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HBsAg Loss with Peg-interferon Alfa-2a in Hepatitis B Patients with Partial Response to Nucleos(t)ide Analog:New Switch Study

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Journal of Clinical and Translational Hepatology 2018年第1期6卷 25-34页

作者： Peng Hu Jia Shang Wenhong Zhang Guozhong Gong Yongguo Li Xinyue Chen Jianning Jiang Qing xie Xiaoguang Dou Yongtao sun Yufang Li Yingxia Liu Guozhen Liu Dewen Mao Xiaoling Chi Hong Tang Xiaoou Li Yao xie Xiaoping Chen Jiaji Jiang Ping Zhao Jinlin Hou Zhiliang gao Huimin Fan Jiguang Ding Dazhi Zhang Hong Ren department of Infectious Diseases The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina department of Infectious Diseases Henan Provincial People's HospitalZhengzhouChina department of Infectious Diseases Huashan HospitalFudan UniversityShanghaiChina department of Infectious Diseases The Second Xiangya Hospital of Central South UniversityChangshaChina department of Infectious Diseases The First Affiliated Hospital of Harbin Medical UniversityHarbinChina International Medical department Beijing YouAn HospitalCapital Medical UniversityBeijingChina department of Infectious Diseases The First Affiliated Hospital of Guangxi Medical UniversityNanningChina department of Infectious Diseases Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina department of Infectious Diseases Shengjing Hospital of China Medical UniversityShenyangChina department of Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina department of Infectious Diseases General Hospital of Ningxia Medical UniversityYinchuanChina department of Infectious Diseases Shenzhen Third People's HospitalShenzhenChina department of Infectious Diseases Xiangya Hospital Central South UniversityChangshaChina Liver Disease department The First Affiliated Hospital of Guangxi University of Chinese MedicineNanningChina Liver Disease department Guangdong Hospital of Traditional Chinese MedicineGuangzhouChina Center of Infectious Diseases West China HospitalSichuan UniversityChengduChina Liver Disease department The Sixth People's Hospital of HangzhouZhejiangChina Liver Disease department Beijing Ditan HospitalCapital Medical UniversityBeijingChina department of Infectious Diseases Guangdong General HospitalGuangzhouChina Center of Liver Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina International Center for Liver Disease Treatment 302 Hospital of PLABeijingChina department of Infectious Diseases and Hepatology Unit Nanfang Ho

Background and Aims:Hepatitis B surface antigen(HBsAg)loss is seldom achieved with nucleos(t)ide analog(NA)therapy in chronic hepatitis B patients but may be enhanced by switching to finite pegylated-interferon(Peg-IFN)*** assessed HBsAg loss with 48-and 96-week Peg-IFN alfa-2a in chronic hepatitis B patients with partial response to a previous ***:Hepatitis B e antigen(HBeAg)-positive patients who achieved HBeAg loss and hepatitis B virus DNA1:1 to receive Peg-IFN alfa-2a for 48(n=153)or 96 weeks(n=150).The primary endpoint of this study was HBsAg loss at end of *** *** identifier is ***:At the end of 48 and 96 weeks'treatment,14.4%(22/153)and 20.7%(31/150)of patients,respectively,who switched from NA to Peg-IFN alfa-2a cleared *** were similar irrespective of prior NA or baseline HBeAg *** those who cleared HBsAg by the end of 48 and 96 weeks'treatment,77.8%(14/18)and 71.4%(20/28),respectively,sustained HBsAg loss for a further 48 *** HBsAg1500 IU/mL and week 24 HBsAg1.4%and 58.7%,respectively).Importantly,extending treatment from 48 to 96 weeks enabled 48.3%(14/29)more patients to achieve HBsAg ***:Patients on long-term NA who are unlikely to meet therapeutic goals can achieve high rates of HBsAg loss by switching to Peg-IFN *** loss rates may be improved for some patients by extending treatment from 48 to 96 weeks,although the differences in our study cohort were not statistically *** and on-treatment HBsAg may predict HBsAg loss with Peg-IFN alfa-2a.

