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***,Regional Chaos:The Unseen Hand in Syria's Crisis

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Beij.ng Review 2024年第51期67卷 20-21页

作者： danny Haiphong 不详

In j.st 12days beginning on November 27,the Syrian Government,led by Bashar al-Assad,was overthrown by insurgent groups supported by a coalition of countries,a process rooted in the Syrian Civil *** long-running conflict,which has been characterized by many political analysts as a U.S.-led proxy war,started in 2011 as an uprising against Assad's rule,which quickly escalated into a violent and protracted civil war involving multiple factions and foreign powers.

关键词： U.S. powers urgent

Cold Cloud Over Paris Olympics

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Beij.ng Review 2024年第34期67卷 22-23页

作者： danny Haiphong 不详

The Olympic Games are a rare occasion where representatives from the world's nations come together to compete in *** the intense competition,the world's largest sporting event promotes a spirit of peace and *** athletes and national teams take great pride in displaying their talent,skill and dedication on the world ***,the Olympics can also become a platform for political tensions.

关键词： peace spite Olympics

Why Young Americans Stand With Gaza

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Beij.ng Review 2024年第19期67卷 28-29页

作者： danny Haiphong the United States

Scenes from college campuses across the *** shocked the *** Columbia University to the University of Texas at Austin,riot police and other heavily-armed security forces have been deployed to suppress encampments of peaceful pro-Palestine *** of students and professors have been *** and college administrators have threatened to call the National Guard to break up the encampments.

关键词： Austin peace Guard

Facile synthesis of insulin fusion derivatives through sortase A ligation

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2719-2725页

作者： Maria M.Disotuar j.ke A.Smith j.nze Li Steve Alam Nai-Pin Lin danny Hung-Chieh Chou Department of Biochemistry School of MedicineUniversity of UtahSalt Lake CityUT 84112USA Division of Endocrinology and Diabetes Department of PediatricsSchool of MedicineStanford UniversityPalo AltoCA 94305USA

Insulin derivatives such as insulin detemir and insulin degludec are *** and Drug Administration(FDA)-approved long-acting insulin currently used by millions of people with *** derivatives are modified in C-terminal B29 lysine to retain insulin *** and efficient methods for facile synthesis of insulin derivatives may lead to new discovery of therapeutic ***,we report a new method using sortase A(SrtA)-mediated ligation for the synthesis of insulin derivatives with high efficiency and functional group tolerance in the C-terminal B *** new insulin molecule(Ins-SA) with an SrtA-recognizing motif can be conj.gated to diverse groups with N-terminal oligoglycines to generate new insulin *** further demonstrated that a new insulin derivative synthesized by this SrtA-mediated ligation shows strong cellular and in vivo *** enzymatic method can therefore be used for future insulin design and development.

关键词： Diabetes mellitus Insulin synthesis Sortase A(SrtA)ligation Albumin-binding peptide SA21 Long-acting insulin

Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asianpopulations

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Cancer Biology & Medicine 2022年第10期19卷 1440-1459页

作者： Zongchao Mo j.nyi Xin Ruichao Chai Peter Y.M.Woo danny T.M.Chan j.guang Wang Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute Shenzhen 518000China Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China Department of Neurosurgery Kwong Wah HospitalHong Kong SARChina Hong Kong Neuro-Oncology Society Hong Kong SARChina Division of Neurosurgery Department of SurgeryPrince of Wales HospitalHong Kong SARChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Hong Kong Center for Neurodegenerative Diseases Hong Kong Science ParkHong Kong SARChina

