检索结果-南通市图书馆

New roles of tumor-derived exosomes in tumor microenvironment

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第2期36卷 151-166页

作者： shiqian Chen Jinzhe Sun Huan Zhou Hongbin Lei Dan Zang Jun Chen Department of Oncology the Second Hospital of Dalian Medical UniversityDalian 116023China Department of Radiotherapy the Second Hospital of Dalian Medical UniversityDalian 116023China

Throughout tumorigenesis, the co-evolution of tumor cells and their surrounding microenvironment leads to the development of malignant phenotypes. Cellular communication within the tumor microenvironment(TME) plays a critical role in influencing various aspects of tumor progression, including invasion and metastasis. The release of exosomes, a type of extracellular vesicle, by most cell types in the body, is an essential mediator of intercellular communication. A growing body of research indicates that tumor-derived exosomes(TDEs) significantly expedite tumor progression through multiple mechanisms, inducing epithelial-mesenchymal transition and macrophage polarization, enhancing angiogenesis, and aiding in the immune evasion of tumor cells. Herein, we describe the formation and characteristics of the TME, and summarize the contents of TDEs and their diverse functions in modulating tumor development. Furthermore, we explore potential applications of TDEs in tumor diagnosis and treatment.

关键词： Tumor-derived exosomes tumorigenesis tumor microenvironment diagnosis treatment

Phonon resonance modulation in weak van der Waals heterostructures:Controlling thermal transport in graphene-silicon nanoparticle systems

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第4期33卷 96-102页

作者：李毅刘一浓胡世谦 School of Physics and Astronomy Yunnan UniversityKunming 650091China

The drive for efficient thermal management has intensified with the miniaturization of electronic devices.This study explores the modulation of phonon transport within graphene by introducing silicon nanoparticles influenced by van der Waals forces.Our approach involves the application of non-equilibrium molecular dynamics to assess thermal conductivity while varying the interaction strength,leading to a noteworthy reduction in thermal conductivity.Furthermore,we observe a distinct attenuation in length-dependent behavior within the graphene-nanoparticles system.Our exploration combines wave packet simulations with phonon transmission calculations,aligning with a comprehensive analysis of the phonon transport regime to unveil the underlying physical mechanisms at play.Lastly,we conduct transient molecular dynamics simulations to investigate interfacial thermal conductance between the nanoparticles and the graphene,revealing an enhanced thermal boundary conductance.This research not only contributes to our understanding of phonon transport but also opens a new degree of freedom for utilizing van der Waals nanoparticle-induced resonance,offering promising avenues for the modulation of thermal properties in advanced materials and enhancing their performance in various technological applications.

关键词： thermal conductivity molecular dynamics phonon resonance van der Waals interaction graphene-silicon nanoparticle heterostructure

Desiccation and osmotic resistance mechanism of Cronobacter spp. isolated from powdered infant formula

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： shiqian Fu Danliangmin Song Xue Qin Lihan Wang Qianyu Zhao Chaoxin Man Xinyan Yang Yujun Jiang Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition College of Food and Pharmaceutical Sciences Ningbo University Key Laboratory of Dairy Science Ministry of Education Department of Food Science Northeast Agricultural University

Cronobacter spp. has strong resistance to desiccation and high permeability in Enterobacteriaceae， and powdered infant formula (PIF) is one of the main contamination routes. In recent years， the contamination of Cronobacter spp. in PIF incidents occur from time to time， causing infant serious diseases or death. In this investigation， matrix-assisted laser desorption/ionization time of flight mass spectrometry was used to identify the phenotypes of 35 Cronobacter strains isolated from PIF and its processing environment. Subsequently， the isolates were evaluated for drying and osmotic pressure tolerance. The results showed that the deactivation rate of the strains ranged from 9.01% to 77.57%， and the highest osmotic pressure condition the strains could tolerate was 6% NaCl. In addition， there was a positive correlation between biofilm formation ability and desiccation resistance. Combined with transcriptomics， Cronobacter spp. can activate biofilm synthesis， produce more trehalose， accumulate betaine and electrolytes to stabilize intracellular structure under the two treatment conditions. 31 and 43 genes were found related to desiccation and permeability resistance， respectively. And some genes (cysM， thuF， ycjO， et al) were found to be associated with two tolerances for the first time.

