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基于布里渊散射光时域分析的形状传感研究

光子学报 2024年第4期53卷 95-103页

作者：刘紫娟武佳琪张立欣李永倩王健健王宽华北电力大学(保定)电子与通信工程学院保定071003 华北电力大学(保定)电子与通信工程学院河北省电力物联网技术重点实验室保定071003 华北电力大学(保定)电子与通信工程学院保定市光纤传感与光通信技术重点实验室保定071003

搭建了基于布里渊散射光时域分析技术的应变测量系统,采用七芯光纤作为分布式形状传感器,通过测量七个纤芯在弯曲时的布里渊散射谱,验证了七芯光纤偏芯之间每两个对称芯所受应变值相等且互为相反数的特点。对比七芯光纤中间芯与偏芯的... 详细信息

搭建了基于布里渊散射光时域分析技术的应变测量系统,采用七芯光纤作为分布式形状传感器,通过测量七个纤芯在弯曲时的布里渊散射谱,验证了七芯光纤偏芯之间每两个对称芯所受应变值相等且互为相反数的特点。对比七芯光纤中间芯与偏芯的布里渊增益谱,测得偏芯在不同弯曲半径下的布里渊频移变化,得到偏芯在每个位置受到的应变值。利用并行传输标架形状重构算法对七芯光纤在曲率直径为0.112 m和0.052 m时的形状进行了重构,当曲率直径为0.112 m时,曲率重构误差为0.375%。

关键词：形状传感布里渊散射光时域分析七芯光纤并行传输标架

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基于经验模态分解的单端BOTDA系统降噪方法研究

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半导体光电 2024年第2期45卷 336-340页

作者：张立欣刘紫娟康清华王磊李永倩华北电力大学电子与通信工程系河北保定071003 华北电力大学河北省电力物联网技术重点实验室河北保定071003 华北电力大学保定市光纤传感与光通信技术重点实验室河北保定071003

针对单端布里渊光时域分析(BOTDA)系统存在噪声大、信噪比较低等不足,提出一种基于经验模态分解的降噪方法。理论分析经验模态分解的降噪原理和少模光纤单端布里渊光时域分析传感原理,通过搭建的单端结构布里渊光时域分析温度传感系统,... 详细信息

针对单端布里渊光时域分析(BOTDA)系统存在噪声大、信噪比较低等不足,提出一种基于经验模态分解的降噪方法。理论分析经验模态分解的降噪原理和少模光纤单端布里渊光时域分析传感原理,通过搭建的单端结构布里渊光时域分析温度传感系统,对经验模态分解的降噪效果进行对比分析。实验和仿真结果表明,经验模态分解算法对温度传感系统具有良好的降噪效果,降噪后信噪比提升了约3.06dB,温度测量精度提升了约0.98℃。

关键词：布里渊光时域分析经验模态分解温度传感降噪方法

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采供血机构开展医学伦理审查的探索与思考

临床输血与检验 2024年第5期26卷 702-708页

作者：刘紫娟王婷张立波傅强何成涛张春南京红十字血液中心江苏210003

目前国内越来越多的采供血机构陆续开展涉及人的生命科学与医学研究,这就要求机构设立医学伦理委员会对其进行伦理审查,以确保医学研究试验的设计和实施合乎道德和法律,同时保护受试者的安全、健康、隐私等权益。本研究结合采供血机构... 详细信息

目前国内越来越多的采供血机构陆续开展涉及人的生命科学与医学研究,这就要求机构设立医学伦理委员会对其进行伦理审查,以确保医学研究试验的设计和实施合乎道德和法律,同时保护受试者的安全、健康、隐私等权益。本研究结合采供血机构的性质与特点,以南京红十字血液中心伦理委员会为例,探索采供血机构医学伦理委员会规范化建设中的经验与不足,并针对采供血机构以献血者血液样本及相关信息开展医学研究和采供血机构医疗器械临床试验的伦理审查提出思考,从而更好地保护受试者权益,促进采供血机构输血医学研究健康平稳发展。

关键词：采供血机构医学伦理委员会伦理审查医疗器械临床试验

Multimodal Omics Approaches to Aging and Age‑Related Diseases

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Phenomics 2024年第1期4卷 56-71页

作者： Qianzhao Ji Xiaoyu Jiang Minxian Wang zijuan Xin Weiqi Zhang Jing Qu Guang‑Hui liu State Key Laboratory of Membrane Biology Instituteof ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and ReproductiveBiology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academyof Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academyof SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China School of Future Technology University of ChineseAcademy of SciencesBeijing 100190China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for GeriatricDisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Centerfor Aging and CancerXuanwu HospitalCapital MedicalUniversityBeijing 100053China

Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated *** increasing body of experimental evidence shows that aging is a complex biological process coordinately regulated by multiple factors at diferent molecular ***,it is difcult to delineate the overall systematic aging changes based on single-layer ***,multimodal omics approaches,in which data are acquired and analyzed using complementary omics technologies,such as genomics,transcriptomics,and epigenomics,are needed for gaining insights into the precise molecular regulatory mechanisms that trigger *** recent years,multimodal omics sequencing technologies that can reveal complex regulatory networks and specifc phenotypic changes have been developed and widely applied to decode aging and age-related *** review summarizes the classifcation and progress of multimodal omics approaches,as well as the rapidly growing number of articles reporting on their application in the feld of aging research,and outlines new developments in the clinical treatment of age-related diseases based on omics technologies.

