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Ent-pimarane and ent-kaurane diterpenoids from Siegesbeckia pubescens and their anti-endothelial damage effect in diabetic retinopathy

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Chinese Journal of Natural Medicines 2025年第2期23卷 234-244页

作者： Mengjia liu Tingting Luo Rongxian Li Wenying yin Fengying Yang Di Ge Na liu School of Biological Science and Technology University of Jinan

Diabetic retinopathy, a prevalent and vision-threatening microvascular complication of diabetes mellitus, is the leading cause of blindness among middle-aged and elderly *** diterpenoids isolated from Siegesbeckia pubescens demonstrate potent anti-inflammatory properties. This study aimed to identify novel bioactive diterpenoids from S. pubescens and investigate their effects on oxidative stress and inflammatory responses in diabetic retinopathy, both in vitro and in vivo. Three new ent-pimarane-type diterpenoids(1–3) and six known compounds(4–9) were isolated from the aerial parts of S. pubescens. Their structures were elucidated through spectroscopic data interpretation, and absolute configurations were determined by comparing calculated and experimental electronic circular dichroism(ECD) spectra. Among these compounds, 14β,16-epoxy-ent-3β,15α,19-trihydroxypimar-7-ene(5) exhibited the most potent protective effect against high glucose and interleukin-1β(IL-1β)-stimulated human retinal endothelial cells. Mechanistically, compound 5 promoted endothelial cell survival while ameliorating oxidative stress and inflammatory response in diabetic retinopathy, both in vivo and in vitro. These findings not only suggest that diterpenoids such as compound 5 are important anti-inflammatory constituents in S. pubescens, but also indicate that compound 5 may serve as a lead compound for preventing or treating vascular complications associated with diabetic retinopathy.

关键词： Diabetic retinopathy Inflammatory response Natural diterpenoid Oxidative stress Siegesbeckia pubescens

Contribution of fungal biomass to persistent soil carbon across natural ecosystems

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Science China Earth Sciences 2025年第2期68卷 444-456页

作者： Xiang WANG Guang-Hui YU Yakov KUZYAKOV Bo-Hao yin Andreas KAPPLER Cong-Qiang liu Bohai Coastal Critical Zone National Observation and Research Station Institute of Surface-Earth System ScienceSchool of Earth System ScienceTianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai RimTianjin UniversityTianjin 300072China Department of Soil Science of Temperate Ecosystems Department of Agricultural Soil ScienceUniversity of GöttingenGöttingen 37077Germany Agro-Technological Institute Peoples Friendship University of Russia(RUDN University)Moscow 117198Russia Geomicrobiology Center for Applied GeosciencesUniversity of TübingenTübingen 72076Germany Cluster of Excellence EXC 2124 Controlling Microbes to Fight InfectionUniversity of TübingenTübingen 72076Germany

Fungi are known to be crucial in the formation and stabilization of soil organic matter through their exudates and dead residues(necromass).Yet,it remains unclear how fungi contribute to the persistence of carbon in soils over millennial scales across ***,this study fills the knowledge gap by linking fungal carbon stocks with minerals-associated carbon stocks across major biomes.A strong correlation between fungal biomass and reactive mineral-associated carbon stocks in soils across six biomes supports the substantial role of fungi in soil carbon persistence at the global *** spatial resolution nanoscale secondary ion mass spectrometry revealed that fungi may stabilize carbon by forming organo-mineral associations through their close physical connection to reactive minerals and weathered *** propose a conceptual model that emphasizes the dualistic role of hypha-mineral interactions:(i)fungi accelerate organic matter decomposition by producing reactive oxygen species on the hypha-mineral interfaces,and(ii)fungi stabilize their residues on mineral surfaces,leading to millennial scale persistence of soil ***,fungi play a fundamental role in ecosystems that extends beyond the decomposition of persistent *** are crucial in stabilizing carbon on mineral surfaces,thereby facilitating the long-term removal of carbon from rapid biotic cycling.

关键词： Biogeography Fungi Mineral-associated organic matter(MAOM) Reactive minerals Soil carbon stability NanoSIMS

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan liu Jie Gao You yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Decoupling the roles of grain boundary strength and grain size hidden in grain-level electro-chemo-mechanical failure of solid-state electrolyte

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Journal of Energy Chemistry 2025年第2期101卷 685-691页

作者： Ming Xu Xuyang Wang Zhengqian Jin Xingxing Jiao Ya Gao Zhongxiao Song Xieyu Xu kai Xi Yangyang liu School of Chemistry Engineering Research Center of Energy Storage Materials and Devices Ministry of Education Xi'an Jiaotong University State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Research Institute of Frontier Science Southwest Jiaotong University School of Instrument Science and Technology Xi'an Jiaotong University

