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A promising strategy against SARS-CoV-2:pyrimidine inhibitors synergize with nucleoside analogues

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Signal Transduction and Targeted Therapy 2022年第4期7卷 953-954页

作者： long min Qiu Sun State Key Laboratory of Biotherapy Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center for Biotherapy610041 ChengduChina

In a recent study published in Nature,David *** et *** a new high-efficient therapy to fight against SARSCoV-2,that is,combining pyrimidine biosynthetic inhibitors with antiviral nucleoside analogues.1 By February 10,2022,SARS-CoV-2 has infected more than 400 million people,including more than 5.79 million *** infected with SARS-CoV-2 usually develop mild to severe symptoms,and several patients lead to severe clinical *** some vaccines or drugs have entered clinical practice,there is still a lack of effective antiviral therapy against the constantly changing virus.

关键词： analogues pyrimidine nucleoside

An Improved Differential Fault Analysis on Block Cipher KLEIN-64

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Computers, Materials & Continua 2020年第11期65卷 1425-1436页

作者： min long Man Kong Sai long Xiang Zhang Changsha University of Science and Technology Changsha410014China School of Computing National University of SingaporeSingapore

KLEIN-64 is a lightweight block cipher designed for resource-constrained environment,and it has advantages in software performance and hardware *** investigation shows that KLEIN-64 is vulnerable to differential fault attack(DFA).In this paper,an improved DFA is performed to *** is found that the differential propagation path and the distribution of the S-box can be fully utilized to distinguish the correct and wrong keys when a half-byte fault is injected in the 10th *** analyzing the difference matrix before the last round of S-box,the location of fault injection can be limited to a small ***,this improved analysis can greatly improve the attack *** the best case,the scale of brute-force attack is only *** for the worst case,the scale of brute-force attack is far less than 232 with another half byte fault injection,and the probability for this case is 1/***,the measures for KLEIN-64 in resisting the improved DFA are proposed.

关键词： Block cipher KLEIN-64 differential fault analysis half-byte fault injection

A high-fat diet:an unexpected role in preventing the metastatic seeding of colorectal cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 301-302页

作者： min long Wenjing Wang Qiu Sun State Key Laboratory of Biotherapy Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center for Biotherapy610041 ChengduChina

Recently,Wei X et *** a study in Signal Transduction and Targeted Therapy,in which they demonstrated that the peritoneal seeding of colorectal cancer(CRC)can be restrained by short-term treatment with a high-fat diet(... 详细信息

关键词： colorectal al cancer

Nitrosonium(NO^+) catalyzed Michael addition of indoles to unsaturated enones

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Chinese Chemical Letters 2008年第1期19卷 55-58页

作者： Guai Li Wu long min Wu State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

An efficient Michael addition of indoles to unsaturated enones, such as chalcones and β-nitrostyrenes, was achieved in the presence of a catalytic amount of nitrosonium tetrafluoroborate in ethyl ether. 2007 long M... 详细信息

关键词： Indole Chalcone Michael addition Nitrosonium

Optimal heat source for the interannual variability of the western North Pacific summer monsoon

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Atmospheric and Oceanic Science Letters 2020年第1期13卷 41-47页

作者： HU Kaiming long Shang-min State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics and Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Oceanography Hohai UniversityNanjingChina State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhouChina

Using 132-member experiments based on a linear baroclinic atmospheric model(LBM), this study investigates the optimal heat source forcing the interannual variability of the western North Pacific summer monsoon(WNPSM). The 132 members are forced by localized atmospheric heat sources distributed homogeneously over regions from 55°S to 55°N, each 10° latitude × 30° longitude in size. The atmospheric responses to all the heating constitute an ensemble to examine the relative contribution of each local heat source to the strength of the WNPSM. The result indicates that the combination of an atmospheric heating(cooling) source over the subtropical Northwest Pacific and a cooling(heating) source over the tropical Indian Ocean and the midlatitudes from China to the southern part of Japan is the pattern most effective at enhancing(weakening) the ***, the optimal heat source pattern identified by the LBM simulations is similar to the observed atmospheric heating anomalies associated with WNPSM interannual variability. The results suggest that any external forcing that leads to a similar heating structure as the optimal thermal forcing pattern could lead to an anomalous WNPSM.

