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新兴人类增强技术的“激进主义”与“保守主义”——共性分析及对立性消解

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探索与争鸣 2023年第11期 58-65,193页

作者：易显飞刘壮湖南师范大学道德文化研究中心、马克思主义学院湖南涉外经济学院马克思主义学院长沙410081

随着“NBRIC会聚技术”时代的到来,出现了与传统增强技术在作用机制与人技关系方面大相径庭的新兴人类增强技术。新兴人类增强技术“激进主义”与“保守主义”之间的论争从未停歇。尽管两者的理论主张看似泾渭分明,但实际上存在一定的共... 详细信息

随着“NBRIC会聚技术”时代的到来,出现了与传统增强技术在作用机制与人技关系方面大相径庭的新兴人类增强技术。新兴人类增强技术“激进主义”与“保守主义”之间的论争从未停歇。尽管两者的理论主张看似泾渭分明,但实际上存在一定的共性,主要表现在三个方面:一是都对增强技术抱有一定的幻想;二是均在论争中反映了人的主体性迷失;三是对各自的命题前提皆存悬置。基于对这些共性的思考与把握,可以勾勒出两者对立消解的可能性界域,即让增强技术“位其所是”,重构人类中心主义,悬置形而上迷思,转向“现实的人”。

关键词：新兴增强技术技术激进主义技术保守主义对立性消解

Carbon Nanotubes in Biology and Medicine:In vitro and in vivo Detection,Imaging and Drug Delivery

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Nano Research 2009年第2期2卷 85-120页

作者： zhuang liu Scott Tabakman Kevin Welsher Hongjie Dai Department of Chemistry Stanford UniversityCA 94305USA

Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few *** this comprehensive review,we summarize the main results from our and other groups in this field and clarify that surface functionalization is critical to the behavior of carbon nanotubes in biological *** detection of biological species with carbon nanotubes can be realized after surface passivation to inhibit the non-specific binding of biomolecules on the hydrophobic nanotube *** nanosensors based on nanotubes provide a label-free approach to biological ***-enhanced Raman spectroscopy of carbon nanotubes opens up a method of protein microarray with detection sensitivity down to 1 fmol/*** vitro and in vivo toxicity studies reveal that highly water soluble and serum stable nanotubes are biocompatible,nontoxic,and potentially useful for biomedical *** vivo biodistributions vary with the functionalization and possibly also size of nanotubes,with a tendency to accumulate in the reticuloendothelial system(RES),including the liver and spleen,after intravenous *** well functionalized,nanotubes may be excreted mainly through the biliary pathway in *** nanotube-based drug delivery has shown promise in various In vitro and in vivo experiments including delivery of small interfering RNA(siRNA),paclitaxel and ***,single-walled carbon nanotubes with various interesting intrinsic optical properties have been used as novel photoluminescence,Raman,and photoacoustic contrast agents for imaging of cells and *** multidisciplinary explorations in this field may bring new opportunities in the realm of biomedicine.

关键词： Carbon nanotubes biomedical applications surface functionalization biosensor drug delivery biomedical imaging

The acidic tumor microenvironment: a target for smart cancer nano-theranostics

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National Science Review 2018年第2期5卷 269-286页

作者： Liangzhu Feng Ziliang Dong Danlei Tao Yicheng Zhang zhuang liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University

The acidic tumor microenvironment(TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article,we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards.

