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超高密度滨海城区的交通规划研究与战略思考——以深圳市南山区为例

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交通与运输 2024年第S1期40卷 7-11页

作者：张文犀彭川子龙漫深圳市城市交通规划设计研究中心股份有限公司深圳518000

为缓解城市大规模扩容对既有交通设施供给造成的冲击,增强滨海城市交通体系的辐射力、承载力和运行效率,研究提出了一套面向超高密度开发、滨海型城区的综合交通规划方案与战略规划理念,并以深圳市南山区为例进行说明。通过城市功能定... 详细信息

为缓解城市大规模扩容对既有交通设施供给造成的冲击,增强滨海城市交通体系的辐射力、承载力和运行效率,研究提出了一套面向超高密度开发、滨海型城区的综合交通规划方案与战略规划理念,并以深圳市南山区为例进行说明。通过城市功能定位分析、分类人群特征分析、交通设施布局梳理、交通组织合理性研判等方式,提炼出区域重大通道对外延伸性不足、重点片区内外交通联系受限、轨网路网设施供给有待挖潜、特色人群存在差异化交通需求、港城客货矛盾冲突严重等高密度开发、滨海城区的典型问题,并研究提出对外延伸端部轨道道路等重大通道、构建重点片区内畅外达的交通体系、优化提升轨网路网设施布局、聚焦特殊人群精细化交通治理、分阶段优化货运组织和港口发展模式等措施,并对规划方案和策略进行综合评估。

关键词：高密度开发滨海城市交通规划战略规划轨道交通道路交通

基于网络药理学及分子对接技术探究黄连解毒汤治疗脓毒症的分子机制

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西部中医药 2024年第2期37卷 54-59页

作者：马世河惠普晟龙漫重庆市开州区人民医院重庆400000 重庆医科大学附属第一医院重庆400000 湖北中医药大学湖北武汉430000

目的:采用网络药理学方法和生物信息学理论,挖掘黄连解毒汤有效成分,预测黄连解毒汤治疗脓毒症的作用机制,为中医治疗该病提供理论依据。方法:利用TCMSP等数据库平台筛选黄连解毒汤有效活性成分。在Gene Card、OMIM及Disgenet数据库中... 详细信息

目的:采用网络药理学方法和生物信息学理论,挖掘黄连解毒汤有效成分,预测黄连解毒汤治疗脓毒症的作用机制,为中医治疗该病提供理论依据。方法:利用TCMSP等数据库平台筛选黄连解毒汤有效活性成分。在Gene Card、OMIM及Disgenet数据库中获得脓毒症相关基因,结合疾病靶点及药物活性成分绘制PPI网络,对关键靶点并进行GO、KEGG富集分析以及运用Autodock软件进行关键靶点分子对接研究。结果:通过检索共筛选出黄连解毒汤有效活性成分59个,在此基础上获得206个预测靶点及关键基因;根据基因本体(gene ontology,GO)分析及京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)结果可知,黄连解毒汤作用于该疾病主要涉及细胞因子活化、免疫和炎症相关过程激活等生物进程如肿瘤坏死因子(tumor necrosis factor,TNF)、白细胞介素17(interleukin-17,IL-17)炎症信号通路及晚期糖基化通路(AGEs-RAGE)等。分子对接结果表明药对的活性成分可以对核心靶点(JUN和TNF)发挥调控作用。结论:黄连解毒汤治疗脓毒症作用机制是多层次、多角度的,其主要机制集中在抗炎及氧化应,为研究黄连解毒汤多成分、多靶点治疗脓毒症网络关系提供了新的研究思路。

关键词：脓毒症黄连解毒汤网络药理分子机制免疫

Seasonal variation of nitrogen and phosphorus in Xiaojiang River-A tributary of the Three Gorges Reservoir

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Frontiers of Environmental Science & Engineering 2009年第3期3卷 334-340页

作者： Zhe LI Jinsong GUO man long Fang FANG Jinping SHENG Hong ZHOU Faculty of Urban Construction&Environmental Engineering Chongqing UniversityChongqing 400045China

