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Cytoplasmic dynein:a key player in neurodegenerative and neurodevelopmental diseases

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Science China(Life Sciences) 2014年第4期57卷 372-377页

作者： CHEN Xiang-Jun XU Huan COOPER Helen M liu yaobo Department of Neurology Huashan Hospital Fudan University Queensland Brain Institute The University of QueenslandBrisbane Institute of Neuroscience Soochow University

Cytoplasmic dynein is the most important molecular motor driving the movement of a wide range of cargoes towards the minus ends of *** a molecular motor protein,dynein performs a variety of basic cellular functions including organelle transport and centrosome *** the nervous system,dynein has been demonstrated to be responsible for axonal retrograde *** studies have revealed direct or indirect evidence of dynein in neurodegenerative diseases such as amyotrophic lateral sclerosis,Charcot-Marie-Tooth disease,Alzheimer’s disease,Parkinson’s disease and Huntington’s *** them,a number of mutant proteins involved in various neurodegenerative diseases interact with *** transport disruption is presented as a common feature occurring in neurodegenerative *** heavy chain mutant mice also show features of neurodegenerative ***,defects of dynein-dependent processes such as autophagy or clearance of aggregation-prone proteins are found in most of these *** of evidence have also shown that dynein is associated with neurodevelopmental *** this review,we focus on dynein involvement in different neurological diseases and discuss potential underlying mechanisms.

关键词： dynein retrograde transport pathogenesis neurodegenerative diseases neurodevelopmental diseases

Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis

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Journal of Pharmaceutical Analysis 2023年第3期13卷 223-238页

作者： Feng He Haijie Wang Pengfei Du Tengfei Li Weiting Wang Tianyu Tan yaobo liu Yanli Ma Yuanshang Wang A.M.Abd El-Aty Institute of Food&Nutrition Science and Technology Shandong Academy of Agricultural SciencesShandong Provincial Key Laboratory of Agro-Products Processing TechnologyKey Laboratory of Novel Food Resources ProcessingMinistry of AgricultureJinan250100China School of Life Sciences and Food Engineering Hebei University of EngineeringHandanHebei056038China College of Life Sciences Yantai UniversityYantaiShandong264005China College of Food Science and Technology Huazhong Agricultural UniversityWuhan430070China Department of Pharmacology Faculty of Veterinary MedicineCairo University12211GizaEgypt Department of Medical Pharmacology Medical FacultyAtaturk University25240ErzurumTurkey

Ensuring food safety is paramount *** effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of *** glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food ***,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food *** amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety *** review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal *** studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are *** perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are *** the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis.

关键词： Food safety Personal glucose meter Signal amplification Point-of-care testing Detection principle

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不同解冻方式对驴肉品质特性的影响

山东农业科学 2024年第2期56卷 131-137页

作者：褚筱然王海洁杜鹏飞柳尧波王维婷王守经马艳丽胡鹏贺红军烟台大学生命科学学院山东烟台264005 山东省农业科学院农产品加工与营养研究所/山东省农产品精深加工技术重点实验室/农业农村部新食品资源加工重点实验室山东济南250100

本文通过自然空气、低温、流水、超声波及微波5种方法对冷冻驴肉进行解冻,分析解冻时间、解冻后驴肉的食用品质(保水性、嫩度、色泽及pH值)、挥发性盐基氮(TVB-N)和硫代巴比妥酸值(TBARS)的变化,并对解冻后的驴肉进行感官评价。结果表明... 详细信息

本文通过自然空气、低温、流水、超声波及微波5种方法对冷冻驴肉进行解冻,分析解冻时间、解冻后驴肉的食用品质(保水性、嫩度、色泽及pH值)、挥发性盐基氮(TVB-N)和硫代巴比妥酸值(TBARS)的变化,并对解冻后的驴肉进行感官评价。结果表明,不同方式解冻冷冻驴肉所需时间差异明显,依次为微波<超声波<流水<自然空气<低温。冷冻驴肉经微波、低温和超声波方式处理后色泽保持最好,微波解冻和低温解冻后驴肉的保水性最好;低温解冻和超声波解冻后驴肉的剪切力显著小于其他解冻方法;微波解冻的TVB-N值和TBARS值最低,但剪切力值较大。低温解冻和微波解冻的驴肉与鲜驴肉相比具有良好的感官体验。综上,微波解冻能够较好地保持驴肉的品质,但解冻条件仍需要进一步优化。

关键词：解冻方式驴肉品质感官评价

Neural Recognition Molecule NB-3 Signaling Mediates the Cross-talk between Post-traumatic Spinal Axons and Scarforming Cells

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Neural Recognition Molecule NB-3 Signaling Mediates the Cros...

