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Brain Pathology in COVID-19:Clinical Manifestations and Potential Mechanisms

Neuroscience Bulletin 2024年第3期40卷 383-400页

作者： Zhixing Xu Hui Wang Siya Jiang Jiao teng Dongxu Zhou Zhong Chen Chengping Wen Zhenghao Xu First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Afliated Lin’an People’s Hospital of Hangzhou Medical College First People’s Hospital of Hangzhou Lin’an DistrictLin’anHangzhou 311300China School of Life Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province College of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Laboratory of Rheumatology and Institute of TCM Clinical Basic Medicine College of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China

Neurological manifestations of coronavirus disease 2019(COVID-19)are less noticeable than the respiratory symptoms,but they may be associated with disability and mortality in *** though Omicron caused less severe disease than Delta,the incidence of neurological manifestations is *** than 30%of patients experienced“brain fog”,delirium,stroke,and cognitive impairment,and over half of these patients presented abnormal neuroimaging *** this review,we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with those in patients with influenza *** also illustrate the structure and cellular invasion mechanisms of SARS-CoV-2 and describe the pathway for central SARS-CoV-2 *** addition,we discuss direct damage and other pathological conditions caused by SARS-CoV-2,such as an aberrant interferon response,cytokine storm,lymphopenia,and hypercoagulation,to provide treatment *** review may offer new insights into preventing or treating brain damage in COVID-19.

关键词： COVID-19 SARS-CoV-2 Brain Neurological pathology

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On Compatible Hom-Lie Triple Systems

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Journal of Mathematical Research with Applications 2024年第5期44卷 633-647页

作者： Wen teng Fengshan LONG Hui ZHANG Jiulin JIN School of Mathematics and Statistics Guizhou University of Finance and Economics School of Information Guizhou University of Finance and Economics Postdoctoral Scientific Research Station Shiji Hengtong Technology Co.Ltd School of Science Guiyang University

In this paper, we consider compatible Hom-Lie triple systems. More precisely, compatible Hom-Lie triple systems are characterized as Maurer-Cartan elements in a suitable bidifferential graded Lie algebra. We also define a cohomology theory for compatible Hom-Lie triple systems. As applications of cohomology, we study linear deformations and abelian extensions of compatible Hom-Lie triple systems.

关键词： compatible Hom-Lie triple system cohomology linear deformations abelian exten-sions

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Microstructure development of Ti scaffold by laser powder bed fusion with chemical polishing and its mechanical properties,biocompatibility

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Biosurface and Biotribology 2024年第2期10卷 52-62页

作者： Changfu Lu Jing Chen teng Ma Yuxin Chen Da Zeng Yiliang Gan Youwen Yang Double Medical Technology Inc. XiamenChina Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchangChina Key Laboratory of Construction Hydraulic Robots of Anhui Higher Education Institutes Tongling UniversityTonglingChina College of Engineering and Applied Science Nanjing UniversityNanjingChina

Titanium(Ti)dental scaffolds are widely used in dental prosthetics due to their excellent mechanical properties and ***,conventional Ti scaffolds manufactured through machining often do not fit perfectly with the bone defect *** powder bed fusion(LPBF)technology enables the personalised manufacturing of custom-made Ti scaffolds.A custom-made Ti scaffold was prepared using LPBF and its surface roughness was improved through chemical *** enhance the surface roughness,a nitric acid mixed solution with a specific composition of HF:HNO_(3):C_(3)H_(6)O_(3)=2:2:3 was *** polishing mechanism was investigated by adjusting the F/Ti ratio to control the formation and dissolution of the oxide *** a result,the surface of the Ti scaffold after polishing exhibited a smooth and flat appearance compared to the LPBF part,with a reduced surface roughness(Ra)of 1.23±0.19μ*** custom-made Ti scaffold also demonstrated favourable mechanical properties,with a bending strength of 335.18±33.62 MPa and stiffness of 2.13±0.21 ***,in vitro cell tests confirmed the excellent biocompatibility of the custom-made Ti *** authors present a feasible strategy for the further clinical application of custom-made Ti scaffolds,offering enhanced surface properties and addressing the limitations of conventional machining methods.

