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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua cai Wenyong cai Wujun cai yijian cai yizhou cai Yuchen cai Haiying cai Huacheng cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Clinical deep remission and related factors in a large cohort of patients with rheumatoid arthritis

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Chinese Medical Journal 2019年第9期132卷 1009-1014页

作者： Jia-Jia liu Ru Li Yu-zhou Gan Rui-jun Zhang Jing Li Yue-ming cai Jin-Xia Zhao Hua liao Jing Xu Lian-jie Shi Ji Li sheng-Guang Li Xiao-Lin Sun Jing He Xu liu Hua Ye Zhan-Guo Li Department of Rheumatology and Immunology Peking University People's HospitalBeijing 100044China Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Beijing 100044China Department of Rheumatology and Immunology Peking University Shenzhen HospitalShenzhenGuangdong 518035China Department of Rheumatology and Immunology Peking University Third HospitalBeijing 100191China Department of Rheumatology and Immunology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100129China Department of Rheumatology and Immunology Peking University International HospitalBeijing 102206China Peking-Tsinghua Center for Life Sciences Beijing 100044China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100044China

Background:Clinical remission is the treatment target in rheumatoid arthritis (RA).This study aimed to investigate clinical remission and related factors in a large cohort of patients with ***:This study composed of 342 patients with *** were collected by face-to-face interview of 1049 patients with RA who visited the Department of Rheumatology of three teaching hospitals from September 2015 to May *** patients with RA were clinically assessed by rheumatologists and a four-page questionnaire was completed on ***,patients fulfilled remission criteria were further *** practicability of different definitions of remission of RA was rated by a panel of *** intensive disease modifying anti-rheumatic drug (DMARD) treatment was defined as a combination treatment with two or more DMARDs for at least 6 ***:In this cohort of 342 patients with RA,the proportions of patients achieving remission were 38.0%,29.5%,24.9%,21.1%,19.0%,18.1%,and 17.0%,based on criteria of disease activity score in 28 joints (DAS28) using CRP (DAS28-CRP),DAS28 using ESR (DAS28-ESR),routine assessment of patient index data 3 (RAPID-3),Boolean,simplified disease activity index (SDAI),clinical disease activity index,and the newly described clinical deep remission (CliDR),*** and CliDR are the best in practicability scored by rheumatologists (7.5 and 8.0,respectively).Compared with the non-sustained intensive group,sustained intensive treatment with DMARDs yielded higher remission rates of 25.6%,23.8%,and 21.3% in patients with RA based on Boolean (χ^2=3.937,P=0.047),SDAI (χ^2=4.666,P=0.031),and CliDR criteria (χ^2=4.297,P=0.038).The most commonly prescribed conventional synthesized DMARDs (csDMARDs) in patients with RA was leflunomide,followed by methotrexate,and *** with the non-remission group,patients achieving remission had a longer median duration of DMARDs (45.0 [22.8–72.3] months,Z=-2.295

关键词： Rheumatoid arthritis Remission Sustained Intensive Disease modifying anti-rheumatic drug

Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

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Military Medical Research 2023年第1期10卷 45-63页

作者： Peng Xia Xu-Dong Xing Cui-Xian Yang Xue-Jiao liao Fu-Hua liu Hui-Huang Huang Chao Zhang Jin-Wen Song Yan-Mei Jiao ming Shi Tian-jun Jiang Chun-Bao zhou Xi-Cheng Wang Qing He Qing-Lei Zeng Fu-sheng Wang Ji-Yuan Zhang Senior Department of Infectious Diseases the Fifth Medical Center of Chi‑nese PLA General HospitalNational Clinical Research Center for Infectious DiseasesSavaid Medical SchoolUniversity of Chinese Academy of SciencesBeijing 100039China Department of Infectious Diseases and Hepatology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Biomedical Pioneering Innovation Center(BIOPIC) School of Life SciencesPeking UniversityBeijing 100871China Yunnan Infectious Disease Hospital Kunming 650301China The Third People’s Hospital of Shenzhen School of MedicineSouthern University of Science and TechnologyShenz‑hen 518112GuangzhouChina

