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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

深圳市龙岗区男男性接触者安全套使用情况调查和影响因素分析

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数理医药学杂志 2019年第12期32卷 1804-1805页

作者：何英俊卢春如曾为民龙清平刘凤仁金玉娟深圳市龙岗区坪地预防保健所

目的:对男男性接触者安全套使用情况进行调查分析。方法:于2016年12月~2017年12月对某区常住男男性接触者进行调查分析,通过调查分析其安全套使用情况。结果:(1)男男性接触者在进行肛交时安全套使用情况比口交时安全套使用情况好,数据... 详细信息

目的:对男男性接触者安全套使用情况进行调查分析。方法:于2016年12月~2017年12月对某区常住男男性接触者进行调查分析,通过调查分析其安全套使用情况。结果:(1)男男性接触者在进行肛交时安全套使用情况比口交时安全套使用情况好,数据差异显著(P<0.05);(2)低于20岁及21~30岁之间男男性接触者安全套使用情况较好,而31~40岁及41岁以上男男性接触者安全套使用情况并不是很理想。结论:我区男男性接触者安全套使用情况比较理想,不使用安全套的因素也比较多,主要与对艾滋病的认识不足、降低了愉悦感、不利于双方亲密接触等有关,应利用宣传等形式增加男男性接触者安全套使用的意识,控制及预防艾滋病的发生。

关键词：男男性接触者安全套使用情况艾滋病

NON-LOCAL MODELING ON MACROSCOPIC DOMAIN PATTERNS IN PHASE TRANSFORMATION OF NiTi TUBES

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Acta Mechanica Solida Sinica 2009年第5期22卷 407-417页

作者： Yongjun He qingping Sun Department of Mechanical Engineering The Hong Kong University of Science and Technology Hong Kong China

Recent experiments revealed many new phenomena of the macroscopic domain patterns in the stress-induced phase transformation of a superelastic polycrystalline NiTi tube during tensile loading. The new phenomena include deformation instability with the formation of a helical domain, domain topology transition from helix to cylinder, domain-front branching and loading-path dependence of domain patterns. In this paper, we model the polycrystal as an elastic continuum with nonconvex strain energy and adopt the non-local strain gradient energy to account for the energy of the diffusive domain front. We simulate the equilibrium domain patterns and their evolution in the tubes under tensile loading by a non-local Finite Element Method （FEM）. It is revealed that the observed loading-path dependence and topology transition of do- main patterns are due to the thermodynamic metastability of the tube system. The computation also shows that the tube-wall thickness has a significant effect on the domain patterns： with fixed material properties and interfacial energy density, a large tube-wall thickness leads to a long and slim helical domain and a severe branching of the cylindrical-domain front.

关键词： martensitic phase transition macroscopic domain patterns NiTi polycrystalline tubes non-local and nonconvex elasticity tube-wall thickness effect metastability and instability

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采用项目化形式进行的化工单元仿真教学

云南化工 2018年第3期45卷 252-254页

作者：李吉昌聂建华龙清平林跃华李平辉李干鹏中山职业技术学院信息工程学院广东中山528400 云南民族大学民族医药学院云南昆明650500

项目化教学作为职业教育领域中一种新的教学模式,在高职院校中得到了广泛的应用。它能较好的将理论与实践有机的结合,突出以学生为主体,促进教师和学生角色的转换,进一步培养学生的职业技能综合素质。文章从课程的基本情况、项目化教学... 详细信息

项目化教学作为职业教育领域中一种新的教学模式,在高职院校中得到了广泛的应用。它能较好的将理论与实践有机的结合,突出以学生为主体,促进教师和学生角色的转换,进一步培养学生的职业技能综合素质。文章从课程的基本情况、项目化教学改革情况、项目化教学的实施方案与过程、教学效果等方面介绍了采用项目化形式进行的化工单元仿真教学。

关键词：项目化教学化工单元仿真应用

Multivariety and multimanufacturer drug identification based on near-infrared spectroscopy and recurrent neural network

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Journal of Innovative Optical Health Sciences 2022年第4期15卷 86-96页

作者： Wenjie Zeng Yunqi Qiu Yanting Huang qingping Sun Zhuoya Luo School of Pharmaceutical Sciences Guangzhou Medical University 1 Xinzao Road Guangzhou 511436 P.R.China NMPA Key Laboratory of Rapid Drug Inspection Technology Guangdong Institute for Drug Control 766 Shenzhou Road Guangzhou 510663P.R.China