关键词： additive manufacturing dental material property surface roughness

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Predator-prey encounters:deciphering the robbery relationship between highwayman flies and their ant victims

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Integrative Zoology 2024年第2期19卷 253-261页

作者： Ying ZHAO Yulong YU Zhi CHEN Ying LI Huidan teng Guillaume CHOMICKI Chuntian ZHANG Gao CHEN Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations KunmingChina CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingChina College of Life Science Shenyang Normal UniversityShenyangChina School of Ecology and Environmental Science Yunnan UniversityKunmingChina University of Chinese Academy of Sciences BeijingChina Ecology and Evolutionary Biology School of BiosciencesAlfred Denny BuildingUniversity of SheffieldWestern BankSheffieldUK

Examples of predator–prey interactions in which flies rob ants are *** date,this behavior has only been recorded in the genus Bengalia Robineau-Desvoidy(Bengaliinae,Diptera,Calliphoridae).These predatory flies ambush ants,and rob them of the food or offspring that they are ***,because of the rarity of this behavior,the reasons and consequences(evolutionary advantages)are unknown,and indeed,the behavior has been sometimes considered *** this study,we employed field investigations and behavioral analyses to investigate whether the sex of the fly Bengalia varicolor,or the weight and quality of the food carried by Pheidole nodus ants influenced fly–ant interactions in their natural *** show that food weight and quality influenced the behavior of *** independent of the fly’s *** behavior by the flies was more successful when the food robbed was of high-quality and light in ***,the weight of the food robbed modulated the escape distance the flies could carry *** then may affect the food quality and weight transported by the *** is a novel example of deciphering the relationship between highwayman flies and their ant *** the widespread distribution of Bengalia flies,we suggest that such interspecific predator–prey encounters may shape the robbery interactions and the carrying behavior of further ant species in nature.

关键词： Bengalia kleptoparasitism Pheidole predatory flies robbing

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NP-MBO:A newton predictor-based momentum observer for interaction force estimation of legged robots

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Biomimetic Intelligence & Robotics 2024年第2期4卷 78-85页

作者： Zhengguo Zhu Weikai Ding Weiliang Zhu Daoling Qin teng Chen Xuewen Rong Guoteng Zhang School of Control Science and Engineering Shandong UniversityJinan 250061China

Swift perception of interaction forces is a crucial skill required for legged robots to ensure safe human-robot interaction and dynamic contact ***-based interactive force is widely applied due to its outstanding cross-platform *** this paper,we present a novel interactive force observer,which possesses superior dynamic tracking *** propose a dynamic cutoff frequency configuration method to replace the conventional fixed cutoff frequency setting in the traditional momentum-based observer(MBO).This method achieves a balance between rapid tracking and noise ***,to mitigate the phase lag introduced by the low-pass filtering,we cascaded a Newton Predictor(NP)after MBO,which features simple computation and *** precision analysis of this method has been *** conducted extensive experiments on the point-foot biped robot BRAVER to validate the performance of the proposed algorithm in both simulation and physical prototype.

关键词： Interaction force estimation Momentum-based observer Newton predictor Force control

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Effect of expansion waves on cowl shock wave and boundary layer interaction in hypersonic inlet

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Propulsion and Power Research 2024年第1期13卷 80-97页

作者： Guangwei Wu Ziao Wang teng Shi Zhibin Zhang Weiyu Jiang Fuxu Quan Juntao Chang Harbin Institute of Technology Harbin 150001China Xi’an Aerospace Propulsion Institute Xi’an 710100China Beijing Power Machinery Institute Beijing 100074China

The interaction of cowl shock wave and boundary layer has a crucial effect on the stability,operability and performance of hypersonic *** studies on inhibiting the sep-aration and managing the strength of the interaction of the shock wave and boundary layer with expansion corner have been ***,the expansion waves near the circular arc shoulder to effectively control the interaction and cowl shock arrangement is little ***,the interaction of the cowl shock wave and boundary layer under thefluence of the expansion waves is studied by inviscid and viscous numerical *** results reveal that the expansion waves have an important impact on the interaction between the cowl shock wave and boundary layer and the strength of shock wave,and that there are four types of inter-action processes with the change of the relative impingement positions of cowl shock *** expansion waves have a different influence on the shock wave and boundary layer inter-action at different incident *** the incident point of the cowl shock wave goes far downstream from the end of the circular arc shoulder,the influence of expansion waves is weakened,and the magnitude of separation zone ***,when the expansion waves are applied to the interaction of the cowl shock wave and boundary layer on the circular arc shoulder,the separation can be effectively *** particular,while the expansion waves interact with the shock wave and boundary layer in the back half of the circular arc shoulder,the separation is best *** with the upstream and downstream inci-dent points,the scale of separation area in the optimal control region is reduced by 65.3%at ***,the total pressure recovery coefﬁcientﬁrst increases and then decreases when the cowl moves from upstream to downstream,and the total pressure recovery coefﬁcient reaches the maximum value of 68.36%at the incident position of cowl shock wave d Z 8.09d0.

