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The role of axon guidance molecules in the pathogenesis of epilepsy

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng liu Chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： zheng liu Changyu Zhang Zipeng Li Wanying Ma Jia liu Xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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碳族单质超导性的第一性原理研究

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原子与分子物理学报 2025年第4期42卷 87-92页

作者：韩沛辰林永熠郑磊刘其军刘正堂高娟西南交通大学物理科学与技术学院成都610031 西北工业大学凝固技术国家重点实验室西安710072

同为第四主族的元素,碳、硅、锗、锡、铅具有相似的价电子排布,但超导性却并不相同.锡和铅在常压下即可实现超导,硅和锗则需要在高压下才具有超导性,而碳的常规晶体结构在常压和高压下均尚未发现其超导性.压力在很大程度上是通过改变晶... 详细信息

同为第四主族的元素,碳、硅、锗、锡、铅具有相似的价电子排布,但超导性却并不相同.锡和铅在常压下即可实现超导,硅和锗则需要在高压下才具有超导性,而碳的常规晶体结构在常压和高压下均尚未发现其超导性.压力在很大程度上是通过改变晶体结构和原子之间的位置进而影响其超导性,本论文基于密度泛函理论的第一性原理计算,对碳、硅、锗、锡、铅五种第四主族元素的单质的晶体结构、电子结构、声子性质以及超导性质进行系统地对比分析.计算结果表明费米能级附近的电子态密度越高,金属体系实现超导所需的压力越小.在具有金属性的体系中价带靠近费米能级处带隙的存在会使电子更容易局域在费米能级附近,从而增大费米能级附近电子态的数目并提高体系的超导性.此研究为探究超导机制并提高材料的超导性提供思路.

关键词：超导性第一性原理计算碳族元素电子结构

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Fatigue-resistant sliding ferroelectricity

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Science China Materials 2024年第10期67卷 3417-3418页

作者： zheng liu School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore

The direction of spontaneous polarization in ferroelectricity can be reoriented by an external electric *** special feature of ferroelectricity is important candidates for fabricating advanced nonvolatile random-access memory[1].However,repeatedly switching polarization induces the ferroelectric device performance degenerates due to a reduction of polarization.

关键词： polarization ferroelectric field.

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An Integrated External Archive Local Disturbance Mechanism for Multi-Objective Snake Optimizer

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Chinese Journal of Electronics 2024年第4期33卷 989-996页

作者： Leifu GAO zheng liu Institute for Optimization and Decision Analytics Liaoning Technical University

It is an interesting research direction to develop new multi-objective optimization algorithms based on meta-heuristics. Both the convergence accuracy and population diversity of existing methods are not *** paper proposes an integrated external archive local disturbance mechanism for multi-objective snake optimizer(IMOSO) to overcome the above shortcomings. There are two improved strategies. The adaptive mating between subpopulations strategy introduces the special mating behavior of snakes with multiple husbands and wives into the original snake optimizer. Some positions are updated according to the dominated relationships between the newly created individuals and the original individuals. The external archive local disturbance mechanism is used to re-search partial non-inferior solutions with poor diversities. The perturbed solutions are non-dominated sorting with the generated solutions by the next iteration to update the next external archive. The main purpose of this mechanism is to make full use of the non-inferior solution information to better guide the population evolution. The comparison results of the IMOSO and 7 state-of-the-art algorithms on WFG benchmark functions show that IMOSO has better convergence and population diversity.

关键词： Accuracy Sociology Metaheuristics Diversity methods Benchmark testing Statistics Convergence

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掺杂单层MoS_(2)电子结构与光催化性质的第一性原理计算

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原子与分子物理学报 2025年第1期42卷 35-40页

作者：徐启远高朋刘正堂九江学院机械与智能制造学院九江332005 西北工业大学材料学院西安710072

为了提高MoS_(2)的光催化能力,本研究基于第一性原理平面波赝势方法,对Cr、W、Fe、Co、Ni替换单层MoS_(2)晶格中的Mo进行研究.结果表明:W的替换能为正值,Cr、Fe、Co、Ni的替换能为负值.Cr、W掺杂晶格产生畸变主要是杂质原子的共价半径... 详细信息

为了提高MoS_(2)的光催化能力,本研究基于第一性原理平面波赝势方法,对Cr、W、Fe、Co、Ni替换单层MoS_(2)晶格中的Mo进行研究.结果表明:W的替换能为正值,Cr、Fe、Co、Ni的替换能为负值.Cr、W掺杂晶格产生畸变主要是杂质原子的共价半径引起的;Fe、Co、Ni掺杂晶格产生畸变主要是掺杂原子的自旋导致的.Cr、W、Fe、Co、Ni掺杂单层MoS_(2)带隙类型没有发生改变,仍然为直接带隙,但禁带宽度变小,吸收带红移,尤其Fe、Co、Ni掺杂,导带下方有杂质能级使费米能级向高能方向移动,可以作为捕获电子陷阱,增加电子密度,减少光激发电子-空穴对的复合,有利于提升光催化能力.