关键词： Antiviral therapy Peg-interferon Nucleos(t)ide treated Chronic hepatitis B

Unsatisfying antiviral therapeutic effect in patients with mother-tochild transmissed chronic hepatitis B virus infection: a prospective multi-center clinical study

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Chinese Medical Journal 2019年第22期132卷 2647-2656页

作者： Jun Li Xiao-Qin dong Zhao Wu An-Lin Ma Shi-Bin xie xu-Qing Zhang Zhan-Qing Zhang Da-Zhi Zhang Wei-Feng Zhao Guo Zhang Jun Cheng Qing xie Jun Li Zhi-Qiang Zou Ying-Xia Liu Gui-Qiang Wang Hong Zhao china Hepatitis B Related Fibrosis Assessment Research Group department of Infectious Diseases Center for Liver DiseasePeking University First HospitalBeijing 100034China department of Infectious Diseases Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China department of Infectious Diseases China-Japan Friendship HospitalBeijing 100029China department of Infectious Diseases The Third Affiliated Hospital Sun Yat-Sen UniversityGuangzhouGuangdong 510000China department of Infectious Diseases South West Hospital Affiliated to Third Military Medical UniversityChongqing 400038China department of Hepatology Shanghai Public Health Clinical CenterFudan UniversityShanghai 200083China department of Infectious Diseases Second Affiliated Hospital of Chongqing Medical UniversityChongqing 404000China department of Infectious Diseases Xinxiang Medical University Third HospitalXinxiangHenan 453003China department of Infectious Diseases The People's Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi 530021China department of Infectious Diseases Di Tan Hospital Affiliated to Capital Medical UniversityBeijing 100015China department of Infectious Diseases Rui Jin HospitalShanghai Jiao Tong University School of MedicineShanghai 200090China department of Infectious Diseases The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 211166China department of Infectious Diseases Yantai City Hospital for Infectious DiseaseYantaiShandong 264001China Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhenGuangdong 518034China The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang UniversityHangzhouZhejiang 310085China department of Infectious Diseases Peking University International HospitalBeijing 102206China 不详

Background:Few data are available regarding the progression of liver disease and therapeutic efficacy in chronic hepatitis B(HBV)carriers infected by mother-to-child transmission(MTCT).This study aimed to investigate these two aspects by comparing the adult chronic HBV carriers in MTCT group with those in horizontal transmission ***:The 683 adult chronic HBV patients qualified for liver biopsy including 191 with MTCT and 492 with horizontal transmission entered the multi-center prospective study from October 2013 to May *** results from 217 patients at baseline and 78 weeks post antiviral therapy were ***:Patients infected by MTCT were more likely to have e antigen positive(68.6%vs.58.2%,x^2=-2.491,P=0.012)than those with horizontal ***,in patients with MTCT,levels of alkaline phosphatase(ALP)(P=0.031),Fibroscan(P=0.013),N-terminal propeptide of Type III procollagen(PIIINP)(P=0.014),and Laminin(LN)(P=0.006)were high,in contrast to the patients with horizontal transmission for whom the levels of albumin(ALB)(P=0.041),matrix metalloproteinase-3(MMP-3)(P=0.001)were *** 47.2% of patients with MTCT and 36.8%of those with horizontal transmission had significant liver fibrosis(P=0.013).Following antiviral therapy for 78 weeks,21.2%and 38.0%patients with MTCT and horizontal transmission acquired hepatitis B e antigen(HBeAg)clearance,respectively(P=0.043),and the virological response rates were 54.7%and 74.1%in the MTCT and horizontal groups,respectively(P=0.005).MTCT was a risk factor for HBeAg clearance and virological ***:Adult patients with MTCT were more prone to severe liver diseases,and the therapeutic efficacy was relatively poor,which underlined the importance of earlier,long-term treatment and interrupting perinatal transmission.

关键词： Chronic Hepatitis B virus infection Horizontal transmission Mother-to-child transmission Progression of disease Therapeutic efficacy

Tenofovir disoproxil fumarate in Chinese chronic hepatitis B patients:Results of a multicenter,double-blind,double-dummy,clinical trial at 96 weeks

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World Journal of Clinical Cases 2021年第18期9卷 4690-4699页

作者： Xiao-Fan Chen Ya-Nan Fan Chong-Wen Si Yan-Yan Yu Jia Shang Zu-Jiang Yu Qing Mao Qing xie Wei Zhao Jun Li Zhi-Liang gao Shan-Ming Wu Hong Tang Jun Cheng Xin-Yue Chen Wen-Hong Zhang Hao Wang Zhong-Nan xu Ling Wang Jun Dai Jing-Hang xu department of Infectious Diseases Center for Liver DiseasesPeking University First HospitalBeijing 100034China department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina department of Infectious Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China department of Infectious Diseases Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China department of Infectious Diseases The Second Affiliated Hospital of Southeast UniversityNanjing 210011Jiangsu ProvinceChina department of Infectious Diseases The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina department of Infectious Diseases The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghai 201052China department of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Center of Hepatology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China department of International Medical Beijing Youan HospitalCapital Medical UniversityBeijing 10069China department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China department of Infectious Diseases Peking University People's HospitalBeijing 100044China Clinical Center Jiangsu Chia-tai Tianqing Pharmaceutical Co.LtdNanjing 210000Jiangsu ProvinceChina