A yearlong monitoring program in the backwater area of Xiaojiang River(XBA)was launched in order to investigate the eutrophication of backwater areas in tributaries of the Yangtze River in the Three Gorges Reservoir(TGR)in China,starting after the impoundment water level of the TGR reached 156 *** March 2007 to March 2008,the average concentration of total nitrogen(TN)and total phosphorus(TP)were(1553484)μg·L^(–1)and(6231)μg·L^(–1),*** mean value of chlorophyll was(9.070.91)μg·L^(–1).The trophic level of XBA was meso-eutrophic,while the general nutrient limitation was *** results indicated that XBA has a strong ability to purify itself and has non-point source pollution from terrestrial *** variation of TN/TP ratio was caused by a variation in TN rather than in TP when TN/TP<22.N-fixation from cyanobacteria occurred and became an important process in overcoming the nitrogen deficit under a low TN/TP *** TN/TP≥22,the variation of TP affected the TN/TP ratio more significantly than *** increase of TP in XBA was caused mainly by particulate phosphorus,which could originate from a non-point source as adsorptive inorganic forms after heavy rainfall and surface *** increase in the river’s flow could also contribute to an unstable environment for the growth of phytoplankton.

关键词： Three Gorges Reservoir eutrophication nitrogen phosphorus seasonal variation chlorophyll

Dietary analysis of the House Swift(Apus nipalensis)in Hong Kong using prey DNA in faecal samples

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Avian Research 2021年第1期12卷 86-101页

作者： Chun Ting Chung Hok Sze Wong man long Kwok Qi Meng King Ming Chan School of Life Sciences The Chinese University of Hong KongSha Tin 999077N.TChina Swift and Swallow Research Group The Hong Kong Bird Watching Society7CV Ga Building532 Castle Peak RoadLai Chi KokKowloonHong Kong 999077China

Background:To understand the dietary composition of the highly aerial swift(Apodidae),ecologists conventionally depend on the morphological identification of prey items from food boluses or stomach contents,but these techniques are often invasive,require expertise in identification,and often cannot produce accurate identifications at the species ***:DNA barcoding was used to analyse the dietary composition of House Swifts(Apus nipalensis)in Hong Kong,*** samples from five different colonial nest sites were collected between 2019 and *** used universal primers to amplify a region of the cytochrome C oxidase gene from prey DNA in the faecal samples for identification ***:Ten different orders and 44 families from three different classes of Arthropoda were identified in the collected faecal ***,Hemiptera and Diptera were the most prevalent groups of prey found in the *** in the dietary composition of House Swifts during the breeding(April to September)and nonbreeding(October to March)season were also ***,particularly ants(Formicidae),were predominant in the diet during the breeding season,whereas Diptera and Hemiptera were predominant during the non-breeding ***:The prey groups identified in this study were similar to those identified in a previous study of the diet of House Swift,which also suggests a possible role of House Swifts in reducing the numbers of local insect *** study demonstrates the usefulness of applying molecular tools for the dietary analysis of aerial *** local forested areas may be crucial for the maintenance of House Swift population.

关键词： Diet DNA barcoding House swift Urbanisation threat

基于小波峭度的土壤表层机油浓度预测方法应用

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科学技术与工程 2024年第12期24卷 4843-4850页

作者：姜宁超景敏司冰琦贺兆南韩亨通陈曼龙陕西理工大学机械工程学院汉中723000 陕西省工业自动化重点实验室汉中723000

机油污染物对于农作物生长和土壤基质产生不可忽视的影响,造成农作物减产甚至绝收等现象。为解决土壤表层中机油污染物质浓度预测的问题,利用荧光诱导技术获得机油光谱曲线,提出以小波峭度作为量化参数进行土壤表层中污染油浓度预测的方... 详细信息

机油污染物对于农作物生长和土壤基质产生不可忽视的影响,造成农作物减产甚至绝收等现象。为解决土壤表层中机油污染物质浓度预测的问题,利用荧光诱导技术获得机油光谱曲线,提出以小波峭度作为量化参数进行土壤表层中污染油浓度预测的方法,以市面出售3种不同机油结合随机森林回归算法进行了比较分析。实验结果表明:选取小波峭度参数的随机森林对3种机油的浓度预测结果利用相关系数R P和均方根偏差(root mean square deviation,RMSD)进行评价,对齿轮油、发动机油、摩托车机油的预测,分别提高了1.2%、2.2%、1.9%和14.9%、32.4%、16.8%;在实验制备的3种机油样本中,从中各选取浓度为0.01~0.3 mL/g的30组样本进行模型预测验证,对其识别准确率δ分别提高了6.67%、6.66%、9.96%;同时也验证了小波峭度参数在多个回归模型中的预测精度均有提高,具有较高的预测性能。研究成果为土壤表层中其他烃类污染物浓度预测回归模型提供了一定的参考,为农业生产和土壤环境的可持续发展提供一种有效的检测手段。

