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Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats

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Neuroscience Bulletin 2020年第4期36卷 333-345页

作者： Pan Gu Zi-Hao Xu Yu-Ze Cao sheng-Hui liao Qian-Fang deng Xian-{3.n Yin Zhuo-Lu wang Zhuo-Hui Chen Xin-Hang Hu Hui wang li-Zhi li Shi-Xin liu Hul Ding Shu-Peng Shi Hong-Lei li Ti-Qiao xiao Bo xiao Meng-Qi Zhang Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China school of Information Science and {1. Central South UniversityChangsha 410008China State Key Laboratory of Drug Research CAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Breast Surgery Hunan Provincial Maternal and Child Health Care HospitalChangsha 410008China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201800China

Characterizing the three-dimensional (3.) morphological alterations of microvessels under both normal and seizure conditions is crucial for a better understanding of epilepsy. However, conventional imaging techniques cannot detect microvessels on micron/sub-micron scales without angiography. In this study, synchrotron radiation(SR)-based X-ray in-line phase-contrast imaging (ILPCI)and quantitative 3. characterization were used to acquire high-resolution, high-contrast images of rat brain tissue under both normal and seizure conditions. The number of blood microvessels was markedly increased on days 1.and 1., but decreased on day 60 after seizures. The surface area, diameter distribution, mean tortuosity, and number of bifurcations and network segments also showed similar trends. These pathological changes were confirmed by histological tests. Thus, SR-based ILPCI provides systematic and detailed views of cerebrovascular anatomy at the micron level without using contrast-enhancing agents. This holds considerable promise for better diagnosis and understanding of the pathogenesis and development of epilepsy.

关键词： Epilepsy Synchrotron radiation 3. Angioarchitecture Blood vessel Remodeling

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Investigation of oil and water migrations in lacustrine oil shales using 20 MHz 2D NMR relaxometry techniques

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Petroleum Science 2022年第3期19卷 1007-1018页

作者： Bo liu {1.-Wen Jiang Long-Hui Bai Rong-sheng Lu Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments Southeast UniversityNanjingJiangsu 211189China State Key Laboratory Cultivation Base for Accumulation and Development of Unconventional Oil and Gas Northeast Petroleum UniversityDaqingHeilongjiang 163318China school of Mechanical {1. Southeast UniversityNanjingJiangsu 211189China State Key Laboratory of Bioelectronics Southeast UniversityNanjingJiangsu 211189China

The behavior of oil and water in tight rocks can change the distribution of oil or water in pores,which affects the production of crude *** Magnetic Resonance(NMR)method is an effective and nondestructive tool for evaluating rocks with comparison and analysis both quantitatively and *** our study,20 MHz NMR Relaxometry is used as a key technique to study the changes of water and oil behaviors in Chinese lacustrine Qingshankou shales under different saturated states(imbibition and evaporation without pressure).The results show that variation in different proton populations(water,oil and organic)can be distinguished using 2D T_(1.-T_(2)*** comparison among T_(1.-T_(2)maps with different saturated states shows that different signal regions changed during oil and water migrations,which the 1. NMR Relaxometry may be not easy to *** with the pyrolysis analysis,T2 shift and differences of signal regions in T_(1.-T_(2)maps can reflect properties such as wettability and composition(organic matter,clay and magnetic minerals)to some *** study provides better insight into oil and water behaviors in lacustrine oil shales with further understanding of 20 MHz NMR 2D T_(1.-T_(2)maps both in qualitative and quantitative analysis.

关键词： NMR Relaxometry Lacustrine oil shales Oil and water migrations T_(1.-T_(2)map

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怀中1.地黄中2-phenylethyl-beta-glucopyranoside通过调节PI3./Akt/mTOR/HIF-1.通路对低氧性肺动脉高压的影响

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中国中药杂志 2024年第14期49卷 3857-3867页

作者：曾梦楠张宇涵郭彭莉张梓玉刘晏灵王茹铁玘美王媛媛常方卓冯卫生郑晓珂河南中医药大学药学院河南郑州450046 河南省中药开发工程技术研究中心河南郑州450046 河南中医药大学呼吸疾病中医药防治省部共建协同创新中心河南郑州450046

研究怀中1.地黄中2-phenylethyl-beta-glucopyranoside(Phe)对低氧诱导肺动脉高压小鼠的保护作用及其机制,为临床治疗肺动脉高压提供理论依据。首先将雄性C57BL/6N小鼠随机分为正常组,模型组,阳性药波生坦组(1.0 mg·kg^(-1.),Phe低、... 详细信息

