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A green cross-linking method for the preparation of renewable threedimensional graphene sponges for efficient adsorption of Congo red dye

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Chinese Journal of Chemical Engineering 2024年第2期66卷 84-93页

作者： zhuang liu Bo Gao Haoyuan Han Yuling Li Haiyang Fu Donghui Wei Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China

Graphene-based materials possess significant potential for the treatment of dye wastewater due to their exceptional adsorption properties toward stubborn ***,their utilization is hindered by high preparation costs,low yields,environmental pollution during synthesis,and challenges in regenerating the *** study proposes a novel approach to address these limitations by developing nitrogen-doped three-dimensional(3D)polyvinyl alcohol(PVA)crosslinked graphene sponges(N-PGA)using a cross-linking method with ammonium *** method offers a relatively mild,environmentally friendly *** carbonate serves as both a reducing and modifying agent,facilitating the formation of the intrinsic structure of N-PGA and acting as a nitrogen ***,PVA is utilized as the cross-linking *** results demonstrate that N-PGA exhibits a favorable internal 3D hierarchical porous structure and possesses robust mechanical *** measured specific surface area(BET)of N-PGA was as high as406.538 m^(2)·g^(-1),which was favorable for its efficient adsorption of Congo red(CR)dye *** an initial concentration of 50 mg·L^(-1),N-PGA achieved an impressive removal rate of 89.6%and an adsorption capacity of 112 mg·g^(-1)for CR ***,it retained 79%of its initial adsorption capacity after 10 cycles,demonstrating excellent regeneration *** summary,the synthesized N-PGA displays remarkable efficacy in the adsorption of CR dye in wastewater,opening up new possibilities for utilizing 3D porous graphene nanomaterials as efficient adsorbents in wastewater treatment.

关键词： Green chemistry Graphene sponge Adsorbents Adsorption Congo red Regeneration

Nanoscale Precise Editing of Multiple Immune Stimulating Ligands on DNA Origami for T Cell Activation and Cell-Based Cancer Immunotherapy

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CCS Chemistry 2024年第3期6卷 719-732页

作者： Lele Sun Fengyun Shen Zijian Xiong Yu Chao Chunhai Fan zhuang liu Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Lab Carbon Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu School of Life Sciences Shanghai UniversityShanghai 200444 School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 201240

The spatial arrangement of activating ligands is known to have great influence on T cell ***,independently studying each ligand’s spatial organization parameter that affects T cell activation remains a great ***,with DNA origami,we precisely organized the CD3ɛantibodies simulating T cell receptor(TCR)ligands and CD28 antibodies simulating co-stimulatory ligands to interrogate the independent role of TCR-ligand spacing and local copy numbers as well as the spacing between TCR ligands and co-stimulatory ligands on T cell *** found that T cell activation benefited fromlocally concentrated TCR ligands with a shorter spacing and was maximized by an∼38 nm spacing between TCR ligands and co-stimulatory *** T cell expander constructed based on our findings could efficiently expand CD8+T cells for tumor ***,the DNA nanostructurebased ligands’precise arrangement can be a unique tool in studying immune cell activations and cellbased immunotherapies.

关键词： DNA origami T cell activation T cell receptor immune cancer immunotherapy

Significant effect of ordered micro-domain on cell boundary phase distribution and demagnetization curve squareness of Sm_(2)Co_(17)-type magnet

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Rare Metals 2024年第4期43卷 1724-1735页

作者： zhuang liu Hai-Chen Wu Chao-Yue Zhang Chao-Qun Zhu Guo-Xin Chen Huan-Ming Lu Ren-Jie Chen Aru Yan CISRI&NIMTE Joint Innovation Center for Rare Earth Permanent Magnets Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China Analytical Center Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China

