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缺血性脑卒中合并肺部感染患者CCL21/CXCR3信号通路表达及其诊断价值

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中华医院感染学杂志 2024年第2期34卷 186-190页

作者：李宏生刘雅林孙志敏刘鲁冀李星光邢台市人民医院神经内科河北邢台054000 石家庄市第三医院神经外科河北石家庄050000 河北医科大学第二医院神经内科河北石家庄050000 元氏县中医院神经外科河北石家庄051130

目的分析缺血性脑卒中肺部感染患者外周血趋化因子21(CCL21)/趋化因子受体3(CXCR3)信号通路表达及其诊断价值。方法选取2021年6月—2022年6月份邢台市人民医院收治的110例缺血性脑卒中患者,根据肺部感染情况分为感染组32例、未感染组78... 详细信息

目的分析缺血性脑卒中肺部感染患者外周血趋化因子21(CCL21)/趋化因子受体3(CXCR3)信号通路表达及其诊断价值。方法选取2021年6月—2022年6月份邢台市人民医院收治的110例缺血性脑卒中患者,根据肺部感染情况分为感染组32例、未感染组78例,检测患者外周血CCL21/CXCR3信号通路表达,采用Pearson相关分析CCL21/CXCR3表达与肺功能指标的相关性,受试者工作特征(ROC)曲线分析CCL21、CXCR3诊断AIS患者肺部感染的临床价值。结果两组患者吸烟史、合并糖尿病、意识障碍、GCS评分、NIHSS评分比较差异有统计学意义(P<0.05);感染组患者CCL21、CXCR3表达水平均高于未感染组(P<0.05),而肺功能指标一秒用力呼气容积(FEV1)、第一秒用力肺活量占用力肺活量的百分比(FEV1/FVC)、最大呼气峰流速(PEF)均低于未感染组(P<0.05);Pearson相关分析显示,CCL21/CXCR3表达水平与FEV1、FEV1/FVC、PEF均呈负相关性(P<0.05);ROC曲线分析显示,CCL21、CXCR3诊断AIS患者肺部感染的曲线下面积分别为0.839(95%CI:0.762~0.915)、0.849(95%CI:0.774~0.924)。结论缺血性脑卒中合并肺部感染患者CCL21/CXCR3信号通路处于高表达状态,且表达水平与肺功能状态密切关联,且诊断肺部感染的临床价值较高。

关键词：缺血性脑卒中肺部感染趋化因子21 趋化因子受体3 肺功能诊断价值

Meranzin Hydrate Improves Depression-Like Behaviors and Hypomotility via Ghrelin and Neurocircuitry

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Chinese Journal of Integrative Medicine 2023年第6期29卷 490-499页

作者： liu ya-lin XU Jian-jun HAN lin-ran liu Xiang-fei lin Mu-hai WANG Yun XIAO Zhe HUANG Yun-ke REN Ping HUANG Xi Institute of Traditional Chinese Medicine-Related Comorbid Depression Nanjing University of Chinese MedicineNanjing(210023)China School of Pharmacy Henan University of Chinese MedicineZhengzhou(450046)China Department of Outpatient Xuzhou Central HospitalXuzhouShangdong Province(221000)China Department of Obstetrics and Gynecology Women's Hospital School of MedicineZhejiang UniversityHangzhou(310006)China Department of Geriatrics Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210023)China

