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Clinical analysis of multiple primary gastrointestinal malignant tumors:A 10-year case review of a single-center

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1204-1212页

作者： Cheng-lou Zhu ling-Zhi Peng The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Multiple primary malignant tumors(MPMTs)was first described by Billroth as early as 1889,with the first report published by Warren and Gates in *** then,numerous cases have been reported.A literature review of 1104269 patients with cancer revealed that the incidence of MPMTs ranged from 0.73 to 11.7%.In recent years,however,there has been a significant upward trend in the incidence of this phenomenon,which may be associated with many different factors,including the advancement of modern diagnostic procedures facilitating the examination and diagnosis of more MPMTs,increased exposure to chemotherapy and radiotherapy that exacerbate the risk of new malignant tumors in patients with cancer,and prolonged survival of patients with cancer allowing sufficient time for the development of new primary *** To analyze the incidence,clinical features,treatment factors,prevalence,and prognosis of patients with MPMTs in the gastrointestinal tract treated in a single ***,we analyzed the different tumor combinations,time interval between the occurrence of tumors,and *** This retrospective cohort study analyzed 8059 patients with pathologically confirmed gastrointestinal malignant tumors treated at the Gansu Province Hospital in Lanzhou,Gansu,China between June 2011 and June *** these,85 patients had *** clinical features,treatment factors,prevalence,and prognosis of this latter cohort were *** The incidence of MPMTs in patients with gastrointestinal malignant tumors was 1.05%(85/8059),including 83 double primary malignant tumors and two triple primary malignant tumors of which 57(67.06%)were synchronous MPMTs(SMPMTs)and 28(32.94%)were metachronous MPMTs(MMPMTs).The most frequent associations were found between the rectum colon cancers within the SMPMT category and the gastric-colon cancers within the MMPMT *** the MMPMTs,the median interval was 53 *** overall 1-,3-and 5-year survival rates f

关键词： Multiple primary malignant tumors Clinical characteristics Gastrointestinal tract Prognosis Epidemiology

Nickel Sulfide Modified NiCu Nanoalloy with Excellent Oxygen Evolution Reaction Properties Prepared through Electrospinning and Heat Treatment

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 320-326页

作者：李涛凌帅 ZHONG Shujie lou Qiongyue Department of Materials Engineering School of Mechanical EngineeringChengdu UniversityChengdu 610106China

Ni^(2+)/Cu^(2+)/SO_(4)^(2-)/polyvinyl alcohol precursor fibers with uniform diameters were prepared through ***-based composite nanoalloys containing Ni,Cu,and S were prepared through heat treatment in an Ar *** experimental results show that the main components of the prepared nanoalloys are NiCu,Ni_(3)S_(2),Ni,and *** nanoalloys exhibit fine grain sizes about 200-500 nm,which can increase with increasing heat treatment *** test results show that the nickel sulfidemodified NiCu nanoalloy composites exhibit excellent oxygen evolution reaction properties,and the oxygen evolution reaction properties gradually improve with the increasing heat treatment *** sample prepared at 1 000℃ for 40 min show a low overpotential of 423 mV and a small Tafel slope of 134 mV·dec^(-1) at a current density of 10 mA·cm^(-2).

关键词： NiCu nanoalloy Ni_(3)S_(2) structure transformation oxygen evolution reaction

Digital signal acquisition system for complex nuclear reaction experiments

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Nuclear Science and Techniques 2024年第1期35卷 124-133页

作者： Wei-Liang Pu Yan-Lin Ye Jian-ling lou Jia-Hao Chen School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100094China

A digital data-acquisition system based on XIA LLC products was used in a complex nuclear reaction experiment using radioactive ion beams.A flexible trigger system based on a field-programmable gate array(FPGA)parametrization was developed to adapt to different experimental sizes.A user-friendly interface was implemented,which allows converting script language expressions into FPGA internal control *** proposed digital system can be combined with a conventional analog data acquisition system to provide more *** performance of the combined system was veri-fied using experimental data.

关键词： Digital signal acquisition system Trigger Programmable logic Timestamp

Pharmacotherapy of urethral stricture

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Asian Journal of Andrology 2024年第1期26卷 1-9页

作者： Hui Luo Ke-Cheng lou ling-Yu Xie Fei Zeng Jun-Rong Zou The First Clinical College Gannan Medical UniversityGanzhou 341000China Department of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Jiangxi Engineering Technology Research Center of Calculi Prevention Ganzhou 341000China

Urethral stricture is characterized by the chronic formation of fibrous tissue,leading to the narrowing of the urethral *** the availability of various endoscopic treatments,the recurrence of urethral strictures remains a common *** pharmacotherapy targeting tissue fibrosis is a promising option for reducing recurrence *** drugs cannot replace surgery,they can be used as adjuvant therapies to improve *** this regard,many drugs have been proposed based on the mechanisms underlying the pathophysiology of urethral *** studies have obtained substantial progress in treating urethral strictures,highlighting the potential for improved drug effectiveness through appropriate clinical delivery ***,this review summarizes the latest researches on the mechanisms related to the pathophysiology of urethral stricture and the drugs to provide a theoretical basis and new insights for the effective use and future advancements in drug therapy for urethral stricture.