研究怀中1.地黄中2-phenylethyl-beta-glucopyranoside(Phe)对低氧诱导肺动脉高压小鼠的保护作用及其机制,为临床治疗肺动脉高压提供理论依据。首先将雄性C57BL/6N小鼠随机分为正常组,模型组,阳性药波生坦组(1.0 mg·kg^(-1.),Phe低、高剂量(20、40 mg·kg^(-1.)组。除正常组外,其余各组均在1.%的低氧环境中连续造模5周,并在第3.开始灌胃给药1. d,探究各组小鼠心肺功能、右心室压力、咳喘指数、肺部损伤、细胞凋亡、氧化应激相关指标、免疫细胞及磷脂酰肌醇3.激酶(phosphatidylinositol 3.kinase,PI3.)/蛋白激酶B(protein kinase B,Akt)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)/缺氧诱导因子(hypoxic inducible facter,HIF)^(-1.α通路相关蛋白或mRNA水平。接着进一步采用缺氧诱导肺动脉平滑肌细胞(pulmonary arterial smooth muscle cell,PASMC)合并PI3.激动剂(740Y-P)对Phe干预肺动脉高压的机制进一步探究。结果显示Phe可显著提高肺动脉高压小鼠的心肺功能,降低右心室压力、咳喘指数及肺部损伤,减少细胞凋亡、氧化应激相关指标及磷酸化蛋白激酶B(phosphorylated protein kinase B,p-Akt)、磷酸化哺乳动物雷帕霉素靶蛋白(phosphorylated mammalian target of rapamycin,p-mTOR)入核水平,抑制HIF^(-1.α和PI3. mRNA与蛋白表达水平,并维持小鼠机体免疫细胞稳态。进一步的机制探究中发现,Phe显著降低缺氧诱导PASMC的细胞活力与迁移能力,减少HIF^(-1.α和PI3.蛋白表达及p-Akt、p-mTOR入核水平,且此作用可被740Y-P阻断。因此,推测Phe可通过减轻肺组织氧化应激失衡与凋亡,调节免疫水平来发挥抗肺动脉高压作用,其机制可能和调控PI3./Akt/mTOR/HIF^(-1.α通路有关。该研究以期为肺动脉高压的治疗提供药物参考及研究思路。

关键词：肺动脉高压怀中1.地黄 2-phenylethyl-beta-glucopyranoside 缺氧 PI3./Akt/mTOR/HIF-1.信号通路

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Cycling hydrogen desorption properties and microstructures of MgH_(2)-AlH_(3.-NbF_(5) hydrogen storage materials

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Rare Metals 2021年第4期40卷 1003-1007页

作者： xiao-{1. liu Hai-{3.n liu Ning Qiu Yan-Bing Zhang Guang-Yao Zhao li Xu Zhi-Qiang Lan Jin Guo Guangxi Novel Battery Materials Research Center of engineering {1. School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Processing for Non-ferrous Metallic and Featured Materials School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Guangxi Colleges and Universities Key Laboratory of Novel Energy Materials and Related technology School of Physical Science and TechnologyGuangxi UniversityNanning 530004China State Key Laboratory of Advanced Power Transmission technology Global Energy Interconnection Research Institute Co.LtdBeijing 102209China Department of AC Construction State Grid Co.LtdBeijing 100031China State Grid DC Project Construction Branch Company Beijing 100052China

Magnesium hydride(MgH_(2)) is a candidate material for hydrogen ***_(2)-AlH_(3. composite shows superior hydrogen desorption properties than pure MgH_(2).However,this composite still suffers from poor cycling *** this work,NbF_(5) was utilized to improve the cycling properties of the MgH_(2)-AlH_(3. *** hydrogen desorption studies show that NbF_(5) significantly improves the cycling stability of MgH_(2)-AlH_(3..The MgH_(2)-AlH_(3.-NbF_(5) composite can release about 2.7 wt% of hydrogen at 3.0℃ for 1.h and the hydrogen desorption capacity can maintain at 2.7 wt% for more than1.0 *** comparison,the hydrogen desorption capacity of the MgH_(2)-AlH_(3. composite is decreasing with the cycle number *** capacity is reduced from a maximum value of 3.3.wt% to about 1.0 wt% after 40 ***-Emmett-Teller(BET) surface area measurements show that the particle size of MgH_(2)-AlH_(3. composite decreases after cycling,which means pulverization of the ***_(5) can to some extent suppress the pulverization of the composite during cycling,which partially contributes to the improvement of the cycling hydrogen desorption properties of the material.

