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LPA_(1) antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities

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Nano Research 2024年第10期17卷 9095-9102页

作者： Jingyue Yan Diana D.Kang Chang Wang Xucheng Hou Shi Du Siyu Wang Yonger Xue Zhengwei liu Haoyuan li Yichen Zhong Binbin Deng David W.McComb Yizhou Dong Division of Pharmaceutics&Pharmacology College of PharmacyThe Ohio State UniversityColumbusOH 43210USA Icahn Genomics Institute Precision Immunology InstituteDepartment of Immunology and ImmunotherapyDepartment of Oncological SciencesTisch Cancer InstituteBiomedical Engineering and Imaging InstituteFriedman Brain InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Center for Electron Microscopy and Analysis The Ohio State UniversityColumbusOH 43212USA Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA

Activated fibroblasts are major mediators of pulmonary *** are generally found in the connective tissue but upon activation can generate excess extracellular matrix(ECM)in the lung interstitial ***,fibroblasts are one of the most targeted cells for treating idiopathic pulmonary fibrosis(IPF).Here,we develop an anti-fibrotic platform that can modulate both the lysophosphatidic acid receptor 1(LPA_(1))and the inflammatory pathway through tumor necrosis factorα-induced protein 3(TNFAIP3,also known as A20)in ***,we synthesized a series of LPA_(1) antagonists,AM095 and AM966,derived amino lipids(LA lipids)which were formulated into LA-lipid nanoparticles(LA-LNPs)encapsulating ***,LA5-LNPs,with AM966 head group and biodegradable acetal lipid tails,showed efficient A20 mRNA delivery to lung fibroblasts in vitro(80.2%±1.5%)and ex vivo(17.2%±0.4%).When treated to primary mouse lung fibroblasts(MLF),this formulation inhibited fibroblast migration and collagen production,thereby slowing the progression of ***,LA5-LNPs encapsulated with A20 mRNA is a novel platform offering a potential approach to regulate fibroblast activation for the treatment of IPF.

关键词： lysophosphatidic acid receptor 1(LPA_(1))antagonist tumor necrosis factorα-induced protein 3(A20) lung fibrosis lipid nanoparticles mRNA

Recent progress on nanomaterial-based electrochemical dissolved oxygen sensors

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Chinese Journal of Chemical Engineering 2024年第4期68卷 103-119页

作者： Shaoqi Zhang Tao liu Zhenyu Chu Wanqin Jin State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Dissolved oxygen(DO)usually refers to the amount of oxygen dissolved in *** the environment,medicine,and fermentation industries,the DO level needs to be accurate and capable of online monitoring to guide the precise control of water quality,clinical treatment,and microbial *** with other analytical methods,the electrochemical strategy is superior in its fast response,low cost,high sensitivity,and portable ***,an electrochemical DO sensor faces a trade-off between sensitivity and long-term stability,which strongly limits its practical *** solve this problem,various advanced nanomaterials have been proposed to promote detection performance owing to their excellent electrocatalysis,conductivity,and chemical ***,in this review,we focus on the recent progress of advanced nanomaterial-based electrochemical DO *** the comparison of the working principles on the main analysis techniques toward DO,the advantages of the electrochemical method are *** is placed on recently developed nanomaterials that exhibit special characteristics,including nanostructures and preparation routes,to benefit DO ***,we also introduce some interesting research on the configuration design of the electrode and device,which is rarely ***,the different requirements of the electrochemical DO sensors in different application fields are included to provide brief guidance on the selection of appropriate ***,the main challenges are evaluated to propose future development prospects and detection strategies for nanomaterial-based electrochemical sensors.

关键词： Nanomaterial Dissolved oxygen Electrochemical sensor Nanostructures Detection principles

Production of linear alkylbenzene over Ce containing Beta zeolites

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Chinese Journal of Chemical Engineering 2024年第3期67卷 220-227页

作者： Shiqi Zhang Shengzhi Gan Baoyu liu Jinxiang Dong School of Chemical Engineering and light Industry Guangdong Provincial Key Laboratory of Plant Resources BiorefineryGuangzhou Key Laboratory of Clean Transportation Energy ChemistryGuangdong University of TechnologyGuangzhou 510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Ce-encapsulated Beta zeolite was synthesized by a one-pot hydrothermal method with citric acid complexing Ce in the absence of Na *** citric acid can effectively prevent the deposition of Ce species during the hydrothermal synthesis of zeolites,leading to uniform distribution of Ce cluster in the framework of Beta ***,the sodium-free synthesis system resulted that the Brønsted acid sites were mainly located on the straight channels and external surface of Beta zeolites,improving the utilization of Brønsted acid *** addition,Ce encapsulated Beta zeolites showed enhanced activity and robust stability in the alkylation of benzene with 1-dodecene based on the synergistic effect between Ce species and Brønsted acid sites,which pave the way for its practical application in the production of alkylbenzene.