Objective To investigate whether meranzin hydrate(MH)can alleviate depression-like behavior and hypomotility similar to Chaihu Shugan Powder(CSP),and further explore the potential common *** Totally 120 Spraque-Dawley rats were randomly divided into 5–8 groups including sham,vehicle,fluoxetine(20 mg/kg),mosapride(10 mg/kg),CSP(30 g/kg),MH(9.18 mg/kg),[D-Lys3]-GHRP-6(Dlys,0.5 mg/kg),and MH+Dlys groups by a random number table,8 rats in each *** 32 mice were randomly divided into wild-type,MH(18 mg/kg),growth hormone secretagogue receptor-knockout(GHSR-KO),and GHSR+MH groups,8 mice in each *** forced swimming test(FST),open field test(OFT),tail suspension test(TST),gastric emptying(GE)test,and intestinal transit(IT)test were used to assess antidepressant and prokinetic(AP)effects after drug single administration for 30 min with absorbable identification in rats and mice,*** protein expression levels of brain-derived neurotrophic factor(BDNF)and phosphorylated mammalian target of rapamycin(p-mTOR)in the hippocampus of rats were evaluated by Western *** differences in functional brain changes were determined via 7.0 T functional magnetic resonance imaging-blood oxygen level-dependent(fMRI-BOLD).Results MH treatment improved depression-like behavior(FST,OFT)and hypomotility(GE,IT)in the acute forced swimming(FS)rats(all Plin antagonist[D-Lys3]-GHRP-6 inhibited the effect of MH on FST and GE(P<0.05).Similarly,MH treatment also alleviated depression-like behavior(FST,TST)in the wild-type mice,however,no effects were found in the GHSR KO ***,administration of MH significantly stimulated BDNF and p-mTOR protein expressions in the hippocampus(both P<0.01),which were also prevented by[D-Lys3]-GHRP-6(P<0.01).Besides,3 main BOLD foci following acute FS rats implicated activity in hippocampus—thalamus—basal ganglia(HTB)***[D-Lys3]-GHRP-6 synchro

关键词： Chinese medicine Gan(Liver)governing freeflow of qi comorbidity depression hypomotility ghrelin blood oxygen level-dependent

Synthesis,Crystal Structure and Anti-ischemic Activity of(E)-1-(4-(Bis(4-methoxyphenyl)methyl)piperazin-1-yl)-3-(4-acetoxy-3-methoxyphenyl)prop-2-en-1-one

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Chinese Journal of Structural Chemistry 2015年第5期34卷 681-687页

作者： ZHONG yan liu ya-lin XU Zhao-Ying XU Yi LI Ping WU Bin School of Chemistry and Chemical Engineering Southeast University School of Pharmacy Nanjing Medical University School of Basic Medical Sciences Nanjing Medical University

A new cinnamide derivative,（E）-1-（4-（bis（4-methoxyphenyl）methyl）piperazin-1-yl）-3-（4-acetoxy-3-methoxyphenyl）prop-2-en-1-one（C31H34N2O6,Mr = 530.60）,has been synthesized by the condensation of 1-（bis（4-methoxyphenyl）methyl）piperazine and（E）-3-（4-acetoxy-3-methoxyphenyl）acrylic *** compound was characterized by 1H NMR,13 C NMR,H RMS and single-crystal X-ray *** crystal belongs to the orthorhombic system,space group P212121 with a = 24.946（5）,b = 7.6380（15）,c = 14.555（3） A,V = 2773.3（10） A^3,Z = 4,Dc = 1.271 g/cm^3,F（000） = 1128,μ = 0.088 mm-1,Mo Kα radiation（λ = 0.71073 A）,the final R = 0.0641 and w R = 0.1170.A total of 3009 unique reflections were collected,of which 1760 with I 〉 2σ（I） were *** C（17）–H（17B）···O（3） and C（22）–H（22A）···O（3） interactions as well as intermolecular C（27）–H（27A）···O（3） hydrogen bonds help to stabilize the crystal *** title compound was evaluated for the anti-ischemic activity in vitro and in *** bioassay results indicated that the title compound displayed efficient activities against glutamine-induced neurotoxicity in PC12 cells and significantly prolonged the survival time of mice subjected to acute cerebral ischemia.

关键词： cinnamide crystal structure synthesis anti-ischemic activity

Advances in memristor based artificial neuron fabrication-materials,models,and applications

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International Journal of Extreme Manufacturing 2024年第1期6卷 27-50页

作者： Jingyao Bian Zhiyong liu Ye Tao Zhongqiang Wang Xiaoning Zhao ya lin Haiyang Xu Yichun liu Key Laboratory for UV Light-Emitting Materials and Technology(Northeast Normal University) Ministry of Education5268 Renmin StreetChangchunPeople’s Republic of China

Spiking neural network(SNN),widely known as the third-generation neural network,has been frequently investigated due to its excellent spatiotemporal information processing capability,high biological plausibility,and low energy consumption *** to the working mechanism of human brain,the SNN system transmits information through the spiking action of ***,artificial neurons are critical building blocks for constructing SNN in *** are drawing growing attention due to low consumption,high speed,and nonlinearity characteristics,which are recently introduced to mimic the functions of biological *** have proposed multifarious memristive materials including organic materials,inorganic materials,or even two-dimensional *** advantage of the unique electrical behavior of these materials,several neuron models are successfully implemented,such as Hodgkin–Huxley model,leaky integrate-and-fire model and integrate-and-fire *** this review,the recent reports of artificial neurons based on memristive devices are *** addition,we highlight the models and applications through combining artificial neuronal devices with sensors or other electronic ***,the future challenges and outlooks of memristor-based artificial neurons are discussed,and the development of hardware implementation of brain-like intelligence system based on SNN is also prospected.