关键词： Hydrogen storage materials Magnesium hydride Aluminum hydride Niobium fluoride Cycling properties

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基于I-D-R阈值模型的滑坡气象预警

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地球科学 2024年第3期49卷 1039-1051页

作者：刘谢攀殷坤龙肖常贵陈丽霞曾韬睿李烨刘真意龚泉冰陈卫群中国地质大学工程学院湖北武汉430074 西安测绘总站陕西西安710054 浙江省地质环境监测中心浙江杭州310007 自然资源部浙江地质灾害野外科学观测研究站浙江杭州310007 中国地质大学地球物理与空间信息学院湖北武汉430074 中国地质大学地质调查研究院湖北武汉430074 磐安县自然资源和规划局浙江磐安322300

建立滑坡灾害多维度气象预警判据和划分“网格化”预警单元能够为滑坡灾害气象预警提供科学依据.本文以浙江省金华市磐安县205个降雨型滑坡为研究对象,首先,基于平均有效降雨强度-降雨历时(I-D)阈值模型,采用普通最小二乘回归(OLSQ)和... 详细信息

建立滑坡灾害多维度气象预警判据和划分“网格化”预警单元能够为滑坡灾害气象预警提供科学依据.本文以浙江省金华市磐安县205个降雨型滑坡为研究对象,首先,基于平均有效降雨强度-降雨历时(I-D)阈值模型,采用普通最小二乘回归(OLSQ)和分位数回归(QR)划分临界阈值曲线;其次,引入当日降雨量(R),进一步优化I-D阈值模型,建立I-D-R阈值模型,采用不同参数估计方法对比不同阈值模型精度,选择最优阈值模型作为磐安县滑坡灾害气象预警判据;最后,基于降雨分布的差异性,在划分地形单元的基础上利用泰森多边形(VD)建立了乡镇级别的“网格化”预警单元.结果显示:(1.I-D-R阈值模型相比于I-D阈值模型具有更好的预警精度,且基于QR的I-D-R阈值模型效果更好,警告及以上阈值等级精度提升到50%,特别注意及以上阈值等级精度提升到88.9%;(2)采用基于QR的I-D-R降雨阈值作为磐安县51.预警单元四级气象预警(红、橙、黄、蓝)的判据,并提出相应的应急响应措施.研究成果提供了一种新的阈值模型,能够为磐安县区域气象预警提供借鉴与参考.

关键词：滑坡气象预警降雨阈值最小二乘回归分位数回归 I-D-R阈值模型工程地质

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结构健康监测中的数据融合技术

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沈阳建筑大学学报（自然科学版） 2005年第1期21卷 18-22页

作者：姜绍飞王留生殷晓志刘明沈阳建筑大学土木学院辽宁沈阳110168 中国石油集团工程设计有限责任公司辽阳分公司辽宁辽阳111003 沈阳市建都工程建设监理有限公司辽宁沈阳110001

目的为了充分利用大型结构健康监测系统中来自不同时间与空间的多传感器信息资源,获得被测对象的一致性决策和估计任务,进而提高确诊率.方法从多传感器数据融合的概念、基本原理出发,探讨了数据融合技术在结构健康监测与诊断中应用的可... 详细信息

目的为了充分利用大型结构健康监测系统中来自不同时间与空间的多传感器信息资源,获得被测对象的一致性决策和估计任务,进而提高确诊率.方法从多传感器数据融合的概念、基本原理出发,探讨了数据融合技术在结构健康监测与诊断中应用的可行性,重点研究了基于人工智能的数据融合技术在结构健康监测及诊断中的应用方法.结果提出了小波概率神经网络数据融合损伤检测技术及其在结构损伤检测中的应用.结论基于多传感器数据融合的健康监测与诊断是可行的、有效的.

