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Chemical Research in Chinese Universities 1997年第1期13卷 93-95页

作者： long rui qiang and wan hui lin (Department of Chemistry and State Key Laboratory for Physical Chemistry of the Solid Surface, Xiamen University, Xiamen, 361005) XIAMEN UNIV DEPT CHEMXIAMEN 361005PEOPLES R CHINA XIAMEN UNIV STATE KEY LAB PHYS CHEM SOLID SURFACEXIAMEN 361005PEOPLES R CHINA

ＴｈｅＡｃｔｉｖｅＯｘｙｇｅｎＳｐｅｃｉｅｓｆｏｒＯｘｉｄａｔｉｖｅＣｏｕｐｌｉｎｇｏｆＭｅｔｈａｎｅｏｖｅｒＣｅＯ２／ＢａＦ２ＣａｔａｌｙｓｔｂｙｉｎＳｉｔｕＣｏｎｆｏｃａｌＭｉｃｒｏｐｒｏｂｅＲａｍａｎＳｐｅｃｔ... 详细信息

ＴｈｅＡｃｔｉｖｅＯｘｙｇｅｎＳｐｅｃｉｅｓｆｏｒＯｘｉｄａｔｉｖｅＣｏｕｐｌｉｎｇｏｆＭｅｔｈａｎｅｏｖｅｒＣｅＯ２／ＢａＦ２ＣａｔａｌｙｓｔｂｙｉｎＳｉｔｕＣｏｎｆｏｃａｌＭｉｃｒｏｐｒｏｂｅＲａｍａｎＳｐｅｃｔｒｏｓｃｏｐｙ＊＊Ｓｕｐｐｏｒｔｅ...

关键词： Oxygen species Oxidative coupling Methane In situ Raman spectroscopy

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian wang Bao-long Shen Zhe Jia Feng-Qi Zhang Wei wang Qi Liu Yang Ren Xun-Li wang Xiao-Ya Cui Xiao-Yang wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-long Gao Jia-Ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu rui Huang ling-Kun Zhang Yi-Ping Lu Xu-Bo Li Huai-Jun lin Yan Ma Wei-Ming Yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang Huang De-Zhuang wang Qing-Feng Liu Fei-Yang wang hui Liu Hong-hui Wu Li-qiang wang Yang Lu Nan wang Tian-Li wang Wei-Bing Liao Yi-Han wang Yuan Wu Yu-Zhen Yin Jie Pan Yi Zhang Qing wang Jian-Yang Zhang Tao Yang Yasir Sohail Jin-Yu Zhang Hua Ji qiang Li Wei-Di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

STUDIES ON BaF2 PROMOTED PRASEODYMIUM OXIDE CATALYSIS FOR THE OXIDATIVE COUPlinG OF METHANE

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Journal of Energy Chemistry 1997年第2期 85-92页

作者： long rui-qiang wan hui-lin(Department of Chemistry and State Key Laboratory for Physical Chemistry of the Solid Surface Xiamen University Xiamen, Fujian 361005)

The catalytic performance for oxidative coupling of methane (OCM) and characterizations of the BaF2 promoted praseodymium oxide catalysts have been studied in this work. The results showed that C2 selectivities and yields over the BaF2 promoted Pr6O11 catalysts were significantly higher than those over Pr6O11 catalyst. In the process of catalyst preparation, the partial exchange between F- and O2- led to the formation of PrOF new phase and the contraction of BaF2 lattice. The increase in C2 selectivity over BaF2 doped Pr6O11 might result from the decrease of specific surface area and mobility of lattice oxygen as well as the dispersion of F- on the surface of the catalysts. No direct relationship between the surface acidity/basicity and the catalytic activity/selectivity was observed over these catalysts.

关键词： methane oxidative coupling praseodymium chide BaF2

Guided chemotherapy based on patient-derived mini-xenograft models improves survival of gallbladder carcinoma patients

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Cancer Communications 2018年第1期38卷 511-519页

作者： Ming Zhan rui-meng Yang hui wang Min He Wei Chen Sun-wang Xu lin-hua Yang qiang Liu Man-mei long Jian wang Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong University160 Pujian RoadShanghai 200127P.R.China Department of Pathology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Pathology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011P.R.China