关键词： Western North Pacific summer monsoon heat source linear baroclinic model

Bi-directional Secure Communication Based on Discrete Chaotic Synchronization

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Communications in Theoretical Physics 2007年第6期47卷 1076-1080页

作者： long min QIU Shui-Sheng PENG Fei College of Computer and Communication Changsha University of Science ＆ Technology Changsha 410076 China College of Electronic ＆ Engineering South China University of Science ＆ Technology Guangzhou 510640 China College of Computer ＆ Communication Hunan University Changsha 410082 China

Discrete chaotic systems are used for bi-directlonal secure communication. Both sides of communication keep sending signals to achieve their synchronization, and then recover the messages. However, the third side without keys cannot get useful information. Known-plaintext attack is also engaged to analyze this method, and the simulation results show that the proposed method can reach high security performance.

关键词： bi-directional secure communication discrete chaotic synchronization

Implementation of a new chaotic encryption system and synchronization

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Journal of Systems Engineering and Electronics 2006年第1期17卷 43-47页

作者： long min Peng Fei Qiu Shuisheng Chen Yanfeng Coll. of Electronic & Information South China Univ. of Technology Guangzhou 510640 P. R. China

A new kind of secure communication system which combines the chaotic encryption means with the conventional encryption method is discussed. With the analysis results and the experiment data, the anti-attack ability of this communication system is significantly improved compared to that of the either method. At the same time, a new method of chaotic synchronization is proposed. With a small mixed discrete chaotic signal, it is quickly to synchronize the communication and a good security performance is ensured.

关键词： secure communication chaotic cryptography chaotic synchronization.

Adsorption of catechol from aqueous solution by aminated hypercrosslinked polymers

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Journal of Environmental Sciences 2005年第4期17卷 584-588页

作者： SUNYue LIXiao-tao XUChao CHENJin-long LIAi-min ZHANGQuan-xing StateKeyLaboratoryofPollutionControlandResourcesReuse SchooloftheEnvironmentNanjingUniversityNanjing210093China.

Adsorption of catechol from aqueous solution with the hypercrosslinked polymeric adsorbent NDA-100 and its derivatives AH-1, AH-2 and AH-3 aminated by dimethylamine, the commercial resin Amberlite XAD-4 and weakly basic anion exchanger resin D301 was compared. It was found that the aminated hypercrosslinked resins had the highest adsorption capacities among the tested polymers. The empirical Freundlich equation was successfully employed to describe the adsorption process. Specific surface area and micropore structure of the adsorbent, in company with tertiary amino groups on matrix affected the adsorption performance towards catechol. In addition, thermodynamic study was carried out to interpret the adsorption mechanism. Kinetic study testified that the tertiary amino groups on the polymer matrix could decrease the adsorption rate and increase the adsorption apparent activation energy.

关键词： hypercrosslinked polymer catechol adsorption thermodynamics kinetics

Assessment of the Southern Ocean Sea Surface Temperature Biases in CMIP5 and CMIP6 Models

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Journal of Ocean University of China 2024年第5期23卷 1135-1150页

作者： GAO Zhen ZHAO Shichang LIU Qinyu long Shang-min SUN Shantong Key Laboratory of Marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210098China College of Oceanography Hohai UniversityNanjing 210098China Laoshan Laboratory Qingdao 266237China Physical Oceanography Laboratory Ocean University of ChinaQingdao 266100China

This work evaluates the performances of climate models in simulating the Southern Ocean(SO)sea surface temperature(SST)by a large ensemble from phases 5 and 6 of the Coupled Model Intercomparison Project(CMIP5 and CMIP6).By combining models from the same community sharing highly similar SO SST biases and eliminating the effect of global-mean biases on local SST biases,the results reveal that the ensemble-mean SO SST bias at 70°-30°S decreases from 0.38℃ in CMIP5 to 0.28℃ in CMIP6,together with increased intermodel *** dominant mode of the intermodel variations in the zonal-mean SST biases is characterized as a meridional uniform warm bias pattern,explaining 79.1% of the intermodel variance and exhibiting positive principal values for most *** ocean mixed layer heat budget further demonstrates that the SST biases at 70°-50°S primarily result from the excessive summertime heating effect from surface net heat *** biases in surface net heat flux south of 50°S are largely impacted by surface shortwave radiation from cloud and clear sky components at different *** of 50°S,the underestimated westerlies reduce the northward Ekman transport and hence northward cold advection in models,leading to warm SST biases *** addition,the westerly biases are primarily traced back to the atmosphere-alone model simulations forced by the observed SST and sea *** results disclose the thermal origin at the high latitude and dynamical origin at the low latitude of the SO SST biases and underscore the significance of the deficiencies of atmospheric models in producing the SO SST biases.

关键词： Southern Ocean CMIP5 CMIP6 SST biases surface heat flux westerlies atmospheric biases cloud simulation