Garnet lithium lanthanum zirconium oxide(Li7La3Zr2O12,LLZO) is a benchmark solid-state electrolyte（SSE） material receiving considerable attention owing to its high conductivity and chemical stability against Li *** its electro-chemo-mechanical failure mechanisms have been much investigated,the equivocal roles of grain boundary strength and grain size of LLZO remain under-explored,hindering further performance *** we decoupled the effects of grain size and grain boundary strength of polycrystalline LLZO via the combination of electrochemical kinetics and the cohesive zone *** discovered that the disintegration of LLZO is initiated by the accumulation of local displacements,which strongly relates to the changes in both grain size and grain boundary ***,variations in grain boundary strength affect the diffusion and propagation pathways of damage,while the failure of LLZO is determined by the grain *** LLZO grains facilitate transgranular damage under low grain boundary strength,which can alter local chemo-mechanics within the bulk of LLZO,leading to more extensive damage *** results showcase the structure optimization pathways by preferentially controlling the growth of lithium dendrites at grain boundaries and their penetration in garnet-type SSE.

关键词： Electro-chemo-mechanics Grain boundary Growth of lithium metal Solid-state electrolyte

CeO2@MnO2 with strong Ce-Mn interaction activating PDS to promote in situ degradation of adsorbed tetracycline

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Journal of Rare Earths 2025年第03期 490-499页

作者： Jinhui Zhang Jiawei Sun Xinfeng Zhu Jingquan liu Linlin Chang Guofeng Li Rongfu Peng Junning Wang Libin Jiang kai Wang Shiqiang yin Xueping liu Chaohai Wang Henan Key Laboratory of Water Pollution Control and Rehabilitation Technology School of Municipal and Environmental EngineeringHenan University of Urban Construction National Engineering Laboratory for VOCs Pollution Control Technology and Equipment School of Light Industry&Chemical Engineering Dalian Polytechnic University

A series of CeO2@MnO2composites was prepared by deposition-precipitation *** materials were used to activate sodium persulfate（PDS） for the oxidation of *** is found that the composites,especially the CeO2@MnO2-1:4 composites,exhibit better tetracycline removal rates than the pure components.X-ray diffraction（XRD）,Raman and scanning electron microscopy（SEM） analyses all indicate that the composite has been successfully prepared with high purity and high *** XPS analysis shows that the strong interaction between the components promotes the electron ***,the kinetic rate constants of CeO2@MnO2-1:4 after 60 min are 3.8 and 12.7 times higher than pure CeO2and MnO2,***2@MnO2-1:4 composite also exhibits excellent catalytic activity for individual and hybrid *** effects of wastewater matrix,pH,circulation and ion stre ngth on the degradation of tetracycline were *** is found that CeO2@MnO2-1:4 composite has good practical application ***2@MnO2composites with synergistic adsorption catalysis can activate PDS and peroxymo no sulfate（PMS） for efficient organic catalytic *** paper provides the theoretical basis and data support for the practical application of the CeO2@MnO2composite materials.

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Pattern-based rapid and robust profiling of gut microbiota and its metabolism with a single fluorescent probe

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Science China Chemistry 2025年第2期68卷 781-788页

作者： Hongli Tan Meizi Zeng Cong Fang Xiaohua Zhu Feng liu ying Long Ruijie Deng Peng yin Meiling liu Haitao Li Youyu Zhang Shouzhuo Yao Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha 410013China College of Biomass Science and Engineering Healthy Food Evaluation Research CenterSichuan UniversityChengdu 610064China

The gut microbiota and the associated metabolism play a pivotal role in maintaining human health,yet their assessment is challenging due to their inherent diversity,variety,and ***,we developed a multichannel sensor array based on a single fluorescent probe,allowing for rapid and robust profiling gut microbiota and their key metabolites including cysteine(Cys),glutathione(GSH),and homocysteine(Hcy).The assay leverages the single fluorescent probe that is with multiple binding sites and the cross-reactive sensing principle to specifically recognize different biological *** analyzing the pattern of biological thiols,the assay is capable of rapidly identifying six gut-derived bacteria including probiotics,neutral,and pathogenic strains based on fluorescent fingerprints within 5 min,and also discriminating bacteria and their mixtures with different *** the assay that enables the simultaneous measurement of multiple gut-derived bacteria and their metabolites,the designed array achieved an accuracy of 0.99 when discriminating colorectal cancer(CRC)patient feces samples from healthy ***,the as-prepared sensor array can also be used to identify various stages of *** simplicity,rapidness,and cost-effectiveness of our approach render it a robust platform for the analysis of gut microbiota.

