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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi liang Wenbo Ji Jianhua Zhuang Yan liu Jie Gao you Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Effects of Polyamines Synthesis Inhibitors Sprayed after Heading on Contents and Components of Polyamines in Rice Grains at the Ripening Stage

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Rice science 2005年第2期12卷 114-118页

作者： JI Xiao-jia Yu Bing-jun ZHANG Da-dong liu you-liang College of Life Sciences Nanjing Agricultural UniversiO Nanjing 210095 China Institute of Agrobiological Genetics and Physiology Jiangsu Academy of Agricultural Sciences Nanjing 210014 China

With a higher polyamine rice （indica variety Jinlingxiang） as experimental material, the changes in contents and components of polyamines （PAs） in rice grains after harvesting were investigated under the treatments by spraying the panicles and flag leaves of rice with PAs synthesis inhibitors, D-Arg （0.5, 1.0, 1.5 and 2.0 mmol/L）, methylglyoxal bis-guanylhydrazone （MGBG）（0.1, 0.5, 1.0 and 1.5 mmol/L） and cyclohexylamine （CHA）（1.0, 5.0, 10.0, 15.0 and 20.0 mmol/L）, at the heading, flowering and grain filling stages. The inhibition of D-Arg on the contents of free and bound PAs and its total amounts in rice grains was significant, especially treated at the flowering and grain filling stages. Treatments with MGBG and CHA affected mainly the components of PAs, and their effects on the total amounts of PAs were not significant except MGBG at the flowering stage and CHA at both heading and flowering stages.

关键词： inhibitors polyamines content regulation

Effects of Aluminum on ATPase Activity and Lipid Composition of Plasma Membranes from Wheat Roots

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Agricultural Sciences in China 2002年第3期1卷 285-290页

作者： HE Long-fei,liu you-liang, SHEN Zhen-guo and WANG Ai-qin(College of Agronomy, Guangxi University, Nanning 530005 Department of Agronomy, NanjingAgricultural University, Nanjing 210095) College of Agronomy Guangxi University Nanning 530005 Department of Agronomy Nanjing Agricultural University Nanjing 210095

The effects of aluminum on ATPase activity and lipid composition of the plasma membranes isolated from root tips of Al-tolerant (Altas 66) or Al-sensitive (Scout 66) cultivar of Triticum aestivum L. was assayed. The results showed that both cultivars had similar changes in H+-ATPase and Ca2+-ATPase activities after aluminum treatment. Exposure of both cultivars to 20 and 100 (mol/L aluminum for 5 d significantly decreased the activities of Ca2 + -ATPase of plasma membranes. The activities of H+-ATPase in plasma membrane increased under 20 μmol/L aluminum and decreased at 100 ***/L aluminum. With aluminum treatment, the PL content of plasma membrane decreased, but GL content increased. The ratio of PL to GL decreased more distinctly in Scout 66 than that in Altas 66. Treated with 20 and 100 μmol/L aluminum, linolenic acid content and the index of unsaturated fatty acids decreaced greatly in Scout 66, but the index of unsaturated fatty acids in Altas 66 increased slightly.

关键词： Aluminum stress H^+-ATPase Ca^(2+)-ATPase H^+-pump activity Lipids

Relationship Between Tonoplast H^+-ATPase Activity, Ion Uptake and Calcium in Barley Roots Under NaCl Stress

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Acta Botanica Sinica 2002年第6期44卷 667-672页

作者：章文华刘友良南京农业大学农学院

Under NaCl stress for 2 d, H+-ATPase activity increased, and H+-PPase activity decreased in the tonoplast of salt-tolerant barley ( Hordeum vulgare L. cv. 'Tanyin 2') roots. La3+ (1 mmol/L), an inhibitor of Ca2+ channel in plasma membrane, and EGTA (5 mmol/L), a Ca2+ chelator, inhibited this NaCl-induced increase in H+-ATPase activity but stimulated the H+-PPase activity. Treatment of barley roots with CaM antagonist (trifluoperazine, TFP, 20 mumol/L) also diminished the increase of H+-ATPase activity induced by NaCl. La3+, TFP or La3+ + TFP increased Na+ uptake and decreased K+ and Ca2+ uptake in barley roots under NaCl stress. These results suggested that the activation of tonoplast H+-ATPase and the regulation of Na+ and K+ uptake under NaCl stress may be related to Ca2+-CaM system.

关键词： tonoplast H+-ATPase H+-PPase Ca2+ ion uptake salt tolerance barley

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植物对Si的吸收、运输和沉积

西北植物学报 2006年第5期26卷 1071-1078页

作者：徐呈祥刘友良南京农业大学生命科学学院

本文综述了植物中的S i及其吸收、运输和沉积的研究进展:(1)植物含S i量因植物种、品种甚至无性系与器官的不同而有较大差异,S i在细胞中呈现区隔化分配;(2)植物中沉积的S i主要是非晶态的S ***2O(又称硅胶、植物蛋白石、植硅石等),是... 详细信息

本文综述了植物中的S i及其吸收、运输和沉积的研究进展:(1)植物含S i量因植物种、品种甚至无性系与器官的不同而有较大差异,S i在细胞中呈现区隔化分配;(2)植物中沉积的S i主要是非晶态的S ***2O(又称硅胶、植物蛋白石、植硅石等),是有机物质矿质化的产物,不同植物所形成的S i化结构及其形态不同,可用于植物分类、鉴定及古气候与环境变化的研究;(3)硅藻和高等植物主要吸收S i(OH)4,高等植物中存在S i主动吸收机制;(4)有机大分子物质(包括多胺、碳水化合物、纤维素)作为有机衬质参与了植物的S i沉积过程;(5)突变体的鉴定和应用,对S i营养研究具有重要作用.

