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＂Takeaway＂ drug delivery： A new nanomedical paradigm

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Nano Research 2017年第7期10卷 2234-2243页

作者： Elena Gonzalez-Domfnguez Benito Rodriguez-Gonzalez Moises Perez-lorenzo Miguel A. Correa-Duarte Department of Physical Chemistry Biomedical Research Center (CINBIO) and Southern Galicia Institute of Health Research (IISGS)Universidade de Vigo 36310 Vigo Spain

An alternative model to the well-established paradigm of the externally switchable drug delivery systems is herein proposed. In contrast to the on--off archetype, here the amount of released drug is pre-set by the application of an external stimulus, and is gradually released after the withdrawal of the exogenous signal. These attributes are achieved through an innovative approach featuring the integration of plasmonic nanovehicles in a polymer-based film. Such a platform is provided with optically responsive capabilities together with multiple diffusional barriers, allowing for an ＂on-demand＂ time-limited release where light acts as a therapeutic ＂starting shot＂. These nanoarchitectured depots have great potential as implantable drug delivery systems in clinical scenarios where a recurrent, sustained, and yet, on--off administration of medication is required. The application of these hybrid materials may extend the implementation of nanomedicine strategies beyond the point-of-care setting.

关键词： release plasmonic nanocapsule hydrogel near infrared (NIR)

Endoscopic shielding technique, a new method in therapeutic endoscopy

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World Journal of Gastroenterology 2017年第21期23卷 3761-3764页

作者： Ignacio Bon Ramon Bartolí Vicente lorenzo-Zúniga Institut Investigació en Ciències de la Salut Germans Trias i Pujol Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Endoscopy Unit Department of GastroenterologyHospital Universitari Germans Trias i Pujol

Prevention of late complications after large endoscopic resection is inefficient with current *** shielding,as a simple and safe technique,has been proposed to improve the incidence of these *** methods,sheets or hydrogels,have showed proven efficacy in the prevention of late bleeding and perforation,as well as the improvement of tissue repair,in experimental models and in clinical practice.

关键词： Endoscopic shielding technique Late complication Therapeutic endoscopy

Vertical stratification of ichneumonid wasp communities： the effects of forest structure and life-history traits

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Insect Science 2015年第5期22卷 688-699页

作者： Filippo Di Giovanni Pierfilippo Cerretti Franco Mason Emma Minari lorenzo Marini Dipartimento di Biologia e Biotecnologie 'Charles Darwin' Universita di Roma 'La Sapienza' Piazzale A. Moro 5 00185 Rome Italy Centro Nazionale per lo Studio e la Conservazione della Biodiversita Forestale Corpo Forestale dello Stato via Carlo Ederle 161A 37100 Verona Italy and DAFNAE Universit& di Padova viale dell'Universita 16 35020 Legnaro Padua Italy

Parasitoid wasp communities of the canopy of temperate forests are still largely unexplored. Very little is known about the community composition ofparasitoids between canopy and understory and how much of this difference is related to forest structure or parasitoid biological strategies. In this study we investigated upon the difference in the community composition of the parasitic wasps Ichneumonidae between canopy and understory in a lowland temperate forest in northern Italy. We used general linear models to test whether parasitic strategy modifies species vertical stratification and the effect of forest structure. We also tested differences in β-diversity between canopy and understory traps and over time within single forest layers. We found that stand basal area was positively related to species richness, suggesting that the presence of mature trees can influence local wasp diversity, providing a higher number of microhabitats and hosts. The ichneumonid community of the canopy was different from that of the understory, and theβ-diversity analysis showed higher values for the canopy, due to a higher degree of species turnover between traps. In our analyses, the vertical stratification was different between groups of ichneumonids sharing different parasitic strategies. Idiobiont parasitoids of weakly or deeply concealed hosts were more diverse in the understory than in the canopy while parasitoids of spiders were equally distributed between the two layers. Even though the ichneumonid community was not particularly species-rich in the canopy of the temperate forests, the extension of sampling to that habitat significantly increased the number of species recorded.

关键词： β-diversity biological traits canopy forest structure Ichneumonidae vertical stratification

Current applications of big data and machine learning in cardiology

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Journal of Geriatric Cardiology 2019年第8期16卷 601-607页

作者： Renato Cuocolo Teresa Perillo Eliana De Rosa lorenzo Ugga Mario Petretta Department of Advanced Biomedical Sciences University of Naples “Federico II”NaplesItaly Department of Translational Medical Sciences University of Naples “Federico II”NaplesItaly

Machine learning (ML) is a software solution with the ability of making predictions without prior explicit programming, aiding in the analysis of large amounts of data. These algorithms can be trained through supervised or unsupervised learning. Cardiology is one of the fields of medicine with the highest interest in its applications. They can facilitate every step of patient care, reducing the margin of error and contributing to precision medicine. In particular, ML has been proposed for cardiac imaging applications such as automated computation of scores, differentiation of prognostic phenotypes, quantification of heart function and segmentation of the heart. These tools have also demonstrated the capability of performing early and accurate detection of anomalies in electrocardiographic exams. ML algorithms can also contribute to cardiovascular risk assessment in different settings and perform predictions of cardiovascular events. Another interesting research avenue in this field is represented by genomic assessment of cardiovascular diseases. Therefore, ML could aid in making earlier diagnosis of disease, develop patient-tailored therapies and identify predictive characteristics in different pathologic conditions, leading to precision cardiology.

