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Neutrophil extracellular traps mediate neuro-immunothrombosis

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Neural Regeneration Research 2024年第8期19卷 1734-1740页

作者： Jianbo lou Jianning Zhang Quanjun Deng Xin Chen Department of Neurosurgery Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institute Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjinChina

Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammato ry *** extracellular trap formation occurs through lytic and non-lytic pathways that can be further classified by formation ***,von Willebrand factor,fibrin,and many other factors participate in the interplay between inflammation and *** summarizes the intricate interplay between inflammation and thrombosis during neural development and the pathogenesis of neurological diseases,providing cutting-edge insights into post-neurotrauma thrombotic *** blood-brain barrier defends the brain and spinal cord against external assaults,and neutrophil extracellular trap involvement in blood-brain barrier disruption and immunothrombosis contributes substantially to secondary injuries in neurological *** research is needed to understand how neutrophil extracellular traps promote blood-brain barrier disruption and immunothrombosis,but recent studies have demonstrated that neutrophil extracellular traps play a crucial role in immunothrombosis,and identified modulators of ***,these neurological diseases occur in blood vessels,and the mechanisms are unclear by which neutrophil extracellular traps penetrate the blood-brain barrier to participate in immunothrombosis in traumatic brain *** review discusses the role of neutrophil extracellular traps in neuro-immunothrombosis and explores potential therapeutic interventions to modulate neutrophil extracellular traps that may reduce immunothrombosis and improve traumatic brain injury outcomes.

关键词： inflammation neuro-immunothrombosis neurologic diseases neurotrauma neutrophil extracellular traps platelet thrombosis traumatic brain injury

Effect of catalyst diesel particulate filter aging and catalyst loadings on particulate emission characteristics from a diesel vehicle

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Journal of Environmental Sciences 2024年第2期136卷 35-44页

作者： Yunhua Zhang Diming lou Piqiang Tan Zhiyuan Hu Liang Fang School of Automotive Studies Tongji UniversityShanghai 201804China

In this study,the effect of new and used catalyzed diesel particulate filter(CDPF)with different catalyst loadings on the particulate emissions including the particle mass(PM),particle number(PN),particle size distribution(PSD)and geometric mean diameter(GMD)from a diesel vehicle were investigated based on a heavy chassis *** showed that more than 97.9%of the PN and 95.4%of the PM were reduced by the CDPF,and the reduction efficiency was enhanced by the catalyst *** using the CDPF,the PSD transformed from bimodal to trimodal with the peak shifting towards smaller particle size,more nucleation mode particles were reduced compared with accumulation mode ones,but the reduction effect on the accumulation mode particles was more significantly influenced by the catalyst ***,the CDPF increased the accumulation mode particles proportion,producing a larger *** the used CDPF,its reduction effect on the particulate emissions enhanced,especially for the PM in accumulation *** PSD returned to bimodal,but the peak at accumulation mode began to be higher than that at nucleation mode,illustrating that more nucleation mode particles was *** aging of the CDPF resulted in greater effect on the PN-based PSD than that of PM-based PSD,but the effect of catalyst loading on the PN and PM emission factors was *** used CDPF further increased the GMD,and the effect of catalyst loading on the GMD was strengthened,a higher catalyst loading led to a reduction in the GMD.

关键词： Catalyzed diesel particulate filter (CDPF) Catalyst loading Aging Particle Particle size distribution Geometric mean diameter

Stability analysis of a liquid crystal elastomer self-oscillator under a linear temperature field

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 337-354页

作者： Haiyang WU Jiangfeng lou Biao ZHANG Yuntong DAI Kai LI School of Civil Engineering Anhui Jianzhu UniversityHefei 230601China

Self-oscillating systems abound in the natural world and offer substantial potential for applications in controllers,micro-motors,medical equipments,and so ***,numerical methods have been widely utilized for obtaining the characteristics of self-oscillation including amplitude and ***,numerical methods are burdened by intricate computations and limited precision,hindering comprehensive investigations into self-oscillating *** this paper,the stability of a liquid crystal elastomer fiber self-oscillating system under a linear temperature field is studied,and analytical solutions for the amplitude and frequency are ***,we establish the governing equations of self-oscillation,elucidate two motion regimes,and reveal the underlying ***,we conduct a stability analysis and employ a multi-scale method to obtain the analytical solutions for the amplitude and *** results show agreement between the multi-scale and numerical *** research contributes to the examination of diverse self-oscillating systems and advances the theoretical analysis of self-oscillating systems rooted in active materials.

