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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim rudolph ETanzi Se Hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Froth flotation of scheelite – A review

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International Journal of Mining Science and Technology 2018年第3期28卷 373-384页

作者： Nathalie Kupka Martin rudolph Helmholtz Zentrum Dresden Rossendorf (HZDR) Helmholtz Institute Freiberg for Resource Technology (HIF)

Froth flotation of scheelite has regained new focus since the 2010s and research regarding floatability and reagents has made great progress over the years. The main objective was and remains the selective flotation of scheelite from other calcium-bearing minerals, in particular calcite, fluorite and apatite. Due to similar properties, most attempts have limited success or only specific application(linked to a type of ore or a location). This article aims at reviewing all general physical-chemical information on froth flotation of scheelite, including electrokinetic properties, influence of p H and already existing reagents as well as ones still under examination. It appears that chelating or mixed collectors and modified versions of sodium silicate and quebracho hold great promise for scheelite flotation, while the use of said depressants and/or promoters seems inevitable.

关键词： Scheelite Froth flotation Calcium-bearing minerals Selectivity challenges Promising reagents

Forensic Readiness: Emerging Discipline for Creating Reliable and Secure Digital Evidence

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Journal of Harbin Institute of Technology(New Series) 2015年第1期22卷 1-8页

作者： Barbara Endicott-Popovsky Nicolai Kuntze Carsten rudolph Institute of Technology University of Washington Fraunhofer Institute of Technology

Traditional approaches to digital forensics reconstruct events within digital systems that often are not built for the creation of evidence; however,there is an emerging discipline of forensic readiness that examines what it takes to build systems and devices that produce digital data records for which admissibility is a requirement. This paper reviews the motivation behind research in this area,a generic technical solution that uses hardware-based security to bind digital records to a particular state of a device and proposed applications of this solution in concrete,practical scenarios. Research history in this area,the notion of secure digital evidence and a technical solution are discussed. A solution to creating hardware-based security in devices producing digital evidence was proposed in 2012. Additionally,this paper revises the proposal and discusses three distinct scenarios where forensic readiness of devices and secure digital evidence are relevant. It shows,how the different requirements of the three scenarios can be realized using a hardware-based solution. The scenarios are:lawful interception of voice communication,automotive black box,precise farming. These three scenarios come from very distinctive application domains. Nevertheless,they share a common set of security requirements for processes to be documented and data records to be stored.

关键词： digital forensics forensic readiness calibration d

Influence of surfactants on selective mechanical separation of fine active materials used in high temperature electrolyzers contributing to circular economy

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Industrial Chemistry & Materials

Industrial Chemistry & Materials 2024年第3期2卷 469-480页

作者： Sohyun Ahn Suvarna Patil Martin rudolph Helmholtz-Zentrum Dresden-Rossendorf Helmholtz Institute Freiberg for Resource TechnologyChemnitzer StraBe 40Freiberg 09599Germany

As one of the promising hydrogen production technologies,the development of water electrolysis systems including recycling of their functional components is actively ***,the focus lies on energy and chemical intensive metallurgical operations and less on mechanical separation processes in most ***,an innovative surfactant-based separation process(using CTAB and SDS)is investigated to contribute to developing a selective physical separation process for ultrafine particles used in high temperature water electrolyzers(composed of NiO,LSM,ZrO_(2),and YSZ).Their different surface charge in alkaline solutions influences the adsorption of surfactants on particle surfaces as well as the modification of particulate wettability,which is a key separation *** the observations of changes in surface charge and wetting behavior in the presence of surfactants,a feasibility of liquid-liquid particle separation(LLPS)is *** performance of LLPS with model particle mixtures shows the potential of selective separation with recovery of NiO in the organic phase,while the rest of the particles remain in the aqueous *** LSM is not considered in this system because it shows a high possibility of being recovered by magnetic *** proposed process can be further optimized by increasing the phase separation stages,and further research is needed on the NiO phase,which showed exceptional behavior in the presence of the surfactants.

关键词： Fine particle separation Solid oxide electrolyzer Recycling Particle surface modification

Easy access to pharmaceutically relevant heterocycles by catalytic reactions involving a-imino gold carbene intermediates

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Frontiers of Chemical Science and Engineering 2020年第3期14卷 317-349页

作者： Ximei Zhao Matthias rudolph Abdullah M.Asiri A.Stephen K.Hashmi Organisch-Chemisches Institut Heidelberg University69120 HeidelbergGermany Chemistry Department Faculty of Science21589 JeddahSaudi Arabia

This review summarizes recent advances in the field of gold-catalyzed synthesis of pharmaceutically relevant aza-heterocycles via in situ generated a-imino gold carbene complexes as intermediates.

关键词： gold heterocycles alkynes

Industrial Ethernet as communication medium of the future

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Industrial Ethernet as communication medium of the future

Relationship between Children’s Body Mass Index and Parents’ Obesity and Socioeconomic Status: A Multilevel Analysis Applied with Luxembourg Data

05'中国自动化产业高峰会议暨中国企业自动化和信息化建设论坛

作者： lorentz Managing Director of IAONA e.V.

