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Atomic insights into synergistic effect of pillared graphene by carbon nanotube on the mechanical properties of polymer nanocomposites

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Nano Materials Science 2022年第3期4卷 235-243页

作者： Zhipeng Zhou hang Zhang Jiali Qiu Pengwan Chen Weifu Sun State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120China School of Mechatronic Engineering Beijing Institute of TechnologyBeijing100081China Explosion Protection and Emergency Disposal Technology Engineering Research Center of the Ministry of Education China Tongda College of Nanjing University of Posts&Telecommunications Yangzhou225127China

Molecular dynamics simulations have been performed to explore the underlying synergistic mechanism of pillared graphene or non-covalent connected graphene and carbon nanotubes(CNTs) on the mechanical properties of polyethylene(PE) nanocomposites. By constructing the pillared graphene model and CNTs/graphene model, the effect of the structure, arrangement and dispersion of hybrid fillers on the tensile mechanical properties of PE nanocomposites was studied. The results show that the pillared graphene/PE nanocomposites exhibit higher Young’s modulus, tensile strength and elongation at break than non-covalent connected CNTs/graphene/PE nanocomposites. The pull-out simulations show that pillared graphene by CNTs has both large interfacial load and long displacement due to the mixed modes of shear separation and normal separation. Additionally, pillared graphene can not only inhibit agglomeration but also form a compact effective thickness(stiff layer), consistent with the adsorption behavior and improved interfacial energy between pillared graphene and PE matrix.

关键词： Molecular dynamics Carbon nanotube Pillared graphene Synergistic effect Polymer nanocomposite

Unidirectional transport in amorphous topological photonic crystals

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Science China(Physics,Mechanics & Astronomy) 2023年第7期66卷 62-68页

作者： Yuting Yang Xinyue Qian Liwei Shi Xiaopeng Shen Zhi Hong hang School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China Institute for Advanced Study Soochow UniversitySuzhou 215006China

Many works on topological insulators have focused on periodic lattice systems,where short-and long-range order is *** we construct a two-dimensional amorphous photonic crystal with short-range order and a controllable level of long-range order and experimentally investigate the transport of topological edge states in this amorphous *** demonstrate that topology properties remain constant with unidirectional edge state propagation,immune to specific disorder *** partition phenomena of edge states are also observed at the intersection of four topological channels in microwave *** proposed amorphous configuration provides new opportunities to explore the relationship between short-range order and topology and may alleviate the fabrication difficulties of topological optical devices for practical applications.

关键词： photonic crystal amorphous material topological insulator

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Novel chinmedomics strategy for discovering effective constituents from ShenQiWan acting on ShenYangXu syndrome

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Chinese Journal of Natural Medicines 2016年第8期14卷 561-581页

作者： ZHOU Xiao-hang Zhang Ai-Hua WANG Liang TAN Yun-long GUAN Yu HAN Ying SUN Hui WANG Xi-Jun National TCM Key Laboratory of Serum Pharmacochemistry Sino-US Chinmedomics Technology Cooperation Center Research Center of Chinmedomics (State Administration of TCM) Laboratory of Metabolomics Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine

Elucidation of the efficacy of traditional Chinese medicine(TCM) is of importance for scientists of modern medicine to understand the value of TCM clinical experience, and it is necessary to have a biological language to scientifically describe the efficacy of TCM. With this background,Chinmedomics has been proposed by our team, which includes integrating serum pharmacochemistry and metabolomics technology, defining theory and research methods for expressing the efficacy of TCMs based on the biomarkers discovery of TCM syndrome and elucidating the efficacy of TCM formulae, discovering effective constituents, and finally elucidating the scientific value of TCM. In the present study, the innovative chinmedomics strategy was conducted to evaluate the therapeutic effects of Shen Qi Wan(SQW) acting on Shen Yang Xu(kidney-yang deficiency syndrome, KYDS). We analyzed the urine metabolic trajectory between the model and control groups, and identified the biomarkers by the multivariate analysis. We found that SQW caused significant restoration of abnormal metabolism of KYDs. Using the method of metabolomics, 17 potential urine biomarkers were analyzed through 4 repeated tests in our serial studies on SQW and KYDS. Under the premise of therapeutic efficacy, a total of 56 peaks were tentatively characterized in vivo by the use of serum pharmacochemistry. Correlation analysis between marker metabolites and in vivo constituents of SQW showed that 28 compositions had a close relationship with urine biomarkers of therapeutic effects, whichmight play a key role in the therapeutic effect of SQW. These compounds were imported into an online database to predict their targets. Twenty-three important potential targets were identified, which were related to the metabolism of steroid hormone, tryptophan utilization, and thyroid hormone. In conclusion, chinmedomics is a useful strategy for discovery of potentially effective constituents from complex TCM formulae.

