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MMP-9 deficiency accelerates the progress of periodontitis

Genes & Diseases 2024年第5期11卷 117-121页

作者： Chun-Yan Wan Yixin Yin Xiaoyan Li Meng Meng liu Graham Goldman Li-An Wu Feng wang Dao-{2. Luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey Zhi Chen {2.o Chen Department of Endodontics The Affiliated Hospital of Qingdao UniversitySchool of StomatologyQingdao UniversityQingdaoShandong 266003China Department of Developmental Dentistry School of DentistryThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Oral Implantology Center Jinan Stomatological HospitalJinanShandong 250001China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong Key Laboratory of Oral Tissue RegenerationShandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationShandong UniversityJinanShandong 250012China Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China Laboratory of Clinical Applied Anatomy Department of Human AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian 350108China Key Laboratory for Oral Biomedical Research of Zhejiang Province Affiliated Hospital of StomatologyMedical CollegeZhejiang UniversityHangzhouZhejiang 310027China Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China UBC Faculty of Dentistry University of British ColumbiaVancouverBC V6T 1Z3Canada school of Graduate Studies and Research Meharry Medical College and Research BiologistResearch Service Nashville VA Medical CenterNashvilleTN 37208USA State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST) Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM)School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone *** one-half of adults in the United States older than 30 years have periodontal disease.2.Though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the *** periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关键词： period eventually untreated

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广义Julia集的参数辨识

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物理学报 2011年第7期60卷 120-128页

作者：孙洁刘树堂乔威山东大学控制科学与工程学院济南250061 山东大学威海分校机电与信息工程学院威海264209 山东大学威海分校实验室与设备管理处威海264209

本文研究了一类相当广泛的复系统Julia集的参数辨识问题.基于非线性反馈控制器和差分方程稳定性理论,设计了普遍适用的自适应同步控制器和参数自适应律的解析表达式.理论证明设计的控制器可使得此类广义复系统Julia集达到同步,并且可以... 详细信息

本文研究了一类相当广泛的复系统Julia集的参数辨识问题.基于非线性反馈控制器和差分方程稳定性理论,设计了普遍适用的自适应同步控制器和参数自适应律的解析表达式.理论证明设计的控制器可使得此类广义复系统Julia集达到同步,并且可以辨识广义Julia集的未知参数.通过仿真实例验证了该方法的有效性.另外,本文特别地讨论了最基本的Julia集的参数辨识问题.

关键词： Julia集参数辨识同步

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Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral Science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong He Jinlin Song Min Hu Yuehua liu Yan liu Jie Guo Fang Jin Yang Cao Lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan Huang Li Rui Zou Yulou Tian Li Gao Rui {2. Jianwei Chen Renkai liu {2.juan Zou Xiaobing Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&Hubei Key Laboratory of Stomatology&Department of Orthodontics&Center for Dentofacial Development and Sleep Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina Department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina Department of Orthodontic&Oral Biomedical Engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina Department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~2.0 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

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自走式果园割草机切割器的设计与试验

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山东农业大学学报（自然科学版） 2024年第2期55卷 244-253页

作者：邢刚王玲刘乐王术波青岛大学自动化学院山东青岛266000 青岛大学智能无人系统研究院山东青岛266000 中国农业大学工学院北京100083 北京市平谷区果品产业服务中心北京101200

山地丘陵果园障碍物密集、地形复杂,一般的切割器无法实现高效除草作业。本文结合传统果园行距、株距较小等特性,实地调研青岛山地丘陵地带果园地势起伏情况、杂草类型等,设计符合山地作业需求的自走式果园割草机切割器。通过对刀盘进... 详细信息

山地丘陵果园障碍物密集、地形复杂,一般的切割器无法实现高效除草作业。本文结合传统果园行距、株距较小等特性,实地调研青岛山地丘陵地带果园地势起伏情况、杂草类型等,设计符合山地作业需求的自走式果园割草机切割器。通过对刀盘进行模态分析以及运动学仿真,验证其结构合理性以及作业可靠性,并在青岛果园对切割器割草性能进行实地试验验证。结果显示实地作业的平均割茬高度为2..15 mm,割幅利用系数为98.96%,漏割损失率为1.54%。试验证明所设计的切割器能提高山地丘陵地形果园除草管理效率,降低除草劳动强度,满足果园除草的作业要求,对助力推动林果生产机械化的进一步提高具有重要意义。

关键词：切割器果园割草机模态分析运动学仿真田间割草试验

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Impact of Saturation Depth Ratio of Iron-Core on Operation Characteristics of PMFCL

Impact of Saturation Depth Ratio of Iron-Core on Operation C...

