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Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2194-2209页

作者： Zhilin Li Qianfeng Zhang Zhiqian Li long Ren Dayi pan Qiyong Gong Zhongwei Gu Hao Cai Kui Luo Department of Radiology Huaxi MR Research Center(HMRRC)Clinical Research Center for BreastDepartment of Breast SurgeryDepartment of Thoracic Surgery and Institute of Thoracic OncologyFrontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China Hospital Sichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Key Laboratory of Research and Development for Natural ProductsSchool of PharmacyYunnan UniversityKunming 650500China

Despite the great potential of anti-PD-L1 antibodies for immunotherapy,their low response rate due to an immunosuppressive tumor microenvironment has hampered their *** address this issue,we constructed a cell membrane-coated nanosystem(mB4S)to reverse an immunosuppressive microenvironment to an immuno-supportive one for strengthening the anti-tumor *** this system,Epirubicin(EPI)as an immunogenic cell death(ICD)inducer was coupled to a branched glycopolymer via hydrazone bonds and diABZI as a stimulator of interferon genes(STING)agonist was encapsulated into *** internalization of mB4S,EPI was acidic-responsively released to induce ICD,which was characterized by an increased level of calreticulin(CRT)exposure and enhanced ATP ***,diABZI effectively activated the STING *** with mB4S in combination with an anti-PD-L1 antibody elicited potent immune responses by increasing the ratio of matured dendritic cells(DCs)and CD8+T cells,promoting cytokines secretion,up-regulating M1-like tumor-associated macrophages(TAMs)and down-regulating immunosuppressive myeloid-derived suppressor cells(MDSCs).Therefore,this nanosystem for co-delivery of an ICD inducer and a STING agonist achieved promotion of DCs maturation and CD8+T cells infiltration,creating an immuno-supportive microenvironment,thus potentiating the therapy effect of the anti-PD-L1 antibody in both 4T1 breast and CT26 colon tumor mice.

关键词： Glycopolymer Polymer prodrug Immunogenic cell death Nanoassembly Epirubicin STING pathway Immuno-supportive microenvironment Immunotherapy

Terpyridine-based metallo-cuboctahedron nanomaterials for efficient photocatalytic degradation of persistent organic pollutants

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Nano Research 2024年第8期17卷 6833-6840页

作者： Qixia Bai Yan Huang Zhihong Chen Yilin pan Xiaohan Zhang Qingwu long Qiaoan Yang Tun Wu Ting-Zheng Xie Mingjian Wang Hongguang Luo Chun Hu Pingshan Wang Zhe Zhang Key Laboratory for Water Quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater Bay AreaGuangzhou UniversityGuangzhou 510006China College of Light Chemical Industry and Materials Engineering Shunde PolytechnicFoshan 528333China Guangdong Guangye Inspection&Testing Group Co. Ltd.Guangzhou 510006China

Metal–organic cage photocatalysts with nanoscale dimensions have received wide attention in the field of photocatalytic environmental pollutant treatment due to their large cavities,easy modification,high tunability,and enriched active ***,we prepared a series of dihydroanthracene-cored terpyridine-based metallo-cuboctahedron nanomaterials through a selfassembly method,which exhibited satisfactory degradation performance for persistent organic pollutants under visible light *** particular,under light conditions,S1-Zn,one of the prepared nanomaterials,produced photogenerated holes oxidizing water molecules to∙OH,which attacked ibuprofen(IBU)for up to 95%***,the corresponding photogenerated electrons reduced the dissolved oxygen in water,producing 66.2μmol/L hydrogen *** obtained supramolecular photocatalytic materials have a stable structure with non-precious metals and do not require a sacrificial *** metal sites of metallo-cuboctahedrons adsorb pollutants and transfer captured holes to them,accelerating degradation and promoting simultaneous H2O2 *** work not only proposes a simple and efficient synthesis method for supramolecular photocatalysts but also opens up opportunities for efficient,low-cost,and multifunctional materials for environmental persistent organic pollutants treatment.

关键词： supramolecular cages self-assembly photocatalytic pollutant degradation H2O2 production

Effects of sepsis on hippocampal volume and memory function

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World Journal of Emergency Medicine 2020年第4期11卷 223-230页

作者： Miao Yuan Ding-yi Yan Fang-shi Xu Yi-di Zhao Yang Zhou long-fei pan Emergency Department the Second Affi liated Hospital of Xi’an Jiaotong UniversityXi’anChina 2 Department of CardiologyXi’an No.3 HospitalXi’anChina

