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乌苏烷型五环三萜的生物合成研究进展

中国医药生物技术 2024年第3期19卷 223-230页

作者：张璐肖瑶刘忞之王伟中国医学科学院药物研究所天然药物活性物质与功能国家重点实验实验室/国家卫生健康委员会天然药物生物合成重点实验室北京100050

乌苏烷型五环三萜化合物是三萜化合物的一种重要类型,具有抗肿瘤、抗炎、抑菌、降糖、降脂等药理活性,可用于医药保健等领域。目前主要的生产方式是从植物中直接提取和化学合成,但限于资源短缺、产率低、成本高等问题。近年来,运用合成... 详细信息

乌苏烷型五环三萜化合物是三萜化合物的一种重要类型,具有抗肿瘤、抗炎、抑菌、降糖、降脂等药理活性,可用于医药保健等领域。目前主要的生产方式是从植物中直接提取和化学合成,但限于资源短缺、产率低、成本高等问题。近年来,运用合成生物学技术,模块化处理目标化合物的代谢途径,为乌苏烷型三萜化合物的大规模生产提供了解决方案。本文综述了近年来乌苏烷型五环三萜生物合成的研究进展,包括乌苏烷型五环三萜骨架的天然生物合成、后修饰酶以及利用代谢工程调控乌苏烷型五环三萜异源高效生产的策略,以期为乌苏烷型五环三萜的高效合成提供借鉴。

关键词：乌苏烷型五环三萜生物合成合成生物学代谢工程

农产品质量安全检验检测体系建设的必要性及措施分析

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中国标准化 2024年第8期 189-193页

作者：燕娜娜周宏霞刘志敏崔敏荣成市检验检测中心威海市食品药品检验检测研究院山东时进检测服务有限公司

打造完善适宜的农产品质量安全检验检测体系能够进一步提升各地区农业执法能力,切实保证农产品的安全性,不断提升农产品品质,这对农业以及整个社会的稳定健康发展均有重要意义。本文首先对农产品质量安全检验检测工作现状做出了简要介绍... 详细信息

打造完善适宜的农产品质量安全检验检测体系能够进一步提升各地区农业执法能力,切实保证农产品的安全性,不断提升农产品品质,这对农业以及整个社会的稳定健康发展均有重要意义。本文首先对农产品质量安全检验检测工作现状做出了简要介绍,然后分析了建设农产品质量安全检验检测体系的必要性,最后从经费支持、挖掘问题以及制度体系等多个方面提出了具体的建设措施,以期助推我国农产品质量安全检验检测活动不断向好发展。

关键词：农产品健康发展质量安全监管改进检验检测体系

Propagation of hermite-cosh-gaussian beams passing through ABCD optical system with an annular aperture

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Optoelectronics Letters 2008年第1期4卷 78-80页

作者： TANG Bin JIANG Xing-fang liu zhi-min School of Mathematics & Physics Jiangsu Polytechnic University Changzhou 213016 China School of Natural Science East China Jiaotong University Nanchang 330013 China

By using the expansion of the aperture function into a finte sum of complex Gaussian functions, the corresponding analytical expressions of Hermite-cosh-Gaussian beams passing through annular apertured paraxially and symmetrically optical systems written in terms of ABCD matrix were derived, and they could reduce to the cases with squared aperture. In a similar way, the corresponding analytical expres- sions of cosh-Gaussian beams through annular apertured ABCD matrix were also given. The method could save more calculation time than that by using the diffraction integral formula directly.

关键词： ABCD光学系统高斯光束光传播环孔径

Contrast Dose and Radiation Dose Reduction in Abdominal Enhanced Computerized Tomography Scans with Single-phase Dual-energy Spectral Computerized Tomography Mode for Children with Solid Tumors

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Chinese Medical Journal 2017年第7期130卷 823-831页

作者： Tong Yu Jun Gao zhi-min liu Qi-Feng Zhang Yong liu Ling Jiang Yon Peng Imaging Center Beijing Children's Hospital Capital Medical University Beijing 100045 China

