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Evoking immune system to potentiate nanocatalytic therapy through activation of cGAS-STING pathway

Science China Chemistry 2024年第10期67卷 3310-3319页

作者： Yi Wei yuan Liang Pengye Du shuyu liu Pengpeng Lei Xiuling liu Hongjie Zhang School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry Tsinghua UniversityBeijing 100084China Research Institute of Changchun University of Science and Technology in Chongqing Chongqing 401120China

Nanocatalytic therapy shows great potential for therapeutic ***,therapeutic efficiency is often limited by unsatisfactory enzyme activity and lack of the coordination of immune ***,engineering nanozymes activity enhancement while activating immune system will be an effective strategy to achieve efficient tumor ***,we synthesize a DSPE-PEG-FA modified manganese dioxide-based dual-atom nanozyme(MDF),on which iridium and platinum atoms are *** obtained MDF can simultaneously mimic four enzyme activities of catalase,oxidase,peroxidase,and glutathione oxidase,set off a reactive oxygen species(ROS)storm,cause tumor cell *** enzyme activity of MDF can be enhanced by its own photothermal ***,MDF can consume intracellular glutathione and release Mn^(2+),which can prevent generated ROS from consumption and further activate cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes(cGAS-STING)pathway and promote the secretion of type I interferon,which will help promote dendritic cells maturation,present antigens to T lymphocytes to help kill tumor ***,MDF shows excellent tumor suppressive *** work provides a new paradigm for the field of nanozymes and offers a new reference for involvement of cGAS-STING pathway activation in tumor catalytic therapy.

关键词： single-atom ROS immune activation cGAS-STING pathway nanocatalytic therapy

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Current trends and hotspots of depressive disorders with colorectal cancer:A bibliometric and visual study

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3687-3704页

作者： Zi-Wei Yan Ying-Nan liu Qian Xu yuan yuan Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Laboratory of GI Cancer Etiology and Prevention in Liaoning Province The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Depression is strongly associated with colorectal cancer(CRC).Few bibliometric analyses have systematically summarized the research focus and recent progress in this *** To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and *** Articles on depression in CRC patients were collected from the Web of Science Core *** and VOSviewer software were used to visualize bibliometric *** From 2001 to 2022,Supportive Care in Cancer,the United States,Tilburg University,and Mols were the most productive and influential journal,country,institution,and author ***-occurrence cluster analysis of keywords placed quality of life,anxiety,and psychological stress in the center of the visual network *** clustering was performed for the clusters with studies of the relevant mechanism of action,which showed that:(1)Cytokines have a role essential for the occurrence and development of depressive disorders in CRC;(2)MicroRNAs have a role essential for the development of depressive disorders in CRC;(3)Some anticancer drugs have pro-depressant activity;and(4)Selective serotonin reuptake inhibitors have both antitumor and antidepressant *** Life quality and psychological nursing of the cancer population were key *** roles of cytokines and microRNAs,the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.

关键词： Depression Colorectal cancer Bibliometric analysis Cytokines Drugs Mechanism

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Cross-diffusion induced Turing instability of Hopf bifurcating periodic solutions in the reaction-diffusion enzyme reaction model

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International Journal of Biomathematics 2024年第4期17卷 133-150页

作者： Haicheng liu Wenshuo yuan Bin Ge Jihong Shen College of Mathematical Sciences Harbin Engineering University Harbin 150001 HeilongjiangP.R.China

Aiming at the spatial pattern phenomenon in biochemical reactions,an enzyme-reaction Sporns-Seelig model with cross-diffusion is chosen as study *** the central manifold theory,normal form method,local Hopf bifurcation theorem and perturbation theory,we study Turing instability of the spatially homogeneous Hopf bifurcation periodic *** last,the theoretical results are verified by numerical simulations.

关键词： Sporns-Seelig model diffusion Hopf bifurcation periodic solutions Turing instability

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Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

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Virologica Sinica 2024年第2期39卷 309-318页

作者： Jian-Bo Cao shu-Tong Zhu Xiao-Shan Huang Xing-yuan Wang Meng-Li Wu Xin Li Feng-Liang liu Ling Chen Yong-Tang Zheng Jian-Hua Wang Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China School of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026China Key Laboratory of Bioactive Peptides of Yunnan Province Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of SciencesKIZCUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 101408China

SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of *** research,along with others',has demonstrated that mast cells(MCs)play a vital role in the initiation of hyper-inflammation caused by *** previous study,we observed that SARS-CoV-2 infection induced the accumulation of MCs in the peri-bronchus and bronchioalveolar-duct junction in humanized ***,we found that MC degranulation triggered by the spike protein resulted in inflammation in alveolar epithelial cells and capillary endothelial cells,leading to subsequent lung *** trachea and bronchus are the routes for SARS-CoV-2 transmission after virus inhalation,and inflammation in these regions could promote viral *** are widely distributed throughout the respiratory ***,in this study,we investigated the role of MCs and their degranulation in the development of inflammation in tracheal-bronchial *** analyses showed the accumulation and degranulation of MCs in the peri-trachea of humanized mice infected with *** degranulation caused lesions in trachea,and the formation of papillary hyperplasia was *** transcriptome analysis in bronchial epithelial cells,we found that MC degranulation significantly altered multiple cellular signaling,particularly,leading to upregulated immune responses and *** administration of ebastine or loratadine effectively suppressed the induction of inflammatory factors in bronchial epithelial cells and alleviated tracheal injury in *** together,our findings confirm the essential role of MC degranulation in SARS-CoV-2-induced hyper-inflammation and the subsequent tissue ***,our results support the use of ebastine or loratadine to inhibit SARS-CoV-2-triggered degranulation,thereby preventing tissue damage caused by hyper-inflammation.