Cu-rich cell boundary phase is difficult to precipitate evenly,resulting in a generally poor demagnetization curve squareness for Fe-rich Sm_(2)Co_(17)-type magnet,which is a key factor limiting the further improvement of magnetic energy *** this study,we report that nanoscale strip-like ordered micro-domains distributed in1:7H disordered matrix phase of the solid solution precursor is a new factor significantly affecting the precipitation and distribution of the cell boundary *** strip-like and continuous micro-twin structure with twin boundaries neatly perpendicular to the C-axis is observed after sintering *** solution treatment,sequential and long strip-like micro-twins gradually transform into disordered state along the basal plane,forming narrow disordered 1:7H(TbCu_(7)-type structure)phase between the separated strip-like ordered *** disordering transformation takes place via broken down of the long strip-like ordered micro-domains,which is accomplished by narrowing along the width direction followed by reduction of the ***,a new model revealing the effect of the ordered micro-domains on the formation of the cell boundary phase is *** boundaries enriched in Cu have already existed in the precursor with long strip-like ordered ***,the Cu-rich cell boundary phase acting as strong pinning centers cannot be precipitated homogeneously and distributed continuously after aging,resulting in a poor demagnetization curve squareness of Sm_(2)Co_(17)-type *** results indicate that significant broken down of the nanoscale ordered micro-domains in solution precursor is the key factor improving the distribution of cell boundary phase in Sm_(2)Co_(17)-type magnets.

关键词： Sm_(2)Co_(17) magnets Solution precursor Ordered micro-domains Disordering transformation Cellular structure

Typhoon-Induced Ocean Waves and Stokes Drift:A Case Study of Typhoon Mangkhut(2018)

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China Ocean Engineering 2024年第4期38卷 711-724页

作者： WU Zhi-yuan GAO Kai CHEN Jie ZHANG Hao-jian DENG Bin JIANG Chang-bo liu Yi-zhuang LYU Zhao YAN Ren School of Hydraulic and Environmental Engineering Changsha University of Science&TechnologyChangsha 410114China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210024China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China School of Civil Engineering Hunan University of TechnologyZhuzhou 412007China

Ocean waves and Stokes drift are generated by *** study investigated the characteristics of ocean waves and wave-induced Stokes drift and their effects during Typhoon Mangkhut using European Centre for MediumRange Weather Forecasts(ECMWF)ERA5 datasets and observational *** results revealed that the typhoon generated intense cyclones and huge typhoon waves with a maximum wind speed of 45 m/s,a minimum pressure of955 h Pa,and a maximum significant wave height of 12 *** Stokes drift caused by typhoon waves exceeded 0.6m/s,the Stokes depth scale exceeded 18 m,and the maximum Stokes transport reached 6 m^(2)/*** spatial distribution of 10-m wind speed,typhoon wave height,Stokes drift,Stokes depth,and Stokes transport during the typhoon was highly correlated with the typhoon *** distribution along the typhoon track showed significant zonal asymmetry,with greater intensity on the right side of the typhoon track than on the left *** findings provide important insights into the impact of typhoons on ocean waves and Stokes drift,thus improving our understanding of the interactions between typhoons and the ocean *** study also investigated the contribution of Stokes transport to the total net transport during typhoons using Ekman-Stokes Numbers as a comparative *** results indicated that the ratio of Stokes transport to the total net transport reached up to 50%within the typhoon radius,while it was approximately 30%outside the *** Stokes transport induced by typhoon waves led to divergence in the transport direction,which resulted in upwelling of the lower ocean as a compensation ***,Stokes transport played a crucial role in the vertical mixing of the ocean during *** findings suggested that Stokes transport should be paid more attention to,particularly in high latitude ocean regions,where strong winds can amplify its effects.

关键词： Stokes drift typhoon waves Ekman-Stokes transport vertical mixing Typhoon Mangkhut

Functional nanoemulsions: Controllable low-energy nanoemulsification and advanced biomedical application

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Chinese Chemical Letters 2024年第2期35卷 57-69页

作者： Maojie Zhang Qiang Cao Yuming Yuan Xiaohan Guo Dawei Pan Rui Xie Xiaojie Ju zhuang liu Wei Wang Liangyin Chu College of Engineering Sichuan Normal UniversityChengdu 610101China School of Chemical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