Background:Gallbladder carcinoma is highly aggressive and resistant to chemotherapy,with no consistent strategy to guide first line ***,patient-derived xenograft(PDX)model has been increasingly used as an effective model for in preclinical study of ***:Mini-PDX model was established using freshly resected primary lesions from 12 patients with gallblad-der to examine the sensitivity with five of the most commonly used chemotherapeutic agents,namely gemcitabine,oxaliplatin,5-fluorouracil,nanoparticle albumin-bound(nab)-paclitaxel,and *** results were used to guide the selection of chemotherapeutic agents for adjunctive treatment after the ***-Meier method was used to compare overall survival(OS)and disease free survival(DFS)with 45 patients who received conventional chemo-therapy with gemcitabine and ***:Cell viability assays based on mini-PDX model revealed significant heterogeneities in drug ***-Meier analysis showed that patients in the PDX-guided chemotherapy group had significantly longer median OS(18.6 months;95%CI 15.9-21.3 months)than patients in the conventional chemotherapy group(13.9 months;95%CI 11.7-16.2 months)(P=0.030;HR 3.18;95%CI 1.47-6.91).Patients in the PDX-guided chemotherapy group also had significantly longer median DFS(17.6 months;95%CI 14.5-20.6 months)than patients in the conventional chemotherapy group(12.0 months;95%CI 9.7-14.4 months)(P=0.014;HR 3.37;95%CI 1.67-6.79).Conclusion:The use of mini-PDX model to guide selection of chemotherapeutic regimens could improve the out-come in patients with gallbladder carcinoma.

关键词： Gallbladder cancer Mini-PDX Chemosensitivity Overall survival Personalized therapy

基于AI的刀具磨损对刨花质量和刨花板性能影响的评估

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林产工业 2024年第3期61卷 30-37页

作者：何雨晨李园郑圣龙杨兆金黄鹤鸣罗邦瑞解林坤杜官本周华万辉西南林业大学材料与化学工程学院云南昆明650223 昆明飞林人造板集团有限公司云南昆明650403 西南林业大学大数据与智能工程学院云南昆明650224

为推动人造板智能制造的发展,本文建立了一种基于AI计算机视觉技术的刨花尺寸与形状的检测方法,能自动识别刨花尺寸大小并区分出杆状、类矩形、类三角形和其他型4种刨花形状。在此基础上,对在不同切削时间的刨花形态变化、刨片机刀具磨... 详细信息

为推动人造板智能制造的发展,本文建立了一种基于AI计算机视觉技术的刨花尺寸与形状的检测方法,能自动识别刨花尺寸大小并区分出杆状、类矩形、类三角形和其他型4种刨花形状。在此基础上,对在不同切削时间的刨花形态变化、刨片机刀具磨损程度和工作电流进行了监测和诊断。同时,用这些刨花分组制备了相应的刨花板,并对其物理力学性能进行测试,建立了刨片机刀具磨损程度、电流消耗量、刨花形态与刨花板性能的数学关系模型,并找到刨片机优化换刀时间。结果表明:基于AI的刨花形态检测不但能够监测刀具磨损过程中刨花形态的变化,还可以有效预测刨花板的产品性能。在给定的生产条件下,刨片机开机运行2~4 h内切削出的刨花所制造的刨花板综合性能最好。

关键词：计算机视觉技术过程控制刀具磨损刨花质量刨花板性能

Biology,invasion and management of the agricultural invader:Fall armyworm,Spodoptera frugiperda(Lepidoptera:Noctuidae)

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Journal of Integrative Agriculture 2021年第3期20卷 646-663页

作者： Jing wan HUANG Cong LI Chang-you ZHOU Hong-xu REN Yong-lin LI Zai-yuan XING long-sheng ZHANG Bin QIAO Xi LIU Bo LIU Cong-hui XI Yu LIU wan-xue wanG Wen-kai QIAN wan-qiang Simon MCKIRDY wan Fang-hao Harry Butler Institute Murdoch UniversityPerthWA 6150Australia Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120P.R.China College of Plant Health and Medicine Qingdao Agricultural UniversityQingdao 266109P.R.China Hubei Engineering Research Center for Pest Forewarning and Management Yangtze UniversityJingzhou 434025P.R.China Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193P.R.China

The fall armyworm(FAW),Spodoptera frugiperda(***),is native to the *** has rapidly invaded 47 African countries and 18 Asian countries since the first detection of invasion into Nigeria and Ghana in *** is regarded as a super pest based on its host range(at least 353 host plants),its inherent ability to survive in a wide range of habitats,its strong migration ability,high fecundity,rapid development of resistance to insecticides/viruses and its gluttonous *** inherently superior biological characteristics of FAW contribute to its *** pest management(IPM)of FAW has relied on multiple applications of monitoring and scouting,agricultural control,chemical pesticides,viral insecticides,sex attractants,bio-control agents(parasitoids,predators and entomopathogens)and *** gaps remain to be filled to:(1)understand the invasive mechanisms of ***;(2)understand how to prevent its further spread and(3)provide better management *** review summarizes the biological characters of FAW,their association with its invasiveness and IPM strategies,which may provide further insights for future management.