BACKGROUND Tenofovir disoproxil fumarate(TDF)is a prodrug of a nucleotide *** an antiviral drug,TDF has been proposed in the first-line treatment of chronic hepatitis B(CHB).Qingzhong,a brand name of TDF,commercialized by Jiangsu Chia-tai Tianqing Pharmaceutical Co Ltd.,and Viread,another brand name of TDF,commercialized by GlaxoSmithKline,have both been approved by the State Food and Drug Administration,*** To investigate the efficacy and safety of the two TDF agents in the treatment of Chinese CHB *** This trial was registered at *** with the identifier number of NCT02287857.A total of 330 Chinese CHB patients,among which 232 were hepatitis B e antigen(HBeAg)-positive,were included in this 5-year-long,multicenter,double-blinded,double-dummy,randomized-controlled,noninferiority phase III *** participants were initially randomized into two groups:Group A(n=161),in which the participants received 300 mg Qingzhong once a day for 48 wk;and Group B,in which the participants received 300 mg Viread once a day for 48 *** from week 49,all the participants in Groups A and B received 300 mg Qingzhong once a day until the 96th *** this study,the primary endpoint was the decrease in plasma level of hepatitis B virus(HBV)DNA at the 96th week,while the secondary endpoints were suppression of HBV replication,alanine aminotransferase(ALT)normalization,HBeAg loss,and HBeAg seroconversion *** For the participants with HBeAg-positive CHB,the decrease in mean HBV DNA level relative to the baseline value was comparable between Groups A and B(5.77 vs 5.73 log10 IU/mL,P>0.05)at the 96th *** addition,similar percentages of HBeAg-positive participants in the two groups exhibited undetectable levels of HBV DNA,HBeAg loss,and HBeAg seroconversion(71.05%vs 77.97%,31.00%vs 27.27%,and 20.22%vs 15.79%,respectively,in Group A vs Group B;P>0.05).For the participants with HBeAg-negative CHB,the decrease in mean HBV DNA level r

关键词： Chronic hepatitis B Hepatitis B virus infection Chronic Tenofovir disoproxil

Expert consensus on clinical standardized application of high-flow nasal cannula oxygen therapy in adults

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Chinese Medical Journal 2020年第11期133卷 1322-1324页

作者： Jian-Qiao xu long-Xiang Su Peng Yan Xing-Shuo Hu Ruo-xuan Wen Kun Xiao Hong-Jun Gu Jin-Gen Xia Bing sun Qing-Tao Zhou Yu-Chao dong Jia-Lin Liu Pin-Hua Pan Hong Luo Qi Li Li-Qiang Song Si-Cheng xu Yan-Ming Li Dao-Xin Wang Dan Li Qing-Yuan Zhan Li-Xin xie 无 Departm ent of Pulmonary&Critical Care Medicine Chinese People Liberation Army(PLA)General HospitalBeijing 100853China department of Critical Care Medicine Peking Union Medical College HospitalBeijing 100005China department of Pulmonary&Critical Care Medicine China and Japan Friendship HospitalBeijing 100029China department of Pulmonary&Critical Care Medicine Beijing Chaoyang Hospital affiliated to Capital Medical UniversityBeijing 100020China department of Pulmonary&Critical Care Medicine Peking University Third HospitalBeijing 100191China department of Respiratory Medicine Changhai HospitalShanghai 200433China department of Respiratory Medicine Ruijin Hospital Affiliated to the Shanghai Jiao Tong University Medical SchoolShanghai 200025China department of Respiratory Medicine XiangYa HospitalCentral South UniversityChangshaHunan 410008China department of Pulmonary&Critical Care Medicine XiangYa Second Hospital of Central South UniversityChangshaHunan 410011China department of Pulmonary&Critical Care Medicine Xinqiao Hospital of the Third Military Medical UniversityChongqing 400037China department of Pulmonary&Critical Care Medicine Xijing Hospital of Fourth Military Medical UniversityXi'anShaanxi 710032China department of Respiratory Medicine The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830000China department of Pulmonary&Critical Care Medicine Beijing HospitalBeijing 100730China department of Respiratory Medicine The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China department of Respiratory Medicine The First Bethune Hospital of Jilin UniversityChangchunJilin 130021China Pulmonary&Critical Care Medicine Group of Chinese Thoracic Society/Pulmonary&Critical Care Medicine Committee of Chinese Association of Chest Physician