关键词： Chinmedomics ShenQiWan ShenYangXu syndrome Metabolomics Serum pharmacochemistry

Bifunctional LiI additive for poly(ethylene oxide)electrolyte with high ionic conductivity and stable interfacial chemistry

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Journal of Energy Chemistry 2022年第8期31卷 218-224,I0007页

作者： Haonan Wang Tianyi Hou hang Cheng Bowen Jiang Henghui Xu Yunhui Huang School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430000HubeiChina

The development of polymer-based solid-state batteries is severely limited by the low ionic conductivity of solid polymer electrolyte and the instable interface between polymer electrolyte and Li-metal *** this work,lithium iodide(LiI)as a bifunctional additive was introduced into the poly(ethylene oxide)(PEO)-based electrolyte to improve the ionic conductivity and to construct a stable interphase at the Li/PEO interface.I-anions offer a strong electrostatic interaction with hydrogen atoms on PEO chains(HPEO)and forming massive I–H bonds that cross-link PEO chains,decrease crystallinity of PEO,and thus improve Li~+interchain *** addition,LiI participates in the formation of an inorganic-rich interphase layer,which decreases the energy barrier of Li+transport across the interface and thus inhibits the growth of lithium *** a result,the composite PEO electrolyte with 2 wt%LiI(PEO-2 LiI)presents a very high ionic conductivity of 2.1×10^(-4) S cm-1 and a critical current density of 2.0 m A cm^(-2) at 45°*** symmetric cell with this PEO-2 LiI electrolyte exhibits a long-term cyclability over 600 h at 0.2 m A cm^(-2).Furthermore,solid-state LiFePO_(4) and LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2) batteries with the PEO-2 LiI electrolyte show an impressive electrochemical performance with outstanding cycling stability and rate capability at 45°C.

关键词： Solid-state battery LiI Electrostatic interaction Crystallinity Interface

Fractional order distance regularized level set method with bias correction

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 64-82页

作者： Cai Xiumei He Ningning Wu Chengmao Liu Xiao Liu hang School of Automation Xi'an University of Posts and TelecommunicationsXi'an 710121China School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China

The existing level set segmentation methods have drawbacks such as poor convergence,poor noise resistance,and long iteration *** this paper,a fractional order distance regularized level set segmentation method with bias correction is *** method firstly introduces fractional order distance regularized term to punish the deviation between the level set function(LSF)and the signed distance *** a series of covering template is constructed to calculate fractional derivative and its conjugate of image *** introducing the offset correction term and fully using the local clustering property of image intensity,the local clustering criterion of image intensity is defined and integrated with the neighborhood center to obtain the global criterion of image ***,the fractional distance regularization,offset correction,and external energy constraints are combined,and the energy optimization segmentation method for noisy image is established by level *** results show that the proposed method can accurately segment the image,and effectively improve the efficiency and robustness of exiting state of the art level set related algorithms.

关键词： image segmentation fractional order distance regularization level set function fractional derivative bias correction

Valleytronic topological filters in silicene-like inner-edge systems

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Chinese Physics B 2024年第1期33卷 66-74页

作者：谢航吕小龙杨加恩 College of Physics Chongqing UniversityChongqing 401331China Chongqing Key Laboratory for Strongly-Coupled Physics Chongqing UniversityChongqing 401331China College of Science Guangxi University of Science and TechnologyLiuzhou 545006China School of Electronics and IoT Chongqing College of Electronic EngineeringChongqing 401331China

Inner edge state with spin and valley degrees of freedom is a promising candidate for designing a dissipationless device due to the topological protection. The central challenge for the application of the inner edge state is to generate and modulate the polarized currents. In this work, we discover a new mechanism to generate fully valley-and spin–valley-polarized current caused by the Bloch wavevector mismatch(BWM). Based on this mechanism, we design some serial-typed inner-edge filters. By using once of the BWM, the coincident states could be divided into transmitted and reflected modes, which can serve as a valley or spin–valley filter. In particular, while with twice of the BWM, the incident current is absolutely reflected to support an off state with a specified valley and spin, which is different from the gap *** findings give rise to a new platform for designing valleytronics and spin-valleytronics.

关键词： topological insulator inner-edge state valley polarization spin polarization quantum transport

Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells

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World Journal of Gastroenterology 2014年第17期20卷 4953-4962页

作者： hang Yuan Ai-Jun Li Sen-Lin Ma long-Jiu Cui Bin Wu Lei Yin Meng-Chao Wu Department of the 2~(nd) Special Treatment Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

