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Effect of Nanobubble Evolution on Hydrate Process: A Review

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Journal of Thermal Science 2019年第5期28卷 948-961页

作者： ZHANG Yue ZHAO Li DENG Shuai ZHAO Ruikai NIE Xianhua liu yinan Key Laboratory of Efficient Utilization of Low and Medium Grade Energy(Tianjin University) Ministry of Education of China Tianjin 300350 China Department of Chemical Engineering KTH Royal Institute of Technology Stockholm SE-100 44 Sweden International Cooperation Research Centre of Carbon Capture in Ultra-low Energy-consumption Tianjin 300350 China

As a huge reserve for potential energy, natural gas hydrates(NGHs) are attracting increasingly extra attentions, and a series of researches on gas recovery from NGHs sediments have been carried out. But the slow formation and dissociation kinetics of NGHs is a major bottleneck in the applications of NGHs technology. Previous studies have shown that nanobubbles, which formed from melt hydrates, have significant promotion effects on dissociation and reformation dynamics of gas hydrates. Nanobubbles can persist for a long time in liquids, disaccording with the standpoint of classical thermodynamic theories, thus they can participate in the hydrate process. Based on different types of hydrate systems(gas + water, gas +water +inhibitors/promoters, gas + water + hydrophilic/hydrophobic surface), the effects of nanobubble evolution on nucleation, dissociation, reformation process and "memory effect" of gas hydrates are discussed in this paper. Researches on the nanobubbles in hydrate process are also summarized and prospected in this study.

关键词： gas hydrates nanobubbles memory effect hydrate process

Effect of hydrogen on grain boundary migration in tungsten

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Science China(Physics,Mechanics & Astronomy) 2015年第7期58卷 75-83页

作者： YU Yi SHU XiaoLin liu yinan NIU LiangLiang JIN Shuo GAO Fei LU GuangHong Department of Physics Beihang University Department of Nuclear Engineering and Radiological Science University of Michigan

Motivated by a grain boundary(GB) healing mechanism that GB turns into a mobile sink through migration to eliminate the vacancies in a bulk, we have further investigated the influence of the retained hydrogen(H) on the GB migration in tungsten using a molecular dynamics simulation. We show that H hinders the GB migration at different H concentrations and temperatures, and such friction of GB migration due to the presence of H increases with the H concentration and decreases with temperature. We demonstrate that H follows the GB-migration as the temperature is higher than 300 K. Most importantly, the presence of H induces a disordering of GB, which affects the GB migration significantly.

关键词： tungsten grain boundary hydrogen migration molecular dynamics disordering

Decorative Wood Fiber/High-Density Polyethylene Composite with Canvas or Polyester Fabric

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Journal of Renewable Materials 2020年第8期8卷 879-890页

作者： Jialin Lv Rao Fu yinan liu Xuelian Zhou Weihong Wang Pengbo Xie Tingwei Hu Key Lab of Bio-Based Material Science&Technology of EducationMinistry Northeast Forestry UniversityHarbin150040China Taizhou University Taizhou318000China

Wood-plastic composite is an environmentally friendly material,due to its use of recycled thermoplastics and plant ***,its surface lacks attractive aesthetic *** this paper,a method of decorating wood fiber/high-density polyethylene(WF/HDPE)without adding adhesive was *** or polyester fabrics were selected as the surface decoration *** influence of hot-pressing temperature and WF/HDPE ratio on the adhesion was *** surface bonding strength,water resistance,and surface color were evaluated,and observation within the infrared spectrum and under scanning electron microscopy was used to analyze the bonding *** results showed that the fabric and WF/HDPE substrate could be closely laminated together depending on the HDPE layer accumulated on the WF/HDPE *** molten HDPE matrix penetrates canvas more easily than polyester fabric,and the canvasveneered composite shows a greater bonding strength than does the polyester fabric-veneered composite.A higher proportion of the thermoplastic component in the substrate improved the *** the hot-pressing temperature exceeded 160°C,the fabric-veneered WF/HDPE panels had greater water resistance,although the canvas fabric changed more obviously in terms of fiber shape and color,compared with the polyester *** the canvas fabric,140°C–160°C was a suitable hot-pressing temperature,whereas 160°C–180°C was more suitable for polyester *** proportion of the thermoplastic component in the composite should be not less than 30%to achieve adequate bonding strength.