Nanoemulsions are widely used as advanced pharmaceutical delivery systems in biomedical field, due to their high encapsulation efficiency and good therapy *** techniques that produce nanoemulsions with controllable sizes and compositions are promising for creating advanced nanoemulsion systems for pharmaceutical *** review summarizes recent advances on low-energy emulsification techniques for producing nanoemulsions, and the use of these nanoemulsions as advanced pharmaceutical delivery systems and as templates to create drug-loaded functional particles for biomedical ***, nanoemulsification techniques that utilize elaborate interfacial physics/chemistry and micro-/nano-fluidics, featured with relatively-low energy input, to produce nanoemulsions with controllable sizes and compositions, are *** of these nanoemulsions to create nanoemulsionincorporated milli-particles, drug-loaded nanoparticles and nanoparticle-incorporated microparticles with sizes ranging from several millimeters to sub-10 nm are *** and efficient use of the nanoemulsions, functional nanoparticles and milli-/micro-particles integrated with nanoemulsions or nanoparticles for advanced pharmaceutical delivery in biomedical field are highlighted, with focus on how the interplay between their sizes and compositions achieve desired pharmaceutical-delivery ***, perspectives on further advances on the controllable production of nanoemulsions are provided.

关键词： Nanoemulsions Interfaces Drug delivery Template synthesis Nanoparticles

Self-fueling ferroptosis-inducing microreactors based on p H-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy

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National Science Review 2024年第1期11卷 74-85页

作者： Chunjie Wang Lei Zhang Zhijuan Yang Dongxu Zhao Zheng Deng Jialu Xu Yumin Wu Yu Hao Ziliang Dong Liangzhu Feng zhuang liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Center of Interventional Radiology & Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University Department of Interventional Radiology The First Afflliated Hospital of Soochow University

Lipiodol chemotherapeutic emulsions remain one of the main choices for the treatment of unresectable hepatocellular carcinoma(HCC) via transarterial chemoembolization(TACE). However, the limited stability of Lipiodol chemotherapeutic emulsions would lead to rapid drug diffusion, which would reduce the therapeutic benefit and cause systemic toxicity of administrated chemotherapeutics. Therefore, the development of enhanced Lipiodol-based formulations is of great significance to enable effective and safe TACE treatment. Herein, a stable water-in-oil Lipiodol Pickering emulsion(LPE) stabilized by pH-dissociable calcium carbonate nanoparticles and hemin is prepared and utilized for efficient encapsulation of lipoxygenase(LOX). The obtained LOX-loaded CaCO3&hemin-stabilized LPE(LHCa-LPE) showing greatly improved emulsion stability could work as a pH-responsive and self-fueling microreactor to convert polyunsaturated fatty acids(PUFAs), a main component of Lipiodol, to cytotoxic lipid radicals through the cascading catalytic reaction driven by LOX and hemin, thus inducing ferroptosis of cancer cells. As a result, such LHCa-LPE upon transcatheter embolization can effectively suppress the progression of orthotopic N1S1 HCC in rats. This study highlights a concise strategy to prepare pH-responsive and stable LPE-based self-fueling microreactors, which could serve as bifunctional embolic and ferroptosis-inducing agents to enable proof-of-concept transarterial ferro-embolization therapy of HCC.

关键词： CaCO3 nanoparticles Pickering emulsion ferroptosis lipid peroxidation transarterial ferro-embolization

Bioinspired anti-freezing 3D-printable conductive hydrogel microfibers for highly-sensitive and wide-range detection of ultralow and high strains

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Green Chemical Engineering 2024年第1期5卷 132-143页

作者： Yi-Min Yang Ting-Yuan Hu Haidong Fan Lu Shi Shi-Yuan Zhang zhuang liu Xiao-Jie Ju Rui Xie Wei Wang Liang-Yin Chu School of Chemical Engineering Sichuan UniversityChengdu610065China Department of Mechanics Sichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China