AIM: To clarify whether histone deacetylase inhibitors histone deacetylase inhibitors (HDACIs) can sensitize hepatocellular carcinoma (HCC) cells to sorafenib treatment. METHODS: Bax, Bcl-2, ATG5-ATG12, p21, and p27 protein levels in Hep3B, HepG2, and PLC/PRF/5 cells were examined by Western blot. CCK8 and a fluoro-metric caspase-3 assay were used to examine cellular viability and apoptosis levels. The effect of Beclin-1 on sensitization of HCC cells to sorafenib was examined by transfecting Beclin-1 siRNA into Hep3B, HepG2, and PLC/PRF/5 cells. RESULTS: Autophagy inhibition enhances the inhibitory effects of vorinostat and sorafenib alone or in combination on HCC cell growth. Vorinostat and sorafenib synergistically induced apoptosis and cell cycle alterations. Western blot data indicated that HDACIs and Beclin- 1 knockdown increased the p53 acetylation level. The knockdown of Beclin-1 enhanced the synergistic effect of the combination of vorinostat with sorafenib. CONCLUSION: HDACIs can sensitize HCC cells to sorafenib treatment by regulating the acetylation level of Beclin-1. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

关键词： Hepatocellular carcinoma Histone deacetylase inhibitors Autophagy Sorafenib Chemoresistance

Detection of antimicrobial resistance and virulence-related genes in Streptococcus uberis and Streptococcus parauberis isolated from clinical bovine mastitis cases in northwestern China

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Journal of Integrative Agriculture 2020年第11期19卷 2784-2791页

作者： Zhang hang YANG Feng LI Xin-pu LUO Jin-yin WANG Ling ZHOU Yu-long YAN Yong WANG Xurong LI Hong-sheng Lanzhou Institute of Husbandry and Pharmaceutical Sciences Chinese Academy of Agricultural Sciences/Key Lab of Veterinary Pharmaceutical DevelopmentMinistry of Agriculture and Rural Affairs/Engineering and Technology Research Center of Traditional Chinese Veterinary MedicineLanzhou 730050P.R.China

The objectives of this study were to investigate antimicrobial resistance of Streptococcus uberis and Streptococcus parauberis isolated from cows with bovine clinical mastitis in China and to examine the distribution of resistance-and virulence-related gene *** susceptibility was determined by the *** encoding antimicrobial resistance and invasiveness factors were examined by PCR.A total of 27 strains were obtained from 326 mastitis milk *** parauberis isolates(n=11)showed high resistance to erythromycin(90.9%),followed by tetracycline(45.5%),chloramphenicol(36.4%)and clindamycin(27.3%).Streptococcus uberis isolates(n=16)were highly resistant to tetracycline(81.3%)and clindamycin(62.5%).Both species were susceptible to *** most prevalent resistance gene in *** was tetM(80.0%),followed by blaZ(62.5%)and ermB(62.5%).However,tetM,blaZ,and ermB genes were only found in 27.3,45.5,and 27.3%,respectively,of *** addition,all of the isolates carried at least one selected virulence-related *** most prevalent virulence-associated gene pattern in the current study was sua+pauA/skc+gapC+hasC detected in 22.2%of the *** *** strain carried 7 virulence-associated genes and belonged to the sua+pauA/skc+gapC+cfu+hasA+hasB+hasC *** than 59.3%of analysed strains carried 4 to 7 virulence-related *** findings demonstrated that *** and *** isolated from clinical bovine mastitis cases in China exhibited diverse molecular ecology,and that the strains were highly resistant to antibiotics commonly used in the dairy cow *** data obtained in the current study contribute to a better understanding of the pathogenesis of bacteria in mastitis caused by these pathogens,and the findings are relevant to the development of multivalent vaccines and targeted prevention procedures.

关键词： bovine mastitis Streptococcus uberis Streptococcus parauberis antimicrobial resistance virulence gene

Typical diseases of a long-span concrete-filled steel tubular arch bridge and their effects on vehicle-induced dynamic response

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Frontiers of Structural and Civil Engineering 2020年第4期14卷 867-887页

作者： Jianling HOU Weibing XU Yanjiang CHEN Kaida Zhang hang SUN Yan LI College of Architecture and Civil Engineering Bejing University of TechnologyBejing 100124China School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150090China

A long-span concrete-filled steel tubular(CFST)arch bridge suffers severe vehicle-induced dynamic responses during its service ***,few quantitative studies have been reported on the typical diseases suffered by such bridges and their effects on vehicle-induced dynamic ***,a series of field tests and theoretical analyses were conducted to study the effects of typical diseases on the vehicle-induced dynamic response of a typical CFST arch *** results show that a support void results in a height difference between both sides of the expansion joint,thus increasing the effect of vehicle impact on the main girder and *** impact factor of the displacement response of the main girder exceeds the design *** variation of the suspender force is significant,and the diseases are found to have a greater effect on a shorter *** theoretical analysis results also show that the support void causes an obvious longitudinal displacement of the main girder that is almost as large as the vertical *** support void can also cause significant changes in the vehicle-induced acceleration response,particularly when the supports and steel box girder continue to collide with each other under the vehicle load.

关键词： long-span arch bridge expansion joint disease vehicle-bridge coupling vibration dynamic response