关键词：

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期 1711-1712页

作者： Haoqi Sun shiqian Shen Robert J.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical Center Harvard Medical School Center for Translational Pain Research Department of Anesthesia Critical Care and Pain Medicine Massachusetis General Hospital Harvard Medical School Division of Pulmonary Critical Care and Sleep Medicine Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Genetics and Aging Research Unit McCance Center for Brain Health Mass General Institute for Neurodegenerative Disease Department of Neurology Massachusetts General Hospital Harvard Medical School

Introduction: Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词：

嵌入全球价值链对地区就业的影响——基于中国城市层面的经验研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

浙江社会科学 2024年第2期 91-107,158,159页

作者：胡世前林明泽刘瑶东北财经大学公共管理学院东北财经大学国际经济贸易学院大连116000

科学评估嵌入全球价值链对地区就业的影响有助于实现区域就业协调发展。本文通过构建城市全球价值链参与度和城市全球价值链参与位置两个测度指标,从城市层面实证检验了嵌入全球价值链的地区就业效应。研究发现:城市全球价值链参与度的... 详细信息

科学评估嵌入全球价值链对地区就业的影响有助于实现区域就业协调发展。本文通过构建城市全球价值链参与度和城市全球价值链参与位置两个测度指标,从城市层面实证检验了嵌入全球价值链的地区就业效应。研究发现:城市全球价值链参与度的提高并未起到促进就业的作用,而城市全球价值链参与位置的提升显著促进了就业,该结论通过了内生性检验和稳健性检验;城市嵌入全球价值链对就业的影响因城市所在区域、城市资源类型的不同而存在差异;就业增长率动态演进的结果表明,全球价值链参与位置对中西部地区城市就业的影响随时间增长呈现先抑制后促进再抑制的动态演进过程,而对东部地区城市就业的促进作用较为稳定。最后,本文发现城市全球价值链参与位置对就业存在非线性影响。

关键词：城市就业全球价值链参与度全球价值链参与位置

基于邻接跳变德布鲁因序列的结构光编解码算法

在线全文

学校读者我要写书评

暂无评论

光学学报 2024年第8期44卷 74-83页

作者：梁正林陈彬伍世虔武汉科技大学信息科学与工程学院湖北武汉430081 武汉科技大学机器人与智能系统研究院湖北武汉430081

德布鲁因序列常被用于结构光条纹的编码,但是序列中相邻的相同码元会导致在相同颜色区域内难以确定码元个数以及每个码元的确切编码范围。为了解决这一问题,提出一种邻接跳变德布鲁因序列,该序列在保留子序列唯一性的基础上保证了相邻... 详细信息

德布鲁因序列常被用于结构光条纹的编码,但是序列中相邻的相同码元会导致在相同颜色区域内难以确定码元个数以及每个码元的确切编码范围。为了解决这一问题,提出一种邻接跳变德布鲁因序列,该序列在保留子序列唯一性的基础上保证了相邻码元的相异性。首先,证明了所提出序列的存在性,并给出了其生成方式。然后,将该序列用于相位周期级次编码,结合正弦相移条纹设计了一种彩色条纹编码方法。在解码阶段,按颜色通道分别提取、计算得到包裹相位和相位周期级次,最终获得展开相位。实验结果表明,所提方法与传统相移法有相似的测量精度,且仅需要4幅投影图像即可完成三维测量,显著提高了测量效率。