Soft strain sensors that can transduce stretch stimuli into electrical readouts are promising as sustainable wearable ***,most strain sensors cannot achieve highly-sensitive and wide-range detection of ultralow and high *** by bamboo structures,anti-freezing microfibers made of conductive poly(vinyl alcohol)hydrogel with poly(3,4-ethylenedioxythiphene)-poly(styrenesulfonate)are developed via continuous microfluidic *** microfibers provide unique bamboo-like structures with enhanced local stress to improve both their length change and resistance change upon stretching for efficient signal *** microfibers allow highlysensitive(detection limit:0.05%strain)and wide-range(0%-400%strain)detection of ultralow and high strains,as well as features of good stretchability(485%strain)and anti-freezing property(freezing temperature:-41.1°C),fast response(200 ms),and good *** experimental results,together with theoretical foundation analysis and finite element analysis,prove their enhanced length and resistance changes upon stretching for efficient signal *** integrating microfluidic spinning with 3D-printing technique,the textiles of the microfibers can be flexibly *** microfibers and their 3D-printed textiles enable highperformance monitoring of human motions including finger bending and throat vibrating during *** work provides an efficient and general strategy for developing advanced conductive hydrogel microfibers as highperformance wearable strain sensors.

关键词： Conductive hydrogel microfibers Microfluidics Sensitive detection Wide detection range Anti-freezing

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幻象与本相:法律人工智能及其他

中国法律评论 2024年第2期56卷 128-138页

作者：刘庄香港大学法律学院中国

本文将澄清我国法学界对数据法学相关学科的两个误解。第一,认为计算法学、数据法学、法律人工智能是全新学科,有着新的方法和范式。出现这样的认识可能是由于不熟悉法律实证研究,特别是定量研究的学术脉络;更本质的,是因为不熟悉统计... 详细信息

本文将澄清我国法学界对数据法学相关学科的两个误解。第一,认为计算法学、数据法学、法律人工智能是全新学科,有着新的方法和范式。出现这样的认识可能是由于不熟悉法律实证研究,特别是定量研究的学术脉络;更本质的,是因为不熟悉统计学、数据科学和计算机科学间的关系,以及近四十年来,这些学科在社会科学中的渗透和应用。第二,对法律人工智能有着幻想化、科幻化的期待,不能理解非通用人工智能(也即当前所有的人工智能)在法律中应用的作用范围及限度。本文将指出,人工智能既难以处理较复杂的法律适用问题,也难以处理无所不在的事实判断问题。在破除幻象的基础上,文章将结合实际案例,探讨数据科学和人工智能对法律研究和实践切实可能的贡献,特别是对测量和理解法律的运行效果及科学立法的作用。法学应当直面真实问题,破除狭隘的学科壁垒和门户之见,学习和发展交叉学科;必须下苦功夫了解其他学科的基本知识和原理,避免被新词汇、新概念而非新思想所牵引。

关键词：法律人工智能法律实证研究数据科学跨学科研究应用和限度

Rational design of a nonclassical liposomal nanoscale drug delivery system for innovative cancer therapy

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BMEMat(BioMedical Engineering Materials) 2024年第3期2卷 51-73页

作者： Chunjie Wang Xiaoqi Sun Liangzhu Feng zhuang liu Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhouChina Department of Pharmaceutical Sciences University of MichiganAnn ArborUSA

Advanced drug delivery systems are widely considered to be powerful approaches for treating cancer and many other diseases because of their superior ability to improve pharmacokinetics,promote lesion-targeted delivery efficacy,and/or reduce the toxic effects of diverse *** to the unique biomimetic structure of lipid bilayers surrounding aqueous cavities,liposomes have been found to encapsulate various therapeutics,ranging from small molecules with different hydrophobicities to *** the advent of surface PEGylation,stealth liposomes with excellent in vivo long-circulating behaviors have been generated,thus these liposomes have been extensively explored for the development of liposomal drugs with greatly improved in vivo pharmacokinetic behaviors by functioning as delivery *** by their successes in clinical practice,stealth liposomes have recently been utilized as the main building scaffold or surface coating layers of other nanoparticulate formulations,which are coined as nonclassical liposomal nanoscale drug delivery systems(NDDSs)in this review,to enable the rational design of nextgeneration liposomal ***,after overviewing the latest progress in the development of conventional liposome-based nanomedicine,we will introduce the development of these nonclassical liposomal NDDSs as well as their innovative cancer treatment *** will subsequently provide a critical perspective on the future development of new cancer nanomedicines based on these rationally designed nonclassical liposomal NDDSs.

关键词： cancer therapy drug delivery lipid bilayer nonclassical liposomal nanoparticles