Background: Mucosal-associated invariant T(MAIT) cells are systemically depleted in human immunodeficiency virus type 1(HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy(cART).This study aimed to identify the mechanism underlying MAIT cell ***: In the present study, we applied flow cytometry, single-cell RNA sequencing and immunohistochemical staining to evaluate the characteristics of pyroptotic MAIT cells in a total of 127 HIV-1 infected individuals, including 69 treatment-naive patients, 28 complete responders, 15 immunological non-responders, and 15 elite controllers, at the Fifth Medical Center of Chinese PLA General Hospital, Beijing, ***: Single-cell transcriptomic profiles revealed that circulating MAIT cells from HIV-1 infected subjects were highly activated, with upregulation of pyroptosis-related genes. Further analysis revealed that increased frequencies of pyroptotic MAIT cells correlated with markers of systemic T-cell activation, microbial translocation, and intestinal damage in cART-naive patients and poor CD4+ T-cell recovery in long-term cART patients. Immunohistochemical staining revealed that MAIT cells in the gut mucosa of HIV-1 infected patients exhibited a strong active gasdermin-D(GSDMD, marker of pyroptosis) signal near the cavity side, suggesting that these MAIT cells underwent active pyroptosis in the colorectal mucosa. Increased levels of the proinflammatory cytokines interleukin-12(IL-12) and IL-18 were observed in HIV-1 infected patients. In addition, activated MAIT cells exhibited an increased pyroptotic phenotype after being triggered by HIV-1 virions, T-cell receptor signals, IL-12 plus IL-18, and combinations of these factors, in ***: Activation-induced MAIT cell pyroptosis contributes to the loss of MAIT cells in HIV-1 infected patients,which could potentiate disease progression and poor immune reconstitution.

关键词： Acquired immune deficiency syndrome Human immunodeficiency virus Mucosal-associated invariant T cells Pyroptosis Immune reconstitution

Insight-HXMT on-orbit thermal control status and thermal deformation impact analysis

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Radiation Detection Technology and Methods 2023年第3期7卷 337-349页

作者： Ai-Mei Zhang yi-Fan Zhang Jin-Yuan liao Yu-Peng Xu Yu-Sa Wang Wen-Bo Luo Yu-Peng zhou Zhi-ying Qian Xiao-Bo Li Fang-jun Lu Shuang-Nan Zhang Li-ming Song Cong-Zhan liu Fan Zhang Jian-yin Nie Juan Wang sheng Yang Tong Zhang Xiao-Jing liu Rui-jie Wang Xu-Fang Li yi-Fei Zhang Zheng-Wei Li Xue-Feng Lu He Xu Di Wu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Beijing Institute of Spacecraft System Engineering CASTBeijing 100094China

Purpose The Hard X-ray Modulation Telescope is China’s first X-ray astronomy satellite launched on june 15,2017,dubbed *** and passive thermal control measures are employed to keep devices at suitable *** this paper,we analyzed the on-orbit thermal monitoring data of the first 5 years and investigated the effect of thermal deformation on the point spread function(PSF)of the *** We examined the data of the on-orbit temperatures measured using 157 thermistors placed on the collimators,detectors and their support structures and compared the results with the thermal control *** thermal deformation was evaluated by the relative orientation of the two star sensors installed on the main support *** effect was estimated with evolution of the PSF obtained with calibration scanning observations of the Crab *** The on-orbit temperatures met the thermal control requirements thus far,and the effect of thermal deformation on the PSF was negligible after the on-orbit pointing calibration.