High-flow nasal cannula oxygen therapy(HFNC)is a novel respiratory support technology and has been extensively applied in clinics in recent *** therapeutic equipment mainly includes an air-oxygen blender,an active humidifier,a high-flow nasal cannula,and a connecting inspiratory *** provides patients a humidified high-flow gas(8-80 L/min)with relatively stable oxygen concentration(21-100%),temperature(31-37℃)and performs oxygen therapy via a nasal cannula,which is very comfortable.

关键词： flow connecting high

A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014–2015

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Infectious Diseases of Poverty 2016年第1期5卷 670-679页

作者： Zhong-Jie Li Wen-Xiao Tu Xiao-Chun Wang Guo-Qing Shi Zun-dong Yin Hai-Jun Su Tao Shen Da-Peng Zhang Jian-dong Li Shan Lv Chun-Li Cao Rui-Qian xie Hong-Zhou Lu Rong-Meng Jiang Zheng Cao Zhi-Jie An Lei-Lei Li Jie xu Yan-Wen Xiong Wei Zang Wei Zhang Hong-Wei Zhang Wen-Sen Chen Hua Ling Wen xu Jian Cai Huan-Jin Luo xue-Sheng Xing Can-Jun Zheng Qiang Wei Xin-xu Li Mei Li Hai Jiang Li-Quan Deng Ming-Quan Chen Xiang Huo Feng xu xue-Hui Lai Xi-Chen Bai long-Jie Ye Jian-Yi Yao Wen-Wu Yin Jiao-Jin sun Lin Xiao Fu-Qiang Liu Xiao-Qiang Liu Hong-Wei Fan Zeng-Qiang Kou Ji-Kun Zhou Hao Zhang Da-Xin Ni Thomas TSamba Qun Li Hong-Jie Yu Yu Wang Xiao-Feng Liang Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Center for Disease Control and PreventionBeijingChina Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijingChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Bureau of Disease Prevention and Control National Health and Family Planning Commission of the People’s Republic of ChinaBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionShanghaiChina Chinese Center for Health Education BeijingChina department of Infectious Diseases Shanghai Public Health Clinical CenterShanghaiChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Health News BeijingChina National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina department of Training Chinese Center for Health EducationBeijingChina Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijingChina Infection Management The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Chongqing Municipal Center for Disease Control and Prevention ChongqingChina Yunnan Provincial Center for Disease Control and Prevention KunmingChina Division of Infectious Disease Control and Prevention Zhejiang Provincial Center for Disease Control and PreventionHangzhouChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouChina Division of Acute Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and PreventionW

Background:The Ebola virus disease spread rapidly in West Africa in 2014,leading to the loss of thousands of *** engagement was one of the key strategies to interrupt Ebola transmission,and practical community level measures needed to be explored in the field and tailored to the specific context of ***:First,community-level education on Ebola virus disease(EVD)prevention was launched for the community’s social mobilizers in six districts in Sierra Leone beginning in November ***,from January to May of 2015,in three pilot communities,local trained community members were organized to engage in implementation of EVD prevention and transmission interruption measures,by involving them in alert case report,contact tracing,and social *** epidemiological indicators of transmission interruption in three study communities were ***:A total of 6016 community social mobilizers from 185 wards were trained by holding 279 workshops in the six districts,and EVD message reached an estimated 631680 *** three pilot communities,72 EVD alert cases were reported,with 70.8%of them detected by trained local community members,and 14 EVD cases were finally *** tracing detected 64.3%of EVD *** median duration of community infectivity for the cases was 1 *** secondary attack rate was 4.2%,and no third generation of infection was *** health worker was infected,and no unsafe burial and noncompliance to EVD control measures were *** community-based measures were modeled to reduce 77 EVD cases,and the EVD-free goal was achieved four months earlier in study communities than whole country of Sierra ***: The community-based strategy of social mobilization and community engagement was effective in casedetection and reducing the extent of Ebola transmission in a country with weak health system. The successfullypractical experience to reduce the risk of Ebola transmission in the

