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First total synthesis,antitumor evaluation and target identification of mornaphthoate E:A new tubulin inhibitor template acting on PI3K/Akt signaling pathway

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2177-2193页

作者： Peipei Shan Tao Ye Ying-De Tang Hui Song chao Wang Kongkai Zhu Feifei Yang Shi-Lei Zhang Pei-Wen Su Shuanhu Gao hua Zhang Institute of Translational Medicine the Affiliated Hospital of Qingdao UniversityCollege of MedicineQingdao UniversityQingdao 266021China School of Biological Science and Technology University of JinanJinan 250022China Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinan 250012China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215127China School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China

Mornaphthoate E(MPE)is a prenylated naphthoic acid methyl ester isolated from the roots of a famous Chinese medicinal plant Morinda officinalis and shows remarkable cytotoxicity against several human tumor cell *** the current project,the first total synthesis of(±)-MPE was achieved in seven steps and 5.6%overall *** the in vitro anti-tumor activity of MPE was first assessed for both enantiomers in two breast cancer cells,with the levoisomer exerting slightly better *** in vivo anti-tumor effect was further verified by applying the racemate in an orthotopic autograft mouse ***,MPE exerted promising anti-metastasis activity both in vitro and in vivo and showed no obvious toxicity on mice at the therapeutic *** investigations demonstrated that MPE acted as a tubulin polymerization stabilizer and disturbed the dynamic equilibrium of microtubules via regulating PI3K/Akt *** conclusion,our work has provided a new chemical template for the future design and development of next-generation tubulin-targeting chemotherapies.

关键词： Mornaphthoate E Tubulin inhibitor Antitumor Anti-metastasis Breast cancer PI3K/Akt

Cognitive impairment in patients with bipolar disorder alone versus those with bipolar disorder comorbid with borderline personality disorder

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World Journal of Psychiatry 2024年第8期14卷 1174-1181页

作者： chao-Min Wang hua Xue Bo Xin Kun Zhang Shuo Wang Jin-Cheng Wang Cui-Xia An Na Li Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental *** often coexists with borderline personality disorders,making the condition more *** To explore the differences in cognitive impairment between patients with BD and those with BD comorbid with borderline personality *** Eighty patients with BD and comorbid borderline personality disorder and 80 patients with BD alone were included in groups A and B,respectively,and 80 healthy volunteers were included as *** function in each group was evaluated using the Chinese version of the repeatable battery for the assess-ment of neuropsychological status(RBANS),the Stroop color-word test,and the Wechsler intelligence scale-revised(WAIS-RC).RESULTS The indices of the RBANS,Stroop color-word test,and WAIS-RC in groups A and B were significantly lower than those of the control group(P<0.05).Group A had significantly longer Stroop color-word test times for single-character,single-color,double-character,and double-color,lower scores of immediate memory,visual breadth,verbal function dimensions and total score of the RBANS,as well as lower scores of verbal IQ,performance IQ,and overall IQ of the WAIS-RC compared with group B(P<0.05).Compared to group B,group A exhibited significantly longer single-character time,single-color time,double-character time,and double-color time in the Stroop color-word test(P<0.05).CONCLUSION The cognitive function of patients with BD complicated with borderline personality disorder is lower than that of patients with BD.

关键词： Bipolar disorder Borderline personality disorder Cognitive impairment Chinese-version repeatable neuropsychological status test Stroop color-word test Wechsler intelligence scale

Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 493-513页

作者： Ying-Qian Ma Ming Zhang Zhen-hua Sun Hong-Yue Tang Ying Wang Jiang-Xue Liu Zhan-Xue Zhang chao Wang Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina School of Graduate Studies Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Clinical Medical Research Center Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Gastrointestinal Surgery Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most aggressive malignancies with limited therapeutic options and a poor ***,a non-flavonoid poly-phenolic compound found in a variety of Chinese medicinal materials,has shown excellent anti-GC ***,its exact mechanisms of action in GC have not been *** To identify the effects of resveratrol on GC progression and explore the related molecular *** Action targets of resveratrol and GC-related targets were screened from public *** overlapping targets between the two were confirmed using a Venn diagram,and a“Resveratrol-Target-GC”network was constructed using Cyto-scape software version *** protein-protein interaction(PPI)network was constructed using STRING database and core targets were identified by PPI network *** Database for Annotation,Visualization and Integrated A total of 378 resveratrol action targets and 2154 GC disease targets were obtained from public databases,and 181 intersection targets between the two were screened by Venn *** top 20 core targets were identified by PPI network analysis of the overlapping *** function analysis mainly involved protein binding,identical protein binding,cytoplasm,nucleus,negative regulation of apoptotic process and response to xenobiotic *** enrichment analysis suggested that the involved signaling pathways mainly included PI3K-AKT signaling pathway,MAPK signaling pathway,IL-17 signaling pathway,TNF signaling pathway,ErbB signaling pathway,*** murine osteosarcoma viral oncogene homolog(FOS)and matrix metallopeptidase 9(MMP9)were selected by differential expression analysis,and they were closely associated with immune *** docking results showed that resveratrol docked well with these two *** treatment arrested the cell cycle at the S phase,induced apoptosis,and weakened viability,migration and invasion in a dose-dependent ***,re