关键词： X-ray Insight-HXMT Thermal control Temperature Star sensor data Pointing PSF

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吸力面翼刀对压气机叶栅内二次流的影响

推进技术 2006年第4期27卷 316-320页

作者：刘艳明钟兢军伍耐明董金钟周盛北京航空航天大学能源与动力工程学院北京100083 大连海事大学机电与材料工程学院辽宁大连116026

对CDA常规直叶栅和具有不同展向位置和高度的吸力面翼刀压气机叶栅内三维粘性流场进行了数值模拟。结果表明,加装位置越高、高度越大的吸力面翼刀对吸力面附近展向流动阻断能力越强;反向翼刀涡的产生与流道内展向流动的强弱息息相关;具... 详细信息

对CDA常规直叶栅和具有不同展向位置和高度的吸力面翼刀压气机叶栅内三维粘性流场进行了数值模拟。结果表明,加装位置越高、高度越大的吸力面翼刀对吸力面附近展向流动阻断能力越强;反向翼刀涡的产生与流道内展向流动的强弱息息相关;具有距端壁一个附面层且高度为一个吸力面附面层厚度的翼刀方案为最佳翼刀方案。

关键词：压气机叶栅吸力面翼刀二次流能量损失

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue Huang Guang-Cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei Jia Fang-jun Lu Xiang Ma Lian Tao Wei Zhang Li Chen Li-ming Song Ti-Pei Li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce cai Zhi Chang Gang Chen Tian-Xiang Chen yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du min-Xue Fu Guan-Hua Gao He Gao min Gao ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua Jiang Wei-Chun Jiang Jing Jin Yong-jie Jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li Wei Li Xian Li Xiao-Bo Li Xu-Fang Li Yang-Guo Li Zheng-Wei Li Xiao-Hua Liang Jing-Yuan liao Bai-sheng liu Guo-Qing liu Hong-Wei liu Xiao-Jing liu yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng yi Nang Jian-yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-ying Song Liang Sun ying Tan You-Li Tuo Chen Wang Guo-Feng Wang Juan Wang Ling-jun Wang Weng-Shuai Wang Yu-Sa Wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-Lin Xiong He Xu Jia-Wei Yang sheng Yang Yan-Ji Yang yi-jung Yang Qi-Bin yi Qian-Qing yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-Zhao Zhang yi Zhang yi-Fei Zhang Yong-jie Zhang Yuan-Hang Zhang Yue Zhang Zhao Zhang Zhi Zhang Zi-Liang Zhang Hai-sheng Zhao Xiao-Fan Zhao Shi-jie Zheng Yao-Guang Zheng Deng-Ke zhou Jian-Feng zhou Yu-Xuan Zhu Ren-Lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)

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Military Medical Research 2022年第4期9卷 389-403页

作者： Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib liu-yi Lan Rui zhou Xian-Tao Zeng Jiao Bai jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-ming Zha Wen-jie Dai Zhi-jun Dai Qin-Yu Feng Qing-jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-ying liao Hong Luo Zheng-Ren liu Jing-Hua Lu Bin Luo Xiao-Peng Ma jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang sheng-Chu Zhang Dai-Wei Zhao Xiang-min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo zhou Gao-Song Wu Department of Thyroid and Breast Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Pathology University of Chicago Pritzker School of MedicineChicagoIL60637USA Department of Surgical Oncology and Breast Surgery Oncology CenterFaculty of MedicineMansoura UniversityMansoura35516Egypt Department of Breast Surgery Beijing University of Chinese MedicineBeijing100700China Department of Infectious Diseases and Tropical Medicine Faculty of MedicineMashhad University of Medical SciencesMashhad***Iran Breast Department KK Women’s and Children’s Hospital100 Bukit Timah RoadSingapore229899Singapore Department of Surgery Department of Public HealthDepartment of BiostatisticsBioinformatics and Medical InformaticsInonu University Faculty of Medicine44280MalatyaTurkey Department of General Surgery Faculty of MedicineÇanakkale Onsekiz Mart University17020ÇanakkaleTurkey Department of Radiology Cancer InstituteImam Khomeini HospitalTehran University of Medical SciencesTehran***Iran Department of Surgery College of Medicine and Medical SciencesArabian Gulf University-BahrainManama26671Bahrain Department of Radiology International Faculty of MedicineIstanbul Medipol University34810IstanbulTurkey Department of General Surgery Faculty of MedicineSakarya University54050SakaryaTurkey Department of Surgery HiU Clinic170Gwongwang-roPaldal-guSuwon16488Korea Department of Radiology Faculty of MedicineAtaturk University25240ErzurumTurkey Academic Support and Education Center Hırkai Serif DistrictKececi Cesmesi StrDoktorlar BuildingB/734091IstanbulTurkey Department of General and Digestive Surgery Hospital General CastellonAvda Benicassim S/N12812004CastellónSpain Radiology Department Ankara Training and Research Hospital305018AnkaraTurkey Department of Surgery The University of Hong KongChina The University of Hong Kong-Shenzhen Hospital Shenzhen518053China University of Miami Health System and Miller School of Medicine 1475 NW 12th AvenueM

Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the *** of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and *** approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.

关键词： Granulomatous mastitis Granulomatous lobular mastitis Idiopathic granulomatous mastitis Diagnosis Treatment

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-Xin Hao Lu Feng Hugh RAJones Jian Li Jing Xu Li-Yong liu Teng-Fei Song Jian-Feng Wang Hua-Lin Chen Yan-jie Xue Huang Shen Yong-Heng Zhao Zhao-Xiang Qi Jian-Rong Shi Yuan Tian Zheng Wang Xia Wang Jin-Liang Hou Jin-ming Bai Ji Yang Xu zhou Yong-Qiang Yao Jia yin Ali Esamdin Guang-Xin Pu Peng Wei Chun-Hai Bai Guo-jie Feng Lu Ma Xuan Zhang Yu liu Chong Pei Zhi-Xia Shen Yun-ying Jiang Jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou Xu Yang jun-Bo Zhang Shi-Long liao Dong-Wei Fan Yun-Fei Xu Jian-Ping Xiong Tai-sheng Yan Xi Zhang Chang-Hua Li yi-Han Tao Si-Cheng Yu Zhi-Song Cao Hong-Shuai Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

液相色谱-质谱联用法鉴定海南枫蓼肠胃康颗粒剂血浆代谢产物

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时珍国医国药 2009年第8期20卷 1869-1870页

作者：张俊清符乃光陈峰刘明生海南医学院.海南省热带药用植物研究与开发重点实验室海南海口571101

目的研究大鼠灌胃枫蓼肠胃康颗粒剂后代谢产物的动态,寻找具有代表性可作为该复方药代动力学研究指标成分的代谢产物。方法大鼠灌胃枫蓼肠胃康颗粒剂溶液〔0.9 g.(100 g)-1〕,血浆样品经过酶(G1512)水解后,进行色谱分析,通过与对照品比... 详细信息

目的研究大鼠灌胃枫蓼肠胃康颗粒剂后代谢产物的动态,寻找具有代表性可作为该复方药代动力学研究指标成分的代谢产物。方法大鼠灌胃枫蓼肠胃康颗粒剂溶液〔0.9 g.(100 g)-1〕,血浆样品经过酶(G1512)水解后,进行色谱分析,通过与对照品比较研究其血浆中代谢产物动态;采用液相色谱-质谱联用仪检测,大气压电喷雾离子源(EPI)负离子条件下进行扫描,对观测到的代谢产物进行结构鉴定。结果色谱分析的结果表明,枫蓼肠胃康颗粒剂血浆代谢产物中有槲皮素等黄酮类化学成分,同时质谱扫描的结果鉴定出槲皮素(m/z→301.0)的化学结构。结论可以槲皮素为指标成分研究该复方的药代动力学。

关键词：枫蓼肠胃康颗粒液相色谱-质谱联用槲皮素代产谢物