关键词： artificial neuron memristor memristive materials neuron model micro-nano manufacturing spiking neural network

Ground state of Rydberg-dressed Bose gas confined in a toroidal trap

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Communications in Theoretical Physics 2024年第1期76卷 29-35页

作者： lin-Xue Wang Hong-Li yang Hui liu Si-lin Chen ya-Jun Wang Xiao-Fei Zhang Department of Physics School of Physics and Information ScienceShaanxi University of Science and TechnologyXi'an 710021China Department of Basic Sciences Air Force Engineering UniversityXi'an 710051China

The experimental realization of Rydberg dressing technology in ultracold atomic systems provides another superior platform for studying novel states of matter and macroscopic quantum *** this work,based on the mean-field theory,we have investigated the ground-state phases of a two-component Bose–Einstein condensate with Rydberg interaction and confined in a toroidal *** effects of the Rydberg interaction and external potential,especially the Rydberg blockade radius,on the ground-state structure of such a system have been investigated in full parameter *** results show that the Rydberg blockade radius,which can be regarded as another controllable parameter,can be used to obtain a variety of ground-state *** interestingly,it is found that for weak Rydberg interactions,the Rydberg blockade radius breaks the spontaneous rotational symmetry of the system,leading to the formation of a discrete unit cell *** strongly interacting cases,it can be used to realize different orders of discrete rotational symmetry breaking.

关键词： Bose-Einstein condensate Rydberg dressing toroidal trap

Pollution source identification methods and remediation technologies of groundwater: A review

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China Geology 2024年第1期7卷 125-137页

作者： ya-ci liu Yu-hong Fei ya-song Li Xi-lin Bao Peng-wei Zhang Fujian Provincial Key Laboratory of Water Cycling and Eco-Geological Processes Institute of Hydrogeology and Environmental GeologyChinese Academy of Geological SciencesXiamen 361000China Key Laboratory of Water and Soil Resources Conservation and Restoration in the Middle and Lower Reaches of Yellow River Basin MNRZhengzhou 450016China

Groundwater is an important source of drinking *** pollution severely endangers drinking water safety and sustainable social *** the case of groundwater pollution,the top priority is to identify pollution sources,and accurate information on pollution sources is the premise of efficient ***,an appropriate pollution remediation scheme should be developed according to information on pollution sources,site conditions,and economic *** methods for identifying pollution sources mainly include geophysical exploration,geochemistry,isotopic tracing,and numerical *** these identification methods,only the numerical modeling can recognize various information on pollution sources,while other methods can only identify a certain aspect of pollution *** remediation technologies of groundwater can be divided into in-situ and ex-situ remediation technologies according to the remediation *** in-situ remediation technologies enjoy low costs and a wide remediation range,but their remediation performance is prone to be affected by environmental conditions and cause secondary *** ex-situ remediation technologies boast high remediation efficiency,high processing capacity,and high treatment concentration but suffer high *** methods for pollution source identification and remediation technologies are applicable to different *** achieve the expected identification and remediation results,it is feasible to combine several methods and technologies according to the actual hydrogeological conditions of contaminated sites and the nature of ***,detailed knowledge about the hydrogeological conditions and stratigraphic structure of the contaminated site is the basis of all work regardless of the adopted identification methods or remediation technologies.

关键词： Groundwater pollution Identification of pollution sources Geophysical exploration identification Geochemistry identification Isotopic tracing Numerical modeling Remediation technology Hydrogeological conditions Hydrogeological survey engineering

Fixed-Time Anti-Disturbance Average-Tracking for Multi-Agent Systems Without Velocity Measurements

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Journal of Systems Science & Complexity 2024年第3期37卷 985-1002页

作者： LI Yuling liu Chenglin ZHANG ya CHEN yangyang Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Institute of AutomationJiangnan UniversityWuci 214122China School of Automation Southeast UniversityNanjing 210096China

In this paper,the authors tackle a fixed-time average-tracking problem for multi-agent systems which do not require velocity measurements and are affected by external mismatched and matched *** objective requires the considered agents with second-order dynamics to follow the average value of several time-varying reference signals,each of which is acquired by only one *** of all,the average value is estimated by using a novel distributed average estimator in a fixed ***,an original observer is created to provide estimated values in a fixed time for external mismatched and matched disturbances as well as unmeasured velocities of ***,the authors propose a novel fixed-time anti-disturbance average-tracking protocol with the aid of the observer and a sliding mode *** the end,the feasibility of theoretical analysis is illustrated by some simulation experiments.