关键词： wood-plastic composites high-density polyethylene polyester fiber canvas surface decoration

Behaviors of helium in vanadium:Stability,diffusion,vacancy trapping and ideal tensile strength

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Progress in Natural Science:Materials International 2013年第5期23卷 459-463页

作者： Lijiang Gui Yuelin liu Weitian Wang yinan liu Kameel Arshad Ying Zhang Guanghong Lu Junen Yao Department of Physics and Key Laboratory of Micro-nano Measurement-Manipulation and Physics (Ministry of Education) Beihang University Department of Physics Yantai University

The behaviors of helium in vanadium including stability,diffusion,and its interaction with vacancy as well as its effects on the ideal tensile strength was investigated by a frst-principles *** activation energy barrier of helium was calculated to be 0.09 eV,which is consistent with the experimental *** results indicated that the vacancy can lead to a directed helium segregation into the vacancy to form a helium cluster since the vacancy provides a "lower atomic and electron density region" as a large driving force for helium *** is easy for a mono-vacancy to trap helium and form a Hen V *** frst-principles computational tensile test demonstrates that helium obviously decreased the tensile strength of vanadium.

关键词： Vanadium Helium Vacancy Tensile strength

m^(6)A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels

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Cancer Communications 2022年第4期42卷 327-344页

作者： yinan liu Ertao Zhai Junting Chen Yan Qian Risheng Zhao Yan Ma Jianqiu liu Zhixin Huang Shirong Cai Jianhui Chen Division of Gastrointestinal Surgery Center the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Gastric Cancer Center Sun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Laboratory of Surgery the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China

Background:Methyltransferase 3(METTL3)-mediated N6-methyladenosine(m^(6)A)RNA modification has been demonstrated to be a potential factor in promoting gastric cancer(GC).METTL3 regulates a series of signaling pathways by modifying various *** study aimed to identify novel METTL3-mediated signaling pathways and explored possible targets for use in the clinical setting of gastric ***:To investigate the proliferation and metastatic capacity ofGCcell lines with METTL3 knockdown,a xenograft,lung metastasis,and popliteal lymph node metastasis model was ***^(6)A-modified RNA immunoprecipitation(Me-RIP)sequence was utilized to explore the target mRNAs of *** counting kit 8 and transwell assays were performed to investigate the promoting function of pre-B cell leukemia homeobox 1(PBX1)and GTP cyclohydrolase 1(GCH1).Western blotting and chromatin immunoprecipitation were employed to confirm the involvement of the METTL3-PBX1-GCH1 *** and liquid chromatography-mass spectrometry were used to explore the biological function of tetrahydrobiopterin(BH_(4)).Results:Knockdown of METTL3 suppressed xenograft tumor growth and lung/lymph node metastasis in ***,we found that METTL3 combined with and stabilized PBX1 *** immunoprecipitation(ChIP)and further experiments suggested that PBX1 acted as a transcription factor inducing GCH1 ***,the METTL3-PBX1-GCH1 axis increased BH_(4)levels in GC cells,thereby promoting tumor ***:This study suggested that METTL3 enzymes promote tumor growth and lung/lymph node metastasis via METTL3-PBX1-GCH1 axis increasing BH_(4)levels in GC.

关键词： BH_(4) gastric cancer GCH1 m^(6)A metabolism reprogramming metastasis METTL3 PBX1 proliferation

Inhibitory Effect of Short-Term Palpebral Margin Cleaning with Antibiotic Eye Drops on Ocular Surface Flora before Cataract Extraction:A New Preoperative Antibacterial Method

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Chinese Medical Sciences Journal 2022年第2期37卷 118-126页

作者： Xiaoyong Chen Hongyuan Cai yinan liu Jing Hong Department of Ophthalmology Peking University Third HospitalBeijing 100191China

Objective To explore the clinical significance of the combined application of palpebral margin cleaning and antibiotic eye drops in inhibiting bacterial growth in the palpebral margin and conjunctival sacs before cataract *** In this study,61 patients(97 eyes)with age-related cataract who underwent phacoemulsification and intraocular lens implantation were selected,and randomly *** the experimental group,the combined application of palpebral margin cleaning with cotton pads and levofloxacin eye drops was given for three days before the *** the control group,levofloxacin eye drops alone were applied for three consecutive *** samples from the conjunctival sac and eyelid margins were cultivated and identified before and three days after taking antimicrobial measures,*** In the experimental group,the positive rates of the two bacteria samples were 100%(50/50)and 40%(20/50)before and 10%(5/50)and 0%(0/50)after the *** the control group,the positive rates of the two bacteria samples were 97.9%(46/47)and 29.8%(14/47)before and 40.4%(19/47)and 10.6%(5/47)after the *** positive rates between the two groups were not significantly different before taking antimicrobial measures(P=0.485 and 0.395),while they were significantly different after taking antimicrobial measures(P=0.001 and 0.024).Conclusion Combined application of eyelid and palpebral margin cleaning with cotton pads and antibiotic eye drops before cataract extraction imparted excellent antibacterial effects.

