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Research 2022年第4期2022卷 531-546页

作者： Guowang Cheng Xueliang liu Yujing liu Yao liu Rui Ma Jingshan Luo Xinyi Zhou Zhenfeng Wu zhuang liu Tongkai Chen Yu Yang Key Laboratory of Modern Preparation of Traditional Chinese Medicine Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Institute of Molecular Medicine(IMM) Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China School of Cellular and Molecular Medicine University of BristolBristol BS81THUK Institute of Functional Nano e Soft Materials Laboratory(FUNSOM) Soochow UniversitySuzhouJiangsu 215123China

Parkinson's disease(PD)is the second most common neurodegenerative disease globally,and there is currently no effective treatment for this *** accumulation of reactive oxygen species(ROs)and neuroinflammation are major contributors to PD ***,ultrasmall nanoscale coordination polymers(NCPs)coordinated by ferric ions and natural product curcumin(Cur)were exploited,showing efficient neuroprotection by scavenging excessive radicals and suppressing *** a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse PD model,such ultrasmall Fe-Cur NCPs with prolonged blood circulation and BBB traversing capability could effectively alleviate oxidative stress,mitochondrial dysfunction,and inflammatory condition in the midbrain and striatum to reduce PD ***,this study puts forth a unique type of therapeutics-based NCPs that could be used for safe and efficient treatment of PD with potential in clinical translation.

关键词： inflammation pathogenesis clinical

Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy

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Nano Research 2019年第6期12卷 1307-1312页

作者： Wenjun Zhu Yu Yang Qiutong Jin Yu Chao Longlong Tian Jingjing liu Ziliang Dong zhuang liu Institute of Functional Nano & Soft Materials(FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologyJiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadTaipaMacao 31608China

Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine *** addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine ***,2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG).Compared to their particulate counterpart,such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production,promising for chemotherapy and photodynamic therapy (PDT),*** the porphyrin structure of TCPP,our 2D NMOFs could be labeled with a diagnostic radioisotope,99mTc,for single photon emission computer tomography (SPECT) imaging,which reveals efficient tumor homing of those 2D NMOFs upon intravenous *** offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT,such 2D NMOFs show efficient biodegradation and rapid renal *** work presents the great promise of 2D NMOFs for nanomedicine applications.

关键词： nanoscale metal-organic-framework two-dimensional nanosheets drug delivery photodynamic therapy combination therapy

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地热水腐蚀与结垢研究现状与展望

科学技术与工程 2024年第25期24卷 10577-10587页

作者：白海涛高俊哲孙玉倩温欣刘壮陈星西安石油大学石油工程学院陕西省油气田特种增产技术重点实验室西安710065 中国石油长庆油田分公司第一采气厂榆林718500

随着全球能源需求的不断增加和环境污染问题的加剧,地热能作为一种清洁、可再生的能源形式备受瞩目。然而,地热水腐蚀和结垢问题一直是地热能开发中的一大难题,也是制约其应用的主要因素之一。腐蚀会导致管道泄漏,造成昂贵的维修费用,... 详细信息

随着全球能源需求的不断增加和环境污染问题的加剧,地热能作为一种清洁、可再生的能源形式备受瞩目。然而,地热水腐蚀和结垢问题一直是地热能开发中的一大难题,也是制约其应用的主要因素之一。腐蚀会导致管道泄漏,造成昂贵的维修费用,还可能导致设备故障;结垢物则会阻碍水的流动或降低传热效率,导致能源成本增加。因此,了解地热水的腐蚀特性和结垢组成对于选择适当的抗腐蚀材料和维护技术、延长设备使用寿命、确保地热能利用系统的稳定运行至关重要。阐述在地热水开发中腐蚀和结垢的特点,梳理地热水的水质特征及腐蚀结垢趋势预测的研究方法,分析影响地热井管网腐蚀的几个重要因素(高温、CO_(2)、溶解氧、Cl^(-)、H_(2) S)造成管道的腐蚀和结垢的特性,总结腐蚀和结垢的机理,以期为地热能的开发和利用提供一定的参考。