关键词： Average-tracking control fixed-time algorithm fixed-time observer mismatched distur-bances multi-agent systems velocity measurements

Mechanism of high-energy pulsed current-assisted rolling of 08AL carbon steel ultra-thin strip

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Journal of Iron and Steel Research International 2024年第2期31卷 416-427页

作者： Zhong-kai Ren ya-nan Xu Jia-zhao Chen He Li Rui-lin Yuan Zhen-hua Wang Tao Wang Xiao liu College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Engineering Research Center of Advanced Metal Composites Forming Technology and Equipment(Ministry of Education) Taiyuan University of TechnologyTaiyuan030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an710016ShaanxiChina

To improve the plastic deformation performance of a 08AL carbon steel ultra-thin strip,a pulsed electric field was integrated into the plastic processing of the ultra-thin strip,and the effects of high-energy current on its deformation ability were ***-assisted tensile tests were employed,and the results clarified that the pulsed current could reduce the activation energy of faults and promoted dislocation slip within grains and at grain boundaries,leading to a decrease in the deformation resistance of the metal and an increase in its plastic *** the current density of 2.0 A/mm2,the yield strength,tensile strength,and elongation of the rolled sample reached 425 MPa,467 MPa,and 12.5%,*** the rolling process,it was found that the pulsed current promoted the dynamic recrystallization of the ultra-thin strip,reduced its dislocation density and deformation resistance,and promoted the coordinated deformation of the metal.

关键词： 08AL ultra-thin strip High-energy pulsed current Mechanical property Dislocation density Dynamic recrystallization

Correcting Climate Model Sea Surface Temperature Simulations with Generative Adversarial Networks:Climatology,Interannual Variability,and Extremes

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Advances in Atmospheric Sciences 2024年第7期41卷 1299-1312页

作者： ya WANG Gang HUANG Baoxiang PAN Pengfei lin Niklas BOERS Weichen TAO Yutong CHEN BO liu Haijie LI State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Earth System Modelling School of Engineering and DesignTechnical University of MunichOttobrunn 85521Germany Potsdam Institute for Climate Impact Research Potsdam 14412Germany Department of Mathematics and Global Systems Institute University of ExeterExeter EX44QEUK CMA Earth System Modeling and Prediction Centre(CEMC) Chinese Academy of Meteorological SciencesBeijing 100081China

Climate models are vital for understanding and projecting global climate change and its associated ***,these models suffer from biases that limit their accuracy in historical simulations and the trustworthiness of future *** these challenges requires addressing internal variability,hindering the direct alignment between model simulations and observations,and thwarting conventional supervised learning ***,we employ an unsupervised Cycle-consistent Generative Adversarial Network(CycleGAN),to correct daily Sea Surface Temperature(SST)simulations from the Community Earth System Model 2(CESM2).Our results reveal that the CycleGAN not only corrects climatological biases but also improves the simulation of major dynamic modes including the El Niño-Southern Oscillation(ENSO)and the Indian Ocean Dipole mode,as well as SST ***,it substantially corrects climatological SST biases,decreasing the globally averaged Root-Mean-Square Error(RMSE)by 58%.Intriguingly,the CycleGAN effectively addresses the well-known excessive westward bias in ENSO SST anomalies,a common issue in climate models that traditional methods,like quantile mapping,struggle to ***,it substantially improves the simulation of SST extremes,raising the pattern correlation coefficient(PCC)from 0.56 to 0.88 and lowering the RMSE from 0.5 to *** enhancement is attributed to better representations of interannual,intraseasonal,and synoptic scales *** study offers a novel approach to correct global SST simulations and underscores its effectiveness across different time scales and primary dynamical modes.

关键词： generative adversarial networks model bias deep learning El Niño-Southern Oscillation marine heatwaves