关键词：建筑结构健康监测多传感器数据融合算法神经网络

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Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-1. patients

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Signal Transduction and Targeted Therapy 2022年第1期7卷 228-242页

作者： Jin-Lan Zhang Yu-Huan li Lu-Lu wang Hong-Qi liu Shuai-Yao Lu Yong liu Ke li Bin liu Su-Yun li Feng-Min Shao Kun wang Ning sheng Rui li Jin-Jin Cui Pei-Chun Sun Chun-Xia Ma Bo Zhu zhe wang Yuan-Hao Wan Shi-Shan Yu Yongsheng Che Chao-Yang wang Chen wang Qiangqian Zhang li-Min Zhao xiao-Zhong Peng zhenshun Cheng Jun-Biao Chang Jian-Dong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medical Biology Chinese Academy of Medical Science and Peking Union Medical CollegeKunming 650031 YunnanChina Genuine Biotech.Inc. Pingdingshan 467000 HenanChina Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan Research Center for Infectious Diseases and CancerWuhan 430071 HubeiChina The First Affiliated Hospital of Henan {1. of Chinese Medicine Zhengzhou 450000 HenanChina Department of Internal Medicine Henan Provincial Peoples HospitalZhengzhou 450003 HenanChina Henan Key Laboratory of Organic Functional Molecule and Drug Innovation School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007 HenanChina National Clinical Research Center for Respiratory Diseases Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China school of Chemistry Zhengzhou UniversityZhengzhou 450001 HenanChina

Azvudine(FNC)is a nucleoside analog that inhibits HIV-1.RNA-dependent RNA polymerase(RdRp).Recently,we discovered FNC an agent against SARS-CoV-2,and have taken it into Phase III trial for COVID-1. *** monophosphate analog inhibited SARS-CoV-2 and HCoV-OC43.coronavirus with an EC_(50) between 1.2 and 4.3.μM,depending on viruses or cells,and selective index(SI)in 1.-83.*** administration of FNC in rats revealed a substantial thymus-homing feature,with FNC triphosphate(the active form)concentrated in the thymus and peripheral blood mononuclear cells(PBMC).Treating SARS-CoV-2 infected rhesus macaques with FNC(0.07 mg/kg, qd,orally)reduced viral load,recuperated the thymus,improved lymphocyte profiles,alleviated in flammation and orga n damage,and lessened grou nd・glass opacities in chest *** gle-cell seque ncing suggested the promotion of thymus function by FNC.A randomized,single-arm c{1.nical trial of FNC on compassionate use(n=3.0}showed that oral FNC(5 mg,qd)cured all COVID-1. patients,with 1.0%viral ribonucleic acid negative conversion in 3.29±2.22 days(range:1.9 days)and 1.0%hospital discharge rate in 9.00±4.93.days(range:2-25 days).The side-effect of FNC is minor and transient dizziness and nausea in 1..1.%(5/3.0}***,FNC might cure COVID-1. through its anti-SARS-CoV-2 activity concentrated in the thymus,followed by promoted immunity.

关键词： patients inhibited concentrated

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CHES: A Space-borne Astrometric Mission for the Detection of Habitable Planets of the Nearby Solar-type Stars

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Research in Astronomy and Astrophysics 2022年第7期22卷 32-59页

作者： Jiang-Hui Ji Hai-Tao li Jun-Bo Zhang liang Fang Dong li Su {3. Yang Cao Lei deng Bao-Quan li Hao Xian xiao-Dong Gao Ang Zhang Fei li Jia-Cheng liu Zhao-Xiang Qi sheng Jin Ya-Ning liu Guo Chen Ming-Tao li Yao Dong Zi Zhu CAS Key Laboratory of Planetary Sciences Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China school of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Key Laboratory of Electronics and Information technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing 100190China university of Chinese Academy of Sciences Beijing 100049China Institute of Optics and Electronics Chinese Academy of SciencesChengdu 610209China Key Laboratory on Adaptive Optics Chinese Academy of SciencesChengdu 610209China Key Laboratory of Science and technology on Space Optoelectronic Precision Measurement Chinese Academy of SciencesChengdu 610209China Innovation Academy for Microsatellites of Chinese Academy of Sciences Shanghai 201306China school of Astronomy and Space Science Nanjing UniversityNanjing 210046China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

The Closeby Habitable Exoplanet survey(CHES) mission is proposed to discover habitable-zone Earth-{1.ke planets of nearby solar-type stars(~1. pc away from our solar system) via microarcsecond relative *** major scientific objectives of CHES are:to search for Earth Twins or terrestrial planets in habitable zones orbi{3.1.0 FGK nearby stars;further to conduct a comprehensive survey and extensively characterize nearby planetary *** primary payload is a high-qua{1.ty,low-distortion,high-stabi{1.ty *** optical subsystem is a coaxial three-mirror anastigmat(TMA) with a 1.2 m-aperture,0°.44 × 0°.44 field of view and 500 nm-900 nm working wave *** camera focal plane is composed of a mosaic of 81.scientific CMOS detectors each with4 k × 4 k *** heterodyne laser interferometric ca{1.bration technology is employed to ensure microarcsecond level(1.μas) relative astrometry precision to meet the requirements for detection of Earth-{1.ke *** CHES satel{1.te operates at the Sun-Earth L2 point and observes all the target stars for 5 *** will offer the first direct measurements of true masses and inc{1.nations of Earth Twins and super-Earths orbi{3. our neighbor stars based on microarcsecond astrometry from *** will definitely enhance our understanding of the formation of diverse nearby planetary systems and the emergence of other worlds for solar-type stars,and finally provide insights to the evolution of our own solar system.