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11th International Conference on Electrical Machines and Systems

作者： Liang Zou~1,Yuan Ma~1,Hong-shun liu~1,Qing-min Li~1,shu-min Sun~2.1 school of Electrical Engineering,shandong {2.,jinan 2.0061,china 2.EPRI of shandong,jinan 2.002.,china.

＜正＞Fault Current Limiter Based on Permanent-Magnet Biased Saturation（PMFCL）is believed to foresee preferable application potentials in power systems due to its obvious advantages in both the technical and economical ***,it is necessary to improve and optimize the operational characteristics of a PMFCL as a result of the deep saturation magnetization effect of the iron-core.A new concept"saturation depth ratio"is then proposed in the paper to describe and quantify the saturation extent of the iron-core. Further,the impact of saturation depth ratio of the iron-core on the operational characteristics of the PMFCL is analyzed adequately and some methods for optimizing saturation depth ratio are thereby presented based on simulations and experiments,both results of which prove that the operational characteristics of the PMFCL can be improved considerably if an optimal saturation depth ratio is applied.

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陆地生态系统碳收支时空变化及影响因素——以湖南省郴州市为例

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长江流域资源与环境 2024年第5期33卷 1066-1075页

作者：杨卓琳刘荣波逄锦光王姝王诗涵冯徽徽中南大学地球科学与信息物理学院湖南长沙410083 山东省第四地质矿产勘察院山东潍坊261021

陆地生态系统碳收支不仅是衡量地表生态环境的重要参数,也是全球碳循环的关键变量。以国家低碳试点城市、可持续发展创新示范区——湖南省郴州市为研究区域,耦合多源遥感数据,结合土壤呼吸地统计模型、趋势分析、地理探测器和残差分析... 详细信息

陆地生态系统碳收支不仅是衡量地表生态环境的重要参数,也是全球碳循环的关键变量。以国家低碳试点城市、可持续发展创新示范区——湖南省郴州市为研究区域,耦合多源遥感数据,结合土壤呼吸地统计模型、趋势分析、地理探测器和残差分析等方法,系统开展了2.01~2.2.年植被净生态系统生产力(NEP)时空变化特征分析及影响因素探究。结果表明:(1)在时间上,2.01~2.2.年郴州市总体表现为碳汇,年均固碳总量达5.943×106 T Ca^(-1),NEP均值310.351 g Cm^(-2.,平均增长速率2.066 g Cm^(-2.a^(-1)。(2.在空间上,NEP总体呈西高东低、北高南低分布,显著增加(P2..100 g Cm^(-2.)>草地(318.650 g Cm^(-2.)>耕地(2.7.509 g Cm^(-2.)。(3)郴州市生态系统碳收支驱动机制复杂。NEP与气温、日照时数、相对湿度和高程等因子呈正相关,而与降水量和地表净辐射呈负相关,双因子对NEP空间分异性的交互作用明显高于单因子。(4)自然因子是郴州市植被NEP变化的主导因素(95.896%),但在城市边缘区等人类活动剧烈的区域,土地利用/覆被变化平均贡献率达59.761%。研究结果有助于准确把握区域陆地生态系统碳收支时空特征及其内在驱动机制,并为区域生态系统管理与可持续发展提供科学依据。

关键词：碳收支植被NEP 土地利用/覆被变化地理探测器土壤呼吸地统计模型

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Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： Ying-shuo wang Yun-Lian Zhou Guan-Nan Bai shu-Xian Li Dan Xu Li-Na Chen Xing Chen Xiao-Yan Dong Hong-Min Fu Zhou Fu Chuang-Li Hao Jian-Guo Hong En-Mei liu Han-Min liu Xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang Man Tian Yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-Lin Zhang De-Yu Zhao shun-Ying Zhao Guo-Hong Zhu Ying-Xue Zou Quan Lu Yuan-Yuan Zhang Zhi-Min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2.00,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 2. chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

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Proteomic Identification of Potential Protein Markers in CSF of Neuromyelitis Optica Patients

Proteomic Identification of Potential Protein Markers in CSF...