关键词： Boundary layer Expansion waves Cowl shock wave Separation Hypersonic inlet Circular arc shoulder Inviscid and viscous numerical simulations

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OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1- p62/SQSTM1 complex

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World Journal of Gastroenterology 2024年第15期30卷 2155-2174页

作者： Nan Wang Chao-Yang Li teng-Fei Yao Xiao-Dan Kang Hui-Shu Guo Clinical Laboratory Medicine The First Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina The Institute of Integrative Medicine Dalian Medical UniversityDalian 116044Liaoning ProvinceChina The Institute of Laboratory Medicine Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Central Laboratory The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Necroptosis has emerged as a novel molecular pathway that can be targeted by chemotherapy agents in the treatment of ***-1,which is derived from the bulbs of Ornithogalum saundersiae Baker,exerts a wide range of pharmaco-logical *** To explore whether OSW-1 can induce necroptosis in colorectal cancer(CRC)cells,thereby expanding its range of clinical *** We performed a sequence of functional experiments,including Cell Counting Kit-8 assays and flow cytometry analysis,to assess the inhibitory effect of OSW-1 on CRC *** utilized quantitative proteomics,employing tandem mass tag label-ing combined with liquid chromatography-tandem mass spectrometry,to analyze changes in protein *** bioinformatic analysis was conducted to elucidate the biological processes associated with the identified *** electron microscopy(TEM)and immunofluorescence studies were also performed to examine the effects of OSW-1 on ***,western blotting,siRNA experiments,and immunoprecipitation were employed to evaluate protein interactions within CRC *** The results revealed that OSW-1 exerted a strong inhibitory effect on CRC cells,and this effect was accompanied by a necroptosis-like morphology that was observable via ***-1 was shown to trigger necroptosis via activation of the RIPK1/RIPK3/MLKL ***,the accumulation of p62/SQSTM1 was shown to mediate OSW-1-induced necroptosis through its interaction with *** We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway,and that this effect is mediated by the RIPK1-p62/SQSTM1 complex,in CRC *** results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.

关键词： OSW-1 Necroptosis RIPK1 P62/SQSTM1 Colorectal cancer

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Effects of organic fertilizers on organic carbon accumulation in alkalized saline soil and silage maize yield

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 159-168页

作者： Lidong Ji Lei Li Rui Wang Xing Xu Fengju Zhang Guilian Mao teng Wang School of Forestry and Prataculture Ningxia UniversityYinchuan750021China School of Agriculture Ningxia UniversityYinchuan750021China School of Ecological Environment Ningxia UniversityYinchuan 750021China School of Life Sciences Ningxia UniversityYinchuan 750021China

To understand the combined effect of organic and chemical fertilizers on soil carbon emissions and carbon balance of a farmland ecosystem,this study investigated the organic fertilizer nitrogen replacing different proportions of chemical fertilizer *** results showed that,compared to F_(100),the O_(15)F_(85) treatment increased the yield and net ecosystem productivity carbon sequestration of silage maize under mild,moderate,and severe salinization levels,as well as the contents of soil organic carbon,microbial carbon,and humin carbon,while reducing plant carbon *** O_(15)F_(85) treatment did not significantly increase soil carbon emissions(CEC),but O_(30)F_(70),O_(45)F_(55) and O_(100) treatments significantly increased *** soil carbon balance analysis showed that the farmland ecosystem was a“sink”for atmospheric CO_(2) under each *** O_(15)F_(85) treatment produced an“excitation effect”to enhance the carbon sink effect of silage maize farmland under mild,moderate and severe salinization levels while maintaining stable production and *** the O_(100) treatment increased the carbon sink of farmland under different salinization levels,the yield was significantly reduced and did not represent practical production *** analysis showed that soil organic carbon components and ecosystem carbon balance were closely related to soil total salt,pH and bulk density,while soil dissolved organic carbon,humus carbon components and carbon emissions were closely related to soil moisture and ***,the purpose of improving the carbon sink of saline-alkali land can be achieved through soil salt inhibition,soil structure remodeling and water supplement and warming regulation,which provides technical and theoretical support for reducing carbon emissions,achieving carbon neutrality and alleviating global warming.