关键词： Resveratrol Gastric cancer Network pharmacology Bioinformatics Molecular docking

Experimental investigation of vibration pretreatment-microwave curing process for carbon fiber reinforced resin matrix composites

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Journal of Central South University 2024年第6期31卷 1838-1855页

作者： ZHANG De-chao ZHAN Li-hua MA Bo-lin YAO Shun-ming GUO Jin-zhan GUAN Cheng-long LIU Shu Light Alloys Research Institute Central South UniversityChangsha 410083China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350108China

The vibration pretreatment-microwave curing process is an efficient,low energy consumption,and high-quality out-of-autoclave curing process for carbon fiber resin matrix *** study aims to investigate the impact of vibration pretreatment temperature on the fiber weight content,microscopic morphology and mechanical properties of the composite laminates by using optical digital microscopy,universal tensile testing machine and thermo-gravimetric ***,the combined mode of Bragg fiber grating sensor and temperature measurement fiber was employed to explore the effect of vibration pretreatment on the strain process during microwave *** study results revealed that the change in vibration pretreatment temperature had a slight impact on the fiber weight content when the vibration acceleration remained *** metallographic and interlaminar strength of the specimen formed at a vibration pretreatment temperature of 80℃ demonstrated a porosity of 0.414% and a 10.69% decrease in interlaminar shear strength compared to autoclave ***,the introduction of the vibration energy field during the microwave curing process led to a significant reduction in residual strain in both the 0°and 90°fiber directions,when the laminate was cooled to 60℃.

关键词： vibration microwave curing porosity interlaminar shear strength thermo-gravimetric analysis curing strain

Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-lin LIN Ru-kun LI Chan CHEN Zhi-jie CHEN Yi-fei LUO chao-hua MO Zhi-xian LIN Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P <0.05), up-regulation of Caspase-3 protein(P<0.05) and ERK1 mRNA(P<0.05) in B16F10 cells. The above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

Individualized anti-thrombotic therapy for acute myocardial infarction complicated with left ventricular thrombus: A case report

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World Journal of Clinical Cases 2024年第4期12卷 835-841页

作者： Yan Song hua Li Xia Zhang Lei Wang Hong-Yan Xu Zhi-chao Lu Xiao-Gang Wang Bo Liu Department of Clinical Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Cardiology Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Imaging Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Pulmonary and Critical Care Medicine Department of Clinical MicrobiologyZibo City Key Laboratory of Respiratory Infection and Clinical MicrobiologyZibo City Engineering Technology Research Center of Etiology Molecular DiagnosisZibo Municipal HospitalZibo 255400Shandong ProvinceChina

BACKGROUND Presently,there is no established standard anti-blood clot therapy for patients facing acute myocardial infarction(AMI)complicated by left ventricular thrombus(LVT).While vitamin K antagonists are the preferred choice for oral blood thinning,determining the best course of blood-thinning medication remains *** is unclear if non-vitamin K antagonist oral blood thinners have different effectiveness in treating *** study significantly contributes to the medical *** SUMMARY The blood-thinning treatment of a patient with AMI and LVT was *** blood-thinning therapy included daily enteric-coated aspirin tablets at 0.1 g,daily clopidogrel hydrogen sulfate at 75 mg,and dabigatran etexilate at 110 mg twice *** 15 d,the patient’s LVT did not decrease but instead *** pharmacists comprehensively analyzed the cases from the perspective of the patient’s disease status and drug *** drug regimen was reformulated for the patient,replacing dabigatran etexilate with warfarin,and was administered for six *** clinical pharmacist provided the patient with professional and standardized pharmaceutical *** patient’s condition was discharged after meeting the international normalized ratio value(2-3)*** patient fully complied with the follow-up,and the time in the therapeutic range was 78.57%,with no serious adverse effects during pharmaceutical *** Warfarin proves to be an effective drug for patients with AMI complicated by LVT,and its blood-thinning course lasts for six months.