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2.08年全国生物化学与分子生物学学术大会

作者： shu-mei Bai~1 Shi-lian liu~1 Ban-qin {2.~1 Zhao-yu Qin~2.Xiao-hong Li~1 Yanjiang Qin~3 1 Institute of Biochemistry and molecular biology,school of Medicine,{2. university.jinan 2.0012.2.Biology Science Department in Marine College.{2. university at Weihai.Weihai 2.42.9 3 Department of Neurology,Qilu Hospital of shandong university,jinan 2.0012

Neuromyelitis optica(NMO),also termed Devic’s syndrome,is an idiopathic inflammatory demyelinating disease of the central nervous system(CNS)predominantly affecting optic nerves and spinal *** better investigate the ...

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灵敏的共振光散射测定核酸的新方法

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山东大学学报（理学版） 2004年第6期39卷 95-100页

作者：王峰杨景和吴霞刘淑芳山东大学化学与化工学院

在表面活性剂十六烷基三甲基溴化铵 (CTAB)存在下 ,姜黄素能与核酸发生作用 .研究表明 ,在pH =4 .3的BR(Britton Robinson)缓冲溶液中 ,核酸与阳离子表面活性剂CTAB可协同增强姜黄素的共振光散射 (RLS)强度 ,其增强程度与核酸的浓度在... 详细信息

在表面活性剂十六烷基三甲基溴化铵 (CTAB)存在下 ,姜黄素能与核酸发生作用 .研究表明 ,在pH =4 .3的BR(Britton Robinson)缓冲溶液中 ,核酸与阳离子表面活性剂CTAB可协同增强姜黄素的共振光散射 (RLS)强度 ,其增强程度与核酸的浓度在一定范围内呈良好的线性关系 .在最佳实验条件下 ,鱼精子脱氧核糖核酸 (fsDNA) ,小牛胸腺脱氧核糖核酸 (ctDNA)和酵母核糖核酸 (yRNA)的线性范围分别为 1～ 10 0 0mg L ,3～ 10 0 0mg L和1～ 10 0 0mg L ,检测限分别为 :0 .10 ,0 .30和 0 .2.5mg L .该方法已成功用于合成样品的测定 .

关键词：共振光散射核酸姜黄素 CTAB

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考虑温度效应的盾构刀盘黏附试验及堵塞防治

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岩土力学 2024年第8期45卷 2299-2310页

作者：王修伟李树忱刘祥坤万泽恩彭科峰山东大学岩土与地下工程研究院山东济南250014 山东大学齐鲁交通学院山东济南250002 中国矿业大学力学与土木工程学院江苏徐州221116

土压平衡盾构在黏性地层掘进时易产生刀盘结泥饼、堵塞等问题,不仅会导致排渣不畅降低掘进效率,并且频繁的开仓处理会增加工程风险,而掘进会产生大量热量影响土体黏附性。采用自主研发的刀盘旋转黏附试验系统,探究刀盘温度与含水率、黏... 详细信息

土压平衡盾构在黏性地层掘进时易产生刀盘结泥饼、堵塞等问题,不仅会导致排渣不畅降低掘进效率,并且频繁的开仓处理会增加工程风险,而掘进会产生大量热量影响土体黏附性。采用自主研发的刀盘旋转黏附试验系统,探究刀盘温度与含水率、黏土含量、黏土类型等因素联合作用下刀盘黏附效果,并分析了泡沫剂、抗黏剂在不同掺入比下堵塞防治效果。研究结果表明:温度升高会使得旋转扭矩与刀盘表面的土体黏附量降低,但会加速黏土硬化;土体含水率、黏土含量对于扭矩影响趋势相反,但对黏附量影响规律相同,随着土体含水率或黏土含量增加,黏附量先增加后降低,含水率在2.%、黏土含量在30%时黏附性最强;膨润土比高岭土黏附性更强;土体含水率、黏土含量与黏土类型对于黏附量的影响可以使用稠度指数进行表征,随着稠度增加黏附量会出现先增加后降低的趋势,稠度指数在0.50~0.75时土体黏附性最强,低稠度指数土体对温度敏感性更强;单独添加泡沫剂会降低土体黏附量,但在注入比为70%时,仍存在大量土体黏附;使用泡沫剂+抗黏剂联合改良在注入比为50%时改良效果较好,继续增加注入比对土体改良效果影响较小。研究成果对于评估黏性地层土压平衡盾构掘进堵塞风险与黏性土渣土改良方案选择具有一定的指导意义。

关键词：土压平衡盾构刀盘堵塞黏性地层温度效应渣土改良

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