BACKGROUND:This study aimed to determine the effects of sepsis on brain integrity,memory,and executive ***:Twenty sepsis patients who were not diagnosed with sepsis-associated encephalopathy(SAE)but had abnormal electroencephalograms(EEGs)were *** control group included twenty healthy persons.A neuropsychological test of memory and executive function and a brain magnetic resonance imaging scan were *** volumes of cortex and subcortex were measured using the FreeSurfer *** Physiology and Chronic Health Evaluation II(APACHE II)score was used to determine the disease ***:In the sepsis group,the levels of immediate free recall,immediate cued recall,and delayed cued recall in the California Verbal Learning Test-II(CVLT-II)were significantly lower;the explicit memory(recollection process)in the process dissociation procedure test was lower;and the volumes of the left and right hippocampi were significantly lower compared with the control *** volume of the presubiculum in the hippocampus of sepsis patients showed statistically signifi cant *** the sepsis group,the volumes of the left and right hippocampi were negatively correlated with the APACHE II score and positively with immediate free recall,immediate cued recall,and delayed cued recall in the CVLT-II;moreover,the hippocampal volume was significantly correlated with recollection but not with ***:Patients with abnormal EEGs during hospitalization but with no SAE still have reduced hippocampal volume and memory defi *** fi nding indicates that sepsis leads to damage to specifi c parts of the hippocampus.

关键词： Hippocampus Magnetic resonance imaging Memory Sepsis-associated encephalopathy

Hydrodynamic Characteristics of Undular Tidal Bores in the Qiantang River Based on Field Observations

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China Ocean Engineering 2024年第3期38卷 505-518页

作者： ZHANG Shu-yu pan Cun-hong ZHANG Shen-yang LI Ruo-hua CHENG Wenlong XIE Dong-feng Zhejiang Tongji Vocational College of Science and Technology Hangzhou 311231China Zhejiang Institute of Hydraulics and Estuary Hangzhou 310020China

Understanding the undular tidal bores in the Qiantang River is essential for effective river management and *** breaking tidal bores have been studied extensively, reports on undular tidal bores in the Qiantang Riverremain limited. Furthermore, observed data on undular tidal bores fulfilling the requirements of short measurementtime intervals, and spring, medium, and neap tide coverage, and providing detailed data for the global vertical stratificationof flow velocity are quite limited. Based on field observations at Qige in the Qiantang estuary, we analyzedthe characteristics of undular tidal bores. The results showed that the flooding amplitude (a) of the first wave isalways larger than its ebbing amplitude (b). Moreover, the vertical distribution of the maximum flood velocity exhibitesthree shapes, influenced by the tidal range, while that of the maximum ebb velocity exhibites a single shape. Duringthe initial phase of the flood tide in the spring and medium tides, the upper water body experiences multiple oscillatingchanges along the flow direction, corresponding to the alternating process of the crest and trough of the tide levelupon the arrival of the tidal bore. The tidal range is a crucial parameter in tidal bore hydrodynamics. By establishingthe relationship between hydrodynamic parameters and tidal range, other hydrodynamic parameters, such as the tidalbore height, maximum flood depth–averaged velocity, maximum flood stratified velocity at the measurement points,and duration of the flood tide current, can be effectively predicted, thereby providing an important reference for rivermanagement and maintenance.

关键词： tidal bores Qiantang Estuary tidal bore height tidal bore velocity propagation speed

Analysis and Prediction of Corrosion Risk in Atmospheric Distillation Tower Overhead System

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China Petroleum Processing & Petrochemical Technology 2021年第1期23卷 21-30页

作者： Niu Luna Han Lei Chen Wenwu pan long Zhang Yanling Qu Dingrong State Key Laboratory of Safety and Control for Chemicals SINOPEC Research Institute of Safety EngineeringQingdao 266101

In order to optimize the atmospheric tower overhead low-temperature system,the physical parameters,multiphase composition,aqueous dew point temperature,and ammonium salt crystallization temperature are simulated with process simulation *** temperature distribution in overhead heat exchanger is calculated by heat transfer *** special parts with elbows near the inlet and outlet of heat exchanger are studied by fluid field *** indicate that under current operating conditions,the aqueous dew point temperature and initial crystallization temperature of NH4Cl are 91°C and 128°C,*** salt appears in the distillation tower and liquid water occurs in heat exchanger tubes,in which the dew point induced corrosion is the most direct factor for heat exchanger *** the heat exchanger,condensate water appearing in the area 2.7 meters away from the bundle inlet can give rise to corrosion risk under the moist NH4Cl and high concentration of acidic solution *** the pipes and elbows located near the inlet and the outlet of heat exchanger,the flow field presents an unsymmetrical *** risk areas are mainly concentrated on the external bend of elbows where the liquid water concentration is *** coupling of simulation methods established thereby is approved as an effective way to evaluate the corrosion risk in the atmospheric column overhead system and can provide a scientific basis for corrosion control.

