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伴8号染色体三体的儿童克罗恩病1例报告

中国当代儿科杂志 2024年第9期26卷 982-985页

作者：邢娇徐娟刘志峰程卫霞南京医科大学附属儿童医院消化科上海交通大学医学院附属新华医院

患儿男，12岁，反复肛周脓肿10年余，伴有反复口腔溃疡及手足关节变形，胃肠镜、胶囊内镜检查结果示消化道多发溃疡，结合组织病理等检查，诊断为克罗恩病。全外显子组测序及外周血染色体核型分析示染色体核型为47,XY,+8，予以升阶梯方... 详细信息

患儿男，12岁，反复肛周脓肿10年余，伴有反复口腔溃疡及手足关节变形，胃肠镜、胶囊内镜检查结果示消化道多发溃疡，结合组织病理等检查，诊断为克罗恩病。全外显子组测序及外周血染色体核型分析示染色体核型为47,XY,+8，予以升阶梯方案进行治疗，患儿临床症状得到控制，内镜下表现显著好转。该病例提示，极早发型炎症性肠病具有遗传易感性，当伴有其他多系统受累时，需考虑存在染色体异常的可能，如8号染色体三体，应引起重视。[中国当代儿科杂志，2024,26 (9):982-985]

关键词：克罗恩病 8号染色体三体极早发型炎症性肠病肛周脓肿儿童

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临沂市河湖采砂监管主要做法与新问题对策

海河水利 2024年第1期 64-66页

作者：刘春伟刘志峰临沂市水利工程保障中心山东临沂276000 山东省海河淮河小清河流域水利管理服务中心山东济南250100

以临沂市河湖采砂管理为例,结合新形势下河湖采砂管理现状和管理做法,分析了当前出现的新问题,提出了强化河湖采砂管理的几点建议,可为下一步做好河湖采砂监管工作提供参考。

关键词：河湖采砂监管临沂市

基于FNN的城市景观照明智能节能控制方法仿真

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计算机仿真 2024年第4期41卷 489-493页

作者：石海啸刘志锋江苏大学江苏镇江212000 江苏大学计算机科学与通信工程学院江苏镇江212000

为了降低景观照明用电能耗,提升节能效果,提出基于FNN的城市景观照明智能节能控制方法。分析城市景观照明需求,依据分析结果建立景观照明区域划分模型,利用上述模型将城市景观照明区域划分为开启区域和关闭区域,并在开关区域之间建立缓... 详细信息

为了降低景观照明用电能耗,提升节能效果,提出基于FNN的城市景观照明智能节能控制方法。分析城市景观照明需求,依据分析结果建立景观照明区域划分模型,利用上述模型将城市景观照明区域划分为开启区域和关闭区域,并在开关区域之间建立缓冲区域,规避城市景观照明控制时出现的延迟误差问题;采集景观照明设备运行状态数据,通过FNN网络对其实施训练学习,获取完整的设备状态数据集;基于获取的数据集通过模糊神经网络设计节能控制器,并利用以上节能控制器实现城市景观照明智能节能控制。实验结果表明,使用该方法对景观照明开展智能节能控制时,调光时长、照明时间以及用电能耗均得到了良好控制,说明其能够满足照明节能需求。

关键词：模糊神经网络城市景观智能节能控制节能控制器照明区域划分模型

Molecularly Imprinted Polymers on Chloromethyl Polystyrene Resin Prepared via RAFT Polymerization

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Chinese Chemical Letters 2006年第4期17卷 549-552页

作者： Zhen Xia DU Hong liu zhi feng FU Wan Tai YANG Key Laboratory for Controlled Chemical Reactions of Education Ministry Beijing University of Chemical Technology Beijing 100029

Surface molecularly imprinted polymers （SMIP） was prepared via the reversible addition-fragmentation chain transfer （RAFT） polymerization on the chloromethyl polystyrene resin （CPR） in the presence of the template D-phenylalanine. The structure of SMIP was characterized by FTIR and SEM. The adsorption behavior of D-phenylalanine of SMIP was preliminarily investigated.

关键词： Surface molecularly imprinted polymers reversible addition-fragmentation chain transfer.

Synthesis of Highly Branched Poly(ε-caprolactone) by Self-condensing Atom Transfer Radical Polymerization of Macroinimers

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Chinese Chemical Letters 2006年第3期17卷 373-376页

作者： Rui Xue liu Yan SHI zhi feng FU Shu Ke JIAO Key Laboratory of Science and Technology of Controllable Chemical Reactions Ministry of Education Beijing University of Chemical Technology Beijing 100029

Branched poly（ε-capmlactone） was synthesized by self-condensing atom transfer radical polymerization of macroinimer, α-acryloyoxy-ω-2-bromopropionyloxy poly（ε-caprolactone）, which was prepared by enzyme-catalyzed ring-opening polymerization of ε-caprolactone with 2-hydroxylethyl acrylate as initiator and esterification of the ω-hydroxyl group of the obtained poly（ε-caprolactone） by 2-bromopropionyl bromide.

关键词： Self-condensing vinyl polymerization atom transfer radical polymerization branched polymers poly(ε-caprolactone).

Astragalus extract inhibits destruction of gastric cancer cells to mesothelial cells by anti-apoptosis

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World Journal of Gastroenterology 2009年第5期15卷 570-577页

作者： Di Na Fu-Nan liu zhi-feng Miao Zong-Min Du Hui-Mian Xu Department of Oncology The First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China

AIM： To determine the inhibitory effect of Astragalus memebranaceushas on gastric cancer cell supernatant- induced apoptosis of human peritoneal mesothelial cells. METHODS： Human peritoneal mesothelial cell （HPMC） line HMrSV5 was co-incubated with gastric cancer cell supernatant （MKN45） and/or Astragalus memebranaceushas. Morphological changes in gastric cancer cells were observed under phase-contrast microscope. Quantitative cell damage was determined by MTT assay. Apoptosis was determined under transmission electron microscope and quantified by detectinr, acridine orange/ethidium bromide-stained （AO/EB） condensed nuclei under fluorescent microscope or by flow cytometry. Expressions of Bcl-2 and Bax were evaluated with immunostaining.