Introduction While single organizations at the beginning of the Ethernet aera were keen on (and partially still are...) providing the all-embracing all-round solution by their own industrial Ethernet implementation, m...

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Health 2014年第17期6卷 2322-2332页

作者： Anastase Tchicaya Nathalie lorentz Living Conditions/Health Research Team CEPS/INSTEAD Esch-sur-Alzette Luxembourg

Obesity in children is a health crisis because the problem is increasing in most developed countries. This study measures the relationship between body mass index (BMI) of children aged 7 - 12 years residing in Luxembourg and the weight and socioeconomic status of their parents. The data used are from the 2007 Socio-Economic Panel Liewen zu L?tzebuerg/European Union-Statistics on Income and Living Conditions survey, which covers a population of approximately 10,000 people. The study sample includes 775 children whose weight and height were recorded to calculate their BMI. The descriptive analysis with the socioeconomic distribution of the children’s BMI and the multilevel logistic regression of the probability to be in overweight or obese were performed. The mean BMI of children was 17.4 kg/m2 for boys and girls. The prevalence of overweight was 21.2% (including 3% who were obese). Weight status, educational level, physical activity, and eating habits of parents were associated with BMI in children. Furthermore, children of foreign nationality had 2.9 times more risk to be overweight or obese than other children of Luxembourg nationality (OR = 2.90, 95%CI: 1.38 - 6.10). Children living in household with at least one parent who was obese were 6.51 times more likely to be in overweight or obese compared to those in household with both parents normal (OR = 6.51, 95%CI: 2.48 - 17.08). Overall, nationality and weight status of parents were the main determinants of children’s weight status. Promoting healthy diets and regular physical activity and educating parents on the consequences of overweight and obesity on children’s health in adulthood are effective strategies to control overweight and obesity.

关键词： BMI Obesity Children Socioeconomic Status Luxembourg

On the impact of grinding conditions in the flotation of semi-soluble salt-type mineral-containing ores driven by surface or particle geometry effects?

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International Journal of Mining Science and Technology 2023年第7期33卷 855-872页

作者： Lucas Pereira Nathalie Kupka Duong Huu Hoang Bruno Michaux Sondos Saquran Doreen Ebert Martin rudolph Helmholtz-Zentrum Dresden-Rossendorf Helmholtz Institute Freiberg for Resource TechnologyFreiberg 09599Germany Maelgwyn Mineral Services Ltd Cardiff CF244PAUnited Kingdom

Grinding and flotation processes are often studied independently, despite the well-established grinding influence on flotation performance, which affects not only particle size and thus liberation but also shape and leads to complex changes in pulp chemistry affecting the particle surface properties relevant for selective bubble attachment. Yet, no study jointly investigated these possible causes and many are limited to single mineral flotation. We relate grinding conditions to changes in pulp chemistry and particle surface properties and assess their impact on upgrading. We studied three non-sulfide ores with different feed grades and valuables: scheelite, apatite, and fluorite. These were dry-, wet-, and wet conditionedground before flotation in a laboratory mechanical cell. Results were evaluated with bulk-and particle-specific methodologies. The selectivity of the process is higher after dry grinding for the fluorite and apatite ores and irrelevant for the scheelite ore. Variations in flotation kinetics of individual particles associated to their size and shape are not sufficient to explain these results. The higher concentration of Ca2+and Mg2+observed in the pulp after wet grinding, altering particle surface properties, better explains the phenomenon. Additionally, we demonstrate how particle shape impacts are system specific and related to both entrainment and true flotation.

关键词： Grinding-flotation interactions Semi-soluble salt-type minerals Geometallurgy Particle-based separation modelling Surface interactions

Nanolaminate-based design for UV laser mirror coatings

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Light(Science & Applications) 2020年第1期9卷 1820-1825页

作者： Meiping Zhu Nuo Xu Behshad Roshanzadeh STPBoyd Wolfgang rudolph Yingjie Chai Jianda Shao Laboratory of Thin Film Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Key Laboratory of Materials for High Power Laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Department of Physics and Astronomy University of New MexicoAlbuquerqueNM 87131USA CREOL The College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA

With ever-increasing laser power,the requirements for ultraviolet(UV)coatings increase *** fundamental challenge for UV laser-resistant mirror coatings is to simultaneously exhibit a high reflectivity with a large bandwidth and high laser *** characteristics are traditionally achieved by the deposition of laser-resistant layers on highly reflective *** propose a“reflectivity and laser resistance in one”design by using tunable nanolaminate layers that serve as an effective layer with a high refractive index and a large optical *** Al_(2)O_(3)-HfO_(2) nanolaminate-based mirror coating for UV laser applications is experimentally demonstrated using ebeam *** bandwidth,over which the reflectance is >99.5%,is more than twice that of a traditional mirror with a comparable overall *** laser-induced damage threshold is increased by a factor of ~1.3 for 7.6 ns pulses at a wavelength of 355 *** tunable,nanolaminate-based new design strategy paves the way toward a new generation of UV coatings for high-power laser applications.

关键词： tunable mirror reflectivity