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Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： hang Shu Xiao-Yu Chen Jie Zhao Pin Li Zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

Semi-supervised learning based hybrid beamforming under time-varying propagation environments

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Digital Communications and Networks 2024年第4期10卷 1168-1177页

作者： Yin long hang Ding Simon Murphy School of Computer Science and Technology Southwest University of Science and TechnologyMianyang621000China Department of Computing Science University of AlbertaEdmontonT6G 2R3Canada

Hybrid precoding is considered as a promising low-cost technique for millimeter wave(mm-wave)massive Multi-Input Multi-Output(MIMO)*** this work,referring to the time-varying propagation circumstances,with semi-supervised Incremental Learning(IL),we propose an online hybrid beamforming ***,given the constraint of constant modulus on analog beamformer and combiner,we propose a new broadnetwork-based structure for the design model of hybrid *** with the existing network structure,the proposed network structure can achieve better transmission performance and lower ***,to enhance the efficiency of IL further,by combining the semi-supervised graph with IL,we propose a hybrid beamforming scheme based on chunk-by-chunk semi-supervised learning,where only few transmissions are required to calculate the label and all other unlabelled transmissions would also be put into a training data *** the existing single-by-single approach where transmissions during the model update are not taken into the consideration of model update,all transmissions,even the ones during the model update,would make contributions to model update in the proposed *** the model update,the amount of unlabelled transmissions is very large and they also carry some information,the prediction performance can be enhanced to some extent by these unlabelled channel *** results demonstrate the spectral efficiency of the proposed method outperforms that of the existing single-by-single ***,we prove the general complexity of the proposed method is lower than that of the existing approach and give the condition under which its absolute complexity outperforms that of the existing approach.

关键词： Hybrid beamforming Time-varying environments Broad network Semi-supervised learning Online learning

Thermal currents obtained and mutually switched by a modified Haldane model in graphene

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Communications in Theoretical Physics 2022年第3期74卷 119-129页

作者： Xiao-long Lü hang Xie College of Science Guangxi University of Science and TechnologyLiuzhou 545006China College of Physics Chongqing UniversityChongqing 400000China Chongqing Key Laboratory for Strongly-Coupled Physics Chongqing UniversityChongqing 400000China

By using the transfer matrix method,we discover three types of current,such as the 100%spinvalley polarized current,pure spin-valley current and pure charge current,in a two-terminal graphene *** types of current can be obtained and mutually switched by modulating the parameters of the modified Haldane model(MHM).In our work,these types of current are driven by the thermal *** with this method of increasing the one-lead temperature(with a fixed temperature difference),the thermal currents can be more effectively strengthened by increasing the temperature difference(with a fixed one-lead temperature).In order to rapidly turn off these currents,we choose to enhance the intensity of the off-resonant circularly polarized light instead of canceling the temperature *** results indicate that the graphene system with the MHM has promising applications in the spin and valley caloritronics.

关键词： graphene modified Haldane model thermal currents

Experimental realization of single-shot nonadiabatic holonomic gates in nuclear spins

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Science China(Physics,Mechanics & Astronomy) 2017年第8期60卷 1-7页

作者： hang Li Yang Liu GuiLu long State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua University Collaborative Innovation Centre of Quantum Matter School of Nuclear Science and Engineering North China Electric Power University Tsinghua National Laboratory for Information Science and Technology

Nonadiabatic holonomic quantum computation has received increasing attention due to its robustness against control errors. However, all the previous schemes have to use at least two sequentially implemented gates to realize a general one-qubit gate. Based on two recent reports, we construct two Hamiltonians and experimentally realized nonadiabatic holonomic gates by a single-shot implementation in a two-qubit nuclear magnetic resonance （NMR） system. Two noncommuting one-qubit holonomic gates, rotating along .~ and ~ axes respectively, are implemented by evolving a work qubit and an ancillary qubit nonadiabatically following a quantum circuit designed. Using a sequence compiler developed for NMR quantum information processor, we optimize the whole pulse sequence, minimizing the total error of the implementation. Finally, all the nonadiabatic holonomic gates reach high unattenuated experimental fidelities over 98%.

关键词： nonadiabatic holonomic quantum computation nuclear magnetic resonance quantum process tomography

Sinc interpolation based method for compensation of ionospheric dispersion effects on BOC signals with high subcarrier rate

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Science China(Information Sciences) 2016年第10期59卷 152-168页

作者： hang RUAN Lei Zhang Teng long Key Laboratory of Electronic and Information Technology in Satellite Navigation (Beijing Institute of Technology) Ministry of Education School of Information and Electronics Beijing Institute of Technology

Binary Offset Carrier(BOC) signals with high subcarrier rate such as Alt BOC(15,10) and cosBOC(15,2.5) have been adopted for the next generation of Global Navigation Satellite System(GNSS) to make full use of the allocated spectrum. However, the two main lobes of the BOC signals are tremendously separated in the frequency spectrum and the group delay of the two lobes are greatly dispersed due to ionospheric dispersion. The signals will suffer extremely severe distortion caused by the group delay dispersion including waveform ripples, power losses and correlation function asymmetries. In this paper, a novel time domain sinc interpolation based ionospheric dispersion compensation method is proposed to eliminate the distortion to the BOC ***, the time domain model of BOC signal under the dispersive ionosphere is developed. Afterwards, based on the model, the two signal main lobes are aligned by sinc interpolation so that the ionospheric dispersion effects are almost mitigated. Taking Galileo E5 Alt BOC(15,10) signal as an example, the performance of the proposed method is evaluated by simulation and test. The results show that the proposed method is able to more effectively compensate the ionospheric dispersion with fewer computational loads versus existing methods.