Near-infrared(NIR)spectral analysis,which has the advantages of rapidness,nondestruction and high-efficiency,is widely used in the detection of feed,food and *** terms of qualitative identification,it can also be used for the discriminant analysis of *** short-term memory(LSTM)neural network,bidirectional long short-term memory(BiLSTM)neural network and gated recurrent unit(GRU)network are variants of the recurrent neural network(RNN).The potential relationship between nonlinear features learned from the sequence by these variants is used to complete the missions infields such as natural language processing,signal classification and video *** the effect of these variants in drug identification is still to be studied,this paper constructs a multiclassifier of these three variants,using compoundα-keto acid tablets produced by four manufacturers and repaglinide tablets produced by five manufacturers as the research ***,the paper analyzes the impacts of seven different preprocessed methods on the drug NIR data by constructing different layers of LSTM,BiLSTM and GRU networks and compares different classification model indicators and training time of each *** the spectrum data are pre-processed by z-score normalization,the GRU-3 model has the best accuracy in all *** BiLSTM models are better for analyzing high coincidence *** method proposed in this paper can be further extended to other NIR spectroscopy data sets.

关键词： Near-infrared spectroscopy long short-term memory bidirectional long short-term memory gated recurrent unit multiple classifiers.

深圳市龙岗区男男性行为者HIV感染状况及其高危行为特征分析

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中国艾滋病性病 2018年第3期24卷 246-249页

作者：李晓霞刘渠谢显清龙清平刘海文叶伟雄覃佩兰刘锦花陈小燕陈绍山农秋苗深圳市龙岗区疾病预防控制中心广东深圳518172 深圳市龙岗区人民医院广东深圳518172 深圳市龙岗区龙岗预防保健所广东深圳518116

目的了解深圳市龙岗区男男性行为者（MSM）的艾滋病病毒（HIV）感染状况及其高危行为特征,分析HIV感染的影响因素,为在龙岗区MSM中采取针对性的干预措施提供参考依据。方法 2015年1月至2016年12月,在龙岗区MSM聚集场所,采用时间场所抽样... 详细信息

目的了解深圳市龙岗区男男性行为者（MSM）的艾滋病病毒（HIV）感染状况及其高危行为特征,分析HIV感染的影响因素,为在龙岗区MSM中采取针对性的干预措施提供参考依据。方法 2015年1月至2016年12月,在龙岗区MSM聚集场所,采用时间场所抽样（TLS）和＂滚雪球＂的抽样方式获取样本,并进行单因素和多因素Logistic回归分析,双侧P〈0.05为检验水准,显示差异有统计学意义。结果共调查研究801人,平均（26.5±4.3）岁,青壮年为主;高中/中专及以上占58.80%。HIV感染率为18.48%（148例）,梅毒感染率为16.48%（132例）,丙型肝炎病毒感染率为0.37%（3例）。梅毒感染[比值比（OR）=3.44,95%可信区间（CI）：1.40~8.46）]、发生肛交（OR=1.86,95%CI：1.07~3.23）是HIV感染的危险因素;肛交时坚持使用安全套（OR=0.34,95%CI：0.17~0.69）是HIV感染的保护因素。结论龙岗区MSM中HIV感染率较高;梅毒感染、发生肛交是导致HIV感染的危险因素。提示应继续强化性病治疗转介服务,提高安全性行为比例,降低MSM艾滋病的发病率。

关键词：男男性行为者艾滋病病毒感染状况高危行为

Reduction-induced interface reconstruction to fabricate MoNi_(4) - based hollow nanorods for hydrazine oxidation assisted energysaving hydrogen production in seawater

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Nano Research 2022年第10期15卷 8846-8856页

作者： Lili Guo qingping Yu Xuejun Zhai Jingqi Chi Tong Cui Yu Zhang Jianping Lai Lei Wang Key Laboratory of Eco-chemical Engineering Key Laboratory of Optic-electric Sensing and Analytical Chemistry of Life ScienceTaishan Scholar Advantage and Characteristic Discipline Team of Eco Chemical Process and TechnologyCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042China

Seawater electrolysis could address the water scarcity issue and realize the grid-scale production of carbon-neutral hydrogen,while facing the challenge of high energy consumption and chloride *** more favorable hydrazine oxidation reaction(HzOR)assisted water electrolysis is efficiency for energy-saving and chlorine-free hydrogen ***,the MoNi alloys supported on MoO_(2) nanorods with enlarged hollow diameter on Ni foam(MoNi@NF)are synthesized,which is constructed by limiting the outward diffusion of Ni via annealing and thermal reduction of NiMoO_(4) *** coupling HzOR and hydrogen evolution reaction(HER)by employing MoNi@NF as both anode and cathode in two-electrode seawater system,a low cell voltage of 0.54 V is required to achieve 1,000 mA·cm^(−2) and with long-term durability for 100 h to keep above 100 mA·cm^(−2) and nearly 100%Faradaic *** can save 2.94 W·h to generate per liter H_(2) relative to alkaline seawater electrolysis with 37%lower energy equivalent input.