关键词： carbon balance carbon component organic carbon organic substitution saline-alkali land

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Treatment of uveitis and scleritis patients in Malaysia

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 518-527页

作者： Sieng teng Seow Iqbal Tajunisah Fei Yee Lee Pooi Wah Lott Sagili Chandrasekhara Reddy Department of Ophthalmology University Malaya Eye Research Centre(UMERC)Faculty of MedicineUniversiti MalayaKuala Lumpur 59100Malaysia Clinical Research Centre Selayang HospitalMinistry of Health MalaysiaSelangor 68100Malaysia Department of Ophthalmology Faculty of Medicine and Defence HealthNational Defence University of MalaysiaKuala Lumpur 57000Malaysia

●AIM:To determine the common causes and visual outcome after treatment among uveitis and scleritis patients.●METHODS:This is a retrospective cohort observational *** consecutive clinical records of patients with newly diagnosed uveitis and scleritis over a 4-year period,from Jan.1,2017 to Dec.31,2020,were *** was collected at the presentation and included a follow-up period of one year.●RESULTS:A total of 288 patients were recruited during the study *** uveitis was the most common anatomical diagnosis(50.0%)followed by panuveitis(25.0%),scleritis(13.5%),posterior uveitis(6.9%),and intermediate uveitis(4.5%).Viral Herpes was the most common cause of infectious cases,while Vogt-Koyanagi-Harada(VKH)disease and human leucocyte antigen(HLA)B27 spondyloarthropathy were the leading causes of identifiable non-infectious *** of patients presented with unilateral,non-granulomatous uveitis with an absence of *** locations like posterior uveitis and panuveitis,and visual acuity worse than 3/60 at presentation were the factors associated with poor visual outcomes(P<0.05).About 60%of patients had an identifiable cause for the uveitis and scleritis,with nearly equal distribution of infectious(n=85,29.5%)and noninfectious causes(n=84,29.2%).About 14.5%of patients were clinically blind at 1y of *** most common complication in our uveitis patients was glaucoma(47.5%),followed by cystoid macula oedema(18.9%)and cataract(13.9%).●CONCLUSION:Uveitis and scleritis are important causes of ocular *** are potentially blinding diseases which can have a good outcome if diagnosed and treated early.

关键词： uveitis scleritis ocular morbidity blindness aetiology

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Capacity degradation analysis and knee point prediction for lithium-ion batteries

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Green Energy and Intelligent Transportation 2024年第5期3卷 13-22页

作者： teng Wang Yuhao Zhu Wenyuan Zhao Yichang Gong Zhen Zhang Wei Gao Yunlong Shang Shandong University Jinan250061China San Diego State University San DiegoUSA

Analyzing capacity degradation characteristics and accurately predicting the knee point of capacity are crucial for the safety management of lithium-ion batteries(LIBs).However,the degradation mechanism of LIBs is complex.A key but challenging problem is how to clarify the degradation mechanism and predict the knee *** to the external characteristics such as capacity decline gradievnt and the peak value of increment capacity curve(IC curve),the capacity degradation can be divided into four stages,including initial decline stage,slow decline stage,transition stage and high-speed decline *** degradation mechanism of LIBs is compared from the longitudinal and horizontal aspects,*** them,the battery usage from the initial stage to the end of life(EOL)is longitudinal *** battery under different conditions,such as charging and discharging,different discharge rate,different cathode material degradation mechanism is horizontal ***,a method based on neural network is proposed to predict the knee *** features are used to predict the capacity and cycle of the knee point,which are the gradient of the capacity degradation curve and the difference of the IC curve with the maximum *** experimental results show that a two-dimensional surface can be obtained using only the first 100 cycles,which can provide a reference for the position of the knee point accurately prediction.

关键词： Lithium-ion batteries Multistage capacity degradation Knee point prediction Neural network

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