumonia rates(OR=2.10,95%CI:1.34-3.27,P=0.001),higher pancreatic fistula rates(OR=1.42,95%CI:1.12-1.79,P=0.003),longer hospital stays(OR=2.86,95%CI:0.44-5.28,P=0.02),higher mortality rates(OR=3.17,95%CI:1.55-6.50,P=0.002),and worse overall survival(hazard ratio=2.81,95%CI:1

关键词： Pancreaticoduodenectomy Sarcopenia Postoperative complications Length of stay Meta-analysis

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最后,还是要看到那一张面孔

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当代作家评论 2024年第3期 6-8页

作者：鲁敏江苏省作家协会

写小说年头不算少了,仍觉结结巴巴,冷暖难以自知。想到总是被人问“怎么想起作这样一个小说的”,觉得稍微能说两句的,还是小说如何发生,即俗谓之且也被大家写得越来越流利的“创作谈”。或者,这勉强也能归到写作发生学中去。当然,写作... 详细信息

写小说年头不算少了,仍觉结结巴巴,冷暖难以自知。想到总是被人问“怎么想起作这样一个小说的”,觉得稍微能说两句的,还是小说如何发生,即俗谓之且也被大家写得越来越流利的“创作谈”。或者,这勉强也能归到写作发生学中去。当然,写作发生是复杂的偶然与裂变,跟所处意识形态、社会生产关系,包括行业机制、资本市场、技术进步、传播方式等也有巨大关联。这些关联可能是决定性和推动性的,还可能是反噬性的,是与逻辑理性相关的,也可能是弹性游离乃至乱麻缠绕的,等等。这里都搁置不谈,只试着从一个写作者角度,并假定是处于一种相对纯粹状态的虚构者,他或她,如何从手执空白纸片的此处出发,抵达那栩栩如生的彼岸。

关键词：社会生产关系逻辑理性创作谈传播方式发生学意识形态写作者

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Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer:a clinical and translational study

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Frontiers of Medicine 2024年第2期18卷 357-374页

作者： Haoyu Wang Zhengyuan Wang Zheng Wang Xiaoyang Li Yuntong Li Ni Yan Lili Wu Ying Liang Jiale Wu Huaxin Song Qing Qu Jiahui Huang Chunkang Chang Kunwei Shen Xiaosong Chen min lu Department of General Surgery Comprehensive Breast Health CenterRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine(Shanghai)Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Hematology Shanghai Institute of HematologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Hematology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200025China

p53 is mutated in half of cancer ***,no p53-targeting drugs have been ***,we reposition decitabine for triple-negative breast cancer(TNBC),a subtype with frequent p53 mutations and extremely poor *** a retrospective study on tissue microarrays with 132 TNBC cases,DNMT1 overexpression was associated with p53 mutations(P=0.037)and poor overall survival(OS)(P=0.010).In a prospective DEciTabinE and Carboplatin in TNBC(DETECT)trial(NCT03295552),decitabine with carboplatin produced an objective response rate(ORR)of 42%in 12 patients with stage IV *** the 9 trialed patients with available TP53 sequencing results,the 6 patients with p53 mutations had higher ORR(3/6 vs.0/3)and better OS(16.0 vs.4.0 months)than the patients with wild-type *** a mechanistic study,isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type *** the DETECT trial,decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line(upregulation by 16-fold)and the most responsive patient with *** integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

关键词： p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response

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结合图对比学习的多图神经网络会话推荐方法

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计算机科学 2024年第5期51卷 54-61页

作者：卢敏原子婷中国民航大学计算机科学与技术学院天津300300 智慧机场理论与系统民航局重点实验室天津300300

会话推荐根据匿名用户短期内的交互数据预测下一个交互物品。针对会话中物品少、物品长尾分布等特性,现有基于图对比学习的会话推荐模型提出对会话内物品采用随机裁剪、扰动等方式构造正负样本。然而,上述随机退出策略进一步缩减较短会... 详细信息

