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Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice

Chinese Journal of Integrative Medicine 2022年第11期28卷 992-999页

作者： ZHENG Yang WANG Lei WANG Jia-hui liu lu-lu ZHAO Tie-jian Department of Medicine Faculty of Chinese Medicine ScienceGuangxi University of Chinese MedicineNanning(530021)China Department of Teaching the First Affiliated Hospital of Guangxi University of Chinese MedicineNanning(530022)China Department of Physiology College of Basic MedicineGuangxi University of Chinese MedicineNanning(530021)China

Objective:To investigate the effect of curcumol on NOD-like receptor thermoprotein domain 3(NLRP3)inflammasomes,and analyze the mechanism underlying curcumol against liver ***:Thirty Kunming mice were divided into a control group,a model group and a curcumol group according to a random number table,10 mice in each *** were intraperitoneally injected with 40% carbon tetrachloride(CCl4:peanut oil,2:3 preparation)at 5 m L/kg for 6 weeks,twice a week,for developing a liver fibrosis *** mice in the control group were given the same amount of peanut oil,twice a week for 6 *** mice in the curcumol group were given curcumol(30 m L/kg)intragastrically,and the mice in the model and control groups were given the same amount of normal saline,once a day for 6 *** in liver structure were observed by hematoxylin and eosin(HE)and Masson *** function,liver fiber indices,and the expression of interleukin(IL)-10 and tumor necrosis factor-α(TNF-α)levels were determined by automatic biochemical analyzer and enzyme linked immunosorbent assay *** and reverse transcription-quantitative PCR(RT-qPCR)were performed to detect the expression of NLRP3 inflammasome-related molecules,TGF-β and ***:HE and Masson staining results showed that the hepatocytes of the model group were arranged irregularly with pseudo-lobular structure and a large amount of collagen *** mice in the curcumol group had a significant decrease in liver function and liver fibers indices compared with the model group(Plusion:A potential anti-liver fib

关键词： curcumol NOD-like receptor thermoprotein domain 3 inflammatory body liver fibrosis

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Regional differences in gully network connectivity based on graph theory:a case study on the Loess Plateau,China

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Journal of Mountain Science 2023年第4期20卷 1035-1050页

作者： CHENG Jian-hua luO Lan-hua LI Fa-yuan liu lu-lu CUI Ling-zhou School of Geography Nanjing Normal UniversityNanjing210023China Key Laboratory of Virtual Geographic Environment Ministry of EducationNanjing Normal UniversityNanjing210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing Normal UniversityNanjing210023China School of Geography and Ocean Science Nanjing UniversityNanjing210023China College of Life and Environmental Science Wenzhou UniversityWenzhou325035China

Material exchange frequently occurs in gullies,and thus the relationship between a gullynetwork structure and sediment transport potential has attracted considerable ***,previous researches ignored the difficulty of material transport from sources to sinks,and did not quantify the connectivity of a network *** this study,we used a graph model structure to model gully networks of six typical sample areas in the Loess Plateau of China and quantified gully network connectivity using four indexes:average node strength,accessibility from sources to sinks,potential flow,and network structural connectivity *** show that:(1)Reflected by different quantitative indexes,the trends of gully network connectivity in different regions are *** north to south,the connectivity of a sample area first increases and then decreases.(2)The more mature gullies have stronger network *** resistance is conducive to material transport in the gullies.(3)The node connectivity index of the gully network shows a significant aggregation distribution in space,and node connectivity on the main channel is often stronger than that on the branch *** results not only deepen the understanding of the process and mechanism of loess gully geomorphic development and evolution but also provide a reference for geomorphic studies.

关键词： Graph theory Gully network Loess Plateau Connectivity Regional difference

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Experimental Investigation of Thermal Lensing in End-pumped Nd∶YVO4 Crystal Using a New Simple Approach

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Chinese Journal of Lasers 1999年第2期8卷 8-13页

作者： liu Junhai lu Jianren lu Junhua SHAO Zongshu JIANG Minhua (National Laboratory of Crystal Materials, Shandong University, Jinan 250100, China) 山东大学晶体材料国家重点实验室山东济南 250100 山东大学晶体材料国家重点实验室山东济南

１ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｈｉｇｈｐｏｗｅｒｓｏｌｉｄｓｔａｔｅｌａｓｅｒｓ，ｐｕｍｐｉｎｄｕｃｅｄｔｈｅｒｍａｌｆｏｃｕｓｉｎｇｉｓｏｆｐｒｉｍａｒｙｉｍｐｏｒｔａｎｃｅｂｅｃａｕｓｅｏｆｉｔｓｓｉｇｎｉ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｈｉｇｈｐｏｗｅｒｓｏｌｉｄｓｔａｔｅｌａｓｅｒｓ，ｐｕｍｐｉｎｄｕｃｅｄｔｈｅｒｍａｌｆｏｃｕｓｉｎｇｉｓｏｆｐｒｉｍａｒｙｉｍｐｏｒｔａｎｃｅｂｅｃａｕｓｅｏｆｉｔｓｓｉｇｎｉｆｉｃａｎｔｉｎｆｌｕｅｎｃｅｓｏ...

关键词： thermal lensing thermal focal length Nd∶YVO 4 crystal resonator stability

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Negative Association of Circulating MicroRNA-126 with High-sensitive C-reactive Protein and Vascular Cell Adhesion Molecule-1 in Patients with Coronary Artery Disease Following Percutaneous Coronary Intervention

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Chinese Medical Journal 2016年第23期129卷 2786-2791页

作者： Jun-Nan Wang You-You Yan Zi-Yuan Guo Ya-Juan Jiang lu-lu liu Bin liu Department of Cardiology The Second Hospital of Jilin University Changchun Jilin 130041 China

Background： Percutaneous coronary intervention （PCI） causes endothelial damage, resulting in an inflammatory response with elevation of markers such as high-sensitive C-reactive protein （hs-CRP） and vascular cell adhesion molecule-1（VCAM-1）, which are associated with restenosis after PCI. Evidence suggests that microRNA-126 （miR-126） plays an important role in vascular inflammation, but its correlation with PCl-mediated inflammation has not been investigated. In this study, we investigated the effect of PCI on circulating miR-126 and inflammation markers such as hs-CRP and VCAM-1. Methods： We enrolled 130 patients with coronary artery disease （CAD） in the Second Hospital of Jilin University from October 2015 to December 2015. Among them, 82 patients with CAD, defined as at least one major epicardial vessel with 〉70% stenosis who planned to undergo PCI, were divided into acute coronary syndrome （ACS） group （46 patients） and stable angina （SA） group （36 patients）. Forty-eight patients confirmed by coronary angiography without PCI were used as controls. The plasmas of all patients were collected prior to PCI and at 30 min, 24 h, and 72 h after PCI. The plasma VCAM-1 and hs-CRP were detected by enzyme-linked immunosorbent assay, and the miR-126 was evaluated by quantitative reverse transcription-polymerase chain reaction. Results： Plasma concentrations of hs-CRP and VCAM-I in patients with either ACS （n = 46） or SA （n = 36） were significantly higher than in controls （n = 48）（P 〈 0.01） prior to PCI, and increased further at 24 h and 72 h after PCI, compared with prior PCI. Moreover, VCAM-1 was positively correlated with balloon time and pressure. In contrast, the plasma concentration of miR-126 was significantly lower in patients with CAD than in controls, and further decreased with time post-PCl. A negative correlation was observed between miR-126 and hs-CRP and VCAM-1 at 72 h after PCI. Conclusion： There was a negative correlation of miR-126 with the PCI-induced marke

关键词： High-sensitivity C-reactive Protein MicroRNA126 Percutaneous Coronary Intervention Vascular Cell Adhesion Molecule- 1

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T型截面拱在拱顶集中力作用下的平面外弯扭失稳

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工程力学 2020年第S01期37卷 151-156页

作者：刘璐璐刘爱荣卢汉文广州大学-淡江大学工程结构灾害与控制联合研究中心广东广州510006 佛山科学技术学院广东佛山528225

该文以在拱顶径向集中力作用下T型截面两端铰接圆弧拱为研究对象,考虑了剪切变形的影响,推导了适用于单轴对称截面的应变与位移函数关系。求解了拱屈曲前精确的内力。再根据势能驻值原理和RayleighRitz法推导了T型截面圆弧拱弯扭屈曲荷... 详细信息