关键词： MoNi@NF hollow nanorods seawater splitting hydrazine oxidation reaction energy-saving hydrogen production

Seed nutrient is more stable than leaf in response to changing multiple resources in an alpine meadow

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Ecological Processes 2023年第1期12卷 589-597页

作者： Jiapu Li Dashuan Tian Kailiang Yu Hongbo Guo Ruiyang Zhang Jinsong Wang qingping Zhou Shuli Niu Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environmental Sciences Nanjing Agricultural UniversityNanjing 210095China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100101China Institute of Qinghai-Tibetan Plateau Southwest Minzu UniversityChengdu 610041China High Meadows Environmental Institute Princeton UniversityPrinceton 02138USA

Background It has been long thought that nitrogen(N),phosphorus(P)concentrations and their ratios(N:P)in metabolically active or functional organs(i.e.,leaves)are less responsive to environmental *** attention,however,has been paid to the reproductive organs-seeds,while seeds may maintain their nutrients more stable for the evolutionary fitness of next *** Here,we conducted a field experiment of N,P addition and drought in an alpine meadow,aiming to compare the difference of leaf and seed nutrients and stoichiometric ratios in response to these resource treatments and their *** dominant species were selected among grass and forb functional groups,including Elymus nutans,Deschampsia caespitosa,Artemisia roxburghiana and Polygonum *** Under natural conditions,leaf N and P concentrations were consistently lower than seed among ***,leaf nutrients were much more sensitive than seed nutrients to N and P ***,N or P addition accordingly increased leaf N or P concentration by 22.20-44.24%and 85.54-93.61%,while only enhanced seed N or P concentration by 5.15-17.20%and 15.17-32.72%,*** N or P concentration was significantly reduced by P or N addition,but seed nutrients remained *** contrast,drought did not change both organ ***,nutrient addition and drought had synergistic interactions on leaf nutrients,but not on seed *** This study highlights that seed nutrient concentrations could be more stable than metabolically active leaf organ when facing multidimensional resource *** complements the traditional view on the‘Stable Leaf Nutrient Hypothesis’with the involvement of reproductive *** less responsiveness of seed nutrients suggests the adaptive strategy to ensure the success of next generations and long-term plant demographic stability.

关键词： Alpine meadow Leaf Multiple resource change Nitrogen concentration N:P ratio Phosphorus concentrations Seed

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Testis Development and Ultrastructural Features During Spermatogenesis in Cultured Small Yellow Croaker,Larimichthys polyactis

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Journal of Ocean University of China 2023年第5期22卷 1412-1426页

作者： ZHENG Xuebin WANG Jingqian GAO Xinming DU Chen HOU Congcong XIE qingping LIU Feng ZHU Junquan LOU Bao Key Laboratory of Applied Marine Biotechnology by the Ministry of Education School of Marine SciencesNingbo UniversityNingbo 315211China Zhejiang Academy of Agricultural Sciences Hangzhou 310021China

The small yellow croaker Larimichthys polyactis is an economically important marine fish in Northeast ***,its natural resources are threatened by overfishing and environmental ***,research on the reproductive system of the fish is ***,we studied the testis development and ultrastructural features of spermatogenesis in cultured *** using anatomical,histological,and ultrastructural techniques.A pair of testes,consisting of a central sperm duct and radial seminiferous lobules,were *** reproduction cycle of testes can be divided into stages I–*** to May was confirmed as the breeding season for male ***,while April is the ideal period for artificial *** male *** can attain sexual maturity within 1 *** spermatogenesis of *** comprised spermatogonium,spermatocyte,spermatid,and mature *** morphology of spermatogenic cells changed obviously during spermiogenesis,including nuclear shaping,midpiece and flagellum *** mature sperms consist of an ellipsoidal head,a short midpiece,and a long *** anterior of the head with a kidney-shaped nucleus can be *** midpiece is located posterior to the head and includes four to six spherical *** flagellum has irregular lateral *** testis of *** is an unrestricted lobular type,with cystic spermatogenesis,type II spermiogenesis,and type II *** features are highly similar to those of other Sciaenid *** findings provide useful insights into the mechanism underlying testis development and spermatogenesis of ***,which can facilitate the artificial breeding of this species.

关键词： testis development spermatogenesis Larimichthys polyactis histology ultrastructure