关键词： Peritoneal carcinomatosis Stomachneoplasm Astragalus plant Mesothelial cell Apoptosis

Determination of oropharyngeal pathogenic colonization in the elderly community

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Chinese Medical Journal 2009年第3期122卷 315-318页

作者： WANG Shuang LI Dong CHU Yun-zhuo ZHU Li-ying liu feng-zhi Department of General Practice First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Infectious Diseases First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Clinical Laboratory First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Training Center for General Practitioners First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China

Background Pneumonia has become the predominant cause of death for the elderly. It is critical to determine the status of oropharyngeal pathogen colonization in the elderly when treating pneumonia. To explore the efficient approaches to treat age-related pneumonia, we determined the status of oropharyngeal pathogenic colonization in the elderly community. Methods Throat swab cultures were used to isolate oropharyngeal pathogens from 706 residents older than 65 years living in the community of Shenyang City. Characteristics of bacterial strains were sorted and identified using drug sensitivity tests. Results Results of bacterial identification showed that 265 out of 706 samples were positive, thereby exhibiting a 37.5% positive rate. There were 290 bacterial strains isolated from the elderly community in total, of which 248 strains were gram-negative bacilli （GNB） and 42 strains were gram-positive cocci （GNC）, accounting for 85.5% and 14.5%, respectively. There were 158 Klebsiella pneumoniae strains, representing 54.4% of the all GNB. Conclusion The rate of oropharyngeal GNB colonization in the elderly community increases and Klebsiella pneumoniae is the most common strain.

关键词： bacterial colonization elderly community pneumonia

IoT-enabled energy efficiency monitoring and analysis method for energy saving in sheet metal forming workshop

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Journal of Central South University 2022年第1期29卷 239-258页

作者： GAN Lei HUANG Hai-hong LI Lei XIONG Wei liu zhi-feng Key Laboratory of Green Design and Manufacturing of Machinery Industry Hefei University of TechnologyHefei 230009China School of Mechanical Engineering Hefei University of TechnologyHefei 230009China

Sheet metal forming,as a typical energy-intensive process,consumes massive *** to the significant difference between sheet metal forming and machining,manufacturers still lack an effective method to monitor and analyze the energy efficiency in the sheet metal forming *** this end,an energy efficiency monitoring and analysis(EEMA)method,which is supported by Internet of Things(IoT),is *** characteristics in a forming workshop are first analyzed,and then the architecture of the method is *** efficiency indicators at machine level,process level,and workshop level are defined,***,a sheet metal forming workshop for the deformation of panels of forklift was investigated to validate the effectiveness and benefits of the proposed *** the application of the IoT-enabled method,various energy-saving decisions can be made by the management of the enterprises for energy efficiency improvement and energy consumption reduction(EEIECR)in the sheet metal forming workshop.

关键词： sheet metal forming workshop energy efficiency monitoring Internet of Things(IoT)

红鳍东方鲀(Takifugu rubripes)耐低温性状和生长性状遗传参数评估

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海洋与湖沼 2024年第2期55卷 517-525页

作者：赵海池刘志峰王新安包玉龙刘圣聪杨明超闫鹏飞马爱军海水养殖生物育种与可持续产出全国重点实验室、中国水产科学研究院黄海水产研究所、中国-东盟海水养殖技术“一带一路”联合实验室(青岛) 山东青岛266071 上海海洋大学水产与生命学院上海201306 唐山牧海水产养殖有限公司河北唐山063205

采用人工控温的方式,对构建的31个F1红鳍东方鲀(Takifugu rubripes)全同胞家系开展低温胁迫实验,获得耐低温性状低温累计存活时间(CDH),基于混合线性模型分别开展耐低温性状和生长性状遗传参数评估,对每一性状是否需要考虑共同环境效应... 详细信息

采用人工控温的方式,对构建的31个F1红鳍东方鲀(Takifugu rubripes)全同胞家系开展低温胁迫实验,获得耐低温性状低温累计存活时间(CDH),基于混合线性模型分别开展耐低温性状和生长性状遗传参数评估,对每一性状是否需要考虑共同环境效应所构建的两种模型进行似然比检验。结果显示,经似然比检验,最终选用模型A和模型BF进行耐低温和生长性状遗传评估;耐低温性状CDH遗传力为(0.27±0.08),属于中等遗传力;体重BW遗传力为(0.36±0.13),属于中等遗传力,体长BL遗传力为(0.14±0.06),属于低等遗传力,经检验,遗传力估计值均达到极显著水平(P<0.01)。CDH和体重、体长的遗传相关分别为(–0.40±0.22)和(–0.44±0.24),表型相关分别为(–0.09±0.06)和(–0.16±0.05),均为负相关;体重和体长之间的遗传相关为(0.92±0.05),表型相关为(0.80±0.02),呈正相关且结果极显著(P<0.01)。研究结果表明,红鳍东方鲀的耐低温性状和生长性状都具有较好的改良潜力,考虑到两性状间存在负遗传相关,在开展耐低温选育时,对首先不同性状进行品系选育,然后利用品系间杂交培育出耐高温、生长快的新品种。该项研究首次完成了红鳍东方鲀耐低温性状的遗传参数评估,为制订红鳍东方鲀耐低温选育育种规划提供了理论依据。

关键词：红鳍东方鲀(Takifugu rubripes) 耐低温性状遗传力遗传相关