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Assessment of ECMWF’s Precipitation Forecasting Performance for China from 2017 to 2022

journal of Tropical Meteorology 2024年第3期30卷 257-274页

作者： PAN liu-jie ZHANG Hong-fang LIANG Mian liu j.a-huimin DAI Chang-ming Shaanxi Meteorological Observatory Xi’an 710014 China Key Laboratory of Eco-Environment and Meteorology for the Qinling Mountains and Loess Plateau Xi’an 710014 China Shaanxi Meteorological Service Centre Xi’an 710014 China

This study used the China Meteorological Administration(CMA)three-source fusion gridded precipitation analysis data as a reference to evaluate the precipitation forecast performance of the European Centre for Medium-Range Weather Forecasts(ECMWF)model for China from 2017 to *** main conclusions are as *** precipitation forecast capability of the ECMWF model for China has gradually improved from 2017 to *** scores such as bias,equitable threat score(ETS),and Fractions Skill Score(FSS)showed improvements for different categories of *** bias of light rain forecasts overall adjusted towards smaller values,and the increase in forecast scores was greater in the warm season than in the cold *** ETS for torrential rain more intense categories significantly increased,although there were large fluctuations in bias across different *** model exhibited higher precipitation bias in most areas of North China,indicating overprediction,while it showed lower bias in South China,indicating *** ETSs indicate that the model performed better in forecasting precipitation in the northeastern part of China without the influence of climatic background *** of the differences between the first period and the second period of the forecast shows that the precipitation amplitude in the ECMWF forecast shifted from slight underestimation to overestimation compared to that of CMPAS05,reducing the likelihood of missing extreme precipitation *** improvement in ETS is mainly due to the reduction in bias and false alarm rates and,more importantly,an increase in the hit *** 2017 to 2022,the area coverage error of model precipitation forecast relative to observations showed a decreasing trend at different scales,while the FSS showed an increasing trend,with the highest FSS observed in *** ETS followed a parabolic trend with increasing neighborhood radius,with the better ETS neighborhood radius generally

关键词： ECMWF forecasting verification neighborhood verification FSS

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Fine classification of rice paddy using multitemporal compact polarimetric SAR C band data based on machine learning methods

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Frontiers of Earth Science 2024年第1期18卷 30-43页

作者： Xianyu GUO junjun YIN Kun LI j.an YANG huimin ZOU Fukun YANG School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China College of Global Change and Earth System Science Beijing Normal UniversityBeijing 100875China

Rice is an important food crop for human *** distinguishing different varieties and sowing methods of rice on a large scale can provide more accurate information for rice growth monitoring,yield estimation,and phenological monitoring,which has significance for the development of modern *** polarimetric(CP)synthetic aperture radar(SAR)provides multichannel information and shows great potential for rice monitoring and ***,the use of machine learning methods to build classification models is a controversial *** this paper,the advantages of CP SAR data,the powerful learning ability of machine learning,and the important factors of the rice growth cycle were taken into account to achieve high-precision and fine classification of rice ***,CP SAR data were simulated by using the seven temporal RADARSAT-2 C-band data ***,20-two CP SAR parameters were extracted from each of the seven temporal CP SAR data *** addition,we fully considered the change degree of CP SAR parameters on a time scale(ΔCP_(DoY)).Six machine learning methods were employed to carry out the fine classification of rice *** results show that the classification methods of machine learning based on multitemporal CP SAR data can obtain better results in the fine classification of rice paddies by considering the parameters ofΔCP_(DoY).The overall accuracy is greater than 95.05%,and the Kappa coefficient is greater than *** them,the random forest(RF)and support vector machine(SVM)achieve the best results,with an overall accuracy reaching 97.32%and 97.37%,respectively,and Kappa coefficient values reaching 0.965 and 0.966,*** the two types of rice paddies,the average accuracy of the transplant hybrid(T-H)rice paddy is greater than 90.64%,and the highest accuracy is 95.95%.The average accuracy of direct-sown japonica(D-j)rice paddy is greater than 92.57%,and the highest accuracy is 96.13%.