关键词： SARS-CoV-2 Mast cell(MC) Bronchial epithelial cell Inflammation Tracheal injury

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Robust zero-watermarking algorithm based on discrete wavelet transform and daisy descriptors for encrypted medical image

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 40-53页

作者： Yiyi yuan Jingbing Li Jing liu Uzair Aslam Bhatti Zilong liu Yen-wei Chen School of Information and Communication Engineering Hainan UniversityHaikouChina Research Center for Healthcare Data Science Zhejiang LabHangzhouChina Graduate School of Information Science and Engineering Ritsumeikan University ShigaJapan

In the intricate network environment,the secure transmission of medical images faces challenges such as information leakage and malicious tampering,significantly impacting the accuracy of disease diagnoses by medical *** address this problem,the authors propose a robust feature watermarking algorithm for encrypted medical images based on multi-stage discrete wavelet transform(DWT),Daisy descriptor,and discrete cosine transform(DCT).The algorithm initially encrypts the original medical image through DWT-DCT and Logistic ***,a 3-stage DWT transformation is applied to the encrypted medical image,with the centre point of the LL3 sub-band within its low-frequency component serving as the sampling *** Daisy descriptor matrix for this point is then ***,a DCT transformation is performed on the Daisy descriptor matrix,and the low-frequency portion is processed using the perceptual hashing algorithm to generate a 32-bit binary feature vector for the medical *** scheme utilises cryptographic knowledge and zero-watermarking technique to embed watermarks without modifying medical images and can extract the watermark from test images without the original image,which meets the basic re-quirements of medical image *** embedding and extraction of water-marks are accomplished in a mere 0.160 and 0.411s,respectively,with minimal computational *** results demonstrate the robustness of the algorithm against both conventional attacks and geometric attacks,with a notable performance in resisting rotation attacks.

关键词： daisy descriptor DCT DWT encryption domain medical image zero-watermarking

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Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy

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World Journal of Gastroenterology 2024年第3期30卷 225-237页

作者： Xin-Yang yuan Yu-Sen Chen Zhou liu Department of Neurology Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Institute of Neurology Guangdong Key Laboratory of Age-Related Cardiac and Cerebral DiseasesZhanjiang 524000Guangdong ProvinceChina

This comprehensive review elucidates the complex interplay between gut microbiota and constipation in Parkinson’s disease(PD),a prevalent non-motor symptom contributing significantly to patients’morbidity.A marked alteration in the gut microbiota,predominantly an increase in the abundance of Proteobacteria and Bacteroidetes,is observed in PD-related *** treatments,although safe,have failed to effectively alleviate symptoms,thereby necessitating the development of novel therapeutic *** interventions such as prebiotics,probiotics,and fecal microbiota transplantation(FMT)hold therapeutic *** prebiotics improve bowel movements,probiotics are effective in enhancing stool consistency and alleviating abdominal *** shows potential for significantly alleviating constipation symptoms by restoring gut microbiota balance in patients with *** promising developments,the causal relationship between changes in gut microbiota and PD-related constipation remains elusive,highlighting the need for further research in this expanding field.

关键词： Parkinson disease Constipation Gut microbiota Prebiotics Probiotics Fecal microbiota transplantation

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Predicting microbial extracellular electron transfer activity in paddy soils with soil physicochemical properties using machine learning

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Science China(Technological Sciences) 2024年第1期67卷 259-270页

作者： OU JiaJun LUO XiaoShan liu JunYang HUANG LinYan ZHOU LiHua yuan Yong School of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangzhou Key Laboratory Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China

Soil extracellular electron transfer(EET)is a pivotal biological process within the realm of ***,EET suffers from a lack of predictive ***,an intricately crafted machine learning model has been developed for the purpose of predicting soil EET by using the physicochemical properties of soil as independent input variables and the EET capabilities in terms of current density(j_(max))and Coulombic charge(C_(out))as dependent output *** autoencoder ensemble stacking(AES)model was developed to address the aforementioned issue by integrating support vector machine,multilayer perceptron,extreme gradient boosting,and light gradient boosting machine algorithms as the stacking *** 10-fold crossvalidation,the AES model exhibited notable improvements in predicting j_(max)and C_(out),with average test R^(2)values of 0.83 and 0.84,respectively,surpassing those of single machine learning(ML)models and the basic ensemble *** utilizing partial correlation plots(PDPs),Shapley Additive explanations(SHAP)values,and SHAP decision plots,we quantitatively explained the impact and contribution of the input molecules on the AES model’s predictions of j_(max)and C_(out).In the context of the SHAP method for the AES model,total carbon(TC)was identified as the most correlated descriptor for j_(max),while total organic carbon(TOC)stood out as the most relevant descriptor for C_(out).In the prediction tasks of j_(max)and C_(out)within the AES model,employing a multitask ML approach allowed the model to benefit from the shared information of input variables,thereby enhancing its overall *** study provides a feasible tool for the prediction of soil EET from soil physiochemical properties and an advanced understanding of the relationship between soil physiochemical properties and EET capability.