关键词： invasive alien species fall armyworm Spodoptera frugiperda biological invasions prevention management biosecurity

Nonhuman Primate Model of Oculocutaneous Albinismwith TYR and OCA2 Mutations

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Research 2020年第1期2020卷 135-145页

作者： Kun-Chao Wu Ji-Neng Lv hui Yang Feng-Mei Yang rui lin qiang lin Ren-Juan Shen Jun-Bin wang Wen-Hua Duan Min Hu Jun Zhang Zhan-long He Zi-Bing Jin Division of Ophthalmic Genetics The Eye HospitalLaboratory for Stem Cell&Retinal RegenerationInstitute of Stem Cell ResearchWenzhou Medical UniversityWenzhou 325027China National Center for International Research in Regenerative Medicine and Neurogenetics National Clinical Research Center for Ocular DiseasesState Key Laboratory of OphthalmologyOptometry and Visual ScienceWenzhou 325027China Institute of Medical Biology Chinese Academy of Medical SciencesAnd Peking Union Medical College(CAMS&PUMC)Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious DiseaseKunming 650118China Department of Ophthalmology The Second People’s Hospital of Yunnan ProvinceFourth Affiliated Hospital of Kunming Medical UniversityKey Laboratory of Yunnan Province for the Prevention and Treatment of OphthalmologyKunming 650021China Laboratory of Retinal Physiology&Disease The Eye HospitalWenzhou Medical UniversityWenzhou 325027China

Human visual acuity is anatomically determined by the retinal *** ontogenetic development of the fovea can be seriously hindered by oculocutaneous albinism(OCA),which is characterized by a disorder of melanin *** people of all ethnic backgrounds can be affected,no efficient treatments for OCA have been developed thus far,due partly to the lack of effective animal *** macaques are genetically homologous to humans and,most importantly,exhibit structures of the macula and fovea that are similar to those of humans;thus,rhesus macaques present special advantages in the modeling and study of human macular and foveal *** this study,we identified rhesus macaque models with clinical characteristics consistent with those of OCA patients according to observations of ocular behavior,fundus examination,and optical coherence *** sequencing revealed a biallelic p.L312I mutation in TYR and a homozygous p.S788L mutation in OCA2,both of which were further confirmed to affect melanin biosynthesis via in vitro *** rhesus macaque models of OCA will be useful animal resources for studying foveal development and for preclinical trials of new therapies for OCA.

关键词： clinical cutaneous ism

INSITUFTIR　SPECTRAL　STUDY　OF　THE　OXYGEN　ADSPECIES　ON　SrF2／La2O3　CATALYST　DURING　THE　OXIDATIVE　COUPlinG　OF　METHANE

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Chinese Chemical Letters 1995年第8期

作者： rui qiang long Shui Qin ZHOU Ya Ping HUANG Hai You wanG hui lin wan Khi rui TSAI(Depatment of Chemistry and State Key Laboratory for Physical Chemistry of the Solid Surface,Xiamen University,Xiamen,361005)

ＩＮＳＩＴＵＦＴＩＲＳＰＥＣＴＲＡＬＳＴＵＤＹＯＦＴＨＥＯＸＹＧＥＮＡＤＳＰＥＣＩＥＳＯＮＳｒＦ＿２／Ｌａ＿２Ｏ＿３ＣＡＴＡＬＹＳＴＤＵＲＩＮＧＴＨＥＯＸＩＤＡＴＩＶＥＣＯＵＰＬＩＮＧＯＦＭＥＴＨＡＮＥ￥ＲｕｉＱｉａ... 详细信息

ＩＮＳＩＴＵＦＴＩＲＳＰＥＣＴＲＡＬＳＴＵＤＹＯＦＴＨＥＯＸＹＧＥＮＡＤＳＰＥＣＩＥＳＯＮＳｒＦ＿２／Ｌａ＿２Ｏ＿３ＣＡＴＡＬＹＳＴＤＵＲＩＮＧＴＨＥＯＸＩＤＡＴＩＶＥＣＯＵＰＬＩＮＧＯＦＭＥＴＨＡＮＥ￥ＲｕｉＱｉａｎｇＬＯＮＧ；ＳｈｕｉＱｉｎＺＨＯ...