关键词： ionospheric dispersion sinc interpolation BOC code tracking bias high subcarrier rate

Emerging role of long non-coding RNA in the development of gastric cancer

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World Journal of Gastrointestinal Oncology 2018年第9期10卷 260-270页

作者： hang Yu long Rong Department of Endoscopic Center Peking University First Hospital

Gastric cancer is a common, worldwide malignancy and has a poor prognosis due to late diagnosis. long non-coding RNAs(lnc RNAs) are a significant subtype of RNA molecules with a length longer than 200 nucleotides(nt) that rarely encode proteins. In recent decades, deregulation of lnc RNAs has been shown to be involved in tumorigenesis and tumor progression in various human carcinomas, including gastric cancer. Accumulating evidence has shown that some lnc RNAs may function as diagnostic biomarkers or therapeutic targets for gastric cancer. Thus, exploring the specific functions of lnc RNAs will help both gain a better understanding of the pathogenesis and develop novel treatments for gastric cancer. In this review, we highlight the expression and functional roles of lncR NAs in gastric cancer, and analyze the potential applications of lncR NAs as diagnostic markers and therapeutic targets.

关键词： Function Tumorigenesis Gastric cancer Therapeutic target long non-coding RNAs Diagnostic marker

A Full Quantum Eigensolver for Quantum Chemistry Simulations

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Research 2020年第1期2020卷 111-121页

作者： Shijie Wei hang Li GuiLu long Beijing Academy of Quantum Information Sciences Beijing 100193China State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology and School of Information Tsinghua University Beijing 100084China Frontier Science Center for Quantum Information Beijing 100084China

Quantum simulation of quantum chemistry is one of the most compelling applications of quantum *** is of particular importance in areas ranging from materials science,biochemistry,and condensed matter ***,we propose a full quantum eigensolver(FQE)algorithm to calculate the molecular ground energies and electronic structures using quantum gradient *** to existing classical-quantum hybrid methods such as variational quantum eigensolver(VQE),our method removes the classical optimizer and performs all the calculations on a quantum computer with faster *** gradient descent iteration depth has a favorable complexity that is logarithmically dependent on the system size and inverse of the ***,the FQE can be further simplified by exploiting a perturbation theory for the calculations of intermediate matrix elements and obtaining results with a precision that satisfies the requirement of chemistry *** full quantum eigensolver can be implemented on a near-term quantum *** the rapid development of quantum computing hardware,the FQE provides an efficient and powerful tool to solve quantum chemistry problems.

关键词： convergence quantum iteration

Experimental quantum Hamiltonian identification from measurement time traces

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Science Bulletin 2017年第12期62卷 863-868页

作者： Shi-Yao Hou hang Li Gui-Lu long Microsystem&Terahertz Research Center and Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang 621999China State Key Laboratory of Low-dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China The Innovative Center of Quantum Matter Beijing 100084China Tsinghua National Laboratory of Information Science and Technology Beijing 100084China

Identifying Hamiltonian of a quantum system is of vital importance for quantum information *** this article, we realized and benchmarked a quantum Hamiltonian identification algorithm recently proposed(Zhang and Sarovar, 2014). we realized the algorithm on a liquid nuclear magnetic resonance quantum information processor using two types of working media with different forms of Hamiltonian. Our experiment realized the quantum identification algorithm based on free induction decay signals. We also showed how to process data obtained in a practical experiment. We studied the influence of decoherence by numerical simulations. Our experiments and simulations demonstrate that the algorithm is effective and robust.

关键词： Quantum informationHamiltonian identificationMeasurement time tracesExperimental realizationNuclear magnetic resonance

Parameter Estimation Based on Set-valued Signals:Theory and Application

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Acta Mathematicae Applicatae Sinica 2019年第2期35卷 255-263页

作者： Ting WANG hang Zhang Yan-long ZHAO The Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of Sciences

This paper summarizes the parameter estimation of systems with set-valued signals, which can be classified to three catalogs: one-time completed algorithms, iterative methods and recursive algorithms. For one-time completed algorithms, empirical measure method is one of the earliest methods to estimate parameters by using set-valued signals, which has been applied to the adaptive tracking of periodic target signals. The iterative methods seek numerical solutions of the maximum likelihood estimation, which have been applied to both complex diseases diagnosis and radar target recognition. The recursive algorithms are constructed via stochastic approximation and stochastic gradient methods, which have been applied to adaptive tracking of non-periodic signals.

关键词： set-valued signals parameter estimation one-time completed algorithms iterative estimation algorithms recursive estimation algorithms