关键词：小波峭度浓度预测土壤回归算法

Microstructure and magnetic properties of sintered CeCo_(4.3252-x)Cu_(0.675)Fe_x magnets

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Rare Metals 2015年第3期34卷 164-167页

作者： Wei Sun Ming-Gang Zhu Yi-Kun Fang Wei Pan man-long Xia Wei Li Division of Functional Materials Central Iron and Steel Research Institute Group

Anisotropic CeCo4.325_xCuo.675Fex （x ： 0.475- 0.875） sintered magnets were prepared by traditional powder metallurgical method. Influence of ball-nfilling time and iron content on microstructure and magnetic properties of the CeCo4,325-xCuo.675Fex sintered magnets were investigated. It is shown that the properties of the magnet produced by mag- netic powders ball-milled for 40 min are better than that for 30 rain. With iron content increasing, remanence Br and maxi- mum energy product （BH）m increase first and then decrease. The optimal magnetic properties are obtained for the CeCo3.65Cuo.675Feo.675 sintered magnet： Br=0.685 T, the intrinsic coercivity Hci = 350 kA.m-1, and （BH）m ： 85.6 kJ.m-3. The increase of Br is mainly influenced by iron content of 1：5 matrix which can properly increase the saturation induction Bs; the rapid increase of the amount of Ce-rich phase and 5：19 phase gives rise to the deterioration of the magnets when x ≥ 0.775.

关键词： Ce-Co-based permanent magnet Remanence Microstructure

Tanshinone ⅡA improves Alzheimer’s disease via RNA nuclearenriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis

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World Journal of Psychiatry 2024年第4期14卷 563-581页

作者： long-Xiu Yang man Luo Sheng-Yu Li Department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Neurology Wuming Hospital of Guangxi Medical UniversityNanning 530199Guangxi Zhuang Autonomous RegionChina

BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and *** ⅡA(Tan-ⅡA),a bioactive compound isolated from Salvia miltiorrhiza plants,has shown potential neuroprotective effects;however,the mechanisms underlying such a function remain *** To investigate potential Tan-ⅡA neuroprotective effects in AD and to elucidate their underlying *** Hematoxylin and eosin staining was utilized to analyze structural brain tissue *** assess changes in oxidative stress and neuroinflammation,we performed enzyme-linked immunosorbent assay and western ***,the effect of Tan-ⅡA on AD cell models was evaluated in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** changes related to the long non-coding RNA(lncRNA)nuclear-enriched abundant transcript 1(NEAT1)/microRNA(miRNA,miR)-291a-3p/member RAS oncogene family Rab22a axis were assessed through reverse transcription quantitative polymerase chain *** In vivo,Tan-ⅡA treatment improved neuronal morphology and attenuated oxidative stress and neuroinflammation in the brain tissue of AD *** vitro experiments showed that Tan-ⅡA dose-dependently ameliorated the amyloid-beta 1-42-induced reduction of neural stem cell viability,apoptosis,oxidative stress,and *** this process,the lncRNA NEAT1-a potential therapeutic target-is highly expressed in AD mice and downregulated via Tan-ⅡA ***,NEAT1 promotes the transcription and translation of Rab22a via miR-291a-3p,which activates nuclear factor kappa-B(NF-κB)signaling,leading to activation of the pro-apoptotic B-cell lymphoma 2-associated X protein and inhibition of the anti-apoptotic B-cell lymphoma 2 protein,which exacerbates ***-ⅡA intervention effectively blocked this process by inhibiting the NEAT1/miR-291a-3p/Rab22a axis and NF-κB *** This study demonstrates that

关键词： TanshinoneⅡA Alzheimer’s disease Nuclear-enriched abundant transcript 1 Member of RAS oncogene family Rab22a Reactive oxygen species

Effect of neodymium doping on structure,magnetic properties and microwave absorption performance of SrMnO_(3)

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Journal of Rare Earths 2024年第2期42卷 354-363,I0005页

