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Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin ming Yang Xuxu Chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

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Proteomic and metabolomic analyses provide insight into the off-flavour of fruits from citrus trees infected with‘Candidatus Liberibacter asiaticus’

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Horticulture Research 2019年第1期6卷 1405-1417页

作者： lixiao Yao Qibin Yu ming Huang Weilun Hung Jude Grosser Shanchun Chen Yu Wang Frederick G.GmitterJr. Citrus Research Institute Southwest UniversityChongqingChina Citrus Research and Education Center University of FloridaLake AlfredFL 33850USA

Orange fruit from trees infected by‘Candidatus Liberibacter asiaticus’(CaLas)often do not look fully mature and exhibit off-flavours described as bitter,harsh,and metallic rather than juicy and *** previous studies have been carried out to understand the effect of CaLas on the flavour of orange juice using metabolomic methods,the mechanisms leading to the off-flavour that occurs in Huanglongbing(HLB)-symptomatic fruit are not well *** this study,fruits were collected from symptomatic and healthy Valencia sweet orange(Citrus sinensis)trees grafted on Swingle(*** X Poncirus trifoliata)*** tags for relative and absolute quantification(iTRAQ)and gas chromatography-mass spectrometry(GC-MS)were used to measure the proteins,sugars,organic acids,amino acids,and volatile *** results showed that most of the differentially expressed proteins involved in glycolysis,the tricarboxylic acid(TCA)cycle and amino-acid biosynthesis were degraded,and terpenoid metabolism was significantly downregulated in the symptomatic ***,limonene,3-carene,linalool,myrcene,andα-terpineol levels were significantly lower in fruit from CaLas-infected trees than from healthy *** phenomena were observed for sucrose and *** study indicated that off-flavour of symptomatic fruit was associated with a reduction in the levels of terpenoid products and the downregulation of proteins in glycolysis,the TCA cycle,and the terpenoid biosynthesis pathway.

关键词： orange insight absolute

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Nonlinear Modeling and Identification of Structural Joint by Response Control Vibration Test

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Transactions of Nanjing University of Aeronautics and Astronautics 2019年第6期36卷 964-976页

作者： LIU Xin WANG lixiao CHEN Qidong SUN Beibei School of Mechanical Engineering Changshu Institute of TechnologyChangshu 215500P.R.China School of Mechanical Engineering Suzhou UniversitySuzhou 215000P.R.China School of Mechanical Engineering Southeast UniversityNanjing 210096P.R.China

Components of mechanical product are assembled by structural joints,such as bolting,riveting,welding,*** joints introduce nonlinearity to some engineering structures,and the nonlinearity need to be modeled *** meet serious quality requirements,it is necessary to detect and identify nonlinearity of mechanical products for structural *** test to acquire a dynamic response has been applied for decades,which provides reliable results for finite element(FE)model *** response control vibration test for identification of nonlinearity is presented.A nonlinear system can be regarded as linearity for particular steady state response,and classical linear analysis tool is applicable to extract modal data for particular ***,its applicability is illustrated by some numerical ***,it is implemented on experimental setup with structural joints by shaking *** stiffness and damping function dependent of relative displacement are fitted to describe its inherent *** spring and damping forces are identified by harmonic balance method(HBM)to predict output *** on the identified results,the procedure is recommended that it allows a reliable measurement of nonlinearity with a certain accuracy.

关键词： nonlinear identification shaking table response control vibration test relative displacement structural joint constant response

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Design and efficient synthesis of novel haptens and complete antigens for the AOZ,a toxic metabolite of furazolidone

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Chinese Chemical Letters 2007年第12期18卷 1490-1492页

作者： Yu Dong Shen Yu Wang Shi Wei Zhang Zhi lixiao Yuan ming Sun Xian Zhang Bu Lian Quan Gu Food Quality and Safety Key Laboratory of Department of Education of Guangdong Province/Institute of Food Quality and Safety South China Agricultural University Guangzhou 510642 China School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou 510080 China

A good strategy was brought forward for designing efficient haptens and complete antigens for 3-amino-2-oxazolidinone （AOZ）. Haptens designed newly were achieved facilely in good yield by using LiCI-N（Et）3 as new catalysis system, the structure of which was elucidated by spectroscopy analysis, such as NMR and MS. Novel antigens for AOZ were prepared successfully by convenient active ester method. The ratios of haptens 3 and 4 to carrier proteins were proven respectively as 41 ： 1 （5a）, 39：1 （6a）, 11：1 （5b） and 9：1 （6b） by trinitrobenzene sulfonic acid （TNBS） method. The results of indirect competitive ELISA （ic-ELISA） of antiserums indicated that the haptens with a short unsaturated side chain can evoke specific immune response effectively.