关键词：植物硅吸收运输沉积

树枝状碳芯结构LiFePO_4/C复合材料的制备及电化学性能

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中国有色金属学报 2010年第11期20卷 2206-2212页

作者：陈晗龚文强刘友良刘建华湖南工业大学冶金工程学院株洲412000

采用环氧树脂为碳源制备树枝状碳芯结构LiFePO4/C复合材料。利用X射线衍射、透射电镜和X射线光电子能谱对复合材料进行分析,采用恒电流充放电和电化学阻抗方法研究试样的倍率性能、循环性能和电化学阻抗。结果表明:树枝状LiFePO4/C复合... 详细信息

采用环氧树脂为碳源制备树枝状碳芯结构LiFePO4/C复合材料。利用X射线衍射、透射电镜和X射线光电子能谱对复合材料进行分析,采用恒电流充放电和电化学阻抗方法研究试样的倍率性能、循环性能和电化学阻抗。结果表明:树枝状LiFePO4/C复合材料的树干是碳芯结构,由无定形碳芯和包覆在碳芯上的纳米LiFePO4颗粒组成;树枝状碳芯结构LiFePO4/C复合材料在15 mA/g的电流密度下,首次放电容量达到167.4 mA.h/g;当电流密度增大到900 mA/g时,放电容量高达120.8 mA.h/g,经过50次循环后,容量保持率高达99.5%。

关键词： LiFePO4 复合材料碳芯结构电化学性能

论《湖南农民运动考察报告》对乡村振兴战略贯彻实施的当代价值

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湖南科技大学学报（社会科学版） 2019年第6期22卷 25-28页

作者：刘优良段东山南昌理工学院工商管理学院

1927年,《湖南农民运动考察报告》总结了并提出了当时农民运动的基本理论和政策,同时也集中体现了毛泽东最初的农村建设思想。2017年,旨在从根本上解决“三农”问题的乡村振兴战略成为全党全社会农村工作的重大主题。正本清源,毛泽东提... 详细信息

1927年,《湖南农民运动考察报告》总结了并提出了当时农民运动的基本理论和政策,同时也集中体现了毛泽东最初的农村建设思想。2017年,旨在从根本上解决“三农”问题的乡村振兴战略成为全党全社会农村工作的重大主题。正本清源,毛泽东提出的创新土地制度、解放农村生产力、综合发展农村事业以搞好农村政治、经济、文化和社会建设等一系列农村建设思想,对当下乡村振兴战略的贯彻实施仍具有重大的当代价值。

关键词：乡村振兴农民问题思想毛泽东

碳前驱体对LiFePO_4/C复合材料的形貌及电化学性能的影响

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功能材料 2010年第3期41卷 473-475,480页

作者：陈晗龚文强刘友良刘建华湖南工业大学冶金工程学院湖南株洲412000

采用葡萄糖、环氧树脂、酚醛树脂为碳源制备了LiFePO4/C复合材料。利用X射线衍射、扫描电镜等方法对复合材料进行研究。结果表明,葡萄糖获得了碳包覆复合材料,而环氧树脂、酚醛树脂则得到了碳芯结构复合材料。碳芯结构复合材料的电化学... 详细信息

采用葡萄糖、环氧树脂、酚醛树脂为碳源制备了LiFePO4/C复合材料。利用X射线衍射、扫描电镜等方法对复合材料进行研究。结果表明,葡萄糖获得了碳包覆复合材料,而环氧树脂、酚醛树脂则得到了碳芯结构复合材料。碳芯结构复合材料的电化学性能优于碳包覆复合材料,电流密度为15mA/g时,试样C、D的放电容量分别为165、167mAh/g;电流密度为600mA/g时,试样C、D的放电容量分别为139.4、145.5mAh/g,经过50循环后容量保持率分别高达99.2%、99.5%。

关键词：锂离子电池 LiFePO4 复合材料碳前驱体电化学性能

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超高扬程及长距离泵站水锤分析及防护设置

中国农村水利水电 2020年第11期 112-117页

作者：刘有亮胡斌超甘肃省水利水电勘测设计研究院有限责任公司兰州730000

基于Bentley HAMMER V8i水锤分析软件对甘肃省引洮供水二期配套秦安县城乡供水好地梁工程中三座超高扬程及长距离泵站进行停泵水锤分析及防护设置,泵站扬程分别为276、199和246 m,三座泵站输水管线受地形影响起伏十分复杂,事故停泵时管... 详细信息

基于Bentley HAMMER V8i水锤分析软件对甘肃省引洮供水二期配套秦安县城乡供水好地梁工程中三座超高扬程及长距离泵站进行停泵水锤分析及防护设置,泵站扬程分别为276、199和246 m,三座泵站输水管线受地形影响起伏十分复杂,事故停泵时管线负压及水锤升压十分明显。通过模拟分析计算,三座泵站采用液控止回偏心半球阀、空气阀、压力波动预止阀等防护设备后,有效消除了事故停泵时管线负压和降低水锤升压。

关键词：高扬程弥合水锤压力波动预止阀空气阀事故停泵