关键词：测量德布鲁因序列结构光相移测量

政策承诺的履约评价:教育数字化评价指标体系建构

在线全文

学校读者我要写书评

暂无评论

暨南学报（哲学社会科学版） 2024年第3期46卷 96-110页

作者：谷世乾党崇雷暨南大学公共管理学院

教育数字化是教育强国战略的核心要件和强力支撑,对其进行科学评价已成为优先级的重要议题。目前率先开展的教育数字化评价指标体系建构工作主要遵循理论、实践和政策三类逻辑。教育法学视域下,教育事业更有可能以国家行使公权力的形式... 详细信息

教育数字化是教育强国战略的核心要件和强力支撑,对其进行科学评价已成为优先级的重要议题。目前率先开展的教育数字化评价指标体系建构工作主要遵循理论、实践和政策三类逻辑。教育法学视域下,教育事业更有可能以国家行使公权力的形式在政策逻辑框架内发展并产生实际作用,而从政策逻辑出发的教育数字化指标设置正面临“评价结果与政策目标偏离”以及“评估结果与公民感受偏离”两类风险。基于政策承诺的创新视角,教育数字化政策被视为政府与公民之间达成的承诺契约。通过选取国家层面与教育数字化相关且仍在有效期的8份政策文本作为分析对象,运用Nvivo11软件针对条款中所做出的承诺内容进行编码,形成由“供给承诺”、“需求承诺”和“环境承诺”3个一级指标以及12个二级指标构成的教育数字化履约评价指标体系,并展望了以公民监督为核心的践行履约评价、优化问责机制、推动政策议程设置三大应用图景。

关键词：教育数字化教育强国契约论政策承诺履约评价

Fabrication of Silane and Desulfurization Ash Composite Modified Polyurethane and Its Interfacial Binding Mechanism

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 288-297页

作者：吴旺华 CHEN Shuichang YE Haodong 李世迁 LIN Yuanzhi 陈庆华 XIAO Liren College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China College of Materials and Package Engineering Fujian Provincial Key Lab of Coastal Basin EnvironmentFujian Polytechnic Normal UniversityFuqing 350300China College of Agriculture Guangxi UniversityGuangxi 530004China

Polyurethane/desulfurization ash(PU/DA)composites were synthesized using"one-pot method",with the incorporation of a silane coupling agent(KH550)as a"molecular bridge"to facilitate the integration of DA as hard segments into the PU molecular chain.The effects of DA content(φ)on the mechanical properties,thermal stability,and hydrophobicity of PU,both before and after the addition of KH550,were thoroughly examined.The results of microscopic mechanism analysis confirmed that KH550 chemically modified the surface of DA,facilitating its incorporation into the polyurethane molecular chain,thereby significantly enhancing the compatibility and dispersion of DA within the PU matrix.When the mass fraction of modified DA(MDA)reached 12%,the mechanical properties,thermal stability,and hydrophobicity of the composites were substantially improved,with the tensile strength reaching 14.9 MPa,and the contact angle measuring 100.6°.

关键词： polyurethane silane coupling agent desulfurization ash modification mechanical property hydrophobicity thermal stability

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高温烟气管道膨胀节稳定失效分析与设计优化

压力容器 2024年第2期41卷 66-71页

作者：刘广厦何海科王佳博李世乾国能新疆化工有限公司乌鲁木齐831400 中石油华东设计院山东青岛266000 洛阳双瑞特种装备有限公司河南洛阳471000

针对某甲醇制烯烃(MTO)装置再生烟气管道波纹管膨胀节稳定失效的故障,分析了管道支座布置和操作工况变化对膨胀节稳定性的影响,结合管道热位移、盲板力的计算,证明了管道支座的选型及合理布置是保证膨胀节安全、有效服役的关键。提出了... 详细信息

针对某甲醇制烯烃(MTO)装置再生烟气管道波纹管膨胀节稳定失效的故障,分析了管道支座布置和操作工况变化对膨胀节稳定性的影响,结合管道热位移、盲板力的计算,证明了管道支座的选型及合理布置是保证膨胀节安全、有效服役的关键。提出了膨胀节的改造应用方案和治理措施,为类似工况膨胀节的应用和失效预防提供了经验。

关键词：膨胀节盲板力支座稳定失效