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Chinese Journal of Natural Medicines 2017年第12期15卷 928-937页

作者： ZOU Yu YAN Chang liu jing-chao HUANG Zhang-Jian XU Jin-Yi ZHOU Jin-Pei ZHANG Hui-Bin ZHANG Yi-Hua State Key Laboratory of National Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical University Nanjing 210009 China

Considering that high levels of nitric oxide(NO) exert anti-cancer effect and the derivatives of oleanolic acid(OA) have shown potent anti-cancer activity, new O^2-vinyl diazeniumdiolate-based NO releasing derivatives(5a–l, 11a–l) of OA were designed, synthesized, and biologically evaluated in the present study. These derivatives could release different amounts of NO in liver cells. Among them, 5d, 5i, 5j, 11g, 11h, and 11j released more NO in SMMC-7721 cells and displayed stronger proliferative inhibition against SMMC-7721 and Hep G2 cells than OA and other tested compounds. The most active compound 5j showed almost 20-fold better solubility than OA in aqueous solution, released larger amounts of NO in liver cancer cells than that in normal ones, and exhibited potent anti-hepatocellular carcinoma activity but little effect on the normal liver cells. The inhibitory activity against the cancer cells was significantly diminished upon addition of an NO scavenger, suggesting that NO may contribute, at least in part, to the activity of 5j.

关键词： Oleanolic acid O^2-Vinyl diazeniumdiolate Cytochrome P450 NO release Anti-hepatocellular carcinoma activity

Research in the Degradation and Antifouling Performance of Copolyesters of L-Lactide and ε-Caprolactonen

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腐蚀与防护 2012年第S2期 49-54页

作者： WANG jing-jing,liu chao,HUANG Cong-shu,JIANG Xue-zhi,XIE Zhi-peng,YE Zhang-ji(Xiamen Branch of Luoyang ship Material Institute,Xiamen 361101,China)

Block copolyesters of L-lactide and ε-caprolactone were synthesized by melt copolymerization of ε-caprolactone and *** degradation performance of copolyesters was investigated by quartz crystal microbalance with dissipation(QCM-D).Diisocyanate terminated copolyesters could obtain via the reaction of copolyesters and *** terminated copolyesters could react with polyol resin to prepare degradable polyurethane which can be used in antifouling *** this paper,we also discussed the degradation products release action and antifouling performance of the copolyesters film.

关键词： L-Lactide ε-Caprolactone copolyesters degradation

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教科书审美对话及其价值实现

湖南科技大学学报（社会科学版） 2022年第5期25卷 158-164页

作者：刘景超湖南科技大学教育学院湖南湘潭411201

教科书审美活动是审美主体间的对话活动。教科书审美对话以编写者与不同主体的对话为起始点,以师生与教科书文本的对话为核心,在师生、生生之间的对话中多维推进,最终走向个体心灵的自我反思性对话。在教科书审美对话展开过程中,教科书... 详细信息

教科书审美活动是审美主体间的对话活动。教科书审美对话以编写者与不同主体的对话为起始点,以师生与教科书文本的对话为核心,在师生、生生之间的对话中多维推进,最终走向个体心灵的自我反思性对话。在教科书审美对话展开过程中,教科书文本的审美意蕴被发现、拓展与丰富;师生在对话中生成与升华美感,走向审美的自由境界;蕴含在教科书审美价值生成中的多重价值随之共同生成。

关键词：教科书审美价值审美本质对话价值生成

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan liu jing Zhang jing Yang jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Solid-State Batteries

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基于STM32的气体分析仪设计

仪表技术与传感器 2018年第8期 28-31页

作者：刘静超西京学院陕西西安710123

针对传统气体分析仪存在测量精确度低、检测气体单一等缺点,设计了基于STM32的多气体分析仪。该仪器把多种传感器相结合,可准确快速地检测出多种气体混合情况下各个分组气体的浓度值,并通过串口通信的方式把数据结果发送到上位机上实时... 详细信息

针对传统气体分析仪存在测量精确度低、检测气体单一等缺点,设计了基于STM32的多气体分析仪。该仪器把多种传感器相结合,可准确快速地检测出多种气体混合情况下各个分组气体的浓度值,并通过串口通信的方式把数据结果发送到上位机上实时显示。实验数据表明,该分析仪测量结果在行业要求误差(±5%)范围内,达到了预期的设计要求。

关键词：气体分析仪 STM32 实时监测电化学传感器

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-chao Chen Xie liu Changqing Xu Da-Jian Wu Ying Cheng Xiao-Jun liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song chao Xu Kai Zhao Guoqiang liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang chao Han Zhongyue Lv Liang Wang jing liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

中国式现代化视域下塑料加工业高质量发展的时代内涵与实践路径

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塑料科技 2023年第4期51卷 121-124页

作者：刘敬超河南科技大学马克思主义学院河南洛阳471023

塑料加工业作为现代产业体系的重要组成部分,是助力我国向制造强国转变的有力支撑。中国式现代化视域下,塑料加工业高质量发展是提升产业集群稳定性能、破解核心科技创新难题、构筑高质高效供给体系、助力行业绿色可持续发展的关键突破... 详细信息

塑料加工业作为现代产业体系的重要组成部分,是助力我国向制造强国转变的有力支撑。中国式现代化视域下,塑料加工业高质量发展是提升产业集群稳定性能、破解核心科技创新难题、构筑高质高效供给体系、助力行业绿色可持续发展的关键突破口。目前,顶层规划渐趋完善、技术攻关力度逐步加大、产业链创新链不断融合、供求体系日渐均衡成为塑料加工业高质量发展的现实基础。面向中国式现代化,应积极促进产业集聚、推动科技创新、深化数字行动、开启低碳循环,为塑料加工业高质量发展赋能。

关键词：中国式现代化塑料加工业高质量发展产业集群

Preparation and Performance of Ternary Early Strength Agent and Quercetin Composite Cement Sealing Material

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 130-140页

作者： liu Jian CHEN Meiting JI Xiaoli XU chao WANG Chunmei Department of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China Key Laboratory of Mine Safety and High Efficient Mining Jointly Built by Province and Education Ministry Anhui University of Science and TechnologyHuainan 232001China Department of Chemical Engineering and Explosives Anhui University of Science and TechnologyHuainan 232001China

A ternary early-strengthening agent consisting of calcium formate+triethanolamine+lithium sulfate was compounded with quercetin to shorten the setting time of cementitious materials while ensuring their early *** optimum ratio of the three early-strengthening agents was determined as 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate by response surface *** effects of the ternary early-strengthening agent composed of calcium formate+triethanolamine(TEA)+lithium sulfate on cementitious pore sealing materials under the synergistic effect of quercetin were studied by means of the performance tests of compressive strength,fluidity,and setting time,and the microstructural characterizations of X-ray powder diffractometer(XRD),thermogravimetry(TG-DSC)and scanning electron microscopy(SEM).The study shows that the synergistic effect of ternary early-strengthening agent and quercetin forms a multi-performance composite admixture for cementitious *** best performance was obtained with the compounding scheme of 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate ternary early-strengthening agent and 0.05%*** compressive strength of 1,3,7,and 28 d are 94.8%,39.8%,42%,and 28%higher than those of the blank group,*** initial time and final setting time are 41 and 57 minutes,*** to the microscopic analysis,the network and fibrous C-S-H gels generated by ternary early-strengthening agents are attached to the surface promoted by quercetin,which forms skeleton support while thickening and solidifying the cement slurry,which enhances the early compressive strength of the cement-based materials.

关键词： sealing material ternary early-strengthening agent quercetin synergetic effect response surface methodology