关键词： atmospheric tower overhead simulation corrosion ammonium salt crystallization fluid field

The population structure and sex ratios of Bursaphelenchus xylophilus under a-pinene stress

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Journal of Forestry Research 2020年第3期31卷 921-926页

作者： Jing Cui Yong-Xia Li Wei Zhang Xuan Wang long pan Yu-Qian Feng Xing-Yao Zhang Research Institute of Forestry New Technology Chinese Academy of ForestryBeijing 100091People’s Republic of China Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjing 210037People’s Republic of China

Pine wood nematode(PWN), Bursaphelenchus xylophilus, is a serious pathogen of pines throughout the world. Previous work indicated that different concentrations of a-pinene could affect nematode reproduction,however the mechanism of that influence is not clear. In order to examine the reproductive strategies of PWN in response to the stress of the volatile material a-pinene, we investigated different aspects of population changes of *** under two concentrations of a-pinene. The results show that a high concentration(214.5 mg ml-1)promoted population growth while a low concentration(56.33 mg ml-1) decreased the population. Population structure was analyzed and it was found that a high concentration of a-pinene decreased the percentage of adults but increased the percentages of larvae and ***, from the results of an evaluation of sex ratios(female/male), it was determined that a high concentration could elevate sex ratios but a low concentration decreased ratios sharply. These results suggest that the PWN could regulate its population by changing sex ratios under stress of a-pinene. This study has provided a theoretical basis for the prevention and control of pine wilt disease caused by the pine wood nematode.

关键词： Pine wood nematode α-Pinene Population structure Sex ratios

An approach for predicting the toxicity of smoke

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中国安全生产科学技术 2013年第8期9卷 72-82页

作者： XING Jia-jia JIANG Yong pan long-wei State Key Laboratory of Fire Science University. of Science and Technology of China Hefei 230026 China Chongqing Municipal Gaoxin District Public Security Fire Brigade Chongqing 400039 P.R. China

The N-GAS model for predicting smoke toxicity has been proposed for many years by ***,almost all the existing CFD software cannot accurately predict the toxicity of smoke using the model because of the absence of the toxic gas concentration of HCN,NO x,HCl and *** this work,an approach for predicting fire smoke toxicity was developed and demonstrated.A detailed mechanism including these fire effluents was constructed firstly,and the subsequent generation of state relationship among fire effluents,mixture fraction and strain rate was conducted by using opposed-flow flame technique.A mixture fraction-based combustion model used in FDS code was modified,and meanwhile the scalar dissipation rate transport equation was numerically *** the concentration of fire effluents as the function of mixture fraction and scalar dissipation rate can be calculated through a look-up table,and the toxic potency based on the 7-gas model can be *** method was applied into an underground commercial street in *** showed that the results between the 7-gas model and 3-gas model(CO,CO 2,and O 2) were obviously *** indicated that there needs some modifications in conclusions and results from 3-gas model for fire-risk assessments.

关键词： combustion gases N-gas model flame surface model fire toxicity

Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2271-2283页

作者： long-Chen Yu Ya-Ping Li Yue-Ming Xin Mai Mao Ya-Xin pan Yi-Xuan Qu Zheng-Dong Luo Yi Zhang Xin Zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityShandong Engineering Research Center of Biomarker and Artificial Intelligence ApplicationJinan 250012Shandong ProvinceChina

The morbidity and mortality of gastrointestinal(GI)malignancies are among the highest in the world,posing a serious threat to human *** of the insidious onset of the cancer,it is difficult for patients to be diagnosed at an early stage,and it rapidly progresses to an advanced stage,resulting in poor treatment and *** nucleatum(***)is a gram-negative,sporefree anaerobic bacterium that primarily colonizes the oral cavity and is implicated in the development of colorectal,esophageal,gastric,and pancreatic cancers via various intricate *** development in novel research suggests that *** may function as a biomarker in GI *** the abundance of *** in stool,saliva,and serum samples of patients may aid in the diagnosis,risk assessment,and prognosis monitoring of GI *** editorial systematically describes the biological roles and mechanisms of *** in GI malignancies focusing on the application of *** as a biomarker in the diagnosis and prognosis of GI malignancies to promote the clinical translation of *** and GI tumors-related research.

关键词： Gastrointestinal malignancies Fusobacterium nucleatum Biomarker Diagnosis Prognosis

连续重整装置生成油脱烯烃技术方案比较和选择

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炼油技术与工程 2022年第1期52卷 33-35页

作者：嵇大勇潘龙盛虹炼化(连云港)有限公司江苏省连云港市222000

从原理、反应条件、脱除效果、一次性投资费用、长周期运行费用等方面,对国内3种典型脱烯烃工艺(白土精制、分子筛脱烯烃和贵金属催化剂加氢脱烯烃)进行了比较。白土脱烯烃工艺一次性投资费用最低,长周期运行费用最高。贵金属催化剂联... 详细信息

从原理、反应条件、脱除效果、一次性投资费用、长周期运行费用等方面,对国内3种典型脱烯烃工艺(白土精制、分子筛脱烯烃和贵金属催化剂加氢脱烯烃)进行了比较。白土脱烯烃工艺一次性投资费用最低,长周期运行费用最高。贵金属催化剂联合白土脱烯烃工艺一次性投资费用最高,是白土脱烯烃工艺一次性投资费用的7.8倍;长期运行费用最低,且运行周期越长,经济效益越明显。从环保角度来看,选用贵金属催化剂联合白土脱烯烃技术方案每年可减少大量危险废物白土。综合对比后,选用贵金属催化剂联合白土脱烯烃技术方案。

关键词：连续重整装置生成油脱烯烃白土精制液相加氢分子筛吸附运行费用