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Potential quality evaluation approach for the absolute growth years’ wild and transplanted Astragali Radix based on anti-heart failure efficacy

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Chinese Journal of Natural Medicines 2020年第6期18卷 460-471页

作者： LI Ke ZHANG Rui LI Shu-Ying liu yue-tao LI Ai-Ping liu Xiao-Jie DU Guan-Hua QIN Xue-Mei Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006China College of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan 030006China Key Laboratory of Chemical Biology and Molecular Engineering Ministry Shanxi UniversityTaiyuan 030006China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

The quality of Astragali Radix(AR) was closely related to the growth period. However, the current commodity grades of AR were only divided by diameter but not directly related to the growth period, which leads to the contradiction between the grade standard and the quality evaluation index. Therefore, solving this problem will be the key for the quality evaluation of AR. The present study established a potential quality evaluation approach for the absolute growth years’ wild Astragali Radix(WAR) and transplanted Astragali Radix(TAR) based on the chemical components and anti-heart failure efficacy through adopting a bare-handed sections approach to rapidly identify the growth years of WAR. In this study, the absolute growth years of WAR were obtained by identifying the growth rings of 1–6 growth years root through the methods. The contents of flavonoids and saponins in 2–6 growth years’ WAR were determined by HPLC-UV-ELSD. The contents of 12 chemical components and the anti-fatigue failure effects of WAR(4-year-old)and TAR were compared on rat models of heart failure induced by doxorubicin. Meanwhile, NMR-based untargeted metabolomics studies were performed to investigate the regulative effects of WAR and TAR. The result shows that the numbers of growth rings were consistent with the actual growth periods of AR. The HPLC-UV-ELSD determination indicated that the content of total flavonoids in WAR was significantly higher than that in TAR. Pharmacodynamics analysis revealed that the effects of WAR on cardiac function parameters(EF, FS and LVIDs), contents of serum CK and BNP were superior to those of TAR. 13 metabolites of heart were identified that had a higher rate of change in WAR group than TAR. Overall, a rapid identification method for the growth years of WAR was established, and the fact that WAR were significantly better than TAR in the heart failure rats was first proved in the paper. This study provided a scientific basis for establishing a novel commodity sp

关键词： Astragali Radix Growth rings Chemical analysis Anti-heart failure

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： tao SUN QINGHUA SONG HUA liu Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

Escobar-Lichnerowicz-Reilly type eigenvalue estimate for the weighted p-Laplacian on manifolds with integral Ricci curvature

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Acta Mathematica Sinica,English Series 2025年

作者： Yong tao liu School of Mathematics and Statistics Ningxia University

Under the assumption of integral m-Bakry-émery Ricci curvature, we give an Escobar-LichnerowiczReilly type eigenvalue estimate for the weighted p-Laplacian on compact smooth metric measure spaces with or without boundaries. This conclusion is a generalization and improvement of Wang-Li’s result in the case of integral Bakry-émery Ricci curvature, and of Seto-Wei’s one to the compact metric measure space setting. Our main tools are the weighted p-Bochner formula and the weighted p-Reilly formula.

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基于CPLD的无刷直流电机全硬件PI控制系统设计

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组合机床与自动化加工技术 2019年第9期 55-59页

作者：杨林刘曰涛山东理工大学机械工程学院

针对传统软件控制方式运行速度慢、精度低、抗干扰能力差、成本高等问题,提出了一种以复杂可编程逻辑器件(Complex Programmable Logic Device,CPLD)为核心的无刷直流电机全硬件PI控制系统,详细分析了控制系统组成电路的工作原理,通过... 详细信息

针对传统软件控制方式运行速度慢、精度低、抗干扰能力差、成本高等问题,提出了一种以复杂可编程逻辑器件(Complex Programmable Logic Device,CPLD)为核心的无刷直流电机全硬件PI控制系统,详细分析了控制系统组成电路的工作原理,通过仿真和实验验证了各电路的可行性。同时,建立了连续的PI控制器和离散的PI控制器的模型,并运用MATLAB进行仿真测试,仿真结果表明相比于离散的PI控制器,连续的PI控制具有更高的响应速度和抗干扰能力。控制系统采用梯形换向控制的策略,配合33kHz的PWM控制,以达到理想的控制效果。最后搭建实验平台,实验结果表明控制系统具有良好的控制性能。

关键词：无刷直流电机复杂可编程逻辑器件全硬件PI控制系统梯形换向控制

Estimation of Chloride Diffusivity in Hydrated Tricalcium Silicate Using a Hydration-Diffusion Integrated Method

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 49-64页

作者： WANG Xin SHEN Dejian tao Sijie liu Ruixin WU Shengxing College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

This study aims to develop a chloride diffusion simulation method that considers the hydration microstructure and pore solution properties during the hydration of tricalcium silicate(C3S).The method combines the hydration simulation,thermodynamic calculation,and finite element analysis to examine the effects of pore solution,including effect of electrochemical potential,effect of chemical activity,and effect of mechanical interactions between ions,on the chloride effective diffusion coefficient of hydrated C3S *** results indicate that the effect of electrochemical potential on chloride diffusion becomes stronger with increasing hydration age due to the increase in the content of hydrated calcium silicate;as the hydration age increases,the effect of chemical activity on chloride diffusion weakens when the number of diffusible elements decreases;the effect of mechanical interactions between ions on chloride diffusion decreases with the increase of hydration age.