关键词： La2O3 SrF2 ON DURING CATALYST ADSPECIES

Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression

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骨研究:英文版 2023年第3期11卷 625-637页

作者： Zhe Ruan Hao Yin Teng-Fei wan Zhi-Rou lin Shu-Shan Zhao Hai-Tao long Cheng long Zhao-hui Li Yu-Qi Liu Hao Luo Liang Cheng Can Chen Min Zeng Zhang-Yuan lin rui-Bo Zhao Chun-Yuan Chen Zhen-Xing wang Zheng-Zhao Liu Jia Cao Yi-Yi wang ling Jin Yi-Wei Liu Guo-qiang Zhu Jing-Tao Zou Jiang-Shan Gong Yi Luo Yin Hu Yong Zhu hui Xie Department of Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China Movement System Injury and Repair Research Center Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Angmedicine ChangshaHunan 410008China Angmedicine Research Center of Central South University ChangshaHunan 410008China The First Affiliated Hospital Department of Metabolism and EndocrinologyHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Due to increasing morbidity worldwide,fractures are becoming an emerging public health *** study aimed to investigate the effect of metformin on the healing of osteoporotic as well as normal *** H vessels have recently been identified as a bone-specific vascular subtype that supports ***,we show that metformin accelerated fracture healing in both osteoporotic and normal ***,metformin promoted angiogenesis in vitro under hypoxia as well as type H vessel formation throughout fracture ***,metformin increased the expression of HIF-1α,an important positive regulator of type H vessel formation,by inhibiting the expression of YAP1/TAZ in calluses and hypoxia-cultured human microvascular endothelial cells(HMECs).The results of HIF-1αor YAP1/TAZ interference in hypoxia-cultured HMECs using si RNA further suggested that the enhancement of HIF-1αand its target genes by metformin is primarily through YAP1/TAZ ***,overexpression of YAP1/TAZ partially counteracted the effect of metformin in promoting type H vessel-induced angiogenesis-osteogenesis coupling during fracture *** summary,our findings suggest that metformin has the potential to be a therapeutic agent for fractures by promoting type H vessel formation through YAP1/TAZ inhibition.

关键词： YAP1 healing fracture

Dihydroergotamine ameliorates liver fibrosis by targeting transforming growth factor β type Ⅱ receptor

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World Journal of Gastroenterology 2023年第20期29卷 3103-3118页

作者： Ke-Xin Zheng Shou-Li Yuan Meng Dong Han-lin Zhang Xiao-Xiao Jiang Chun-long Yan Rong-Cai Ye hui-Qiao Zhou Li Chen rui Jiang Zi-Yu Cheng Zhi Zhang Qi wang wan-Zhu Jin Wen Xie Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Graduate School University of the Chinese Academy of SciencesBeijing 100049China Graduate School Agriculture College of Yanbian UniversityYanji 133002Jilin ProvinceChina

BACKGROUND The transforming growth factor β(TGFβ) signaling pathway plays a crucial role in the development of liver fibrosis by activating TGFβ type Ⅱ receptor(TGFβR2), followed by the recruitment of TGFβR1 finally triggering downstream signaling *** To find drugs targeting TGFβR2 that inhibit TGFβR1/TGFβR2 complex formation, theoretically inhibit TGFβ signaling pathway, and thereby ameliorate liver *** Food and Drug Administration-approved drugs were screened for binding affinity with TGFβR2 by virtual molecular docking. We identified 6 candidates and further explored their potential by Cell Counting Kit-8(CCK-8) cell cytotoxic experiment to validate toxicity and titrated the best cellular working concentrations. Next, we further demonstrated the detailed molecular working mechanisms using mutagenesis analysis. Finally, we used a mouse model to investigate its potential anti-liver fibrosis *** We identified 6 drug candidates. Among these 6 drugs, dihydroergotamine(DHE) shows great ability in reducing fibrotic gene expressions such as collagen, p-SMAD3, and α-SMA in TGFβ induced cellular model of liver fibrosis in LX-2 cells. Furthermore, we demonstrated that DHE binds to TGFβR2. Moreover, mutation of Leu27, Phe30, Thr51, Ser52, Ile53, and Glu55 of TGFβR2 disrupted the binding of TGFβR2 with DHE. In addition, DHE significantly improved liver fibrosis, as evidenced by Masson’s trichrome staining of liver sections. This is further supported by the width and the velocity of the portal vein, and serum markers of liver function. In line with those observations, DHE also decreased macrophages infiltration and extracellular matrix deposition in the *** DHE alleviates liver fibrosis by binding to TGFβR2 thereby suppressing TGFβ signaling pathway. We show here that as far as drug repurposing, DHE has great potential to treat liver fibrosis.

关键词： Liver fibrosis Transforming growth factorβ(TGFβ)signaling pathway TGFβtype II receptor(TGFβR2) Virtual screening Drug-repurposing Dihydroergotamine