关键词： compact polarimetric(CP)SAR rice paddy machine learning fine classification multitemporal

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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including jN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian Li Mengxin Xu jingyi Yang Li Zhou Lin liu Min Li Shasha Wang Mei-Qin liu Zhixiang Huang Zhen Zhang Shuning liu Yunqi Hu Haofeng Lin Bowen liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen huimin Yan Yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

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Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

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Signal Transduction and Targeted Therapy 2024年第1期9卷 326-337页

作者： You Zhai Yicong Du Guanzhang Li Mingchen Yu huimin Hu Changqing Pan Di Wang Zhongfang Shi Xu Yan Xuesong Li Tao j.ang Wei Zhang Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingPR China Department of Urology Peking University First HospitalInstitute of UrologyPeking UniversityNational Urological Cancer CenterBeijingPR China Department of Pathophysiology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China China National Clinical Research Center for Neurological Diseases BeijingPR China Center of Brain Tumor Beijing Institute for Brain DisordersBeijingPR China Research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijingPR China Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingPR China

Chimeric antigen receptor(CAR)T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid *** instances of rapid tumor remissions have been observed in animal models and clinical trials,tumor relapses occur with multiple therapeutic resistance ***,while the mechanisms underlying the long-term therapeutic resistance are well-known,short-term adaptation remains less ***,more views shed light on short-term adaptation and hold that it provides an opportunity window for long-term *** this study,we explore a previously unreported mechanism in which tumor cells employ trogocytosis to acquire CAR molecules from CAR-T cells,a reversal of previously documented *** mechanism results in the depletion of CAR molecules and subsequent CAR-T cell dysfunction,also leading to short-term antigen loss and antigen *** type of intercellular communication is independent of CAR downstream signaling,CAR-T cell condition,target antigen,and tumor cell ***,it is mainly dependent on antigen density and CAR sensitivity,and is associated with tumor cell cholesterol *** mitigation of this trogocytosis-induced CAR molecule transfer can be achieved by adaptively administering CAR-T cells with antigen density-individualized CAR ***,our study reveals a dynamic process of CAR molecule transfer and refining the framework of clinical CAR-T therapy for solid tumors.

关键词： Together instance depletion

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Danggui Shaoyao powder improves hepatic lipid metabolism in atherosclerosis mice via PPARγ-LXRα-ABCA1 pathway regulation

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journal of Traditional Chinese Medical Sciences 2024年第2期11卷 199-206页

作者： Xue Pian Yang Tang Yuemeng Sun Yuhan Sheng Shuxin Yan huimin Yuan Yan Sun j.an Cui Yuhang Li School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China School of Traditional Chinese Medicine Inner Mongolia Medical UniversityHohhot010110China Columbia University Irving Medical Center New YorkNY 10032USA

Objective To observe the effects of Danggui Shaoyao powder(DSP)on hepatic lipid metabolism and further explore its mechanism of action by peroxisome proliferator-activated receptor(PPARγ)-liver X receptor(LXRα)-adenosine triphosphate(ATP)-binding cassette transporter A1(ABCA1)pathway *** Eight C57BL/6j male mice were selected as the control group,and 24 ApoE^(−/−)male mice were randomly divided into the atherosclerosis model(AS)group,atorvastatin calcium(AC)group,and DSP group(n=8 each group).To establish an AS model,ApoE^(−/−)mice were fed a high-fat diet for 16 *** changes in the aortic vasculature and liver were identified using Oil Red O ***(TG),cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)levels were determined in the livers using a single-reagent GPO-PAP *** quantitative polymerase chain reaction and western blot were used to observe and evaluate the mRNA and protein expression of the PPARγ-LXRα-ABCA1 intermediates in the *** After 16 weeks of a high-fat diet,ApoE−/−mice showed more Oil Red O staining in the aorta and liver compared to the CONT *** to the AS group,the DSP and AC treatment reduced aortic plaque and hepatic lipid deposition to varying ***,DSP significantly reduced the hepatic lipid area in ApoE^(−/−)mice(P<.001)and decreased the levels of TG,TC,and LDL-C in liver(P<.001,P=.027,P<.001,respectively).DSP also significantly increased the levels of PPARγ,LXRα,ABCA1,and ABCG1 mRNA expression,as well as the PPARγ,LXRα,ABCA1,and ABCG1 protein expression in *** DSP improved hepatic lipid metabolism via PPARγ-LXRα-ABCA1 pathway modulation for AS treatment.