关键词： Astrometry and Celestial Mechanics planets and satellites:detection planets and satellites:terrestrial planets stars:solar-type

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2000—2020年岷江上游干旱河谷区植被时空变化及其地形效应

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现代地质 2024年第3期38卷 589-598页

作者：周雪妮肖成志刘磊计扬曹亚廷李小红巴仁基中国地质调查局军民融合地质调查中心四川成都610036 自然资源要素耦合过程与效应重点实验室北京100055 成都理工大学环境与土木工程学院四川成都610059 中国地质大学(武汉)地球物理与空间信息学院湖北武汉430074

针对岷江上游干旱河谷区生态极其脆弱的特点,利用NDVI数据通过像元二分法反演了岷江上游干旱河谷区2000—2020年的植被覆盖度(FVC),运用线性趋势分析和F显著性检验法,定量分析了FVC的时空变化规律,结合地形数据剖析岷江上游干旱河谷区FV... 详细信息

针对岷江上游干旱河谷区生态极其脆弱的特点,利用NDVI数据通过像元二分法反演了岷江上游干旱河谷区2000—2020年的植被覆盖度(FVC),运用线性趋势分析和F显著性检验法,定量分析了FVC的时空变化规律,结合地形数据剖析岷江上游干旱河谷区FVC趋势变化与海拔、坡度、坡向之间的关系。结果表明:(1.2000—2020年,研究区植被覆盖度呈波动增加趋势,年均FVC由2000年0.62增加至2020年的0.67。(2)在空间上,植被覆盖度由低海拔至高海拔呈现增高趋势,低等级和中低等级植被覆盖度主要分布在岷江干流及岷江支流杂谷脑河两岸,中等级和中高等级植被覆盖度集中分布在河谷两岸低中山和中山区,高等级植被覆盖度则主要分布在远离河谷的高中山和中高山区。(3.高等级植被覆盖面积随海拔增加呈先减小后增加的趋势,在1.00~1.00 m和3.00~3.00 m区域达到峰值;高等级植被覆盖度面积随坡度增加呈现先增加后减少的趋势,1.°~20°和3.°~40°是植被覆盖度高等级和中高-高等级的峰值区;总体上阳坡植被覆盖度高于阴坡。植被覆盖状况受海拔、坡度以及坡向影响较大,对岷江上游干旱河谷区生态保护应考虑地形影响,因地制宜采取措施。

关键词：植被覆盖度时空变化地形效应岷江上游干旱河谷

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Hydrothermal Synthesis,Crystal Structure and Spectroscopic Investigations of [Y(C_6NO_2H_5)_3.H_2O)_2]_n(1.5nZnCl_4)·nH_2O with Unprecedented Polycationic Chains

引用

Chemical Research in Chinese Universities 2008年第5期24卷 529-533页

作者： FANG xiao-niu CHEN Wen-tong {1. Dong-sheng school of Chemistry and Chemical {1. Jinggangshan University Ji＇an 343009 P. R. China

A new heterometallic 4f-3. complex [Y（C6NO2H5）3.H2O）2]n（1.5nZnCl4）·nH2O（1., was synthesized via a hydrothermal reaction and structurally characterized. Complex 1.crystallized in the monoclinic system with space group P21.c： a=0.94847（9） nm, b=2.0947（2） nm, c=1.6001.2） nm, β=1.4.467（2）°, V=3.0781.5） nm3. Mr=823.04, Dc=1.776 g/cm3. S=1.009, μ（Mo Kα）=3.603.mm-1. F（000）=1.3., R=0.0787, and wR=0.2273. Complex 1. with four formula units in a cell, was characteristic of a one-dimensional polycationic chain-like structure. Photoluminescent investigation showed that the title complex displayed a strong emission in the blue region, which was attributed to the intraligand π-π＊ transition of the nicotinic ligands. Optical absorption spectrum of complex 1.revealed the presence of a wide optical bandgap of 4.1. eV.

关键词： Crystal structure Yttrium Nicotinic acid Rare earth Zinc

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