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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi luo Nan Zhang Yuntao liu Beibei Du Xuan Wang Tianxu zhao Bingqiang liu shishun zhao Jiazhang qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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The total flow control equations and the characteristics of unsteady gradually varied flow in open channels

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Journal of Hydrodynamics 2019年第1期31卷 177-185页

作者： shi-he liu Qian-yi zhao qiu-shi luo State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Yellow River Engineering Consulting Co. LtdZhengzhou 450003China

Most unsteady channel flows in nature and practical engineering appear as gradually varied ones,and in the free surface,the deformation conforms to the long wave ***-dimensional total flow models were usually used to for the numerical simulation of long-term and long-distance reaches to describe the water movements,however,the models lack a clear relationship between the three-dimensional flow field and the total flow ***,few studies of the variations of the roughness coefficient against the time in unsteady flows were *** following results are obtained through the theoretical analysis and the numerical simulations in this paper.(1) One-dimensional total flow control equations of the unsteady gradually varied flow in open channels are obtained directly from the mathematical model of the viscous fluid motion,and can both reflect the influence of the turbulence and provide an explicit expression of the energy slope *** equations establish a direct connection between the descriptions of the three-dimensional flow fields and the one-dimensional total flows.(2) Synchronous prototype observation data and planar two-dimensional numerical simulation results are used to extract the one-dimensional total flow information and discuss the total flow characteristics.(3)The orders of magnitude for terms in the total flow motion equation are compared,and the variation of the roughness coefficient against the time is analyzed.

关键词： Open channel unsteady flow total flow characteristics control equations

NUMERICAL SIMULATION OF ATOMIZATION RAINFALL AND The GENERATED FLOW ON A SLOPE

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Journal of Hydrodynamics 2012年第2期24卷 273-279页

作者： liu shi-he TAI Wei FAN Min luo qiu-shi State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan430072 China Yellow River Engineering Consulting Co. Ltd Zhengzhou 450003 China

This article studies the atomization rainfall and the generated flow on a slope by numerical *** atomization rainfall is simulated by a unified model for splash droplets and a suspended mist,and the distribution of the diameter of splash rain drops is *** slope runoff generated by the atomization rainfall is simulated by a depth-averaged 2-D model,and the localization of the rainfall intensity in space is specially *** simulation results show that：（1） the median rain size of the atomization rainfall increases in the longitudinal direction at first,then monotonously decreases,and the maximum value is taken at the longitudinal position not in consistent with the position where the maximum rain intensity is *** the lateral direction the median rain size monotonously decreases,（2） since the atomization rainfall is distributed in a strongly localized area,it takes a longer time for its runoff yield to reach a steady state than that in the natural rainfall,the variation ranges of the water depth and the velocity in the longitudinal and lateral directions are larger than those in the natural rainfall.

关键词： atomized flow unified model slope runoff numerical simulation

SIMULATION OF SEDIMENT-LADEN FLOW BY DEPTH-AVERAGED MODEL BASED ON UNSTRUCTURED COLLOCATED GRID

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Journal of Hydrodynamics 2007年第4期19卷 525-532页

作者： liu shi-he luo qiu-shi MEI Jun-ya School of Water Resource and Hydropower Wuhan University Wuhan 430072 China

The 2-D depth-averaged mathematical model for sediment-laden flows has been widely used in river control and other related engineering problems, and now it is usually solved on structured grids. Since the natural river is usually very complicated in plane boundary, and unstructured grids are more attractive in solving the problems with complicated domains, the following questions about solving 2-D depth-averaged model were discussed in this article：（1） a modified Bowyer algorithm was suggested to generate unstructured grids for natural rivers, （2） the Finite Volume Method （FVM） is employed to discretize the governing equations of the 2-D depth-averaged model and an implicit scheme was suggested with unstructured collocated grids, （3） the observed hydrological data of the Chenglingji Reach in the Yangtze River are used for verification of the presented method It seems that the suggested numerical scheme works very well, and the simulation results of both hydraulic characteristics and river bed deformation are in good agreement with the observed ones.

关键词： Bowyer algorithm unstructured grid SIMPLE algorithm

Satellite anomaly detection based on reconstruction discrepancy theory utilizing a new dual-branch reconstruction model

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Science China(Technological Sciences) 2024年第10期67卷 3294-3307页

作者： zhao HaoTian qiu shi liu Ming CAO XiBin Research Center of Satellite Technology School of AstronauticsHarbin Institute of TechnologyHarbin 150001China

To enhance the accuracy of deep learning methods based on reconstruction discrepancy in satellite anomaly detection tasks,this study proposes a dual-branch reconstruction model(DBRM)and designs a comprehensive satellite anomaly detection framework around this ***,we introduce the temporal-channel mixer(TC-Mixer)module,which mainly comprises a self-attention layer for capturing long-range temporal dependencies in telemetry data,and two types of feed-forward networks(FFN)for extract-ing complex patterns in the temporal and channel dimension of telemetry *** design endows the TC-Mixer module with robust capabilities for extracting complicated dependencies in telemetry ***,with the TC-Mixer module as the main component,we designed the *** model utilizes a shared latent representation layer,allowing the regeneration branch and forecasting branch of the DBRM to share most of the feature extraction network *** approach significantly en-hances the model’s regression accuracy while reducing computational ***,using the DBRM as the core network model,we devised a comprehensive satellite anomaly detection *** includes an anomaly criterion that considers the reconstruction discrepancy of both the regeneration and forecasting branches,the peak-over-threshold(POT)method for anomaly thresholding,and the MIC-based feature engineering method,***,we conducted comparative experiments with several SOTA anomaly detection algorithms on two public and one private satellite anomaly detection *** experimental results validate the effectiveness and superiority of our proposed method.

