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Effects of Membrane Separation on Compression/Condensation / Membrane Process for Propylene Recovery（摘要）

华东理工大学学报（自然科学版） 2011年第1期37卷 15-15页

作者： liu hong-jing yao hui zhao wei School of Petrochemical Technology Shenyang University of Technology Shenyang 110044 China

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian Wu hui hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： zhao-Jun Zhang Wen-wei Wang jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang zhao-Xian Li wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Characteristics analysis and parameters optimization for the grating eddy current displacement sensor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第7期10卷 1029-1037页

作者： hong-li QI hui zhao wei-wen liu Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

The grating eddy current displacement sensor (GECDS) for distance or position measurement used in watertight electronic calipers was described. The sensor relies on repetitive variation of inductance against displacement caused by the change of coupling areas between moving coils and static reflectors. The investigations focused on setting up and utilizing a computer model of the 3D eddy current fields and geometry to analyze causes of the production of measurement blind areas, and to investigate effects of the sensor parameters, such as axial gap between coils and reflectors, reflector length and reflector width on characteristics of the sensor. Simulation results indicated that the sensor has the smallest nonlinearity error of 0.15%, which agrees well with the experimental results.

关键词： Grating eddy current displacement sensor (GECDS) Watertight electronic calipers Parameters optimization Nonlinearity

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Mechanical properties and wear resistance of ultrafine bainitic steel under low austempering temperature

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 483-493页

作者： wei liu You-hui Jiang hui Guo Yue Zhang Ai-min zhao yao Huang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Mechanical Engineering Weifang University of Science and TechnologyShouguang 262700China China Electric Power Research Institute Beijing 100192China

The mechanical properties and wear resistance of the ultrafine bainitic steel austempered at various temperatures were *** electron microscopy(SEM)and X-ray diffraction were used to analyze the *** worn surfaces were observed via laser scanning confocal microscopy and *** indicated that,under low austempering temperatures,the mechanical properties differed,and the wear resistance remained basically *** tensile strength of the samples was above 1800 MPa,but only one sample austempered at 230°C had an elongation of more than 10%.The weight loss of samples was approximately linear with the cycles of wear and nonlinear with the *** samples showed little difference in wear resistance at different isothermal temperatures,whereas the thickness of their deformed layers varied *** results are related to the initial hardness of the sample and the stability of the retained ***,the experimental results showed that the effect of austempering temperature on the wear resistance of ultrafine bainitic steel can be neglected under low applied loads and low austempering temperature.

关键词： bainitic steel mechanical properties wear resistance austempering temperature

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Enhancing personalized exercise recommendation with student and exercise portraits

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Journal of Electronic Science and Technology 2024年第2期22卷 91-109页

作者： wei-wei Gao hui-Fang Ma Yan zhao jing Wang Quan-hong Tian College of Computer Science and Engineering Northwest Normal UniversityLanzhou730070China Computer Center of Gansu Province Lanzhou730070China

The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning *** solutions generally follow a collaborative filtering paradigm,while the implicit connections between students(exercises)have been largely *** this study,we aim to propose an exercise recommendation paradigm that can reveal the latent connections between student-student(exercise-exercise).Specifically,a new framework was proposed,namely personalized exercise recommendation with student and exercise portraits(PERP).It consists of three sequential and interdependent modules:Collaborative student exercise graph(CSEG)construction,joint random walk,and recommendation list ***,CSEG is created as a unified heterogeneous graph with students’response behaviors and student(exercise)***,a joint random walk to take full advantage of the spectral properties of nearly uncoupled Markov chains is performed on CSEG,which allows for full exploration of both similar exercises that students have finished and connections between students(exercises)with similar ***,we propose to optimize the recommendation list to obtain different exercise *** analyses of two public datasets,the results demonstrated that PERP can satisfy novelty,accuracy,and diversity.