关键词： Cardiac imaging techniques Cardiology Electrocardiography Machine learning Review

Emergingγ-soft-like spectrum in^(196)Pt in the SU3-IBM(Ⅰ)

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Chinese Physics C 2024年第9期48卷 150-163页

作者： Tao Wang Bing-Cheng He Chun-Xiao Zhou Dong-Kang Li lorenzo Fortunato College of Physics Tonghua Normal UniversityTonghua 134000China Physics Division Argonne National LaboratoryLemontIllinois 60439USA College of Mathematics and Physics Science Hunan University of Arts and ScienceChangde 415000China Dipartimento di Fisica e Astronomia"G.Galilei"-Universitàdi Padova via Marzolo 8I-35131 PadovaItaly INFN-Sez.di Padova via Marzolo 8I-35131 PadovaItaly

Recently,studies have argued that a spherical-like spectrum emerges in the SU3-IBM,thus creating new approaches to understanding y-softness in realistic *** a previous study,γ-softness with degeneracy of the ground and quasi-y bands was *** this paper,another special point connected to the middle degenerate point is *** is found to be related to the properties of^(196)*** emergentγ-softness is also shown to be important for understanding the prolate-oblate asymmetric shape phase *** low-lying spectra,B(E2)values,and quadrupole moments in^(196)Pt are discussed,and we show that the new model can account for several observed *** is the first part of the discussion on theγ-soft-like spectrum of^(196)Pt.

关键词： SU3-IBM ^(196)Pt γ-soft-like spectrum

Use of oral vancomycin in children with autoimmune liver disease:A single centre experience

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World Journal of Hepatology 2021年第12期13卷 2113-2127页

作者： Angelo Di Giorgio Anna Tulone Emanuele Nicastro lorenzo Norsa Aurelio Sonzogni lorenzo D'Antiga Pediatric Hepatology Gastroenterology and TransplantationHospital Papa Giovanni XXIIIBergamo 24127Italy Liver Pathology Hospital Papa Giovanni XXIIIBergamo 24127Italy

BACKGROUND Previous reports showed some beneficial effect of oral vancomycin treatment(OVT)in children with primary sclerosing cholangitis;conversely,the experience in patients with other autoimmune liver diseases(AILD),including autoimmune hepatitis(AIH)and autoimmune sclerosing cholangitis(ASC),is *** To assess the response to immunosuppressive treatment(IS)and to OVT in children diagnosed with *** Retrospective study of children diagnosed with AIH(normal biliary tree at cholangiography)and ASC(abnormal biliary tree at cholangiography)in the last 10 *** underwent standard immunosuppressive therapy(IS),but nonresponders received also *** remission[normal aspartate aminotransferase(AST)]and immunological remission(normal IgG and negative autoantibodies)rates and Sclerosing Cholangitis Outcomes in Pediatrics(SCOPE)index were assessed and compared during the follow *** 75 children were included[69%female,median age 10.5 years(5.6-13.4 years),AIH=54,ASC=21].Sixty-three patients(84%,AIH=52,ASC=11)were treated with standard IS and 61 achieved biochemical remission,whereas 12 not responding to IS[16%,F=75%,median age 13.5 years,(12.2-15.7),10 with ASC]required OVT and 8 achieved biochemical *** OVT increased the biochemical remission rate of the whole group of AILD patients from 81%(61/75)to 92%(69/75).Median values of AST,alanine aminotransferase(ALT)and gamma-glutamyl transferase(GGT)decreased significantly after OVT start(P<0.05).Complete normalization of livers enzymes(AST,ALT and GGT)was observed in 6/12 patients(50%).Decrease in SCOPE index score was reported in 5/12 patients(42%).At last follow up(median of 4.4 years,range 0.6-13.8 years)all 75 patients are alive,6(8%,1 with ASC)successfully discontinued medications,1(with ASC)required liver *** Children with AIH and ASC respond well to IS *** may represent a valuable treatment option to achieve biochemical remission in patients

关键词： Autoimmune hepatitis Autoimmune sclerosing cholangitis Autoimmune liver disease Vancomycin Children Liver transplantation

Foreign exchange trading and management with the stochastic dual dynamic programming method

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Financial Innovation 2023年第1期9卷 583-620页

作者： lorenzo Reus Guillermo Alexander Sepulveda‑Hurtado Escuela de Negocios Universidad Adolfo IbanezDiagonal Las Torres2640 SantiagoChile