会话推荐根据匿名用户短期内的交互数据预测下一个交互物品。针对会话中物品少、物品长尾分布等特性,现有基于图对比学习的会话推荐模型提出对会话内物品采用随机裁剪、扰动等方式构造正负样本。然而,上述随机退出策略进一步缩减较短会话中的可用物品,使得会话更加稀疏,引起会话兴趣学习偏差。为此,提出了结合图对比学习的多图神经网络会话推荐方法。其核心思想是:在物品局部图、物品全局图等上提取融入物品局部和全局的高阶邻域物品表示,并生成物品级的会话表示,然后设计会话-会话图并学习会话级的会话表示,最后递归利用不同级别会话兴趣生成正负样本对,通过对比学习机制增强会话兴趣区分性。与退出策略相比,所提模型保留了完整的会话信息,实现了真正的数据扩充。在两个基准数据集上进行了大量实验,结果表明,该算法的推荐性能远优于主流基线方法。

关键词：会话推荐图对比学习图神经网络会话兴趣正负样本

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金融强国与金融新质生产力:构建以数智化驱动的金融高质量发展新生态

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中国流通经济 2024年第5期38卷 18-27页

作者：陆岷峰南京工业大学互联网金融创新发展研究中心江苏南京210041

在数字化时代背景下,金融强国的构建与金融新质生产力的提升紧密相连,关键在于构建以数智化为驱动的金融高质量发展新生态。通过深入分析相关文献,揭示数智化、金融新质生产力、金融业发展及金融强国之间的内在联系,强调数智化技术在金... 详细信息

在数字化时代背景下,金融强国的构建与金融新质生产力的提升紧密相连,关键在于构建以数智化为驱动的金融高质量发展新生态。通过深入分析相关文献,揭示数智化、金融新质生产力、金融业发展及金融强国之间的内在联系,强调数智化技术在金融领域应用的重要性,为金融行业转型升级提供理论支持和实践指导。当前,金融行业面临前所未有的机遇与挑战,数智化不仅推动了金融服务的智能化、创新化,还促进了金融行业的可持续发展。在构建金融高质量发展新生态的过程中,数智化技术的应用提高了金融服务效率,增强了金融产品的创新能力,优化了风险管理和决策过程,同时为金融科技生态的构建提供了强大动力。要实现金融高质量发展,必须依托数智化技术,重点在于数据驱动的决策、智能化服务体验、金融产品和业务模式的创新以及风险管理与监控的优化。此外,构建数智化驱动的金融高质量发展新生态还需采取一系列策略和措施,包括加强数智化技术投入、保障数据安全、推动金融科技创新、促进行业合作、加强监管规范以及提升金融人才素质等。通过构建以数智化驱动的金融高质量发展新生态,可以有效促进金融强国建设和金融新质生产力的提升,为实现金融行业的智能化、创新化和可持续发展奠定坚实基础。未来的研究与实践应进一步深化对数智化技术与金融业发展关系的认识,不断优化金融发展生态,推动金融行业向更高质量、更高水平的发展迈进。

关键词：金融强国数智化金融新质生产力金融业发展新生态构建

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西方女性主义思潮在中国的流变与影响

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山东女子学院学报 2024年第2期 36-43页

作者：卢敏武汉大学马克思主义学院湖北武汉430072

西方女性主义思潮与女权运动相伴相生,是历史发展的产物,一定程度上反映了西方资产阶级对社会进步和性别平等的推动。同时,这种进步和平等是有限度的,重点突出和维护部分西方女性的利益,具有强调西方女性经验的形而上学性,并表现出非同... 详细信息

西方女性主义思潮与女权运动相伴相生,是历史发展的产物,一定程度上反映了西方资产阶级对社会进步和性别平等的推动。同时,这种进步和平等是有限度的,重点突出和维护部分西方女性的利益,具有强调西方女性经验的形而上学性,并表现出非同一般的依附性。20世纪80年代以来,全球化浪潮推动西方女性主义思潮在中国广泛传播、演变,对我国社会产生了双重影响。在我国全面推进中国式现代化道路上,坚持和发展中国特色社会主义妇女理论与实践,必须积极扬弃西方女性主义理论,通过落实国家制度、牢牢掌握舆论主动权和主导权、加强女性学研究、提升女性主体意识等促进性别平等,保障社会主义妇女事业行稳致远,为推动社会关系和谐发展乃至每个人的自由全面发展创造条件。

关键词：西方女性主义思潮社会影响性别平等妇女解放

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