关键词：掺杂单层二硫化钼光催化电子结构

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Recognition of dynamically varying PRI modulation via deep learning and recurrence plot

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Journal of Systems Engineering and Electronics 2023年第4期34卷 815-826页

作者： WANG Pengcheng liu Weisong liu zheng College of Electronic Science and Technology National University of Defense TechnologyChangsha 410000China

Recognition of pulse repetition interval(PRI)modulation is a fundamental task in the interpretation of radar ***,the existing PRI modulation recognition methods mainly focus on single-label classification of PRI *** prerequisite for the effectiveness of these methods is that the PRI sequences are perfectly divided according to different modulation types before identification,while the actual situation is that radar pulses reach the receiver continuously,and there is no completely reliable method to achieve this division in the case of non-cooperative *** on the above actual needs,this paper implements an algorithm based on the recurrence plot technique and the multi-target detection model,which does not need to divide the PRI sequence in *** with the sliding window method,it can more effectively realize the recognition of the dynamically varying PRI mo dulation.

关键词： you look only once(YOLO) pulse repetition interval(PRI)modulation recurrence plot

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Solidified structure and solute segregation in Al_2O_3/A356-La alloy composites

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Rare Metals 2006年第3期25卷 231-236页

作者： liu zheng TU Tao Faculty of Material and Chemical Engineering Jiangxi University of Science ＆ Technology Ganzhou 341000 China

Al2O3/A356-La alloy composites were fabricated by squeeze casting, and the effects of La on the solidified structure and the solute segregation during alloy solidification were studied. The results indicate that the structure of the matrix alloy becomes fine and small by the addition of La. La has been richened at the interface to help improve the wettability between the fiber and Al alloy, but there are no intermetallic compounds richening La found at the interface yet. There is no special influence of La on the Mg segregation in the matrix alloy. The distribution of Mg and La in the composites has been at the same position--near the interface.

关键词： composite solidified structure solute segregation A356-La alloy

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Refining mechanism of yttrium on primary α-Al in semi-solid Al alloy

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Acta Metallurgica Sinica(English Letters) 2010年第4期23卷 277-284页

作者： zheng liu Yongmei HU Xiaomei liu Faculty of Mechanical and Electronic Engineering Jiangxi University of Science and Technology Ganzhou 341000 China Jiangxi Nonferrous Metal Processing Engineering Research Center Ganzhou 341000 China Engineering Institute Jiangxi University of Science and Technology Ganzhou 341000 China

Semi-solid Al7Si0.3Mg alloy slurry, which is grain-refined by yttrium, is manufactured by low temperature pouring. The effects of grain-refined by yttrium on the morphology and the grain size of the primary α-Al in semi-solid Al7Si0.3Mg alloy are researched. The results indicate that semi-solid Al7Si0.3Mg alloy with particle-like and rosette-like primary α-Al can be prepared by low temperature pouring from liquid Al7Si0.3Mg alloy grain-refined by yttrium. The grain size and particle morphology of primary α-Al in Al7Si0.3Mg alloy are markedly improved by 0.5 wt pet Y. The refining mechanism of Y on the morphology and the grain size of the primary α-Al in semi-solid Al7Si0.3Mg alloy are delved.

关键词： Semi-solid Yttrium Al7Si0.3Mg alloy Refining mechanism

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A seismogram digitization and database management system

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Acta Seismologica Sinica(English Edition) 2001年第3期14卷 333-341页

作者： liu zheng-kai 1. Department of Electronic Engineering and Information Science University of Science and Technology of China 230026 Hefei China 2. Seismological Bureau of Shanghai 200063 Shanghai China 3. Institute of Geophysics China Seismological Bureau 100081 Beijing China 4. Seismological Bureau of Anhui Province 230031 Hefei China

This paper introduces a 'Seismogram Digitization and Database Management System' (SDDMS), which is developed using Delphi3, and present the key technique of automatically extracting wave data from paper seismograms. The system have various functions, such as paper seismogram digitization, database management and data analysis, etc. With this system it is possible to analyze historical paper seismograms using modern computers. Application of this system will be of help to the progress in earthquake prediction and seismological researchers.

关键词： seismogram digitization database management wave data extraction P315.63

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