关键词： Myocardial infarction Left ventricular thrombus Dabigatran etexilate Warfarin Clinical pharmacist Case report

Deformation,structure and potential hazard of a landslide based on InSAR in Banbar county,Xizang(Tibet)

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China Geology 2024年第2期7卷 203-221页

作者： Guan-hua Zhao Heng-xing Lan Hui-yong Yin Lang-ping Li Alexander Strom Wei-feng Sun chao-yang Tian College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Key Laboratory of Ecological Geology and Disaster Prevention Ministry of Natural ResourcesXi’an 710054China University of Chinese Academy of Sciences Beijing 100049China JSC“Hydroproject Institute” Moscow 125993Russia

The Tibetan Plateau is characterized by complex geological conditions and a relatively fragile ecological *** recent years,there has been continuous development and increased human activity in the Tibetan Plateau region,leading to a rising risk of *** landslide in Banbar County,Xizang(Tibet),have been perturbed by ongoing disturbances from human engineering activities,making it susceptible to instability and displaying distinct *** this study,small baseline subset synthetic aperture radar interferometry(SBAS-InSAR)technology is used to obtain the Line of Sight(LOS)deformation velocity field in the study area,and then the slope-orientation deformation field of the landslide is obtained according to the spatial geometric relationship between the satellite’s LOS direction and the ***,the landslide thickness is inverted by applying the mass conservation *** results show that the movement area of the landslide is about 6.57×10^(4)m^(2),and the landslide volume is about 1.45×10^(6)m^(3).The maximum estimated thickness and average thickness of the landslide are 39 m and 22 m,*** thickness estimation results align with the findings from on-site investigation,indicating the applicability of this method to large-scale earth *** deformation rate of the landslide exhibits a notable correlation with temperature variations,with rainfall playing a supportive role in the deformation process and displaying a certain *** activities exert the most substantial influence on the spatial heterogeneity of landslide deformation,leading to the direct impact of several prominent deformation areas due to human ***,utilizing the long short-term memory(LSTM)model to predict landslide displacement,and the forecast results demonstrate the effectiveness of the LSTM model in predicting landslides that are in a continuous development and movement *** landslide is still active,and based

关键词： Landslide InSAR Human activity Deformation Structure LSTM model Engineering construction Thickness Neural network Machine learning Prediction and prevention Tibetan Plateau Geological hazards survey engineering

A lithium–tin fluoride anode enabled by ionic/electronic conductive paths for garnet-based solid-state lithium metal batteries

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Rare Metals 2024年第2期43卷 575-587页

作者： Lei Zhang Qian-Kun Meng Xiang-Ping Feng Ming Shen Yu-Qing Zhang Quan-chao Zhuang Run-Guo Zheng Zhi-Yuan Wang Yan-hua Cui Hong-Yu Sun Yan-Guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China School of Materials and Physics China University of Mining&TechnologyXuzhou221116China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang621900China

The high energy density and stability of solid-state lithium metal batteries(SSLMBs)have garnered great ***-type oxides,especially Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),with high ionic conductivity,wide electrochemical window,and stability to Li metal anode,are promising solid-state electrolyte(SSEs)materials for ***,Li/LLZTO interface issues including high interface resistance,inhomogeneous Li deposition,and Li dendrite growth have hindered the practical application of ***,a multi-functional Li–SnF_(2) composite anode with Li,LiF,and Li-Sn alloy was specifically designed and *** composite anode improves the wettability to LLZTO,constructing an intimate contact interface between it and ***,ionic/electronic conductive paths in situ formed at the interface can effectively uniform Li deposition and suppress Li *** solid-state symmetric cell exhibits low interface resistance(11Ω·cm^(2)) and high critical current density(1.3 mA·cm^(−2))at 25℃.The full SSLMB based on LiFePO_(4) or LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode also shows stable cycling performance and high rate *** work provides a new composite anode strategy for achieving high-energy density and high-safety SSLMBs.

关键词： Solid-state lithium metal batteries(SSLMBs) Lithium-tin fluoride anode Ionic/electronic conductive Interface resistance Lithium dendrite

Gastric metastasis of small cell lung carcinoma:Three case reports and review of literature

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World Journal of Gastroenterology 2024年第31期30卷 3717-3725页

作者： Shan Yang Qing-Yun He Qing-Jing Zhao Han-Tao Yang Zheng-Yi Yang Wen-Yi Che hua-Mei Li Hui-chao Wu Department of Gastroenterology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Guizhou Hospital of The First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of Gastroenterology Zhejiang Provincial People's Hospital Bijie HospitalBijie 551700Guizhou ProvinceChina Department of Gastroenterology Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Small cell lung carcinoma(SCLC)is highly susceptible to metastasis in the early stages of the ***,the stomach is an uncommon site of metastasis in SCLC,and only a few cases of this type of metastasis have been ***,SCLC gastric metastases have not been systematically characterized and are easily missed and *** SUMMARY We report three cases of gastric metastasis from SCLC in this *** first patient presented primarily with cough,hemoptysis,and epigastric *** other two patients presented primarily with abdominal discomfort,epigastric distension,and *** patients underwent gastroscopy and imaging ***,the immunohistochemical results of the lesions in three patients were suggestive of small cell ***,the three patients were diagnosed with gastric metastasis of SCLC through a comprehensive *** three patients did not receive appropriate treatment and died within a short *** Here,we focused on summarizing the characteristics of gastric metastasis of SCLC to enhance clinicians'understanding of this disease.

关键词： Small cell lung cancer Gastric neoplasms Neoplasm metastasis Diagnosis Case report