Understanding the racial specificities of diseases—such as adult diffuse glioma,the most common primary malignant tumor of the central nervous system—is a critical step toward precision ***,we comprehensively review studies of gliomas in East Asian populations and other ancestry groups to clarify the racial differences in terms of epidemiology and genomic ***,we observed a lower glioma incidence in East Asians than in Whites;notably,patients with glioblastoma had significantly younger ages of onset and longer overall survival than the *** genome-wide association studies of various cohorts have revealed single nucleotide polymorphisms associated with overall and subtype-specific glioma ***,only 3 risk loci—5p15.33,11q23.3,and 20q13.33—were shared between patients with East Asian and White ancestry,whereas other loci predominated only in particular *** instance,risk loci 12p11.23,15q15-21.1,and 19p13.12 were reported in East Asians,whereas risk loci 8q24.21,1p31.3,and 1q32.1 were reported in studies in White *** the somatic mutational profiles of gliomas between East Asians and non-East Asians were broadly consistent,a lower incidence of EGFR amplification in glioblastoma and a higher incidence of 1p19q-IDH-TERT triple-negative low-grade glioma were observed in East Asian *** summarizing large-scale disease surveillance,germline,and somatic genomic studies,this review reveals the unique characteristics of adult diffuse glioma among East Asians,to guide clinical management and policy design focused on patients with East Asian ancestry.

关键词： Glioma East Asian epidemiology germline somatic

Investigation of contact behavior on a model of the dual-mobility artificial hip j.int for Asians in different inner liner thicknesses

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World j.urnal of Orthopedics 2024年第4期15卷 321-336页

作者： Taufiq Hidayat Muhammad Imam Ammarullah Rifky Ismail Eko Saputra M danny Pratama Lamura Chethan K N Athanasius Priharyoto Bayuseno j.j.mari Department of Mechanical Engineering Universitas Muria KudusKudus 59352Central JavaIndonesia Department of Mechanical Engineering Universitas DiponegoroSemarang 50275Central JavaIndonesia Undip Biomechanics Engineering&Research Centre Universitas DiponegoroSemarang 50275Central JavaIndonesia Center for Biomechanics Biomaterials Biomechatronics and Biosignal Processing Universitas DiponegoroSemarang 50275Central JavaIndonesia Department of Mechanical Engineering Politeknik Negeri SemarangSemarang 50275Central JavaIndonesia Department of Aeronautical and Automobile Engineering Manipal Institute of TechnologyManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia

BACKGROUND The four components that make up the current dual-mobility artificial hip j.int design are the femoral head,the inner liner,the outer liner as a metal cover to prevent wear,and the acetabular *** acetabular cup and the outer liner were constructed of 316L stainless *** the same time,the inner liner was made of ultra-high-molecular-weight polyethylene(UHMWPE).As this new dual-mobility artificial hip j.int has not been researched extensively,more tribological research is needed to predict *** thickness of the inner liner is a significant component to consider when calculating the contact *** To make use of finite element analysis to gain a better understanding of the contact behavior in various inner liner thicknesses on a new model of a dual-mobility artificial hip j.int,with the ultimate obj.ctive of determining the inner liner thickness that was most suitable for this particular type of dual-mobility artificial hip *** In this study,the size of the femoral head was compared between two diameters(28 mm and 36 mm)and eight inner liner thicknesses ranging from 5 mm to 12 *** the finite element method,the contact parameters,including the maximum contact pressure and contact area,have been evaluated in light of the Hertzian contact *** simulation was performed statically with dissipated energy and asymmetric *** types of interaction were surface-to-surface contact and normal contact *** The maximum contact pressures in the inner liner(UHMWPE)at a head diameter of 28 mm and 36 mm are between 3.7-13.5 MPa and 2.7-10.4 MPa,*** maximum von Mises of the inner liner,outer liner,and acetabular cup are 2.4–11.4 MPa,15.7–44.3 MPa,and 3.7–12.6 MPa,respectively,for 28 mm *** the maximum von Mises stresses of the 36 mm head are 1.9-8.9 MPa for the inner liner,9.9-32.8 MPa for the outer liner,and 2.6-9.9 MPa for the acetabular cup.A head with a diameter of 28 mm should have an inner line

关键词： Contact behavior Contact pressure Finite element analysis Dual-mobility Artificial hip j.int

