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Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

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Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu Zhang Quan jin Haitao Zhang Zhao liu Yuyang Wu Longfei Zhang Renzhang Yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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酸浆五种部位醇提物的活性比较研究

食品工业科技 2016年第16期37卷 113-116页

作者：丁盼刘金娟周小琪薛羚伟孙勇蒋继宏江苏师范大学生命科学学院江苏省药用植物生物技术重点实验室江苏徐州221116

目的:探讨酸浆根、茎、叶、宿萼和浆果醇提物的抑菌、抗氧化、抗肿瘤和抑炎活性。方法:采用牛津杯法检测酸浆五种部位醇提物对金黄色葡萄球菌、大肠杆菌和枯草芽孢杆菌的抑菌活性;DPPH清除法检测其抗氧化活性;Alamar Blue法检测其对人... 详细信息

目的:探讨酸浆根、茎、叶、宿萼和浆果醇提物的抑菌、抗氧化、抗肿瘤和抑炎活性。方法:采用牛津杯法检测酸浆五种部位醇提物对金黄色葡萄球菌、大肠杆菌和枯草芽孢杆菌的抑菌活性;DPPH清除法检测其抗氧化活性;Alamar Blue法检测其对人乳腺癌细胞株MCF-7、MDA-MB-231和肝癌细胞株Bel7402的抑制效果;一氧化氮检测试剂盒测定其抗炎活性。结果:浆果对金黄色葡萄球菌和大肠杆菌的抑菌效果最好,叶对枯草芽胞杆菌抑菌活性较明显,抑菌圈分别为(16.63±0.49)、(14.97±0.37)、(15.83±0.29)mm。宿萼的抗氧化活性最高,浓度为5 mg/m L时对DPPH的清除率为96.79%±2.09%,基本和同剂量的VC效果相当。酸浆各部位醇提物对肿瘤细胞的抑制作用呈现浓度依赖性,其中根对MCF-7的抑制活性较强,宿萼对MDA-MB-231和Bel7402的活性较强,IC50分别为(31.46±1.49)、(48.84±1.69)、(65.48±1.82)μg/m L。叶的抗炎效果最佳,茎抗炎效果较弱,10μg/m L时NO产生量分别为11.01、27.73μmol/L。结论:酸浆具有一定的抑菌、抗氧化、抗肿瘤和抗炎活性,为酸浆的功能开发及活性成分分离提供一定的理论依据。

关键词：酸浆抑菌活性抗氧化活性抗肿瘤活性抗炎活性

“寒门贵子”是“补偿”还是“选拔”出来的?——对两所精英大学2018—2023年高校专项计划招生的追踪研究

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华东师范大学学报（教育科学版） 2025年第1期43卷 113-126页

作者：金文旺柳夕浪北京师范大学中国教育与社会发展研究院北京100875 山东师范大学教育学部济南250014

高校专项计划是我国促进高质量教育公平、破解农村学生上好大学难而出台的一项入学机会补偿政策。综合运用描述性统计方法,本研究对两所精英大学2018—2023年间高校专项计划的选录情况进行了持续追踪研究。从初审、降分、录取人数的总... 详细信息

高校专项计划是我国促进高质量教育公平、破解农村学生上好大学难而出台的一项入学机会补偿政策。综合运用描述性统计方法,本研究对两所精英大学2018—2023年间高校专项计划的选录情况进行了持续追踪研究。从初审、降分、录取人数的总体规模及变化趋势看,近几年高校专项计划政策力度不断加大,越来越多的寒门子弟进入精英高校。同时,精英大学高校专项计划实际招生呈现“补偿不均,选拔有余”的鲜明特点,经济欠发达、教育发展水平薄弱省域的农村学生和学校在该计划中并未获得更多优质高校入学机会的补偿,一个重要原因在于他们在高校自主选拔和高考选拔中处于劣势。为此,应调整高校专项计划招生办法及相关政策,确立“补偿为主,兼顾选拔”的价值导向并切实付诸实践,推进“实质的公平”。

关键词：高校专项计划补偿选拔教育公平精英大学

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao juan-Han Yu Yi-Hua Wang Yi-Xin liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

溪洛渡水电站左岸泄洪洞龙落尾开挖支护施工技术研究

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四川水力发电 2010年第6期29卷 44-45页

作者：吴登明张元继刘金娟中国水利水电第七工程局有限公司四川成都610081

溪洛渡水电站左岸泄洪洞龙落尾体型采用奥奇曲线、直线与圆弧反弧线结合,岩石开挖与支护施工难度大。通过在其中部增设施工支线并结合混凝土顶拱掺气进行施工设计,采用了两侧分区、上下分层、多个工作面同时作业,而且一次形成溜渣斜井,... 详细信息