关键词： Danggui Shaoyao powder Atherosclerosis PPARγ-LXRα-ABCA1 pathway Reverse cholesterol transport

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Distinct Effects of Three Tea Varieties Made Green Teas on Improving Diabetic Dyslipidemia Induced by High-Fat Diet in C57BL/6j Mice

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Food Science and Human Wellness 2024年

作者： Wei Gu Zhutong Wang Guohuo Wu huimin Guo Huijun Cheng Cong Li Linbo Chen Daxiang Li Zhongwen Xie State Key Laboratory of Tea Plant Biology and Utilization， School of Tea and Food Sciences & Technology， Anhui Agricultural University Center for Biotechnology， Anhui Agricultural University College of Life Sciences， Anhui Agricultural University Tea Research Institute， Yunnan Academy of Agricultural Sciences

Currently， cultivated tea plants are classified into three varieties， namely， C. sinensis var. sinensis， C. sinensis var. assamica， and C. sinensis var. kucha. Three tea varieties made green teas (TVGTs) are widely consumed worldwide. However， a comparative investigation of the beneficial effects， mechanism， and characteristic compounds of TVGTs has not been reported. Here， three representative tea plant varieties， namely， C. sinensis var. sinensis cv. Fuding (FD)， C. sinensis var. assamica cv. Yunkang 10 (YK)， and C. sinensis var. kucha (KC)， planted in the same garden， were used to make green teas utilizing the same standard procedure. Our findings show that the TVGTs effectively improved hyperglycemia， obesity， dyslipidemia， fatty liver， and mesenteric artery (MA) hypercontractility in mice with diabetes and obesity induced by a high-fat diet (HFD) after 11- and 22-week interventions， with YK being the most effective at 22 weeks. Liver lipidomics indicated that the TVGTs restored the glycerophospholipid and sphingolipid balance and reduced triglycerides， with YK demonstrating superior effects. The TVGTs， particularly YK， suppressed triglyceride synthesis through the ARV1-FXR-SHP-SREBP-1c pathway. A chemical profile analysis revealed that YK green tea had enriched active compounds， including caffeine， quinic acid， L-theanine， gallic acid， and catechins， compared with FD and KC green teas， which may contribute to ameliorating diabetic dyslipidemia via synergistic action. As a representative tea variety of C. sinensis var. assamica， YK green tea was found to be superior to the other two green teas in preventing and treating diabetic dyslipidemia， especially with long-term consumption. These data provide important information for tea plant breeders and tea consumers.

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建立基于适体-纳米金的比色生物传感器用于快速检测Lp-PLA2

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中华检验医学杂志 2024年第8期47卷 936-944页

作者：牛会敏佘毅军刘恭序邱抒倩陈娟张胜行福建医科大学福总临床医学院(第九〇〇医院)检验科福州350025 福建中医药大学福总教学医院(第九〇〇医院)福建省适配体技术重点实验室福州350025

目的筛选血管炎性标志物脂蛋白相关磷脂酶A2(Lp-PLA2)的DNA适体, 并建立以非标记核酸适体-纳米金为探针的可视化检测方法。方法方法学建立。通过磁珠固定SELEX技术经孵育结合、ssDNA分离、PCR扩增、单链回收的8轮循环筛选Lp-PLA2适体, ... 详细信息

目的筛选血管炎性标志物脂蛋白相关磷脂酶A2(Lp-PLA2)的DNA适体, 并建立以非标记核酸适体-纳米金为探针的可视化检测方法。方法方法学建立。通过磁珠固定SELEX技术经孵育结合、ssDNA分离、PCR扩增、单链回收的8轮循环筛选Lp-PLA2适体, 利用表面等离子体共振技术和流式细胞术验证适体的亲和力和特异性, 并通过计算机软件模拟适体二级结构及其与靶蛋白的三维分子对接。随后制备适体-纳米金复合物, 利用靶标竞争结合导致纳米金溶液在盐诱导下凝聚引起颜色变化, 分光光度计检测溶液的吸光度检测靶标浓度, 建立样品溶液中Lp-PLA2浓度与吸光度的线性关系。结果筛选获得3条高亲和力、强特异性的Lp-PLA2核酸适体B76-2、B76-4及B76-5, 解离常数分别为1.07、1.26及1.75 nmol/L;并成功基于B76-2适体构建纳米金比色传感方法, 其线性范围和检测限分别是20~500 ng/ml和78 ng/ml, 反应时间30 min, 可特异性区分靶标与其他血栓标志物如凝血酶和髓过氧化物酶。结论利用核酸适体-纳米金显色实现了简单、快速、特异的Lp-PLA2可视化检测。

关键词： SELEX适体技术纳米金比色生物传感器心血管疾病

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如何提升职业教育吸引力——基于法国职业教育近五年系列改革的启示