该文以在拱顶径向集中力作用下T型截面两端铰接圆弧拱为研究对象,考虑了剪切变形的影响,推导了适用于单轴对称截面的应变与位移函数关系。求解了拱屈曲前精确的内力。再根据势能驻值原理和RayleighRitz法推导了T型截面圆弧拱弯扭屈曲荷载解析解,并与有限元数值结果进行了比较,二者吻合较好,证明了理论解的正确性。研究发现,单轴对称参数βx对弯扭屈曲荷载的影响明显,且剪切变形对较浅的拱影响较为明显。

关键词：圆弧拱 T型截面拱顶径向集中力弯扭失稳单轴对称参数

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流激孔腔噪声特征及控制方法研究

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船舶力学 2017年第4期21卷 493-502页

作者：刘璐璐吕世金刘进中国船舶科学研究中心船舶振动噪声重点实验室江苏无锡214082

文章利用大涡模拟方法,建立了流激孔腔自噪声及辐射噪声预报方法,分析了腔深、来流速度及孔腔流向尺寸对剪切振荡特征的影响,并给出了流激孔腔近场辐射噪声特性。在此基础上探索了流激孔腔噪声控制方法,研究了孔腔开口加格栅对流激孔腔... 详细信息

文章利用大涡模拟方法,建立了流激孔腔自噪声及辐射噪声预报方法,分析了腔深、来流速度及孔腔流向尺寸对剪切振荡特征的影响,并给出了流激孔腔近场辐射噪声特性。在此基础上探索了流激孔腔噪声控制方法,研究了孔腔开口加格栅对流激孔腔涡流场和噪声特征的影响。

关键词：大涡模拟流激孔腔剪切振荡格栅

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Clinicopathological Characteristics as Predictive Factrs for Lymph Node Metastasis in Submucosal Gastric Cancer

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Chinese Journal of Clinical Oncology 2007年第4期4卷 237-240页

作者： Caigang liu Ping lu Yang lu lua Li Ruishan Zhang Huimian Xu Shubao Wang Junqing Chen Department of Oncology First Affiliated Hospital of China Medial University Shenyang 110001. China.

OBJECTIVE To identify clinicopathological characteristics as predictive factors for lymph node metastasis in submucosal gastric cancer, and in addi- tion to establish objective criteria as indications for endoscopic submucosal dissection (ESD). METHODS Data from 130 patients with submucosal gastric cancer were collected, and the relationship between their clinicopathological characteris- tics and the presence of lymph node metastasis was retrospectively analyzed by multivariate analysis. RESULTS In the multivariate logistic regression model, a tumor size of 2 cm or more and an undifferentiated histologic type were found to be inde- pendent risk clinicopathological characteristics for lymph node metastasis. Among 130 patients with submucosal carcinoma, no lymph node metastases were observed in 17 patients who showed neither of the two risk clinicopath- ological characteristics. Lymph node metastasis occurred in 61.1% (22/36) of the patients who had both risk clinicopathological characteristics. CONCluSION A tumor size of 2 cm or more and an undifferentiated histologic type were significantly and independently related to lymph node metastasis in submucosal gastric cancer. It is rational for the paitients with neither of these two independent risk clinicopathological characteristics to undergo an ESD.

关键词： early gastric cancer lymph node metastasis clinicopathological characteristics endoscopic mucosal resection.

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基底材料对NiCrBSiC合金激光熔覆层组织和磨损性能的影响

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材料工程 2006年第9期34卷 45-48页

作者：孙荣禄牛伟刘录录天津工业大学机械电子学院天津300160

采用横流CO2激光在45钢和TC4钛合金表面熔覆NiCrBSiC合金涂层，利用XRD，SEM和TEM分析了激光熔覆层的微观组织，测试了激光熔覆层的硬度和摩擦磨损性能。结果表明，NiCrBSiC合金激光熔覆层的组织和性能与基底材料的种类密切相关。45钢... 详细信息

采用横流CO2激光在45钢和TC4钛合金表面熔覆NiCrBSiC合金涂层，利用XRD，SEM和TEM分析了激光熔覆层的微观组织，测试了激光熔覆层的硬度和摩擦磨损性能。结果表明，NiCrBSiC合金激光熔覆层的组织和性能与基底材料的种类密切相关。45钢表面激光熔覆层由γ-Ni，Ni3B，Cr7C8和CrB相组成，硬度在HV800～900之间；TC4合金表面激光熔覆层由γ-Ni，Ni3B，TiC和TiB2相组成，硬度在HV900～1100之间。TC4合金表面NiCrBSiC激光熔覆层的摩擦系数和质量磨损率分别低于45钢表面NiCrBSiC激光熔覆层的摩擦系数和质量磨损率。