中国神经科学学会第十二届全国学术会议

作者： Zhenhui Huang Yarong Gao Yuhui Sun Yasushi Shimoda Kazutada Watanabe yaobo liu The laboratory of neural circuits development and repair Institute of NeuroscienceSoochow University Department of Bioengineering Nagaoka University of Technology

Little is known about the molecules mediating the cross-talk between posttraumatic axons and scar-forming cells after spinal cord injury. We found that a sustained NB-3 induction was simultaneously present in the terminations of post-traumatic corticospinal axons and scar forming cells at the spinal lesion site, where they were in direct contact when axons tried to penetrate the glial scar. The regrowth of corticospinal axons was enhanced in vivo with NB-3 deficiency or interruption of NB-3 transhomophilic interactions. Biochemical, in vitro and in vivo evidence demonstrated that NB-3 homophilically interacted in trans to initiate a growth inhibitory signal transduction from scar-forming cells to neurons by modulating mTOR activity via CHL1 and PTPσ. Our findings demonstrate that NB-3 trans homophilic interactions mediate the cross-talk between post-traumatic axons and scar forming cells and impair the intrinsic growth ability of injured axons.

关键词： NB-3 glial scar axon regeneration hemophilic binding mTOR

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基于微观面板数据的中国农民预防性储蓄研究

世界经济 2007年第2期30卷 40-49页

作者：刘兆博马树才辽宁大学经济学院

本文基于CHNS数据集,采用面板数据模型方法对1996～2003年中国农民的预防性储蓄行为进行经验研究。我们发现,中国农民存在显著的预防性储蓄行为。农民的不确定性感受引发的预防性储蓄动机在于通过积累性的储备来抵御未来的风险,农民持... 详细信息

本文基于CHNS数据集,采用面板数据模型方法对1996～2003年中国农民的预防性储蓄行为进行经验研究。我们发现,中国农民存在显著的预防性储蓄行为。农民的不确定性感受引发的预防性储蓄动机在于通过积累性的储备来抵御未来的风险,农民持久收入的稳定提高能显著减少其预防性储蓄动机。我们还注意到,农民受教育程度的提高反而促使其增加预防性储蓄动机,对此的一个合理解释就是,农民所承受的教育负担相对过重。

关键词：预防性储蓄不确定性持久收入面板数据

NB-3 signaling in axonal projection and plasticity

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NB-3 signaling in axonal projection and plasticity

基于PNI磁罗盘的矿用筛管手持式轨迹仪研究

中国神经科学学会第十届全国学术会议

作者： Zhenhui Huang Yuhui Sun Yang Yu Yarong Gao Chao Zhang Yue Ying Yasushi Shimoda Kazutada Watanabe yaobo liu Institute of Neuroscience Soochow University Institute of Biophysics Chinese Academy of Sciences The Medical School of Lanzhou University Department of Bioengineering Nagaoka University of Technology

Neural recognition molecules of the immunoglobulin（Ig） superfamily play important roles not only in the formation of axon trajectories and synaptic connections during development but also in synaptic plasticity and memory in ***-3 is a member of the contactin subgroup of the immunoglobulin superfamily,which contains six Ig-lite domains and four fibronectin type in like domains with a glycosylphosphatidyl inositol moiety at the COOH *** our previous study,we found that the temporal expression of NB-3 in the deep layers of the motor cortex in mice was coincident with the development of the corticospinal tract（CST）,meanwhile NB-3 was expressed specifically in the projecting CST *** tracing of CST axons in NB-3"’’ mice at different developmental stages revealed that the descending of CST and the branching of CST axons into spinal gray matter were obviously delayed in NB-3"’" mice compared with wild-type（WT） mice from the embryonic to postnatal *** adult mice,we found that NB-3 was induced coincidently in the distal end of injured axons and in the reactive cells of lesion area after spinal cord *** anterograde and retrograde tracing in NB-3"’" mice after spinal cord injury,we observed the enhancement of axonal sprouting out and regeneration in lesion area of the spinal ***,we also observed some of NB-3"’"mice exhibited locomotion recovery after spinal cord ***,we speculate that injury-induced NB-3 in both axons and reactive cells mediated a contact-inhibit effect on axon regeneration after spinal cord *** data suggest that NB-3 signaling pathway is involved in the projection,branching of developing CST axons and the axonal plasticity after spinal cord injury.