Background：Contrast dose and radiation dose reduction in computerized tomography （CT） scan for adult has been explored successfully,but there have been few studies on the application of low-concentration contrast in pediatric abdominal CT *** was a feasibility study on the use of dual-energy spectral imaging and adaptive statistical iterative reconstruction （ASiR） for the reduction of radiation dose and iodine contrast dose in pediatric abdominal CT patients with solid ***：Forty-five patients with solid tumors who had initial CT （Group B） and follow-up CT （Group A） after chemotherapy were *** initial diagnostic CT scan （Group B） was performed using the standard two-phase enhanced CT with 320 mgI/ml concentration contrast,and the follow-up scan （Group A） was performed using a single-phase enhanced CT at 45 s after the beginning of the 270 mgI/ml contrast injection using spectral *** percent ASiR was used for the images in Group B and monochromatic images with energy levels ≥60 keV in Group *** addition,filtered back-projection （FBP） reconstruction was used for monochromatic images 〈60 keV in Group *** total radiation dose,total iodine load,contrast injection speed,and maximum injection pressure were compared between the two *** 40 keV and 60 keV spectral CT images of Group A were compared with the images of Group B to evaluate overall image ***：The total radiation dose,total iodine load,injection speed,and maximum injection pressure for Group A were decreased by 19%,15%,34.4%,and 18.3%,*** optimal energy level in spectral CT for displaying the abdominal vessels was 40 *** this level,the CT values in the abdominal aorta and its three branches,the portal vein and its two branches,and the inferior vena cava were all greater than 340 hounsfield unit （HU）.The abdominal organs of Groups A and B had similar degrees of absolute and relative enhancement （t =0.36 and-1.716 for liver,0.153 and-1.546

关键词： Contrast Dose Reduction Pediatric Radiation Dose Reduction Solid Tunlors

Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats

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Chinese Medical Journal 2012年第20期125卷 3675-3680页

作者： WANG Huai-qing ZOU Jun-jie ZHOU Xiang-hai JI Li-nong liu zhi-min Department of Endocrinology and Metabolism Peking University People's HospitalPeking University Diabetes CenterBeijing 100044China Department of'Endocrinology and Metabolism First People's Hospital of YichangChina Three Gorges UniversityYichangHubei 443000China Department of Endocrinology'and Metabolism Changzheng HospitalSecondary Military Medical UniversityShanghai 200003China

Background Oxidative stress has been implicated in the onset and progression of diabetes. Tongxinluo is a traditional Chinese medicine with potent antioxidant properties. The aim of this study was to test the hypothesis that pretreatment with Tongxinluo has similar effects as melatonin on preventing hyperglycemia and beta-cell damage in a rat model of streptozotocin （STZ）-induced diabetes. Methods Forty male Sprague Dawley rats were randomly assigned to four groups （n=10 each）： normal control （NC） group; STZ group （70 mg/kg, i.p.）; Tongxinluo （1.0 g-kg-^-d-1） pretreated （TXL＋STZ） group and melatonin （200 iJg-kg-~.d-1） pretreated （MLT＋STZ） group. Tongxinluo and melatonin were administered by gavage beginning 8 days before STZ injection and continuing until the end of the study （15 days after STZ administration）. Blood glucose levels and body weights, malondialdehyde （MDA）, and reduced glutathione （GSH） levels were measured, and immunofluorescence studies were performed in all of the groups. Results Pretreatment with Tongxinluo, as with melatonin, attenuated severe hyperglycemia and weight loss induced by STZ.. In pancreatic homogenates, MDA levels were significantly lower and GSH levels were significantly higher in Tongxinluo pretreated group and in melatonin pretreated group than those in STZ group. Values of insulin staining were significantly improved in Tongxinluo pretreated group and in melatonin pretreated group as compared with those in STZ group. Conclusions Tongxinluo, as melatonin, prevented hyperglycemia and beta-cell destruction induced by STZ in rats through reducing oxidative stress in pancreatic tissues. Tongxinluo may provide an alternative therapy for the prevention and treatment of diabetes.

关键词： Tongxinluo streptozotocin diabetes," oxidative stress," antioxidants beta-cell function

Ningbo thyroid dysfunction prevalence study： a cross-sectional survey in an employees-cohort

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Chinese Medical Journal 2010年第13期123卷 1673-1678页

作者： MAO Yu-shan liu zhi-min CHEN Chang-xi ZHU Zhong-wei HONG Zhong-li Department of Endocrinology Shanghai Changzheng Hospital Second Affiliated Hospital of Second Military Medical University Shanghai 200003 China Department of Internal Medicine Zhenhai Lianhua Hospital Ningbo Zhejiang 315207 China Department of Cardiology Affiliated Hospital of Ningbo University Ningbo Zhejiang 315003 China