关键词： tricalcium silicate simulation method chloride diffusion coefficient pore solution

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混合原料高浓度酒精发酵工艺优化

中国酿造 2017年第8期36卷 80-84页

作者：刘燕刘钺柯涛南阳师范学院生命科学与技术学院河南南阳473000 河南天冠企业集团有限公司试验中心河南南阳473000

在单因素试验的基础上,对混合原料高浓度酒精发酵工艺进行正交试验优化,结果表明,影响高浓度酒精发酵因素的主次顺序为发酵温度>糖化酶添加量>发酵时间>接种量>摇床转速,最佳发酵条件参数为发酵温度33℃、糖化酶添加量160 U/g、发酵时间... 详细信息

在单因素试验的基础上,对混合原料高浓度酒精发酵工艺进行正交试验优化,结果表明,影响高浓度酒精发酵因素的主次顺序为发酵温度>糖化酶添加量>发酵时间>接种量>摇床转速,最佳发酵条件参数为发酵温度33℃、糖化酶添加量160 U/g、发酵时间60 h、接种量25%、摇床转速140 r/min。在此最佳工艺条件下,发酵醪酒精度可达到15.95%vol。

关键词：混合原料高浓度酒精发酵优化

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng Qing Zhao Mengjie tao Jijun Du Xingxi Huang Chengjun liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

Distributed fiber optic sensing system for vibration monitoring of 3D printed bridges

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Optoelectronics Letters 2025年第1期21卷 28-34页

作者： ZHAO Shuai ZHOU Ran LUO Mingming liu Jianfei liu Xiongfei ZHOU tao School of Electronic Information Engineering Hebei University of Technology Tianjin Key Laboratory of Electronic Materials and Devices School of Civil Engineering and Transportation Hebei University of Technology Tianjin Jinhang Institute of Technical Physics

The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities, including design, construction, and maintenance of bridges, tunnels, ports and other infrastructures. In this paper, a distributed vibration sensing system is proved to be responsive to a single touch over a 1.8-m-long equivalent fiber segment, covering a vibration frequency from 5 Hz to 25 kHz. The sensing fiber was arranged as an S type layout on the bridge to recognize the standing state, windblown disturbance, and walking vibration. Moreover, the knocking and climbing events are recognized fiber laying spinning lines and hanging on the fences, respectively. The demonstration shows an accurate positioning and sensitive vibration monitoring applied on the automated three-dimensional(3D) printed bridge, which is applicable to all kinds of 3D printed facilities as intelligent sensory neuro-networks.

关键词： Spinning (fibers)

Metabolomics approach reveals vital role of Huangqi in Huangqi Jianzhong Tang against chronic atrophic gastritis coupled with molecular docking and BAWP

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中国药理学与毒理学杂志 2019年第10期 909-909页

作者： LI Xin-qi liu yue-tao QIN Xue-mei Modern Research Center for Traditional Chinese Medicine Shanxi University College of Chemistry and Chemical Engineering Shanxi University

OBJECTIVE To explore the monarch contribution of Huangqi（HQ） to the classical prescription Huangqi Jianzhong Tang（HQJZ） in the treatment of chronic atrophic gastritis（CAG）. METHODS We used;H-NMR and LC-MS based metabolomics to analyze the serum and mitochondria metabolic profiles related to the action of HQJZ with or without HY（HQJZ knocked out HQ）. Meanwhile, bodyweight variety, pathological examination, biochemical indexes of gastric juice and mitochondria, were also used to evaluate the efficacy of HQJZ and HY. RESULTS The results showed that HQJZ was better in the regulation of the traditional pharmacology indexes than HY against CAG. Metabolomics analysis showed that the serum and mitochondria metabolic features of HQJZ and HY deviated from CAG rats. 12 and 6 involved metabolic pathways were characterized as the metabolic efficacy of HQJZ and HY by Metabo Analyst 4.0. Six out of them were deduced to involve into the monarch role of HQ in the whole formula. Three important pathways, including linoleic acid metabolism,glycolysis or gluconeogenesis, butanoate metabolism,were further screened out to be the most important pathways related to the efficacy of HQ by Systems Dock analysis and binding ability weighted polypharmacology index（BAWP）. CONCLUSION A novel method was constructed to study the mechanism of HQ in the treatment of CAG based on metabolomics coupled with molecular docking and BAWP.

关键词： chronic atrophic gastritis Huangqi Huangqi Jianzhong Tang metabonomic systemsdock