关键词： Furazolidone AOZ Antigen Hapten Immunoassay

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Understanding land for high-quality development

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Journal of Geographical Sciences 2023年第2期33卷 217-221页

作者： JIN Gui PENG Jian ZHANG lixiao ZHANG Zhengyu School of Economics and Management China University of GeosciencesWuhan 430074China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China School of Environment Beijing Normal UniversityBeijing 100875China School of Public Administration China University of GeosciencesWuhan 430074China

Land is the basis for human survival and production,providing food,fuel,fiber,and other ecosystem services(Verburg et al.,2013;Jin et al.,2021).Land-use change is both a cause and consequence of many biophysical and socioeconomic changes(Van and Verburg,2013).Human land-use activities have a great impact on biodiversity and the ecological environment by changing the ecosystem(Newbold et al.,2015;Asamoah et al.,2017;Tilman,2017;Zheng et al.,2020).Research by Song et al.(2018)showed that 60%of all land change is related to direct human activities and 40%to indirect drivers such as climate *** research is needed to deepen the understanding of the land system mechanism and the ecological impact of land *** such as land-use dynamic changes,interactions between humans and the natural environment in the land-use process,and the sustainability of land use have aroused widespread concern in the international academic community(Verburg et al.,2015;Liu,2018;Jin et al.,2019;Peng et al.,2020).

关键词： services ecosystem ecological

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Correlation of Leaf and Root Senescence During Ripening in Dry Seeded and Transplanted Rice

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Rice science 2018年第5期25卷 279-285页

作者： LIU Hongyan WANG Weiqin HE Aibin NIE lixiao National Key Laboratory of Crop Genetic Improvement Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River Ministry of Agriculture College of Plant Science and Technology Huazhong Agricultural University Wuhan 430070 China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen 518000 China Hubei Collaborative Innovation Center for Grain Industry Yangtze University Jingzhou 434023 China

Dry seeding is a resource-saving rice establishment method. With an equivalent yield, dry seeded flooded rice （DSR） has been considered as a replacement for traditional transplanted flooded rice （TFR）. However, the differences in leaf and root senescence during grain filling between DSR and TFR were seldom identified. In this study, the root length, root tip number and leaf senescence of rice varieties Huanghuazhan and Yangliangyou 6 during ripening were compared between DSR and TFR. Results showed that top three leaves in DSR had the characteristics of relatively lower SPAD value, lower N content and premature leaf senescence. In addition, both the total root length and total root tip number of DSR were significantly lower than those of TFR. In conclusion, premature and quick leaf senescence was related with inadequate root length and root tip number during ripening, which might result from the deficiency of nitrogen supply in DSR. Techniques on improving leaf nitrogen status and delaying the leaf senescence during grain-filling in DSR should be developed in future researches.

关键词： dry seeded rice transplanted flooded rice SPAD value leaf senescence root length root tip number

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Fast and Slow Responses of the North Pacific Mode Water and Subtropical Countercurrent to Global Warming

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Journal of Ocean University of China 2013年第2期12卷 216-221页

作者： XU lixiao XIE Shang-Ping LIU Qinyu Physical Oceanography Laboratory and Key Laboratory of Ocean-Atmosphere Interaction and Climate in Universities of Shandong Ocean University of China Scripps Institution of Oceanography University of California at San DiegoLa JollaCA 92093-0230USA International Pacific Research Center and Department of Meteorology University of HawaiiHonoluluHI 96822USA

Six coupled general circulation models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) are em-ployed for examining the full evolution of the North Pacific mode water and Subtropical Countercurrent (STCC) under global warming over 400 years following the Representative Concentration Pathways (RCP) 4.5. The mode water and STCC first show a sharp weakening trend when the radiative forcing increases, but then reverse to a slow strengthening trend of smaller magnitude after the radiative forcing is stablized. As the radiative forcing increases during the 21st century, the ocean warming is surface-intensified and decreases with depth, strengthening the upper ocean's stratification and becoming unfavorable for the mode water formation. Moving southward in the subtropical gyre, the shrinking mode water decelerates the STCC to the south. After the radiative forcing is stabilized in the 2070s, the subsequent warming is greater at the subsurface than at the sea surface, destabilizing the upper ocean and becoming favorable for the mode water formation. As a result, the mode water and STCC recover gradually after the radiative forc-ing is stabilized.