关键词：地热水腐蚀结垢水化学性质机理

Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures

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Nano Research 2016年第1期9卷 139-148页

作者： Yu Yang Jingjing liu Xiaoqi Sun Liangzhu Feng Wenwen Zhu zhuang liu Meiwan Chen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macao Avenida da Universidade Taipa Macao China Institute of Functional Nano & Soft Materials Laboratory (FUNSOM) Soochow University Suzhou 215123 China

Stimuli-activated targeted delivery systems for highly accurate treatment of tumors have received considerable attention in recent years. Herein, we reveal a light-activable cancer-targeting strategy that uses a complementary DNA sequence to hybridize and mask sgc8 aptamers conjugated onto photothermal agents such as gold nanorods or single-walled carbon nanotubes （SWNTs）. Upon exposure to near-infrared （NIR） laser, localized photothermal heating of the surface of those nano-agents results in dehybridization of the double-stranded DNA and uncaging of the aptamer sequence to allow specific cancer-cell targeting. Utilizing doxorubicin-loaded SWNTs as a model system, targeted drug delivery to cancer cells activated by NIR light was achieved. This work demonstrates the concept of NIR-activable tumor-targeting delivery systems with controllable cancer-cell binding to potentially enable highly specific and efficient cancer therapy.

关键词： near-infrared(NIR)-activable drug delivery aptamer gold nanorods single-walled carbonnanotubes

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上海淀浦河水质评价及成因分析

绿色科技 2024年第6期26卷 169-173页

作者：余磊刘壮杨婷贾文飞刘黎明上海普适导航科技股份有限公司上海201702

采用单因子评价和内梅罗综合污染指数法对上海市淀浦河枯丰水期的水质进行评价。结果表明:淀浦河枯水期七莘路断面未达到水质目标,南港大桥和七莘路断面在丰水期未达到水质目标。枯水期内梅罗综合污染指数大于枯水期,总体上枯水期的水... 详细信息

采用单因子评价和内梅罗综合污染指数法对上海市淀浦河枯丰水期的水质进行评价。结果表明:淀浦河枯水期七莘路断面未达到水质目标,南港大桥和七莘路断面在丰水期未达到水质目标。枯水期内梅罗综合污染指数大于枯水期,总体上枯水期的水质较差于丰水期。河道沿程水质依次变差,其中下游七莘路断面的水质最差,与水质功能区目标相差较大。通过主成分分析法初步识别出淀浦河的水质污染源为农业面源污染和城市生产生活的综合污染源,农业面源污染的主要贡献因子为TP、NH_(3)-N、EC和浊度,城市生产生活污染源的主要贡献因子为EC、COD_(Mn)和DO。

关键词：淀浦河单因子评价内梅罗综合污染指数方法主成分分析

维普期刊数据库博看期刊

EFFECT OF THE PHASE STRUCTURE EVOLUTION ON THE PROPERTIES OF FILMS FORMED FROM PBA/P(St-co-MMA) COMPOSITE LATEX

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Chinese Journal of Polymer Science 2008年第1期26卷 39-45页

作者： Huo, Dong-xia Yuan, Xian-yong liu, Da-zhuang Zhang, Li Wang, Fang Zhengzhou Univ Sch Mat Sci & Engn Zhengzhou 450052 Peoples R China

A group of heterogeneous latexes poly(butyl acrylate)/poly(styrene-co-methyl methacrylate)(PBA/P(St-co-MMA)) were prepared by a semi-continuous seeded emulsion polymerization process under monomer starved *** glass transition temperature(T_g)and the mechanical properties of the film formed from the composite latex changed with the evolution of the particle morphology.A photon transmission method was used to monitor the phase structure evolution of films which were prepared from core-shell PBA/P(S...