关键词： Educational data mining Exercise recommend Joint random walk Nearly uncoupled Markov chains Optimization Personalized learning

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Parameters optimization and nonlinearity analysis of grating eddy current displacement sensor using neural network and genetic algorithm

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1205-1212页

作者： hong-li QI hui zhao wei-wen liu Hai-bo ZHANG Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Instrumentation Science and Dynamic Measurement Laboratory North University of China Taiyuan 030051 China

A grating eddy current displacement sensor(GECDS) can be used in a watertight electronic transducer to realize long range displacement or position measurement with high accuracy in difficult industry *** parameters optimization of the sensor is essential for economic and efficient *** paper proposes a method to combine an artificial neural network(ANN) and a genetic algorithm(GA) for the sensor parameters optimization.A neural network model is developed to map the complex relationship between design parameters and the nonlinearity error of the GECDS,and then a GA is used in the optimization process to determine the design parameter values,resulting in a desired minimal nonlinearity error of about 0.11%.The calculated nonlinearity error is 0.25%.These results show that the proposed method performs well for the parameters optimization of the GECDS.

关键词： Grating eddy current displacement sensor (GECDS) Artificial neural network (ANN) Genetic algorithm (GA) Parameters optimization Nonlinearity error

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Protonation effect on catalytic water oxidation activity of a mononuclear Ru catalyst containing a free pyridine unit

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Journal of Energy Chemistry 2018年第5期27卷 1402-1408页

作者： zhao liu Yan Gao jing Wang Ya’nan yao Yu wei Xuyang Chen State Key Laboratory of Fine Chemicals Institute of Artificial Photosynthesis DUT-KTH Joint Education and Research Center on Molecular Devices Dalian University of Technology (DUT)

Two efficient single-site Ru water oxidation catalysts [Ru（bda）（pic）（Ln）] （bda=2,2＇-bipyridine- 6,6＇-dicarboxylic acid, pic=picoline, Ll=4,5-bipyridine-2,7-di-tett-butyl-9,9-dimethylxanthene, L2=4- pyridine-5-phenyl-2,7-di-tert-butyl-9,9-dimethylxanthene） were only synthesized containing different xanthene ligands at the axial site. These complexes have been thoroughly characterized by spectroscopic （UV-vis, NMR） and electrochemical （CV and DIV） techniques. Kinetic analysis proved that the mechanism of water oxidation comprises the water nucleophilic attack process on high-valence ruthenium species. It is found that the catalyst I displayed higher activity than catalyst 2 on water oxidation, caused by the protonation of the axial ligand LI with a free pyridine.

关键词： WOCs Artificial photosynthesis Water splitting Ruthenium catalyst Protonation

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Generation mechanism of quarter buckle in hot-rolled temper rolling

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Journal of Iron and Steel Research International 2022年第10期29卷 1619-1632页

作者： hui Li Guan-yu Zhou An-rui He Zhi-hong Zhang Chi-huan yao Chao liu Jian-wei zhao wei-gang Li Jian Shao Institute of Engineering Technology University of Science and Technology BeijingBeijing100083China Handan Iron and Steel Group Co. Ltd.Handan056015HebeiChina Engineering Research Centre for Metallurgical Automation and Measurement Technology of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina

To reveal the generation mechanism of the quarter buckle in the process of hot-rolled temper rolling,the elastic–plastic finite element method is used to calculate the deformation of the roll and the strip during the temper *** change of the cross section of the strip and the distribution of the longitudinal stress are analysed under different bending forces to obtain the boundary conditions of the quarter *** generation of the quarter buckle is further analysed from the bending and contact flattening of the roll system and the elastic recovery of the strip after *** found that the quarter buckle is closely related to the high-order distribution of the contact flattening between the work roll and the strip and is less affected by the bending deformation of the roll and the contact flattening between the ***,a new work roll contour of the locally variable crown is proposed to change the distribution of contact flattening between the work roll and the *** is verified through theoretical calculations and industrial applications that the new contour can effectively improve the quarter buckle.

关键词： Quarter buckle Contact flattening Roll contour Finite element method Hot-rolled temper rolling

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