关键词： tumor microenvironment cancer targeting nanomedicine theranostics

Graphene-based membranes for molecular and ionic separations in aqueous environments

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Chinese Journal of Chemical Engineering 2017年第11期25卷 1598-1605页

作者： zhuang liu Wei Wang Xiaojie Ju Rui Xie Liangyin Chu School of Chemical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM) Nanjing 211816China

Graphene-based laminar materials open up to new applications for molecular and ionic separations in aqueous environments due to the atomic thickness, mechanical strength, chemical stability and other fantastic *** advances on controlling the structure and chemical functionality of graphene-based membranes can potentially lead to new classes of tools for desalination, dehydration, toxicant rejection, specific ionic separation and so on. The recent developments of graphene-based membranes prepared by using a concept to form interlayer space between graphene sheets and creating nanoscale or sub-nanoscale pores in a graphene lattice, together with their mass-transfer mechanisms and potential applications in aqueous environments are reviewed. A summary and outlook is further provided on the opportunities and challenges in this arising *** article is expected to address the intricate details of mass transport through two distinct graphene-based membranes in aqueous environment and to optimize the fabrication of graphene-based membranes as a fascinating separation system for a wide range of applications.

关键词： Graphene membranesTwo-dimensional materialsSeparationWater treatmentDesalinationion selectivity

超高效液相色谱-串联质谱检测蔗糖中47种农药残留量的方法

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药物分析杂志 2024年第6期44卷 979-989页

作者：谭菊英蒋洁刘庄蔚何虹杨欣智朱健萍邓鸣徐光辉王健赵庄卢日刚广西壮族自治区药品检验研究院南宁530021 中粮崇左糖业有限公司/广西壮族自治区甘蔗产业链延伸工程研究中心崇左532200 中粮营养健康研究院有限公司/营养健康与食品安全北京市重点实验室北京102209

目的:建立超高效液相色谱-串联质谱(UPLC-MS/MS)同时测定蔗糖中47种农药残留量的方法。方法:蔗糖样品经酸性乙腈提取,氮气吹干浓缩,采用LC-MS/MS进行分析检测,在多反应检测模式(MRM)下,用空白基质标准曲线-内标法进行定量。结果:各待测... 详细信息

目的:建立超高效液相色谱-串联质谱(UPLC-MS/MS)同时测定蔗糖中47种农药残留量的方法。方法:蔗糖样品经酸性乙腈提取,氮气吹干浓缩,采用LC-MS/MS进行分析检测,在多反应检测模式(MRM)下,用空白基质标准曲线-内标法进行定量。结果:各待测物质在一定浓度范围内线性良好(r>0.995),检测限为0.01~2.00μg·kg^(-1)。分别在蔗糖样品中添加47种农药标准溶液10、25、50μg·kg^(-1),进行标准添加回收试验,方法回收率为71.0%~106.0%,重复性RSD为0.90%~8.5%。15批蔗糖样品中2批检出噻虫嗪、噻虫胺,其余均未检出。结论:该方法具有前处理简单快捷、灵敏、准确等优点,符合农药残留检测要求,满足蔗糖中农药残留检测需要,可用于蔗糖的质量控制。

关键词：蔗糖农药残留液相色谱-质谱多反应监测模式基质效应内标法

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市政给排水施工中长距离顶管施工技术研究

科学技术创新 2024年第16期 183-186页

作者：刘壮兰春雨戴志福涂斌中国电建集团江西省水电工程局有限公司江西南昌南昌大学设计研究院江西南昌南昌工程学院江西南昌江西胜绩通工程咨询有限公司江西南昌

本文简要分析市政给排水施工中长距离顶管施工技术,并以市政给排水施工中长距离顶管施工技术应用分析作为切入点,对施工准备、工艺方法、技术要点以及施工效果等方面进行研究,期望能够为相关人员提供参考,以此来加强市政给排水施工中长... 详细信息

本文简要分析市政给排水施工中长距离顶管施工技术,并以市政给排水施工中长距离顶管施工技术应用分析作为切入点,对施工准备、工艺方法、技术要点以及施工效果等方面进行研究,期望能够为相关人员提供参考,以此来加强市政给排水施工中长距离顶管施工技术研究,提高市政给排水施工质量。