关键词： Beta zeolites Catalysis Alkylation Long-chain olefins

基于谐振效应的自激振荡脉冲超临界二氧化碳射流最优冲击靶距研究

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煤炭学报 2024年第7期49卷 3129-3142页

作者：邓玉洁刘勇魏建平沈荷莲李翔李海超河南理工大学瓦斯地质与瓦斯治理国家重点实验室培育基地河南焦作454000 煤炭安全生产与清洁高效利用省部共建协同创新中心河南焦作454000

超临界二氧化碳(SC-CO_(2))射流在钻井工程中具有广泛应用前景,并且其破煤压力阈值低、效率高,能够提高钻井效率。但因其较高的破煤门限压力和系统能耗,限制了其推广应用。自激振荡脉冲SC-CO_(2)射流的高脉冲压力和谐振效应可有效降低... 详细信息

超临界二氧化碳(SC-CO_(2))射流在钻井工程中具有广泛应用前景,并且其破煤压力阈值低、效率高,能够提高钻井效率。但因其较高的破煤门限压力和系统能耗,限制了其推广应用。自激振荡脉冲SC-CO_(2)射流的高脉冲压力和谐振效应可有效降低破煤门限压力,显著提高破煤效率。基于此,开展了自激振荡脉冲SC-CO_(2)射流脉冲频率和脉冲压力幅值对谐振破煤的综合作用研究。采用大涡模拟分析了射流流场结构,明确了流场轴向上脉冲频率和脉冲压力幅值的变化规律;通过脉冲特征测试实验研究了靶距对射流冲击频率和冲击压力的影响,并通过冲击破煤实验研究了脉冲特征对破煤的综合影响,得到了以下结论:自激振荡脉冲SC-CO_(2)射流脉冲频率和压力幅值在射流轴向处并不会保持不变,随着靶距的不断增大均呈现逐渐减小的趋势。仅考虑脉冲频率并不能将谐振效应最大化,需要综合考虑脉冲频率和压力幅值对谐振效应的影响。采用位移响应振幅表征谐振效果,能够反映频率和幅值对谐振的综合影响。靶距较小时,即0~15 mm,位移响应振幅的主要影响因素为脉冲压力幅值;靶距较大时,即15~30 mm,其主要影响因素转变为脉冲频率。减小脉冲频率并增加压力幅值能够有效提高位移响应振幅。不同喷嘴结构条件下,位移响应振幅主要影响因素的转变位置不同,同时最优靶距也并不相同。该研究中,喷嘴a的最优靶距是22 mm,此处的位移响应振幅最大,破煤效果最好,而喷嘴b的最优靶距是26 mm。

关键词：自激振荡脉冲SC-CO_(2)射流靶距脉冲频率压力幅值位移响应振幅

High-efficiency crystalline white organic lightemitting diodes

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light(Science & Applications) 2024年第4期13卷 747-759页

作者： Yijun liu Feng Zhu Yue Wang Donghang Yan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China. School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China. State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

Crystalline white organic light-emitting diodes(C-WOLEDs)are promising candidates for lighting and display *** is urgently necessary,however,to develop energy-saving and high-efficiency C-WOLEDs that have stable and powerful emission to meet commercial ***,we report a crystalline host matrix(CHM)with embedded nanoaggregates(NA)structure for developing high-performance C-WOLEDs by employing a thermally activated delayed fluorescence(TADF)material and orange phosphorescent dopants(Phos.-D).The CHM-TADFNA-D WOLED exhibit a remarkable EQE of 12.8%,which is the highest performance WOLEDs based on crystalline *** device has a quick formation of excitons and a well-designed energy transfer process,and possesses a fast ramping of luminance and current *** to recently reported high-performance WOLEDs based on amorphous material route,the C-WOLED achieves a low series-resistance Joule-heat loss ratio and an enhanced photon output,demonstrating its significant potential in developing the next-generation WOLEDs.

关键词： diodes dopant crystalline

Effect of operating conditions on the performance of riser reactor for oxidative coupling of methane Author links open overlay panel

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Particuology 2024年第8期91卷 235-248页

作者： Min Cai Shuangzhu Kong Mengxi liu Chunxi Lu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China

Oxidative coupling of methane(OCM)is characterized by high temperature and strong heat released.A riser reactor is designed for the OCM process to improve gas-solid contacting and heat *** work illustrates the effect of hydrodynamic conditions and feed gas composition on the performance of an OCM riser *** findings suggest that oxidative reactions predominantly occur within the acceleration zone and developed flow ***,at the low superficial gas velocity accompanied by a high solid circulating rate,the C_(2)yield initially increases in the acceleration zone,followed by a decrease in the developed flow zone and deceleration *** optimal operating conditions are a specific region corresponding to the solids holdup ranges from 0.015 to ***,the C_(2)yield can be elevated using an appropriate feed mixture.