关键词： Multimodal omics approaches Aging Genome Epigenome

Wavefield Separation of Distributed Acoustic Sensing Vertical Seismic Profile Data Based on Multichannel Vector Median Filtering

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Journal of Earth Science 2024年第2期35卷 712-716页

作者： zijuan Ma Jun Lu Feng Zhang Pinbo Ding Zhidong Cai Key Laboratory of Intraplate Volcanoes and Earthquakes Ministry of EducationChina University of GeosciencesBeijing 100083China College of Geophysics China University of PetroleumBeijing 102249China New Resources Geophysical Exploration Division BGP Inc.CNPCZhuozhouHebei 072751China

INTRODUCTION Distributed acoustic sensing(DAS)is a novel and popular technology for vertical seismic profile(VSP)data acquisition because of its many advantages,including full vertical coverage,high sampling density,low cost,and resistance to stressors(high temperature and pressure).The current industrial application of DAS in borehole exploration acquires single-mode *** records strain rates,which are then converted to particle velocities by the modem before being written to the disk.

关键词： Seismic Vertical borehole

Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging

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Protein & Cell 2024年第8期15卷 612-632页

作者： Qinchao Hu Bin Zhang Yaobin Jing Shuai Ma Lei Hu jingyi Li Yandong Zheng zijuan Xin Jianmin Peng Si Wang Bin Cheng Jing Qu Weiqi zhang Guang-Hui liu Songlin Wang State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou 510060China Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Laboratory of Oral Health and Beijing Stomatological HospitalCapital Medical UniversityBeijing 100050China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuan Wu HospitalCapital Medical UniversityBeijing 100053China Intemational Center for Aging and Cancer Hainan Medical UniversityHaikou 571199China Aging Biomarker Consortium Beijing 100101China

Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis,a worldwide prevalent inflammatory ***,a systematic characterization and comprehensive understanding of the regulatory mechanism underlying gingival aging is still ***,we systematically dissected the phenotypic characteristics of gingiva during aging in primates and constructed the first single-nucleus transcriptomic landscape of gingival aging,by which a panel of cell type-specific signatures were *** cells were identified as the most affected cell types by aging in the *** analyses pinpointed the crucial role of YAP in epithelial self-renew and homeostasis,which declined during aging in epithelial cells,especially in basal *** decline of YAP activity during aging was confrmed in the human gingival tissues,and downregulation of YAP in human primary gingival keratinocytes recapitulated the major phenotypic defects observed in the aged primate gingiva while overexpression of YAP showed rejuvenation *** work provides an in-depth understanding of gingival aging and serves as a rich resource for developing novel strategies to combat aging-associated gingival diseases,with the ultimate goal of advancing periodontal health and promoting healthy aging.

关键词： single-nucleus RNA-sequencing primate gingiva aging YAP

Integrated assessment of yield,nitrogen use efficiency and ecosystem economic benefits of use of controlled-release and common urea in ratoon rice production

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Journal of Integrative Agriculture 2024年第9期23卷 3186-3199页

作者： zijuan Ding Ren Hu Yuxian Cao Jintao Li Dakang Xiao Jun Hou Xuexia Wang College of Agriculture Yangtze University/MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River(Co-construction by Ministry and Province)Jingzhou 434025China College of Life Science Yangtze UniversityJingzhou 434025China Institute of Plant Nutrition Resources and EnvironmentBeijing Agricultural Forestry Academy SciencesBeijing 100097China