关键词：市政给排水工程施工技术控制要点

市政给排水预应力钢筋混凝土管道施工技术研究

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科学技术创新 2024年第16期 131-134页

作者：兰春雨刘壮戴志福涂斌中国电建集团江西省水电工程局有限公司江西南昌南昌大学设计研究院江西南昌南昌工程学院江西南昌江西胜绩通工程咨询有限公司江西南昌

本文以钢筋混凝土管道施工技术为研究对象,首先分析了准备环节工作内容,需要从技术、材料和设备三个方面做好准备工作。其次需要根据施工方案落实施工,应保证施工严格执行质量标准,提高施工质量。最后进行质量验收。

关键词：预应力钢筋混凝土管道施工技术

Effect of adding a smart potassium ion-responsive copolymer into polysulfone support membrane on the performance of thin-film composite nanofiltration membrane

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 400-414页

作者： Meibo He zhuang liu Tong Li Chen Chen Baicang liu John C.Crittenden Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu 610207China College of Architecture and Environment Sichuan UniversityChengdu 610065China School of Chemical Engineering Sichuan UniversityChengdu 610065China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Litree Purifying Technology Co. LtdHaikou 571126China Brook Byers Institute for Sustainable Systems School of Civil and Environmental EngineeringGeorgia Institute of TechnologyAtlantaGA 30332USA

Thin-film composite (TFC) nanofiltration (NF) membranes were fabricated via the interfacial polymerization of piperazine (PIP) and 1,3,5-benzenetricart)oiiyl trichloride on polysulfone (PSf) support membranes blended with K^+-responsive poly(N-isopropylacryamideco- acryloylamidobenzo-15-crown-5)(P(NIPAM-co- AAB15C5)). Membranes were characterized by attenuated total reflection Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, atomic force microscope, scanning electron microscope, contact angle, and filtration tests. The results showed that:(1) Under K^+-free conditions, the blended P(NIPAM-co-AAB15C5)/PSf supports had porous and hydrophilic surfaces, thereby producing NF membranes with smooth surfaces and low MgSO4 rejections;(2) With K^+ in the PIP solution, the surface roughness and water permeability of the resultant NF membrane were increased due to the K^+-induced transition of low-content P(NIPAM-co-AAB15C5) from hydrophilic to hydrophobic;(3) After a curing treatment at 95℃, the improved NF membrane achieved an even higher pure water permeability of 10.97 L·m^-2·h^-1 - bar1 under 200 psi. Overall, this study provides a novel method to improve the performance of NF membranes and helps understand the influence of supports on TFC membranes.

关键词： nanofiltration interfacial polymerization support membrane potassium ion-responsive thin-film composite

A Utility-Based Scheduling Scheme for MIMO-OFDMA Downlink Systems

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Journal of Harbin Institute of Technology(New Series) 2014年第2期21卷 1-5页

作者： zhuang liu Xi Li Hong Ji Key Laboratory of Universal Wireless Communications Ministry of EducationBeijing University of Posts and Telecommunications

In this paper,a utility-based feedback delay-aware and buffer status-aware( FABA) scheduling scheme is proposed for downlink multiuser multiple-input multiple-output orthogonal frequency-division multiple-access( MIMO-OFDMA) systems. The FABA scheme allocates subcarriers to multiusers with an objective of not only maximizing the total system capacity but reducing the system packet loss rate as well. We design a utility function which consists of a feedback estimate module,a proportional fairness module and a buffer monitoring module. The feedback estimate module is used to improve the system throughput by utilizing the Automatic Repeat-reQuest( ARQ) feedback information to combat the fast time-varying fading condition. The proportional fairness module can guarantee the scheduling fairness among users,and the buffer monitoring module can utilize the transmitting buffer status information to avoid high packet loss rate of the system caused by the system congestion. The FABA scheme then formulates the scheduling problem into a problem of overall system utility maximization. We solve the problem by using a heuristic algorithm with low computational complexity. The simulation results show that the proposed FABA scheme outperforms the existing algorithms in terms of the system throughput and the packet loss rate and can also guarantee the fairness demand among users.

关键词： packet scheduling MIMO-OFDMA ARQ feedback buffer status packet loss rate