关键词： Oxidative coupling of methane Riser Hydrodynamics Solids holdup

Velocity-Incorporated Wear Model of Rolling Guide Shoe Material Selection

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 118-135页

作者： Longye Chen lingyu Yan Chengliang liu Zhinan Zhang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China

To ensure an accurate selection of rolling guide shoe materials,an analysis of the intricate relationship between linear speed and wear is *** element simulations and experimental measurements are employed to evaluate four distinct types of materials:polyurethane,rubber,polytetrafluoroethylene(PTFE),and *** speed-index of each material is measured,serving as a preparation for subsequent ***,the velocity-wear factor is determined,providing insights into the resilience and durability of the material across varying ***,a wear model tailored specifically for viscoelastic bodies is explored,which is pivotal in understanding the wear mechanisms within the *** this model,wear predictions are made under higher speed conditions,facilitating the choice of material for rolling guide *** validate the accuracy of the model,the predicted degree of wear is compared with experimental data,ensuring its alignment with both theoretical principles and real-world *** comprehensive analysis has verified the effectiveness of the model in the selection of materials under high-speed conditions,thereby offering confidence in its reliability and ensuring optimal performance.

关键词： Archard model Wear model Speed-index Wear prediction

Research progress and prospect of low-carbon biological technology for nitrate removal in wastewater treatment

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 1-21页

作者： Ru Zheng Kuo Zhang lingrui Kong Sitong liu College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China Key Laboratory of Water and Sediment Sciences Ministry of Education of ChinaBeijing 100871China Eco-Environment and Resource Efficiency Research Laboratory School of Environment and EnergyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Wastewater treatment plants are the major energy consumers and significant sources of greenhouse gas emissions,among which biological nitrogen removal of wastewater is an important contributor to carbon ***,traditional heterotrophic denitrification still has the problems of excessive residual sludge and the requirement of external carbon ***,the development of innovative low-carbon nitrate removal technologies is *** review outlines the key roles of sulfur autotrophic denitrification and hydrogen autotrophic denitrification in low-carbon wastewater *** discovered nitrate/nitrite dependent anaerobic methane oxidation enables sustainable methane emission reduction and nitrogen removal by utilizing available methane in *** microorganisms exhibited a promising potential to achieve carbon-negative nitrate ***,the algal-bacterial symbiosis system and photogranules offer effective and prospective low-carbon options for nitrogen ***,the emerging nitrate removal technology of photoelectrotrophic denitrification and the underlying,photoelectron transfer mechanisms are ***,we summarize and prospect these technologies,highlighting that solar-driven biological nitrogen removal technology is a promising area for future sustainable wastewater *** review has important guiding significance for the design of low-carbon wastewater treatment systems.

关键词： Carbon emissions Low-carbon Biological nitrogen removal Denitrification

Calculation and Analysis of TVMS Considering Profile Shifts and Surface Wear Evolution Process of Spur Gear

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 136-150页

作者： Wenzheng liu Rupeng Zhu Wenguang Zhou Jingjing Wang College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjingChina

Profile shift is a highly effective technique for optimizing the performance of spur gear transmission ***,tooth surface wear is inevitable during gear meshing due to inadequate lubrication and long-term *** profile shift and tooth surface wear(TSW)can impact the meshing characteristics by altering the involute tooth *** this study,a tooth stiffness model of spur gears that incorporates profile shift,TSW,tooth deformation,tooth contact deformation,fillet-foundation deformation,and gear body structure coupling is *** model efficiently and accurately determines the time-varying mesh stiffness(TVMS).Additionally,an improved wear depth prediction method for spur gears is developed,which takes into consideration the mutually prime teeth numbers and more accurately reflects actual gear meshing *** show that consideration of the mutual prime of teeth numbers will have a certain impact on the TSW ***,the finite element method(FEM)is employed to accurately verify the values of TVMS and load sharing ratio(LSR)of profile-shifted gears and worn *** study quantitatively analyzes the effect of profile shift on the surface wear process,which suggests that gear profile shift can partially alleviate the negative effects of *** contribution of this study provides valuable insights into the design and maintenance of spur gear systems.

关键词： Profile shift Tooth surface wear Structure coupling effect Improved wear depth prediction method TVMS