关键词： anomaly detection reconstruction discrepancy dual-branch reconstruction model(DBRM) satellite telemetry data time series

TheORETICAL ANALYSIS AND NUMERICAL SIMULATION OF TURBULENT FLOW AROUND SAND WAVES AND SAND BARS

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Journal of Hydrodynamics 2009年第2期21卷 292-298页

作者： liu shi-he XIONG Xiao-yuan luo qiu-shi State Key Laboratory of Water Resource and Hydropower Engineering Science Wuhan University Wuhan 430072 China School of Water Resource and Hydropower Wuhan University Wuhan 430072 China Changjiang River Administration of Navigation Affairs MC Wuhan 430014 China

Natural rivers usually possess sand waves and sand bars. In this article, the rapid distortion theory was used to study the turbulent flow over sand waves. The results show that the pre-existing sheafing motion and upstream anisotropy of the turbulence flow would have significant effect on the turbulent structures, and hence the memory effect should be taken into consideration. Furthermore, the 2-D mathematical model was employed to simulate the unsteady flow around the Taiping Sand Bar in the lower reach of the Yangtze River and the time step effect on the unsteady flow simulation with the implicit scheme was discussed at the same time. The results show that the implicit scheme keeps effective until the time step reaches a certain number, and the calculated water levels and velocities are in agreement with the observed data.

关键词： sand wave sand-bar rapid distortion theory numerical simulation

Elliptical Galaxies with Emission Lines from the Sloan Digital Sky Survey

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Chinese Journal of Astronomy and Astrophysics 2006年第1期6卷 15-24页

作者： Ying-he zhao qiu-Sheng Gu Zhi-Xin Peng Lei shi Xin-Lian luo qiu-he Peng Department of Astronomy Nanjing University Nanjing 210093

As part of a study of star formation history along the Hubble sequence, we present here the results for 11 elliptical galaxies with strong nebular emission lines. After removing the dilution from the underlying old stellar populations by use of stellar population synthesis model, we derive the accurate fluxes of all the emission lines in these objects, which are then classified, using emission line ratios, into one Seyfert 2, six LINERs and four HII galaxies. We also identify one HII galaxy （A1216＋04） as a hitherto unknown Wolf-Rayet galaxy from the presence of the WolfRayet broad bump at 4650A. We propose that the star-forming activities in elliptical galaxies are triggered by either galaxy-galaxy interaction or the merging of a small satellite/a massive star cluster, as has been suggested by recent numerical simulations.

关键词： Galaxies: elliptical and lenticular cD Galaxies: starburst - Galaxies:individual: A1212+06 A1216+04 CGCG13-83 IC 225

RAIN INTENSITY DISTRIBUTION IN The SPLASH REGION OF ATOMIZED FLOW

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Journal of Hydrodynamics 2006年第3期18卷 362-366页

作者： DUAN Hong-dong liu shi-he luo qiu-shi HUANG Wei School of Water Resource and Hydropower Wuhan University Wuhan 430072China Water Resources and Hydropower Planning and Design General Institute MWR Beijing 100011 China

Atomized flow is an unnatural two-phase flow produced while water discharges in water release structures. This flow might threaten the normal operation of hydraulic and hydroelectric installations owing to the unnatural and high-density rain as well as the unnatural and dirty mist. The splash region, the region with the highest rain intensity, hence should receive much attention during the design and operation of the hydraulic and hydroelectric installations. In this paper rain intensity distribution in the splash region of the atomized flow is investigated experimentally, and the method of random simulation is used to predict the rain intensity distribution in the splash region.

关键词： atomized flow splash rain intensity

Fabrication of high-capacity cation-exchangers for protein adsorption: Comparison of grafting-from and grafting-to approaches

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 120-132页

作者： Ming zhao Run liu Jian luo Yan Sun Qinghong shi Department of Biochemical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300350 China Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University Tianjin 300072 China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

In this work, we have synthesized two polymer-grafted cation exchangers: one via the grafting-from approach, in which sulfopropyl methacrylate (SPM) is grafted through atom transfer radical polymerization onto Sepharose FF (the thus resulting exchanger is referred as Sep-g-SPM), and another via the grafting-to approach, in which the polymer of SPM is directly coupled onto Sepharose FF (the thus resulting exchanger is called as Sep-pSPM). Protein adsorption on these two cation exchangers have been also investigated. At the same ligand density, Sep-g-SPM has a larger accessible pore radius and a smaller depth of polymer layer than Sep-pSPM, due to the controllable introduction of polymer chains with the regular distribution of the ligand. Therefore, high-capacity adsorption of lysozyme and γ-globulin could be achieved simultaneously in Sep-g-SPM with an ionic capacity (IC) of 308 mmol·L^-1. However, Sep-pSPM has an irregular chain distribution and different architecture of polymer layer, which lead to more serious repulsive interaction to proteins, and thus Sep-pSPM has a lower adsorption capacity for γ-globulin than Sep-g-SPM with the similar IC. Moreover, the results from protein uptake experiments indicate that the facilitated transport of adsorbed γ-globulin occurs only in Sep-pSPM and depends on the architecture of polymer layers. Our research provides a clear clue for the development of high-performance protein chromatography.

关键词： polymer-grafted ionic exchanger grafting technique protein adsorption atom transfer radical polymerization γ-globulin