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职业技术教育 2024年第13期45卷 73-80页

作者：李桂婷白玲邓会敏江西科技师范大学教育学部南昌330000 江西科技师范大学教育学部中国式职业教育现代化发展研究院南昌330000

职业教育作为培养技术技能型人才的主阵地,是我国建设社会主义现代化强国、构建技能型社会的关键支撑。然而,目前职业教育在整个教育体系中的吸引力明显不足,溯史追渊,主要由于职业教育鄙薄观念古已有之,也因当前职业教育制度设计存有... 详细信息

职业教育作为培养技术技能型人才的主阵地,是我国建设社会主义现代化强国、构建技能型社会的关键支撑。然而,目前职业教育在整个教育体系中的吸引力明显不足,溯史追渊,主要由于职业教育鄙薄观念古已有之,也因当前职业教育制度设计存有缺陷、职业教育机制运行不够顺畅。法国近年来为进一步提升职业教育吸引力,持续推进职业教育改革,继2018年发布11份改革文件后,2023年5月又发布《使职业高中成为年轻人和企业未来选择的12项措施》,从理念引领、内容优化、主体赋权、共同体施力四大方面发力,通过强调以学习者为中心、深耕课教改革、增强教师教育动能、倡导利益相关者共筑职业学校等举措增强职业教育吸引力,对我国提升职业教育吸引力具有重要借鉴价值。

关键词：职业教育吸引力法国职业教育中等职业教育

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链路预测方法在药物重定位中的应用研究

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福建电脑 2024年第3期40卷 39-43页

作者：翁慧敏福建师范大学计算机与网络空间安全学院福州350000

为了找到适用于中成药数据集进行药物重定位的链路预测模型,本文将六个经典的链路预测模型TransE、RotatE、Dismult、ComplEx、InteractE和DeepE分别应用于中成药数据集。通过学习实体和关系的嵌入向量,深入研究了这些模型的性能,并使... 详细信息

为了找到适用于中成药数据集进行药物重定位的链路预测模型,本文将六个经典的链路预测模型TransE、RotatE、Dismult、ComplEx、InteractE和DeepE分别应用于中成药数据集。通过学习实体和关系的嵌入向量,深入研究了这些模型的性能,并使用链路预测评估指标对这六个链路预测模型进行了评估,比较了它们之间的性能差异。实验结果表明,与其它五个链路预测模型相比,DeepE模型在中成药数据集中的MRR、Hit@1和Hit@10指标分别提高了3.7%-20.1%、4.8%-24.7%和0.8%-11%,因此更适用于药物重定位任务。

关键词：药物重定位链路预测知识图谱

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含磷霉素的联合抗菌方案治疗耐碳青霉烯革兰阴性杆菌感染疗效:系统评价与荟萃分析

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中国抗生素杂志 2024年第6期49卷 686-699页

作者：郑慧敏刘彩玉梁炜杰黄美佳王凌阮君山福建医科大学省立临床医学院福建省立医院福州350001 福建医科大学药学院福州350004

目的评价含磷霉素联合治疗碳青霉烯耐药革兰阴性菌(carbapenem-resistant Gram-negative organism,CRO)感染的疗效。探讨含磷霉素联合治疗CRO感染的最佳方案。方法系统检索中国知网、PubMed、Embase、Web of Science、Cochrane Library数据库,收集建库至2023年7月6日公开发表的关于磷霉素治疗CRO感染的相关文献,按照纳入排除标准进行筛选,使用RevMan5.4.1软件进行荟萃分析。主要结局指标包括临床死亡率。使用R软件对含磷霉素的联合治疗方案进行网状Meta分析。使用Cochrane偏差风险评估工具和Newcastle-Ottawa scale量表评估文献质量。本研究已在PROSPERO注册,CRD42022344659。结果最初检索到11806篇文献,其中有16篇、6篇分别纳入死亡率的Meta分析和网状Meta分析。含磷霉素的联合抗菌治疗方案和其他方案治疗CRO感染的总死亡率分别为25%(76/304)和42.63%(350/821),差异有统计学意义[优势比(odds ratio,OR)=0.44;95%CI=0.32-0.62P0.05,I^(2)=91%)。在网络荟萃分析中,多利培南+磷霉素治疗CRO感染的死亡率最低。结论含磷霉素的联合治疗方案可显著降低CRO感染患者的死亡率。此外,多利培南加磷霉素可能是最佳的组合方案。

关键词：磷霉素碳青霉烯耐药革兰阴性菌联合治疗 CRO 临床结局

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