溪洛渡水电站左岸泄洪洞龙落尾体型采用奥奇曲线、直线与圆弧反弧线结合,岩石开挖与支护施工难度大。通过在其中部增设施工支线并结合混凝土顶拱掺气进行施工设计,采用了两侧分区、上下分层、多个工作面同时作业,而且一次形成溜渣斜井,解决了施工溜渣和排水问题,开创了泄洪洞龙落尾岩石开挖与支护施工的最优方案。

关键词：溪洛渡水电站泄洪洞龙落尾开挖与支护先进水平

34例口腔颌面部组织瓣血管危象的原因分析及护理

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当代护士（中旬刊） 2020年第11期27卷 81-83页

作者：刘秋玲张丽萍吴娟黄敏红刘金娟方玲中山大学孙逸仙纪念医院口腔科病房广州510120

报告了34例口腔颌面部组织瓣修复术后患者发生血管危象的原因分析及护理对策。分析主要原因为:吻合动脉痉挛血管栓塞;组织肿胀导致皮岛穿支於堵、受压,皮瓣供血受阻;放疗后受区血管条件欠佳;术区积液长期浸润,外部刺激致血管破裂;凝血... 详细信息

报告了34例口腔颌面部组织瓣修复术后患者发生血管危象的原因分析及护理对策。分析主要原因为:吻合动脉痉挛血管栓塞;组织肿胀导致皮岛穿支於堵、受压,皮瓣供血受阻;放疗后受区血管条件欠佳;术区积液长期浸润,外部刺激致血管破裂;凝血功能差,局部渗血多,压迫血管蒂等。本组完善术前个体化评估准备;术后密切的生命体征监测、个体化皮瓣观察、有效体位、营养支持、预防感染、避免出血,加强心理护理,保持患者情绪稳定,可降低血管危象的发生,提高皮瓣成活率。

关键词：口腔颌面部组织瓣血管危象观察护理

贵州地方猪品种雌激素受体基因内含子1多态性

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山地农业生物学报 2009年第3期28卷 230-234页

作者：冉雪琴刘金娟王嘉福贵州大学动物科学学院贵州贵阳550025 贵州大学农业生物工程省重点实验室贵州贵阳550025

为了探索雌激素受体(estrogen receptor,ESR)基因与贵州地方猪品种繁殖性状之间的关系,采用SSCP和RFLP方法,以大约克、外三元杂交猪和梅山猪为对照,对贵州地方猪品种香猪、糯谷猪和柯乐猪ESRα基因进行了多态性分析,共检测到AA、AB和BB ... 详细信息

为了探索雌激素受体(estrogen receptor,ESR)基因与贵州地方猪品种繁殖性状之间的关系,采用SSCP和RFLP方法,以大约克、外三元杂交猪和梅山猪为对照,对贵州地方猪品种香猪、糯谷猪和柯乐猪ESRα基因进行了多态性分析,共检测到AA、AB和BB 3种基因型,测序结果证实,B等位基因产生的原因是:121 bp扩增片段中第54和57位碱基均突变为C,获得了1个Pvu Ⅱ酶切位点,使AA基因型多出一条带;A等位基因在国外猪品种中占优势,国内猪品种以B等位基因为主,香猪的BB基因型频率最高(79.4%),糯谷猪和柯乐猪均较低(30%、29.8%)。说明贵州地方猪品种的杂合度较高,应加强选育,B等位基因可能与低繁殖率相关。

关键词： ESR基因多态性 SSCP RFLP 猪品种贵州

In Situ Transmission Electron Microscopy Observations of the Growth Process of Fe3O4–Ag Nanoparticles

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Acta Metallurgica Sinica(English Letters) 2020年第9期33卷 1283-1288页

作者： jing-Hua liu jin-Jun liu Qiang Zheng Bao-Ru Bian juan Du School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China CAS Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201China Institute of Materials Shanghai UniversityShanghai 200444China

The properties of nanocrystals are highly dependent on their morphology, composition and structure. To obtain full control over their properties, the behavior of nanocrystals under external stimuli, such as heat treatment, needs to be understood. Herein, to in situ observe their microstructure and morphology changes, Fe3O4–Ag heterodimers were selected as a model system. Their structural changes after heat treatment were investigated by in situ transmission electron microscopy. A combination of real-time imaging with elemental analysis enabled observation of the transformation of Fe3O4–Ag heterodimers having a loose interface configuration to those with a Janus structure at the atomic scale after heating from room temperature to 600 °C. After incubation at 600 °C for 32 min, two kinds of Janus structures could be seen, including a clear linear interface in the Fe3O4–Ag heterodimers and a semi-crescent-shaped interface between the Ag and Fe3O4 nanoparticles(NPs). These dynamic observations provide unique insights into NP growth mechanisms, which are essential for understanding and controlling the structure and morphology of nanoparticles.

关键词： In situ TEM Fe3O4–Ag heterodimer Nanoparticle Janus structure Interface