Using Geographic Information Systems (GIS) for Targeted National Recruitment of Community-Dwelling Caregivers Managing Dementia-Related Behavioral and Psychological Symptoms: A Recruitment Approach for a Randomized Clinical Trial

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j.urnal of Geographic Information System 2021年第3期13卷 302-317页

作者： danny L. Scerpella Nicole G. Bouranis Melinda j. Webster Maria Dellapina Sokha Koeuth Lauren j. Parker Helen C. Kales Laura N. Gitlin School of Public Health Johns Hopkins University Baltimore USA College of Nursing and Health Professions Drexel University Philadelphia USA Department of Psychiatry University of California-Davis Sacramento USA

Over 16 million caregivers of people living with dementia require support in a range of issues, including self-care, disease education, and guidance for how to manage behavioral and psychological symptoms of dementia (BPSD). Non-pharmacological interventions are needed to address these areas, and online applications have been shown to be safe and effective. To ensure the efficacy of such interventions, racially, ethnically, geographically, and socioeconomically diverse participants must be recruited to increase the generalizability of study outcomes. This protocol paper describes a recruitment plan using Geographic Information Systems (GIS) to reach a representative sample of caregivers across the United States for a national Phase III clinical study. Using publicly available census data from the American Community Survey (ACS), combined with location data for local aging resources such as Area Agencies on Aging (AAA), recruitment will be derived from data analysis conducted in ESRI ArcGIS v10.7.1. Datasets including age, gender, income, and education will be assessed nationally at the county and census tract spatial scale in a nine-step process to develop recruitment priority areas containing high concentrations of eligible participants living in the community. Overall, the current protocol will demonstrate the value of GIS in tailoring targeted outreach strategies to recruit community-dwelling populations through local resource institutions. This novel approach may have far-reaching implications in future recruitment initiatives and help to secure racially/ethnically diverse samples.

关键词： Geographic Information Systems Recruitment Clinical Trial GIS Dementia or Caregiving

Difficulties in Recruitment for a Randomised Controlled Trial of Lifestyle Intervention for Type 2 Diabetes: Implications for Diabetes Management

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Open j.urnal of Endocrine and Metabolic Diseases 2012年第4期2卷 53-57页

作者： George A. j.linek Emily Hadgkiss Craig Hassed Bernard Crimmins Peter Schattner danny Liew Rick Kausman Warrick j. Inder Siegfried Gutbrod Tracey j. Weiland Department of General Practice Faculty of Medicine Nursing and Health Sciences Monash University Clayton Australia Department of Medicine Faculty of Medicine and Health Sciences The University of Melbourne Royal Melbourne Hospital Melbourne Australia East Bentleigh General Practice Melbourne Australia Emergency Practice Innovation Centre St Vincent’s Hospital Melbourne Australia Formerly Department of Endocrinology St Vincent’s Hospital Melbourne Australia Manningham General Practice Melbourne Australia The Butterfly Foundation Malvern Australia The Gawler Foundation Yarra Junction Australia

Obj.ctive: To report our experience of attempting a randomised controlled trial of an intensive lifestyle intervention for early type 2 diabetes delivered in a residential setting. Methods: We established a trial requiring 84 participants (46 standard care and 38 intervention) to detect a 1% difference in HbA1c between intervention and control groups at 12 months, allowing for attrition. Ethics approval was obtained from Monash University. Results: The study was abandoned after five months of consistent promotion due to recruitment failure (four subj.cts recruited). Conclusion: It appears to be difficult for patients with diabetes to commit to a live-in period of education regarding lifestyle modification as a means of treating the illness. We recommend better education of patients and their doctors about the potential health benefits of lifestyle change to manage type 2 diabetes, and further research into novel methods of delivering lifestyle advice which are both effective and sustainable.

关键词： Type 2 Diabetes Mellitus Randomised Controlled Trial Management Lifestyle Risk Factors

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