关键词： Film formation Latex Evolution Composite Phase

The enhanced permeability and retention effect based nanomedicine at the site of injury

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Nano Research 2020年第2期13卷 564-569页

作者： Yingjun liu Dongdong Sun Qin Fan Qingle Ma Ziliang Dong Weiwei Tao Huiquan Tao zhuang liu Chao Wang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine School of Integrated Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210023China

The enhanced permeability retention(EPR)effect based nanomedicine has been widely used for tumor targeting during the past *** we unexpectedly observed the similar"EPR effect"at the site of *** found that the temporary dilated and leaky blood vessels caused by the potent vasodilator histamine in response to injury allowed the injected nanoparticles to pass through the vasculature and reached the injured *** finding shows the potential underline mechanism of"EPR effect"at the injured *** loading with antibiotics,we further demonstrated a new strategy for prevention of infection at the site of injury.

关键词： enhanced permeability retention(EPR)effect injured tissue polymeric nanoparticles histamine immune response

EFFECTS OF RARE EARTH ON METHANE SENSORS ACTIVATION IN CATALYSIS REACTION

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Journal of Wuhan University of Technology(Materials Science) 1997年第Z1期12卷 9-13页

作者： liu Yongjian zhuang Hong Ou Zechen China University of Mining and Technology China University of Mining and Technology

The partial replacement of the noble metal Pt with rare-earth compound and the application of the compound to the inclusion and modification of traditional methane's catalyst used in oxidation reaction has demonstrate... 详细信息

关键词： methane catalysis activation

Wear-resistance and anti-scuffing of multi-arc ion plating molybdenum films

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 391-394页

作者： WANG Hai-dou XU Bin-shi liu Jia-jun zhuang Da-ming National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 China Department of Mechanical Engineering Tsinghua University Beijing 100084 China Department of Mechanical Engineering Tsinghua University Beijing 100084 China

The multi-arc ion plating technology was employed to prepare the molybdenum films with thickness of 3 μm on the AISI 1045 steel. The wear and scuffing tests were carried out on the ball-on-disc tester. AFM and SEM equipped with EDS were adopted to observe and analyze the morphologies and element compositions of surface,cross-section and worn scar of the Mo film. The phase structure was studied by XRD and the bonding strength between Mo film and substrate was measured by scratching tester. The tribological experiments show that the Mo film possesses a good wear-resistance and an excellent anti-scuffing property. The failure mechanism of Mo film under extreme condition is flaking off.

关键词： multi-arc ion plating molybdenum film wear and scuffing

Rapid odor perception in rat olfactory bulb by microelectrode array

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第12期13卷 1015-1023页

作者： Jun ZHOU Qi DONG liu-jing zhuang Rong LI Ping WANG Biosensor National Special Lab Key Lab for Biomedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhou 310027China

Responses of 302 mitral/tufted (M/T) cells in the olfactory bulb were recorded from 42 anesthetized freely breathing rats using a 16-channel microwire electrode *** vapors of four pure chemicals,anisole,carvone,citral and isoamyl acetate were *** aligning spike trains to the initial phase of the inhalation after odor onset,the responses of M/T cells showed transient temporal features including excitatory and inhibitory *** odor-evoked patterns indicated that mammals recognize odors within a short respiration cycle after odor *** to the small amount of information received from a single cell,we pooled results from all responsive M/T cells to study the ensemble *** firing rates of the cell ensembles were computed over 100 ms bins and population vectors were *** high dimension vectors were condensed into three dimensions for visualization using principal component *** trajectories of both excitatory and inhibitory cell ensembles displayed strong dynamics during odor *** distances among cluster centers were enlarged compared to those of the resting ***,we presumed that pictures of odor information sent to higher brain regions were depicted and odor discrimination was completed within the first breathing cycle.

关键词： Rapid odor perception Mitral/tufted cell Multielectrode array Odor trajectory