关键词： mode water STCC fast and slow response CMIP5 radiative forcing

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Changes in Mixed Layer Depth and Spring Bloom in the Kuroshio Extension under Global Warming

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Advances in Atmospheric Sciences 2016年第4期33卷 452-461页

作者： Ruosi ZHANG Shang-Ping XIE lixiao XU Qinyu LIU Physical Oceanography Laboratory Qingdao Collaborative Innovation Center of Marine Science and TechnologyKey Laboratory of Ocean-Atmosphere Interaction and Climate in Universities of Shandong Ocean University of China Scripps Institution of Oceanography University of California San Diego

The mixed layer is deep in January-April in the Kuroshio Extension region. This paper investigates the response in this region of mixed layer depth （MLD） and the spring bloom initiation to global warming using the output of 15 models from CMIP5. The models indicate that in the late 21st century the mixed layer will shoal and the MLD reduction will be most pronounced in spring at about 33~N on the southern edge of the present deep-MLD region. The advection of temperature change in the upper 100 m by the mean eastward flow explains the spatial pattern of MLD shoaling in the models. Associated with the shoaling mixed layer, the onset of spring bloom inception is projected to advance due to the strengthened stratification in the warming climate.

关键词： mixed layer depth global warming temperature advection spring bloom

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Adsorption of catechol from aqueous solution by aminated hypercrosslinked polymers

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Journal of Environmental Sciences 2005年第4期17卷 584-588页

作者： SUNYue lixiao-tao XUChao CHENJin-long LIAi-min ZHANGQuan-xing StateKeyLaboratoryofPollutionControlandResourcesReuse SchooloftheEnvironmentNanjingUniversityNanjing210093China.

Adsorption of catechol from aqueous solution with the hypercrosslinked polymeric adsorbent NDA-100 and its derivatives AH-1, AH-2 and AH-3 aminated by dimethylamine, the commercial resin Amberlite XAD-4 and weakly basic anion exchanger resin D301 was compared. It was found that the aminated hypercrosslinked resins had the highest adsorption capacities among the tested polymers. The empirical Freundlich equation was successfully employed to describe the adsorption process. Specific surface area and micropore structure of the adsorbent, in company with tertiary amino groups on matrix affected the adsorption performance towards catechol. In addition, thermodynamic study was carried out to interpret the adsorption mechanism. Kinetic study testified that the tertiary amino groups on the polymer matrix could decrease the adsorption rate and increase the adsorption apparent activation energy.

关键词： hypercrosslinked polymer catechol adsorption thermodynamics kinetics

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Degradation characteristics of two Bacillus strains on the Microcystis aeruginosa

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Journal of Environmental Sciences 2005年第2期17卷 205-207页

作者： PEIHai-yan HUWen-rong QUYin-bo MURui-min lixiao-cai StateKeyLaboratoryofMicrobiology ShandongUniversityJinan250061China SchoolofEnvironmentScienceandEngineering ShandongUniversityJinan250061China

The degradation kinetics of strains P05 and P07 and the degradation effects of mixed strain on Microcystis aeruginosa were studied. The results showed that: (1) The degradation processes of strains P05 and P07 on Microcystis aeruginosa accorded with the first-order reaction model when the range of Chl-a concentration was from 0 to 1500 μg/L. (2) The initial bacterium densities had a strong influence on the degradation velocity. The greater the initial bacterium density was, the faster the degradation was. The degradation velocity constants of P05 were 0.1913, 0.2175 and 0.3092 respectively, when bacterium densities were 4.8×10 5, 4.8×10 6, 2.4×10 7 cells/ml. For strain P07, they were 0.1509, 0.1647 and 0.2708. The degradation velocity constant of strain P05 was higher than that of P07 when the bacterium density was under 4.8×10 5 cells/ml, but the constant increasing of P07 was quicker than that of P05. (3) The degradation effects of P05 and P07 strains did not antagonize. When the concentration of Chl-a was high, the degradation effects of mixed strain excelled that of any single strains. But with the decrease of the Chl-a concentration, this advantage was not clear. When the concentration was less than 180 μg/L, the degradation effects of mixed were consistent with that of strain P07.

关键词： Bacillus sp. Microcystis aeruginosa characteristic degradation kinetics velocity constant

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