关键词：激光熔覆 NiCrBSiC合金显微组织摩擦磨损性能

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Distribution of solitary Iymph nodes in primary gastric cancer:A retrospective study and clinical implications

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World Journal of Gastroenterology 2007年第35期13卷 4776-4780页

作者： Cai-Gang liu Ping lu Yang lu Feng Jin Hui-Mian Xu Shu-Bao Wang Jun-Qing Chen Department of Surgical Oncology First Affiliated Hospital of China Medial University Heping Shenyang110001 Liaoning Province China

AIM： To investigate the distribution pathway of metastatic lymph nodes in gastric carcinoma as a foundation for rational lymphadenectomy. METHODS： We investigated 173 cases with solitary or single station metastatic lymph nodes （LN） from among 2476 gastric carcinoma patients. The location of metastatic LN, histological type and growth patterns were analyzed retrospectively. RESULTS： Of 88 solitary node metastases cases, 65 were limited to perigastric nodes （N1）, while 23 showed skipping metastasis. Among 8 tumors in the upper third stomach, 3 involved right paracardial LN （station number： No.1）, and one in the greater curvature was found in No.1. In the 28 middle third stomach tumors, 10 were found in LN of the lesser curvature （No.3） and 6 in LN of the left gastric artery （No.7）; 5 of the 20 cases on the lesser curvature spread to No.7, while 2 of the 8 on the greater curvature metastasized to LN of the spleen hilum （No.10）. Of 52 lower third stomach tumors, 13 involved in No.3 and 19 were detected in inferior pyloric LN （No.6）; 9 of the 29 cases along the lesser curvature were involved in No.6. CONCluSION： Transversal and skipping metastases of sentinel lymph nodes （SLN） are notable, and rational lymphadenectomy should, therefore, be performed.

关键词： Gastric cancer Metastatic lymph node,Lymph node dissection Rational lymphadenectomy Sentinel lymph node

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Effects of wind barriers on the aerodynamic characteristics of bridge-train system for a road-rail same-story truss bridge

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Journal of Central South University 2022年第8期29卷 2690-2705页

作者： liu lu-lu ZOU Yun-feng HE Xu-hui WANG Zhen ZHOU Xu-hong School of Civil Engineering Central South UniversityChangsha 410075China Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structure Changsha 410075China School of Civil Engineering Chongqing UniversityChongqing 400044China

Wind barriers are commonly adopted to prevent the effects of wind on high-speed railway trains,but their wind-proofing effects are greatly affected by *** investigate the effects of wind barriers on the aerodynamic characteristic of road-rail same-story truss bridge-train systems,wind tunnel experiments were carried out using a 1:50 scale *** a wind barrier with a porosity of 30%as an example,the aerodynamic characteristics of the bridge train system under different wind barrier layouts(single-sided and double-sided),positions(inside and outside)and heights(2.5 m,3.0 m,3.5 m and 4.0 m)were *** results indicate that the downstream inside wind barrier has almost no effect on the aerodynamic characteristics of the train-bridge system,but the downstream outside wind barrier increases the drag coefficient of the bridge and reduces both the lift coefficient and drag coefficient of the train due to its effect on the train􀆳s wind pressure distribution,especially on the train􀆳s leeward *** the wind barriers are arranged on the outside,their effects on the drag coefficient of the bridge and shielding effect on the train are greater than when they are arranged on the *** the height of the wind barrier increases,the drag coefficient of the bridge also gradually increases,and the lift coefficient and drag coefficient of the train gradually decrease,but the degree of variation of the aerodynamic coefficient with the height is slightly different due to the different wind barrier *** 3.0 m high double-sided wind barriers are arranged on the outside of the truss bridge,the drag coefficient of the bridge only increases by 12%,while the drag coefficient of the train decreases by 55%.

关键词： wind barriers road-rail same-story truss bridge high-speed railway aerodynamic coefficients train-bridge system wind tunnel test

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