作者： Jixiang Yue Lichun Cheng Jilei Xiong Qingrong Yao man Wang Yucheng Chen Qianxin long Xiaojian Guo School of Materials Science and Engineering Guilin University of Electronic TechnologyGuilin541004China Guangxi Key Laboratoryof Information Materials Guilin University of Electronic Technology Guilin541004China Anhui Jihua New Materials Co. Ltd.Anqing246300China

A simple composite Sr_(1-x)Nd_(x)MnO_(3)(x=0,0.05,0.1,0.15,0.2) nano powders were successfully prepared by the sol-gel method as a light-weight broadband electromagnetic wave *** effect of Nd^(3+)doping on the structure,microstructure and properties of SrMnO_(3) was *** is found that with the doping of Nd^(3+),the space group of the SrMnO_(3) changes from p63/mmc to pm3m,and the crystalline shape starts to change from hexagonal to cubic *** electron microscopy(SEM) and Brunauer-Emmett-Teller(BET) tests confirm that the particle sizes of the sample decrease and the specific surface area increases,which are attributed to the inhibition of grain growth after Nd^(3+)is doped.X-ray photoelectron spectroscopy(XPS) shows that after Nd^(3+)doping,the content of oxygen vacancy increases,and Mn^(4+) converts to Mn^(3+).Due to the defects of the materials,the polarization effect is enhanced,thus,the dielectric and magnetic properties of the doped samples are *** maximum reflection loss of the Sr_(0.85)Nd_(0.15)MnO_(3) is-33.41 dB at 7.84 GHz for a thickness of 2.4 mm,while Sr_(0.9)Nd_(0.1)MnO_(3) has the best bandwidth performance at 2.32 GHz with a reflection loss below-10dB.

关键词： Sr_(1-x)Mn_xO_(3) Crystal structure Microwave absorption Magnetic properties Nano powder Rare earths

Wing patterning genes of Nilaparvata lugens identification by transcriptome analysis, and their differential expression profile in wing pads between brachypterous and macropterous morphs

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Journal of Integrative Agriculture 2015年第9期14卷 1796-1807页

作者： LI Kai-yin HU Ding-bang LIU Fang-zhou long man LIU Si-yi ZHAO Jing HE Yue-ping HUA Hong-xia Hubei Insect Resources Utilization and Sustainable Pest management Key Laboratory College of Plant Science and TechnologyHuazhong Agricultural University

The brown planthopper, Nilaparvata lugens is an economically important pest on rice plants. This species produces macropterous and brachypterous morphs in response to environmental cues, which makes it very dififcult to control. The molecular basis of wing patterning in N. lugens is stil unknown. It is necessary to identify wing patterning genes of N. lugens, and also to clarify the expression differences of wing patterning genes between macropterous and brachypter-ous morphs. High-throughput deep sequencing of transcriptome of N. lugens wing pad yielded 116 744 580 raw reads and 113 042 700 clean reads. Al the reads were assembled into 55 963 unigenes with an average length of 804 bp. With the E-value cut-off of 1.0E–5,18 359 and 2 883 unigens had hits in NCBI-NR (NCBI non-redundant protein sequences) and NCBI-NT (NCBI nucleotide sequences) databases, respectively. A total of 16 502 unigenes were assigned to GO (gene ontology) classiifcation, 9 709 ungenes were grouped into 26 COG (cluster of orthologous groups of proteins) classiifcations, and 6 724 unigenes were assigned to different KEGG (Kyoto encyclopedia of genes and genomes) path-ways. In total, 56 unigenes which are homologous to wing patterning genes of Drosophila melanogaster or Tribolium castaneum were identiifed. Out of the 56 unigenes, 24 unigenes were selected, and their expression levels across the ifve nymphal stages between macropterous strain and brachypterous strain were examined by qRT-PCR. Two-way ANOVA analysis showed that development stage had signiifcant effects on the expression level of al the 24 genes (P<0.05). The expression levels of 8 genes (Nlen, Nlhh, Nlsal, NlAbd-A, Nlwg, Nlvg, Nlexd and NlUbx) were signiifcantly affected by wing morph. This is the ifrst transcriptome analysis of wing pads of hemimetabolous insect, N. lugens. The identiifed wing patterning genes would be useful resource for future exploration of molecular basis of wing development. The 8 differential y expressed win

关键词： Nilaparvata lugens wing pad transcriptome wing patterning genes