关键词： adjuvant therapy pathophysiology pharmacotherapy urethra urethral stricture

Ren-integrable and ren-symmetric integrable systems

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Communications in Theoretical Physics 2024年第3期76卷 62-69页

作者： S Y lou School of Physical Science and Technology Ningbo UniversityNingbo315211China

A new type of symmetry,ren-symmetry,describing anyon physics and corresponding topological physics,is ***-symmetry is a generalization of super-symmetry which is widely applied in super-symmetric physics such as super-symmetric quantum mechanics,super-symmetric gravity,super-symmetric string theory,super-symmetric integrable systems and so *** and Grassmann numbers are,in some sense,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-symmetry are exposed which allow one to derive,in principle,some new types of integrable systems including ren-integrable models and ren-symmetric integrable *** examples of ren-integrable KdV-type systems and ren-symmetric KdV equations are explicitly given.

关键词： symmetries integrable systems anyon physics extended supersymmetry ren-symmetry

Metal-Organic Framework Nanozyme Enabling Dual-Functional Photo-lnduced Charge Transfer and Biomimetic Precipitation for Advanced Organic Photoelectrochemical Transistor Bioanalysis

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Chinese Journal of Chemistry 2024年第17期42卷 1999-2004页

作者： Ke-Xin Xu Cheng Yuan Hao lou Feng-Zao Chen ling Zhang Guangxu Chen De-Man Han Wei-Wei Zhao state Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210023China School of Pharmaceutical and Chemical Engineering Taizhou UniversityTaizhouJjiangsu 318000China School of Environment and Energy State Key Laboratory of Luminescent Materials and DevicesGuangdong Provincial Key Laboratory of Atmospheric Environment and Pollution ControlSouth China University of TechnologyGuangzhouGuangdong 510006China

We report herein the first observation of MoF nanozyme enabling dual-functional photo-induced charge transfer and biomimetic precipitation for advanced organic photoelectrochemical transistor(OPECT)***,Fe/Co-MIL-88,serving simultaneously as the semiconductor and nanozyme,was explored as a dual-functional gating module in *** light llumination,it could accelerate the charge transfer of the photogate to produce enhanced photo-induced ***,its catalytic property could efficiently produce biomimetic precipitation to block the nanopores in Fe/Co-MIL-88 and thus alter the device characteristics.

关键词： Metal-organic frameworks Nanozymes Organic transistor Photoelectrochemical Biosensing Electrodes

A flexible,modular and versatile functional part assembly toolkit for gene cluster engineering in Streptomyces

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Synthetic and Systems Biotechnology 2024年第1期9卷 69-77页

作者： Xuejin Zhao Yeqing Zong Qiuli lou Chenrui Qin Chunbo lou CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Center for Cell and Gene Circuit Design Key Laboratory of Quantitative Synthetic BiologyShenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences1068 Xueyuan AvenueUniversity TownNanshanShenzhen518055China Peking-Tsinghua Joint Center for Life Sciences Peking UniversityBeijing100871China Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesSchool of PhysicsPeking UniversityBeijing100871China College of Life Sciences University of Chinese Academy of SciencesBeijing100149China

Streptomyces has enormous potential to produce novel natural products(NPs)as it harbors a huge reservoir of uncharacterized and silent natural product biosynthetic gene clusters(BGCs).However,the lack of efficient gene cluster engineering strategies has hampered the pace of new drug ***,we developed an easy-to-use,highly flexible DNA assembly toolkit for gene cluster *** DNA assembly toolkit is compatible with various DNA assembling approaches including Biobrick,Golden Gate,CATCH,yeast homologous recombination-based DNA assembly and homing endonuclease-mediated *** compatibility offers great flexibility in handling multiple genetic parts or refactoring large gene *** demonstrate the utility of this toolkit,we quantified a library of modular regulatory parts,and engineered a gene cluster(act)using characterized promoters that led to increased ***,this work provides a powerful part assembly toolkit that can be used for natural product discovery and optimization in Streptomyces.

关键词： Streptomyces Standard toolkit DNA assembly Gene cluster Synthetic biology

Decomposition solutions and Bäcklund transformations of the B-type and C-type Kadomtsev-Petviashvili equations

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Communications in Theoretical Physics 2024年第6期76卷 34-44页

作者： Xiazhi Hao S Y lou College of Science Zhejiang University of TechnologyHangzhou 310014China School of Physical Science and Technology Ningbo UniversityNingbo 315211China

This paper introduces a modified formal variable separation approach,showcasing a systematic and notably straightforward methodology for analyzing the B-type Kadomtsev-Petviashvili(BKP)*** the application of this approach,we successfully ascertain decomposition solutions,Bäcklund transformations,the Lax pair,and the linear superposition solution associated with the aforementioned ***,we expand the utilization of this technique to the C-type Kadomtsev-Petviashvili(CKP)equation,leading to the derivation of decomposition solutions,Bäcklund transformations,and the Lax pair specific to this *** results obtained not only underscore the efficacy of the proposed approach,but also highlight its potential in offering a profound comprehension of integrable behaviors in nonlinear ***,this approach demonstrates an efficient framework for establishing interrelations between diverse systems.

关键词： decomposition solution Backlund transformation Lax pair linear superposition solution

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TAB OLB工艺在LCM制造中的应用

现代显示 2005年第4期 53-56页

作者：娄双玲电子科技大学光电信息学院502教研室四川成都610054

本文介绍了TAB器件及其制造工艺,通过讲述ACF特性,细致地阐述了TAB OLB的工艺原理及参数设定方法,并对工艺中容易出现的不良现象进行了分析。

关键词：液晶生产带载封装异向性导电薄膜