关键词： Ebola virus disease Community engagement Health education Outbreak control

Reliability and validity of generalized anxiety disorder 7-item scale in early pregnant women

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Reproductive and Developmental Medicine 2022年第4期6卷 249-253页

作者： Li-Li Gong Xiao-long xie Si-Tong Liu Wei-Hong Hu Yu-Jie Niu Yi sun Jun-Sheng Liu Xian Xia department of Obstetrics Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China School of Psychology and Cognitive Science East China Normal UniversityShanghai 200062China

Objective:This study aimed to evaluate the structural reliability and validity of generalized anxiety disorder 7-item(GAD-7)scale in early pregnant ***:In this cross-sectional study,30,823 patients in early pregnancy registered in the Obstetrics and Gynecology Hospital of fudan university completed the GAD-7 scale and patient health questionnaire-9 item(PHQ-9).The discriminative ability,reliability,construct validity,and criterion validity were assessed to evaluate the psychometric properties and factor *** with a discrimination parameter(α)of0.40 in two or more factors simultaneously were deleted from the ***:All GAD-7 scale items exhibited a high discrimination *** reliability of the GAD-7 scale was good(Cronbach’s alpha coefficient=0.891).Exploratory factor analysis extracted one factor with eigenvalues of greater than 1.0,which explained 61.930%of the common *** factor analysis confirmed that the one-factor structure fitted the data *** correlation coefficient with the PHQ-9 was ***:The Chinese version of the GAD-7 scale can be used as a screening tool for early pregnant *** performs well in terms of discriminative ability,reliability,construct validity,and criterion *** women who screen positive may require more attention and investigation to confirm the presence of generalized anxiety disorder.

关键词： Reliability Validity GAD-7 PHQ-9 Early pregnancy

桩–土–斜拉桥动力相互作用体系振动反应特性试验研究

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岩土工程学报 2019年第7期41卷 1319-1328页

作者：谢文孙利民宁波大学建筑工程与环境学院浙江宁波315211 同济大学土木工程防灾国家重点实验室上海200092

大跨斜拉桥结构自振频率和阻尼较低,其地震响应可能受桩基础和场地土特性的影响较大,然而目前为止,由于试验条件和技术所限,尚缺乏相关的包括桩基础、场地土和上部结构在内的全模型振动台试验研究。以一座试设计的主跨1400 m超大跨斜拉... 详细信息

大跨斜拉桥结构自振频率和阻尼较低,其地震响应可能受桩基础和场地土特性的影响较大,然而目前为止,由于试验条件和技术所限,尚缺乏相关的包括桩基础、场地土和上部结构在内的全模型振动台试验研究。以一座试设计的主跨1400 m超大跨斜拉桥为原型,设计并完成了一座几何相似比为1/70,且包括群桩、人工土和上部结构在内的试验模型,采用多点振动台试验技术,研究了不同加速度峰值和不同频率成分地震作用下桩-土-斜拉桥动力相互作用体系的振动反应特性。试验结果表明:桩-土-结构相互作用对斜拉桥地震响应产生影响,其影响程度与地震输入频谱特性密切相关;在纵向一致激励下,桩-土-结构相互作用受地震动加速度峰值的影响不明显,在横向一致激励下,桩-土-结构相互作用随地震动加速度峰值的增大而减小;主塔高阶振型对其地震响应的贡献明显;地震输入频谱特性影响桩-土-斜拉桥动力相互作用体系的地震响应,特别是在具有丰富长周期成分的Mexico City波作用下主梁竖向地震响应显著增大。

关键词：大跨斜拉桥振动台试验桩-土-结构相互作用高阶振型频谱特性

搜寻第二个地球——系外地球(ET)巡天计划

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空间科学学报 2024年第3期44卷 400-424页

作者：葛健陈雯陈永和宋宗玺王坚张辉李岩臧伟呈周丹张永帅陈琨阳应权毛淑德黄煦药新雨李兴隆姜海娇于涌唐正宏董峰高伟张鸿飞申超王峰涛魏传新杨宝玉李豫东文林张朋军张聪聪谢基伟马波邓洪平刘慧根段旭亮王昊宇黄江江高扬王伊菲王磊秦根健刘欣宇高婕中国科学院上海天文台上海200030 中国科学院微小卫星创新研究院上海201304 中国科学院上海技术物理研究所上海200083 中国科学院西安光学精密机械研究所西安710119 中国科学技术大学合肥230026 清华大学天文系北京100190 南昆士兰大学天体物理中心图文巴QLD4350 中国航天科技集团公司第八研究院803研究所上海201109 中国科学院新疆理化技术研究所乌鲁木齐830011 南京大学天文系南京210023 中山大学物理与天文学院珠海519082