Controlled-release urea(CRU)is commonly used to improve the crop yield and nitrogen use efficiency(NUE).However,few studies have investigated the effects of CRU in the ratoon rice *** rice is the practice of obtaining a second harvest from tillers originating from the stubble of the previously harvested main *** this study,a 2-year field experiment using a randomized complete block design was conducted to determine the effects of CRU on the yield,NUE,and economic benefits of ratoon rice,including the main crop,to provide a theoretical basis for fertilization of ratoon *** experiment included four treatments:(i)no N fertilizer(CK);(ii)traditional practice with 5 applications of urea applied at different crop growth stages by surface broadcasting(FFP);(iii)one-time basal application of CRU(BF1);and(iv)one-time basal application of CRU combined with common urea(BF2).The BF1 and BF2 treatments significantly increased the main crop yield by 17.47 and 15.99%in 2019,and by 17.91 and 16.44%in 2020,respectively,compared with FFP *** BF2 treatment achieved similar yield of the ratoon crop to the FFP treatment,whereas the BF1 treatment significantly increased the yield of the ratoon crop by 14.81%in 2019 and 12.21%in 2020 compared with the FFP *** BF1 and BF2 treatments significantly improved the 2-year apparent N recovery efficiency,agronomic NUE,and partial factor productivity of applied N by 11.47-16.66,27.31-44.49,and 9.23-15.60%,respectively,compared with FFP *** BF1 and BF2 treatments reduced the chalky rice rate and chalkiness of main and ratoon crops relative to the FFP ***,emergy analysis showed that the production efficiency of the BF treatments was higher than that of the FFP *** BF treatments reduced labor input due to reduced fertilization times and improved the economic benefits of ratoon *** with the FFP treatment,the BF1 and BF2 treatments increased the net income by 14.21-16

关键词： ratoon rice controlled-release urea yield nitrogen use efficiency economic benefit

二甲双胍联合门冬胰岛素注射液治疗儿童1型糖尿病的有效性评价

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智慧健康 2022年第6期8卷 85-87页

作者：刘子绢云南省曲靖市第一人民医院内分泌代谢科云南曲靖655000

目的探讨对儿童1型糖尿病患者采取二甲双胍+门冬胰岛素注射液进行治疗有效性以及可行性。方法将我院2017年7月-2020年4月收治的88例儿童1型糖尿病患者数字奇偶法分组;联合用药组(44例):采用二甲双胍+门冬胰岛素注射液展开糖尿病治疗;单... 详细信息

目的探讨对儿童1型糖尿病患者采取二甲双胍+门冬胰岛素注射液进行治疗有效性以及可行性。方法将我院2017年7月-2020年4月收治的88例儿童1型糖尿病患者数字奇偶法分组;联合用药组(44例):采用二甲双胍+门冬胰岛素注射液展开糖尿病治疗;单一用药组(44例):采用门冬胰岛素注射液展开糖尿病治疗;就组间低血糖发生次数、胰岛素日用量、血糖达标时间、住院天数、不同时间段2hBG水平、FBG水平以及总不良反应率展开对比。结果联合用药组儿童1型糖尿病患者低血糖发生次数、胰岛素日用量少于单一用药组明显,血糖达标时间、住院天数短于单一用药组明显(P0.05),治疗后,联合用药组2hBG、FBG水平低于单一用药组明显(P<0.05);两组儿童1型糖尿病患者不良反应集中于低血糖、腹泻以及恶心呕吐几方面;最终发现联合用药组总不良反应率(2.27%)低于单一用药组(15.91%)明显(P<0.05)。结论二甲双胍+门冬胰岛素注射液药物有效应用,可实现儿童1型糖尿病患者低血糖发生次数、胰岛素日用量减少,血糖达标时间、住院天数缩短,2hBG水平、FBG水平降低以及不良反应减少,最终实现儿童1型糖尿病患者有效预后。

关键词：二甲双胍门冬胰岛素注射液儿童1型糖尿病低血糖胰岛素日用量血糖达标时间住院天数 2hBG水平 FBG水平不良反应

中国康养旅游政策的央地互动逻辑及地方响应异质性

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西南交通大学学报（社会科学版） 2022年第2期23卷 12-23页

作者：刘紫娟陈秋萍华侨大学旅游学院

“健康中国”发展战略下,康养旅游成发展大势,中央和各级地方政府在政策上的互动也成为产业发展的关注点。运用文本分析法对我国中央与地方多份康养旅游政策进行央地互动逻辑剖析和地方响应解读,发现:问题源流、政治源流、政策源流共同... 详细信息

“健康中国”发展战略下,康养旅游成发展大势,中央和各级地方政府在政策上的互动也成为产业发展的关注点。运用文本分析法对我国中央与地方多份康养旅游政策进行央地互动逻辑剖析和地方响应解读,发现:问题源流、政治源流、政策源流共同推进我国康养旅游政策发展,可分为“顶层设计—示范推行—提质升级”三个阶段;“自下而上”的试点与“自上而下”的推行相呼应是我国康养旅游政策发展的重要方式;康养旅游政策发展在东、中、西部间既存在共同取向又有所差异,体现了政策响应的在地性。因此,应积极构建央地政府间常态化的反馈机制,以提高央地互动的紧密性、及时性和系统性,加强精细化专项政策指导,同时以需求为导向动态调整和优化产业政策。

关键词：康养旅游央地互动政策响应产业升级政策变迁旅游业顶层设计扎根理论