关键词： self-oscillation stability analysis multi-scale method liquid crystal elastomer linear temperature field

Clinical analysis of multiple primary gastrointestinal malignant tumors:A 10-year case review of a single-center

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1204-1212页

作者： Cheng-lou Zhu Ling-Zhi Peng The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Multiple primary malignant tumors(MPMTs)was first described by Billroth as early as 1889,with the first report published by Warren and Gates in *** then,numerous cases have been reported.A literature review of 1104269 patients with cancer revealed that the incidence of MPMTs ranged from 0.73 to 11.7%.In recent years,however,there has been a significant upward trend in the incidence of this phenomenon,which may be associated with many different factors,including the advancement of modern diagnostic procedures facilitating the examination and diagnosis of more MPMTs,increased exposure to chemotherapy and radiotherapy that exacerbate the risk of new malignant tumors in patients with cancer,and prolonged survival of patients with cancer allowing sufficient time for the development of new primary *** To analyze the incidence,clinical features,treatment factors,prevalence,and prognosis of patients with MPMTs in the gastrointestinal tract treated in a single ***,we analyzed the different tumor combinations,time interval between the occurrence of tumors,and *** This retrospective cohort study analyzed 8059 patients with pathologically confirmed gastrointestinal malignant tumors treated at the Gansu Province Hospital in Lanzhou,Gansu,China between June 2011 and June *** these,85 patients had *** clinical features,treatment factors,prevalence,and prognosis of this latter cohort were *** The incidence of MPMTs in patients with gastrointestinal malignant tumors was 1.05%(85/8059),including 83 double primary malignant tumors and two triple primary malignant tumors of which 57(67.06%)were synchronous MPMTs(SMPMTs)and 28(32.94%)were metachronous MPMTs(MMPMTs).The most frequent associations were found between the rectum colon cancers within the SMPMT category and the gastric-colon cancers within the MMPMT *** the MMPMTs,the median interval was 53 *** overall 1-,3-and 5-year survival rates f

关键词： Multiple primary malignant tumors Clinical characteristics Gastrointestinal tract Prognosis Epidemiology

An Interactive Collaborative Creation System for Shadow Puppets Based on Smooth Generative Adversarial Networks

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Computers, Materials & Continua 2024年第6期79卷 4107-4126页

作者： Cheng Yang Miaojia lou Xiaoyu Chen Zixuan Ren Department of Industrial Design Hangzhou City UniversityHangzhou310000China College of Computer Science and Technology Zhejiang UniversityHangzhou310000China

Chinese shadow puppetry has been recognized as a world intangible cultural ***,it faces substantial challenges in its preservation and advancement due to the intricate and labor-intensive nature of crafting shadow *** ensure the inheritance and development of this cultural heritage,it is imperative to enable traditional art to flourish in the digital *** paper presents an Interactive Collaborative Creation System for shadow puppets,designed to facilitate the creation of high-quality shadow puppet images with greater *** system comprises four key functions:Image contour extraction,intelligent reference recommendation,generation network,and color adjustment,all aimed at assisting users in various aspects of the creative process,including drawing,inspiration,and content ***,we propose an enhanced algorithm called Smooth Generative Adversarial Networks(SmoothGAN),which exhibits more stable gradient training and a greater capacity for generating high-resolution shadow puppet ***,we have built a new dataset comprising high-quality shadow puppet images to train the shadow puppet generation *** qualitative and quantitative experimental results demonstrate that SmoothGAN significantly improves the quality of image generation,while our system efficiently assists users in creating high-quality shadow puppet images,with a SUS scale score of *** study provides a valuable theoretical and practical reference for the digital creation of shadow puppet art.

关键词： Shadow puppets deep learning image generation co-create

Population Dynamics in an Advective Environment

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Communications on Applied Mathematics and Computation 2024年第1期6卷 399-430页

作者： King-Yeung Lam Ray Lee Yuan lou Department of Mathematics The Ohio State UniversityColumbusOH43210USA School of Mathematical Sciences CMA-Shanghai and MOE-LSCShanghai Jiao Tong UniversityShanghai200240China

We consider a one-dimensional reaction-diffusion equation describing single-and two-species population dynamics in an advective environment,based on the modeling frameworks proposed by Lutscher et *** *** analyze the effect of rate of loss of individuals at both the upstream and downstream *** the single-species case,we prove the existence of the critical domain size and provide explicit formulas in terms of model *** further derive qualitative properties of the critical domain size and show that,in some cases,the critical domain size is either strictly decreasing over all diffusion rates,or monotonically increasing after first decreasing to a *** also consider competition between species differing only in their diffusion *** two species having large diffusion rates,we give a sufficient condition to determine whether the faster or slower diffuser wins the *** also briefly discuss applications of these results to competition in species whose spatial niche is affected by shifting isotherms caused by climate change.