系外地球科学卫星(ET)将通过采用空间大视场超高精度测光这一关键技术在国际上率先突破生命起源中的系外地球存在及其演化这一重大前沿科学问题. ET卫星将在日地拉格朗日L2点晕(Halo)轨道部署由6台广角凌星望远镜和1台微引力透镜望远镜... 详细信息

系外地球科学卫星(ET)将通过采用空间大视场超高精度测光这一关键技术在国际上率先突破生命起源中的系外地球存在及其演化这一重大前沿科学问题. ET卫星将在日地拉格朗日L2点晕(Halo)轨道部署由6台广角凌星望远镜和1台微引力透镜望远镜构成的空间天文台,结合凌星法和微引力透镜法,利用空间超大视场和超高精度的光学测光观测,首次发现富有重要意义、被广泛关注的系外地球,并确定其发生率,对目前了解甚少的类地行星和流浪行星进行国际上第一次大规模的种群普查,首次发现流浪地球,并确定其发生率,揭示类地行星和流浪行星起源,为地外生命探寻提供候选者和新方向. ET卫星的观测结果、统计研究以及和对理论的检验将回答系外地球在宇宙中有多普遍,类地行星是如何形成和演化的,流浪行星又是如何起源的这些亟待解决的前沿科学问题.对ET卫星发现的系外地球样本的后随观测,将精确测量其质量、密度和大气成分,有助于深入分析宜居性特征.此外,对ET新发现的大量各种系外行星样本的研究,以及对理论的检验将推动这些种类的行星形成和演化规律的更深入认识, ET的大量高精度、高频次和长基线测光数据将推动星震学、银河系考古学、时域天文学、双星和双星黑洞等领域的研究.

关键词：系外行星类地行星宜居带凌星微引力透镜测光

Repair, protection and regeneration of peripheral nerve injury

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Neural Regeneration Research 2015年第11期10卷 1777-1798页

作者： Shan-lin Chen Zeng-gan Chen Hong-lian Dai Jian-xun Ding Jia-song Guo Na Han Bao-guo Jiang Hua-jun Jiang Juan Li Shi-pu Li Wen-jun Li Jing Liu Yang Liu Jun-xiong Ma Jiang Peng Yun-dong Shen Guang-wei sun Pei-fu Tang Gu-heng Wang Xiang-hai Wang Liang-bi Xiang Ren-guo xie Jian-guang xu Bin Yu Li-cheng Zhang Pei-xun Zhang Song-lin Zhou department of Hand Surgery Beijing Jishuitan Hospital department of Orthopedic Surgery Zhongshan Hospital Fudan University State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Biomedical Materials and Engineering Research Center of Hubei Province Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences department of Histology and Embryology Southern Medical University Key Laboratory of Tissue Construction and Detection of Guangdong Province Institute of Bone Biology Academy of Orthopedics Peking university People's Hospital department of Orthopedics First Affiliated Hospital of Dalian Medical University The First Affiliated Hospital of Dalian Medical university Laboratory of Biotechnology Dalian Institute of Chemical PhysicsChinese Academy of Sciences department of Orthopedics General Hospital of Shenyang Military Area Command of Chinese PLA Rescue Center of Severe Wound and Trauma of Chinese PLA Institute of Orthopedics Chinese PLA General Hospital The Neural Regeneration Co-innovation Center of Jiangsu Province department of Hand Surgery Huashan Hospital Fudan University department of Hand and Upper Extremity Surgery Jing’an District Centre Hospital department of Orthopedics General Hospital of People's Liberation Army department of Hand Surgery Affiliated Hospital of Nantong University Trauma Center Department of Orthopedic Surgery Shanghai First People’s Hospital Shanghai Jiao Tong University School of Medicine Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of Neuroregeneration Nantong University

Reading guide 1778Repair of long-segment peripheral nerve defects1779Bionic reconstruction of hand function after adult brachial plexus root avulsion1780Optimized design of regeneration material for the treatment of peripheral nerve injury1781Synergism of electroactive polymeric materials and electrical stimulation promotes peripheral nerve repair1783Schwann cell effect on peripheral nerve repair and regeneration .

关键词： cell protection and regeneration of peripheral nerve injury Repair