关键词： antibiotic prophylaxis cataract extraction eyelid cleaning microbiota

Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation

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Protein & Cell 2019年第1期10卷 20-30页

作者： Haibo Li Chaoran Zhao Jun Xu Yaxing Xu Chunmei Cheng yinan liu Ting Wang Yaqin Du Liangfu Xie Jingru Zhao Yanchuang Han Xiaobao Wang Yun Bai Hongkui Deng Department of Cell Biology School of Basic Medical SciencesPeking University Stem Cell Research CenterState Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and DifferentiationCollege of Life SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100191China Shenzhen Stem Cell Engineering Laboratory Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program College of Life SciencesPeking UniversityBeijing 100871China BeiHao Stem Cell and Regenerative Medicine Translational Research Institute BeijingChina

One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem(ES)cells,which is used to produce gene-targeted mice for wide applications in ***,a major bottleneck in this approach is that the robustness of germiine transmission of gene-targeted ES cells can be significantly reduced by their genetic and epigenetic instability after long-term culturing,which impairs the efficiency and robustness of mouse model ***,we have established a new type of pluripotent cells termed extended pluripotent stem(EPS)cells,which have superior developmental potency and robust germline competence compared to conventional mouse ES *** this study,we demonstrate that mouse EPS cells well maintain developmental potency and genetic stability after long-term *** on gene targeting in mouse EPS cells,we established a new approach to directly and rapidly generate gene-targeted mouse models through tetraploid complementation,Haibo Li and Chaoran Zhao contributed equally to this *** supplementary material The online version of this article(https://***/10.1007/s13238-018-0556-1)contains supplementary material,which is available to authorized *** could be accomplished in approximately 2 ***,using this approach,we successfully constructed mouse models in which the human interleukin 3(IL3)or interleukin 6(IL6)gene was knocked into its corresponding locus in the mouse *** study demonstrates the feasibility of using mouse EPS cells to rapidly generate mouse models by gene targeting,which have great application potential in biomedical research.

关键词： tetraploid complementation EPS mouse model CRISPR/Cas9

Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells

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Cellular & Molecular Immunology 2010年第4期7卷 279-287页

作者： Xiaohui Zhu Lina Wu Li Zhang Peng Hao Shuai Zhang Jing Huang Jie Zheng yinan liu Wenjun Li Yingmei Zhang Chunyan Zhou Youhui Zhang C Cameron Yin Xiaoyan Qiu Peking University Center for Human Disease Genomics BeijingChina Department of Biochemistry School of Basic Medical SciencePeking UniversityBeijingChina Department of Immunology Cancer InstituteChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Hematopathology University of Texas M.D.Anderson Cancer CenterHoustonTXUSA These authors contributed equally to this work

The restriction of immunoglobulin(Ig)expression to B lymphocytes is well ***,several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal *** aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene *** results show that the Ig promoter of VH4-59 was activated in several non-B cancer cell ***,two novel positive regulatory elements,an enhancer-like element at 2800 to 2610 bp and a copromoter-like element at 2610 to 2300 bp,were identified in two epithelial cancer cell lines,HeLa S3 and *** octamer element(59-ATGCAAAT-39)located in the Ig promoter,a crucial element for B-cell-derived Ig gene transcription,was also very important for non-B-cell-derived Ig gene *** importantly,we confirmed that octamer-related protein-1(Oct-1),but not Oct-2,was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer *** results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells.

关键词： Ig gene transcription Oct-1 promoter transcription regulation VH4-59

去中心化金融的行业自治:一种协同监管的路径

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现代经济探讨 2023年第9期 119-132页

作者：刘毅楠厦门大学法学院厦门361005 厦门大学金融法研究中心厦门361005

去中心化金融是深度融合区块链技术的新兴金融业态,有着广阔发展空间。然而其代码治理、弱金融中介的特点导致单一的硬性监管模式难以充分释放效能。为兼顾金融安全与金融创新,辅之以行业自治手段可发挥缓解监管理念与业务规则的潜在冲... 详细信息

去中心化金融是深度融合区块链技术的新兴金融业态,有着广阔发展空间。然而其代码治理、弱金融中介的特点导致单一的硬性监管模式难以充分释放效能。为兼顾金融安全与金融创新,辅之以行业自治手段可发挥缓解监管理念与业务规则的潜在冲突、填充硬性监管空白的重要作用。行业自治通过浸润正确的金融理念、引入去中心化自治组织治理模式调节硬性规制思维;通过柔性方式协同公权力机关实现对本行业的业务监管、数据监管与科技监管。此外,建设声誉机制、完善自治规范、落实赋权与控权等举措,可以激励去中心化金融行业自治长足生效。

关键词：去中心化金融行业自治金融监管协同监管去中心化自治组织