关键词： extracellular electron transfer paddy soil machine learning prediction autoencoder ensemble stacking model

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Multidomain Hybrid Direct DG and Central Difference Methods for Viscous Terms in Hyperbolic-Parabolic Equations

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NUMERICAL MATHEMATICS-THEORY METHODS AND APPLICATIONS 2024年第1期17卷 1-36页

作者： yuan, Weixiong liu, Tiegang Zhang, Bin Cao, Kui Wang, Kun Beihang Univ LMIB Beijing 100191 Peoples R China Beihang Univ Sch Math Sci Beijing 100191 Peoples R China

A class of multidomain hybrid methods of direct discontinuous Galerkin (DDG) methods and central difference (CD) schemes for the viscous terms is proposed in this paper. Both conservative and nonconservative coupling modes are discussed. To treat the shock wave, the nonconservative coupling mode automatically switch to conservative coupling mode to preserve the conservative property when discontinuities pass through the artificial interface. To maintain the accuracy of the hybrid methods, the Lagrange interpolation polynomials and their derivatives are reconstructed to handle the coupling cells in the DDG subdomain, while the values of ghost points for the CD subdomain are calculated by the approximate polynomials from the DDG methods. The linear stabilities of these methods are demonstrated in detail through von-Neumann analysis. The multidomain hybrid DDG and CD methods are then extended to one- and two-dimensional hyperbolic-parabolic equations. Numerical results validate that the multidomain hybrid methods are high-order accurate in the smooth regions, robust for viscous shock simulations and capable to save computational cost.

关键词： Direct discontinuous Galerkin central difference schemes multidomain hybrid methods viscous terms hyperbolic-parabolic equations FINITE-ELEMENT-METHOD DISCONTINUOUS GALERKIN METHOD NAVIER-STOKES EQUATIONS CONSERVATION-LAWS EFFICIENT IMPLEMENTATION DG/FV METHODS CONVERGENCE RATE ORDER SCHEMES APPROXIMATIONS

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Controllable Construction of Vinyl Sulfones and β-Keto Selenosulfones via Selective Oxidative Sulfonylation of Alkenes

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Chinese Journal of Chemistry 2024年第12期42卷 1367-1372页

作者： Xiang liu yuan Zhang Yi Zheng Changfeng Huang Hua Cao School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshanGuangdong 528458China

Comprehensive Summary The selective oxidative sulfonylation of alkenes with selenium sulfonate depended on the reaction *** electrochemical C—H sulfonylation proceeded smoothly to afford(E)-vinyl sulfones with good selectivity in an undivided cell without external *** aerobic trifunctionalization of alkenes occurred in the presence of KI in the air,which providesβ-keto selenosulfones via the formation of C—O,C—S,and C—Se bonds in *** control experiments,a plausible mechanism is proposed to rationalize the experimental results.

关键词： Synthetic methods Alkenes Difunctionalization Selenylation Sulfonylation

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A model for aircraft cabin evacuation considering passenger type

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Journal of Safety Science and Resilience 2024年第1期5卷 83-90页

作者： Yaping Ma Jinfeng yuan Lingling Tan Quanyi liu Mengling Li Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province Civil Aviation Flight University of ChinaGuanghan 618307China School of Safety Science and Emergency Management Wuhan University of TechnologyWuhan 430070China

Pedestrian safety evacuation in aircraft cabins has been a challenging problem because of the aircraft’s unique characteristics,such as the diversity of passengers and the restricted evacuation *** is difficult to reproduce evacuation activities in aircraft cabin due to safety concerns and cost *** fill this gap,an improved cellular automaton model of crowd evacuation for aircraft cabin is established by incorporating the characteristics of cabin space structures and passenger *** are divided into healthy individual passengers and disabled-healthy group passengers,whose movement mechanisms are *** on the constructed model,simulation experiments are conducted using the configuration cabin layout of B737-800 as an *** results show that the evacuation time is prolonged with increased passenger density and the number of disabled ***,the overall evacuation time is insignificantly affected by whether disabled-healthy group passengers’seats are close to the aisle or window,and the evacuation efficiency is best when their seats are evenly distributed in the *** evacuation time is the shortest when all cabin doors are open,and pedestrians are evacuated the slowest when the central emergency doors are *** study pro-vides valuable insights into effective strategies for pedestrian evacuation and crowd emergency management of civil aircraft.

关键词： Aircraft cabin evacuation Passenger type Cellular automaton model Pedestrian distribution Evacuation efficiency

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