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工业仪表与自动化装置 2020年第5期 71-76页

作者：刘耀波中煤科工集团西安研究院有限公司西安710077

该文研究了一种基于PNI磁罗盘的矿用筛管手持式轨迹仪,设计了仪器的总体技术方案,完成了测量探管的硬件设计与试制,并且开发了基于Android Studio集成开发环境的APP软件。为了测试样机的实际工作性能,开展了现场工业性试验。测量结果表... 详细信息

该文研究了一种基于PNI磁罗盘的矿用筛管手持式轨迹仪,设计了仪器的总体技术方案,完成了测量探管的硬件设计与试制,并且开发了基于Android Studio集成开发环境的APP软件。为了测试样机的实际工作性能,开展了现场工业性试验。测量结果表明:测量数据与矿方已知数据完全一致,真实反映了钻孔轨迹的实际走势。所研制的手持式轨迹仪完全克服了传统轨迹测量仪器对于钻机推送方式的依赖,极大简化了施工难度,有效提高了轨迹测量工作的时间安排灵活性,得到了矿方的认可与好评。

关键词：矿用筛管磁罗盘轨迹测量

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基于PNI磁传感器的低功耗电子罗盘研究

电子测量技术 2020年第12期43卷 158-162页

作者：刘耀波中煤科工集团西安研究院有限公司西安710077

研究了一种基于PNI磁性传感器的低功耗电子罗盘,分析了倾角、工具面向角和方位角的测量原理,研究了电子罗盘的硬件总体方案并详细设计了加速度传感电路、磁传感电路和微处理器电路。为了提高电子罗盘的测量精度,分析了电子罗盘的系统误... 详细信息

研究了一种基于PNI磁性传感器的低功耗电子罗盘,分析了倾角、工具面向角和方位角的测量原理,研究了电子罗盘的硬件总体方案并详细设计了加速度传感电路、磁传感电路和微处理器电路。为了提高电子罗盘的测量精度,分析了电子罗盘的系统误差并开发了基于VC++的误差标定软件。为了测试研制的电子罗盘的测量精度,对其进行了测试,测量结果表明:倾角在-90°~90°的测量范围内达到±0.3°的测量精度,工具面向角在0°~360°范围内达到±0.15°,方位角在0°~360°范围内达到±1.5°,完全能够满足当前市场对于电子罗盘的测量要求。

关键词： PNI磁传感器加速度传感器电子罗盘

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便携式多功能钻孔成像测量系统的研制

工业仪表与自动化装置 2021年第1期 104-108页

作者：刘耀波中煤科工集团西安研究院有限公司陕西西安710077

该文研究了一种基于OMAP4460嵌入式平台的便携式多功能钻孔成像测量系统,设计了钻孔成像测量系统的总体方案,详细阐述了微处理器、图像采集模块、深度采集模块、光源模块以及电源模块的硬件设计。为了实现钻孔成像测量系统的人机交互和... 详细信息

该文研究了一种基于OMAP4460嵌入式平台的便携式多功能钻孔成像测量系统,设计了钻孔成像测量系统的总体方案,详细阐述了微处理器、图像采集模块、深度采集模块、光源模块以及电源模块的硬件设计。为了实现钻孔成像测量系统的人机交互和信息展示,开发了钻孔成像测量系统APP,能够完成图像预览、拍照、录像、姿态显示、深度显示、参数设置、数据存储等功能。为了测试该钻孔成像测量系统的应用效果,选取了一个地面水文地质观测孔进行测量。试验结果表明:钻孔成像测量系统能够清晰观测孔内情况,准确采集钻孔轨迹和深度信息,完全满足目前地质勘测领域的测量要求。

关键词：钻孔成像图像采集深度测量