Background The prevalence and the spectrum of thyroid dysfunction in the mainland of China are not adequately understood. We performed a population-based study to determine the prevalence of major thyroid dysfunctions including overt and subclinical hyper- and hypothyroidism in a stable cohort. Methods All active and retired employees aged 20 years and older （11 067） of Sinopec Zhenhai Refining ＆ Chemical Company in Ningbo participated in the cross-sectional survey with a questionnaire and blood samples. Results A total of 10 405 individuals attended for screening. Using biochemical definitions 95.5% were euthyroid. The prevalence of former diagnosed hyperthyroidism was 1.1% in females and 0.4% in males, hypothyroidism 1.7% and 0.3%, and thyroid surgery 1.2% and 0.3%, respectively. In both sex the prevalence increased with age. Twenty-four percent of individuals with thyroid surgery or medications had abnormal thyroid-stimulating hormone （TSH） levels. In individuals without a history of thyroid disease, the prevalence of pathological TSH values in females and males were TSH 〉10 mU/L 0.60% and 0.29%; TSH 4.8-9.9 mU/L 5.71% and 2.25%; TSH 〈0.3 mU/L 0.87% and 0.41%, respectively. Overt hyper- and hypothyroidism were uncommon （0.2%, 0.3%, respectively）. The prevalence of subclinical hyper- and hypothyroidism was 0.4% and 3.4%, respectively. Subclinical hypothyroidism was more common in females （male 2.4% vs. female 5.8%, P 〈0.001） and with increasing age （P 〈0.001）. Conclusions The prevalence of thyroid dysfunction is 4.5% in the cohort. Among individuals with thyroid medications or surgery, only 75.7% were within the normal range of TSH. These results indicate that thyroid dysfunction is common in Chinese adults.

关键词： thyroid dysfunction thyroid-stimulating hormone epidemiology

Remove cooking fume using catalytic combustion over Pt/La-Al_2O_3

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Journal of Environmental Sciences 2007年第6期19卷 644-646页

作者： WANG Jian-li ZHONG Jun-bo GONG Mao-chu liu zhi-min ZHAO ming CHEN Yao-qiang College of Chemistry Sichuan University Chengdu 610064 Sichuan ChinaI

Five monolithic catalysts with low noble metal content were prepared by irnmerge method （Pt/γ=Al2O3, Pt/La-Al2O3, Pt/YSZ-AI203, Pt＋Pd/La-Al2O3 and Pd/La-Al2O3） and their activity measurements were carried out in a conventional fixed-bed flow reactor. The results show that La-Al2O3 can promote activity of the prepared catalysts and can decrease the complete conversion temperature of cooking fume. The Pt/La-Al2O3 catalyst has the highest activity and can be applied in wide range of gas hourly space velocity （GHSV）. Some characterizations （XRD, TPR） were carried out with the objective to explain differences in catalytic behaviors. The prepared catalyst showed a great potential for application.

关键词： cooking fume monolithic catalyst remove catalytic combustion

Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

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Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI zhi-min WANG Xia liu Xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

Thrice-daily biphasic insulin aspart 30 may be another therapeutic option for Chinese patients with type 2 diabetes inadequately controlled with oral antidiabetic agents

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Chinese Medical Journal 2009年第14期122卷 1704-1708页

作者： YANG Wen-ying JI Qiu-he ZHU Da-long YANG Jin-kui CHEN Lu-lu liu zhi-min YU De-min YAN Li Department of Endocrinology China-Japan Friendship HospitalBeijing 100029 China Department of Endocrinology Xijing Hospital Affiliated to 4thMilitary Medical University Xi'an Shaanxi 710032 China Department of Endocrinology Nanjing Drum Tower HospitalNanjing Jiangsu 210008 China Department of Endocrinology Beijing Tongren Hospital Beijing100730 China Department of Endocrinology Wuhan Union Hospital WuhanHubei 430022 China Department of Endocrinology Shanghai Changzheng HospitalShanghai 200003 China Department of Endocrinology Metabolic Disease HospitalAffiliated to Tianjin Medical University Tianjin 300070 China Department of Endocrinology Sun Yat-sen Memorial HospitalAffiliated to Zhongshan University Guangzhou Guangdong 510120 China

In subjects with type 2 diabetes inadequately controlled with oral antidiabetic agents （OADs）, insulin therapy is usually started to improve glycaemic control after failure of diet, exercise and OADs.1 Although there is no standard way to introduce insulin treatment, premixed formulations are a popular option. They offer an alternative to basal-bolus therapy and provide basal and prandial coverage with a single injection. Indeed, Koivisto et al2 in 1999 reported that 39% of patients with type 2 diabetes worldwide used premixed insulin as part of their therapeutic regimen, The modern premixed insulins, such as biphasic insulin aspart 30 （BIAsp 30） are most frequently prescribed twice-daily （BID） in clinical practice. However,

关键词： biphasic insulin aspart 30 diabetes mellitus, type 2 weight gain hypoglycaemia China