关键词： Reaction-diffusion-advection Critical domain size Competition Climate change

Multi-stream signals separation based on space-time-isomeric (SPATIO) array using metasurface antennas

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Science China(Information Sciences) 2024年第2期67卷 181-200页

作者： Yangming lou Liang JIN Huiming WANG Zhou ZHONG Junyan DAI PLA Strategic Support Force Information Engineering University School of Information and Communications Engineering Xi'an Jiaotong University 3. State Key Laboratory of Millimeter WavesSoutheast University

In spatial domain signal processing, it is necessary to equip more antennas at the receiver to improve spatial demultiplexing capability. However, increasing the number of antennas under restricted space will reduce antenna spacing and raise the channel correlation, making the number of signal streams spatially demultiplexed much smaller than that of antennas. This paper proposes a method to design a space-timeisomeric(SPATIO) array based on metasurface antennas under wireless multipath conditions. Each antenna in this array has a different pattern and varies independently with time, reducing the channel correlation by superposing multipath at distinct positions and moments. Based on the SPATIO array, we present an array parameter design scheme based on infinity norm minimization, which can maximize the received energy of each stream while separating multi-stream received signals. Simulation results illustrate the performance of the SPATIO array for multi-stream signal reception. Compared with conventional multiple-input multipleoutput arrays, the proposed array can reduce the bit error rate by one order of magnitude under the same simulation conditions.

关键词： multiple-input multiple-output metasurface antenna space-time-isomeric array multipath channel degree of freedom

Visible-light-induced Synthesis of Organic Peroxides via Decarboxylative Couplings of Carboxylic Acids, Alkenes and tert-Butyl Hydroperoxide

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 863-873页

作者： Huang, Qiuwei lou, Chenhao Lv, Leiyang Li, Zhiping Renmin Univ China Sch Chem & Life Resources Key Lab Adv Light Convers Mat & Biophoton Beijing 100872 Peoples R China

Herein, we present a photoinduced, CeCl3-catalyzed three-component decarboxylative reaction that couples carboxylic acids, alkenes and tert-butyl hydroperoxide for the formation of various organic peroxides. The ligand-to-metal charge transfer (LMCT) excitation mode allows the decarboxylative alkylation-peroxidation reaction to occur under mild conditions, and is well applicable to primary, secondary and tertiary carboxylic acids and styrene derivatives.

关键词： Visible-light catalysis Difunctionalization Carboxylic acid Alkene Organic peroxide CATALYZED CARBONYLATION-PEROXIDATION OXIDATIVE DECARBOXYLATION RADICAL-ADDITION ALDEHYDES ALKYLATION KETONES SCOPE MILD

Determination of global geodetic parameters using satellite laser ranging to Galileo,GLONASS,and BeiDou satellites

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Satellite Navigation 2024年第1期5卷 240-257页

作者： Xingxing Li Jiaqing lou Yongqiang Yuan Jiaqi Wu Keke Zhang School of Geodesy and Geomatics Wuhan University129 Luoyu RoadWuhan430079HubeiChina

The new Global Navigation Satellite System(GNSS)satellites,including GLONASS,Galileo,and BeiDou system,are equipped with Laser Retroreflector Arrays(LRA)to support Satellite Laser Ranging(SLR)tracking,which contributes to the estimation of global geodetic *** this study,we estimate the global geodetic parameters using the SLR observations to GNSS satellites and also investigate the effects of different data processing strategies on the estimated Earth Rotation Parameters(ERP),geocenter motion,and terrestrial *** results indicate that setting range bias parameters for each satellite-station pair can effectively account for the satellite-specific biases induced by LRAs,leading to smaller Root Mean Square Errors(RMSE)of the post-fit SLR ***,estimating the range biases for each satellite-station pair improves the accuracy of the estimated station coordinates and *** also examine the impact of different arc lengths on the estimates of ERP,geocenter motion,and terrestrial *** results show that extending arc length can significantly reduce the formal error of *** 7-day strategy produces the smallest RMSEs of 473 microarcseconds and 495 microarcseconds for the estimated X-and Y-component of pole coordinates,and 52 microseconds for length-of-day,***,the estimated geocenter motion is less affected by the arc length,even the shortest 1-day arc strategy can capture the seasonal variations of geocenter motion in Z *** scale estimation,extending the arc length notably improves the accuracy of the estimated station coordinates and scale,but this advantage becomes less noticeable in longer *** 7-day solution also obtains the closet scale results compared to ITRF2014,with the RMSE of 2.10×10^(–9).

关键词： Satellite laser ranging GNSS Geodetic parameters Earth rotation parameters Geocenter motion Terrestrial scale