关键词： gut microbiota biological thiols sensor array fluorescent probe

A review on global spatial distribution,sources and toxicity of perfluoroalkyl acid and prospect in the cryosphere

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Journal of Mountain Science 2025年第1期22卷 167-183页

作者： LI Bowen Du Wentao KANG Shichang CHEN Jizu JIANG Youyan yin Lichen LU Changsheng liu Hongyi State Key Laboratory of Cryospheric Science and frozen soil engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences(CAS)Lanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Gansu Provincial Industry Technology Center of Intelligent Equipment and Big Data for Disaster Prevention Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences(CAS)Lanzhou 730000China Lanzhou Regional Climate Center Lanzhou 730000China School of Earth Sciences and Spatial Information Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730000China Zhangye Meteorological Service Zhangye 734000China

Perfluoroalkyl acid analogs(PFAAs)are a class of chemically stable environmentally persistent organic pollutants(POPs)that are difficult to degrade and have a strong capacity to accumulate in the human *** have been found to be biotoxic to humans and have been detected in various environmental media,especially in the cryosphere at trace *** cryosphere,sensitively responds to climate change,plays a crucial role in the global water,carbon and energy ***,researches on cryosphere PFAAs especially in Tibetan Plateau(TP)is ***,we summarize the physicochemical properties,physiological toxicity,spatiotemporal distribution,sources,diffusion and migration pathways,as well as analysis and removal methods of PFAAs in the cryosphere *** results show that PFAAs pollutants are mainly produced and distributed in the more economically developed countries in Europe and the United States,as well as in East Asia,and PFAAs can be transported by atmospheric circulation and water cycle to remote regions including cryosphere *** current detection methods for PFAAs in cryosphere need to be further refined for increased accuracy and *** is also a need to develop more effective removal methods that will reduce the environmental and human threats posed by these ***,we propose key scientific questions for future research in cryosphere including PFAAs redistribution influenced by cryosphere changes,human activities,and the interaction of other spheres.

关键词： Perfluoroalkyl acid Cryosphere Physiological toxicity Analytical method Removal method

Genome-wide association study reveals that enolase gene OsEE1 regulates coleoptile elongation in rice under anaerobic conditions

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Crop Journal 2025年第1期13卷 215-226页

作者： Li, Dandan liu, kai Su, Ling Li, Jinrui Guo, Yuanyuan Guo, Tao liu, Hong Rao, Dehua College of Agriculture South China Agricultural University Guangdong Guangzhou 510642 China Jiangxi Academy of Eco-Environmental Sciences and Planning/Jiangxi Key Laboratory of Environmental Pollution Control Jiangxi Nanchang 330039 China

Submergence can induce anaerobic stress on germinating seedlings in direct seeded rice paddy fields, limiting the practice of direct seeding. Longer coleoptiles improves the anaerobic tolerance of rice seedlings under submerged conditions. In a search for genes that could be beneficial for developing submergence-tolerant varieties 148 non-repetitive SNP loci were detected in on a genome-wide association study (GWAS) of coleoptile length (CL), coleoptile surface area (CSA), coleoptile volume (CV), and coleoptile diameter (CD) of 591 rice accessions subjected to 4 d of anaerobic conditions. Integration of GWAS results and gene expression data identified OsEE1, an early embryogenesis-specific enolase 1 gene associated with coleoptile length (CL) in rice grown in anaerobic conditions. Disruption of OsEE1 caused reduced CL in plants seeded under anaerobic conditions, whereas CL of OE-OsEE1 overexpression lines was significantly increased compared with the wild type. Functional analysis revealed that OsEE1 affects coleoptile length by modulating the glycolysis and tricarboxylic acid cycle pathways. Transcriptome sequencing of ko-osee1-1 knock out mutants highlighted enrichment in energy and carbohydrate metabolism, glycolysis, amino acid metabolism, and hormone signal transduction. Metabolite analysis indicated decreased levels of key metabolites in the tricarboxylic acid cycle and glycolysis pathways in ko-osee1-1 mutants compared to the wild type under anaerobic conditions. Overall, these findings shed light on the role of OsEE1 in determination coleoptile length of rice seedlings under anaerobic conditions. © 2024 Crop Science Society of China and Institute of Crop Science, CAAS

关键词： Coleoptile length Early embryogenesis-specific enolase 1 GWAS OsEE1 Rice

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冬奥会奖牌“冰雪”图像的表征与意涵

吉林艺术学院学报 2020年第4期 96-100,106页

作者：刘寅凯吉林师范大学博达学院吉林四平136099

奖牌是历届冬奥会荣耀的象征,凝聚着奥林匹克精神。总结历届冬奥会奖牌的艺术风格,从表征与意涵两个方面来探察冬奥会奖牌的艺术风格、组成元素和材质,总结出其美学价值。冬奥会奖牌不仅体现出冰雪体育运动之美,还融入了举办地的历史和... 详细信息

奖牌是历届冬奥会荣耀的象征,凝聚着奥林匹克精神。总结历届冬奥会奖牌的艺术风格,从表征与意涵两个方面来探察冬奥会奖牌的艺术风格、组成元素和材质,总结出其美学价值。冬奥会奖牌不仅体现出冰雪体育运动之美,还融入了举办地的历史和文化,宣扬了奥林匹克精神,表现出人与自然和谐相处的理念。通过对历届冬奥会奖牌"冰雪"图像的分析,为即将举行的2022年北京冬奥会提供了借鉴和思考;探索和构建独特的冰雪视觉文化体系,为我国冰雪文化产业的创新发展提供了理论依据和启发。

关键词：冬奥会奖牌冰雪图像