We present a novel tool for generating speculative and hedging foreign exchange(FX)trading *** solution provides a schedule that determines trades in each rebalancing period based on future currency prices,net foreign account positions,and incoming(outgoing)flows from business *** obtain such policies,we construct a multistage stochastic programming(MSP)model and solve it using the stochastic dual dynamic programming(SDDP)numerical method,which specializes in solving high-dimensional MSP *** construct our methodology within an open-source SDDP package,avoiding implementing the method from *** measure the performance of our policies,we model FX prices as a mean-reverting stochastic process with random events that incorporate stochastic *** calibrate this price model on seven currency pairs,demonstrating that our trading policies not only outperform the benchmarks for each currency,but may also be close to ex-post optimal *** also show how the tool can be used to generate more or less conservative strategies by adjusting the risk tolerance,and how it can be used in a vari-ety of contexts and time scales,ranging from intraday speculative trading to monthly hedging for business ***,we examine the impact of increasing trade policy uncertainty(TPU)levels on our *** findings show that the volatility of currencies from emerging economies rises in comparison to currencies from devel-oped *** discover that an increase in the TPU level has no effect on the aver-age profit obtained by our ***,the risk exposure of the policies increases(decreases)for the group of currencies from emerging(developed)markets.

关键词： FX trading FX risk SDDP Multistage stochastic programming Julia Trade policy uncertainty

Advances in diamond nanofabrication for ultrasensitive devices

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Microsystems & Nanoengineering 2017年第1期3卷 80-95页

作者： Stefania Castelletto lorenzo Rosa Jonathan Blackledge Mohammed Zaher Al Abri Albert Boretti School of Engineering RMIT UniversityBundooraVictoria 3083Australia Swinburne University of Technology Centre for Micro-Photonics(H74)HawthornVictoria 3122Australia Department of Information Engineering University of ParmaParma 43121Italy Military Technological College Muscat 111Sultanate of Oman Dublin Institute of Technology Rathmines RoadDublin 6Ireland Department of Petroleum and Chemical Engineering Sultan Qaboos UniversityPO Box 33Al-KhoudMuscat 123Sultanate of Oman Water Research Center Sultan Qaboos UniversityPO Box 17Al-KhoudMuscat 123Sultanate of Oman Department of Mechanical and Aerospace Engineering Benjamin M.Statler College of Engineering and Mineral ResourcesWest Virginia UniversityP.O.Box 6106325 Engineering Sciences BuildingMorgantownWV 26506USA

This paper reviews some of the major recent advances in single-crystal diamond nanofabrication and its impact in nano-and micromechanical,nanophotonics and optomechanical *** constituents of integrated devices incorporating specific dopants in the material provide the capacity to enhance the sensitivity in detecting mass and forces as well as magnetic field down to quantum mechanical limits and will lead pioneering innovations in ultrasensitive sensing and precision measurements in the realm of the medical sciences,quantum sciences and related technologies.

关键词： nano-diamonds nanofabrication nanomechanics nanophotonics optomechanics

Improved Peptidyl Linkers for Self-Assembly of Semiconductor Quantum Dot Bioconjugates

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Nano Research 2009年第2期2卷 121-129页

作者： lorenzo Berti Paola Serena D'Agostino Kelly Boeneman Igor L.Medintz CNR-INFM National Research Center on nanoStructures and bioSystems at Surfaces(S3)Via Campi213/A 41100 ModenaItaly University of California Davis Medical Center SacramentoCA 95817USA Center for Bio/Molecular Science and Engineering Code 6900 U.S.Naval Research LaboratoryWashingtonDC 20375USA

We demonstrate improved peptide linkers which allow both conjugation to biomolecules such as DNA and self-assembly with luminescent semiconductor quantum dots.A hexahistidine peptidyl sequence was generated by standard solid phase peptide synthesis and modified with the succinimidyl ester of iodoacetamide to yield a thiol-reactive iodoacetyl polyhistidine *** reactive peptide was conjugated to dye-labeled thiolated DNA which was utilized as a model target *** gel electrophoresis and fluorescence resonance energy transfer analysis confirmed that the linker allowed the DNA to self-assemble with quantum dots via metal-affinity driven *** contrast to previous peptidyl linkers that were based on disulfide exchange and were thus labile to reduction,the reactive haloacetyl chemistry demonstrated here results in a more stable thioether bond linking the DNA to the peptide which can withstand strongly reducing environments such as the intracellular *** thiol groups occur naturally in proteins,can be engineered into cloned proteins,inserted into nascent peptides or added to DNA during synthesis,the chemistry demonstrated here can provide a simple method for self-assembling a variety of stable quantum dot bioconjugates.

关键词： Semiconductor quantum dot peptide DNA nanocrystal bioconjugation iodoacetyl sulfhydryl polyhistidine metal-affinity fluorescence fluorescence resonance energy transfer(FRET)