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Peroxisome proliferator-activated receptor gamma coactivator-1(PGC-1)family in physiological and pathophysiological process and diseases

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1249-1292页

作者： Lu Qian Yanli Zhu Chao Deng Zhenxing Liang Junmin Chen Ying Chen Xue Wang yanqing liu Ye Tian Yang Yang Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases Xi'an No.3 HospitalThe Affiliated Hospital of Northwest UniversityNorthwest UniversityXi'an 710021China Xi'an Key Laboratory of Innovative Drug Research for Heart Failure Faculty of Life Sciences and MedicineNorthwest University229 Taibai North RoadXi'an 710069China Department of Cardiovascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University277 Yanta West RoadXi'an 710061China Department of Cardiothoracic Surgery The First Affiliated Hospital of Zhengzhou University1 Jianshe EastZhengzhou 450052China Department of Hematology The First Affiliated Hospital of Xi'an JiaotongUniversity277 Yanta West RoadXi'an 710061China

Peroxisome proliferator-activated receptor gamma coactivator-1(PGC-1)family(PGC-1s),consisting of three members encompassing PGC-1a,PGC-1β,and PGC-1-related coactivator(PRC),was discovered more than a quarter-century ago.PGC-1s are essential coordinators of many vital cellular events,including mitochondrial functions,oxidative stress,endoplasmic reticulum homeostasis,and inflammation.Accumulating evidence has shown that PGC-1s are implicated in many diseases,such as cancers,cardiac diseases and cardiovascular diseases,neurological disorders,kidney diseases,motor system diseases,and metabolic disorders.Examining the upstream modulators and co-activated partners of PGC-1s and identifying critical biological events modulated by downstream effectors of PGC-1s contribute to the presentation of the elaborate network of PGC-1s.Furthermore,discussing the correlation between PGC-1s and diseases as well as summarizing the therapy targeting PGC-1s helps make individualized and precise intervention methods.In this review,we summarize basic knowledge regarding the PGC-1s family as well as the molecular regulatory network,discuss the physio-pathological roles of PGc-1s in human diseases,review the application of PGC-1s,including the diagnostic and prognostic value of PGC-1s and several therapies in pre-clinical studies,and suggest several directions for future investigations.This review presents the immense potential of targeting PGC-1s in the treatment of diseases and hopefully facilitates the promotion of PGC-1s as new therapeutic targets.

关键词： diseases life precise

Effects of Traditional Chinese Medicine on the survival of patients with stage Ⅰ gastric cancer and high-risk factors:a real-world retrospective study

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Journal of Traditional Chinese Medicine 2023年第3期43卷 568-573页

作者： HOU Chao ZHANG Yusen YANG Die LI Yifei ZHANG Xiaochun liu yanqing Department of Oncology and Hematology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033China College of Medicine Yangzhou UniversityYangzhou 225001China the Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine Yangzhou 225001China Oncology Department Yangzhou Hospital of Traditional Chinese MedicineYangzhou 225009China

OBJECTIVE:To investigate the benefits of Traditional Chinese Medicine(TCM) therapy for improving the survival of patients with stage I gastric cancer(GC) and high-risk factors in a real-world setting.METHODS:The clinical data of patients who were diagnosed with stage I GC from March 1,2012 to October 31,2020 were collected.Prognostic analysis was performed to explore the high-risk factors that affected the survival of the patients.A Cox multivariate regression model was used to compare the hazard ratios for the mortality risk of patients,especially those with high-risk factors.Kaplan-Meier survival curve and log-rank test were utilized to assess the survival time.RESULTS:Prognostic analysis demonstrated that female sex,tumor invasion into blood vessels,and Ib stage were independent risk factors.The 1-,3-,and 5-year survival rates of the TCM group vs those of the non-TCM group were 100.0% vs 91.0%,97.6% vs 64.5%,and 81.4% vs 55.5%,respectively.A significant difference in median overall survival(m OS) was found between the two groups(χ2 = 7.670,P = 0.006).Subgroup analysis showed that the m OS of female patients and stage Ib patients in the TCM group were longer than those in the non-TCM group (P ≤ 0.001 and 0.001,respectively).CONCLUSIONS:TCM treatment can improve the survival of patients with stage I GC and high-risk factors.

关键词： stomach neoplasms overall mortality integrative medicine medicine Chinese traditional real-world

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矿井智能通风与关键技术研究

煤炭科学技术 2024年第1期52卷 178-195页

作者：张浪刘彦青煤科通安(北京)智控科技有限公司北京100013 煤炭科学技术研究院有限公司北京100013 智能开采与岩层控制全国重点实验室北京100013

为使智能通风系统建设更加有序、可控,提出了矿井智能通风流程环节,将矿井智能通风流程按照生产环节划分为6个板块,即感知监测、分析诊断、智能决策、方案审批、远程集控联控、执行反馈,共包含24个具体环节,建立了各个环节输入输出要素... 详细信息

为使智能通风系统建设更加有序、可控,提出了矿井智能通风流程环节,将矿井智能通风流程按照生产环节划分为6个板块,即感知监测、分析诊断、智能决策、方案审批、远程集控联控、执行反馈,共包含24个具体环节,建立了各个环节输入输出要素和环节之间的功能逻辑关系。按照“矿井通风系统整体规划+采掘用风区域重点细化”思路,提出了矿井全系统智能通风应用场景实现方案和采煤工作面与掘进工作面2个细化的智能通风应用场景实现方案,将矿井智能通风各个具体环节融入具体的应用场景中。为实现智能通风应用场景,基于逻辑分层思想优化了矿井智能通风系统整体架构,规划了由硬件驱动层、功能模块层、计算处理层、数据存储层、数据采集层构成的矿井智能通风管控平台。针对通风感知监测、分析诊断、智能决策、远程集控联控4个矿井智能通风关键板块中涉及的风量风速监测感知、通风阻力在线监测、全风网风量风压解算、灾源判识和灾变定位、矿井动态需风量计算、通风系统故障诊断、风量按需调控方案决策、应急控风方案决策、无人化远程控风、无人化应急控风10个关键环节,总结分析了目前各个关键环节关键技术现状,提出了各个关键环节关键技术实现路径,通过关键技术迭代升级,最终实现矿井通风系统全生命周期内时刻处于稳定可靠、安全可控、高效节能、应急降灾的运行状态。

关键词：智能通风通风流程管控平台智能决策数据采集

Jianpi Fuzheng Decoction in the Treatment of Gastric Cancer-Related Fatigue

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Proceedings of Anticancer Research 2024年第1期8卷 37-42页

作者： Weiwei liu Xiaobing Qin Haiyan Wang Xiao Chen yanqing liu Xuzhou Tongshan Traditional Chinese Medicine Hospital Xuzhou 221116Jiangsu ProvinceChina The Affiliated Hospital of Xuzhou Medical University Xuzhou 221116Jiangsu ProvinceChina Yangzhou University Yangzhou 225001Jiangsu ProvinceChina

Objective:To observe the clinical effects of Jianpi Fuzheng Decoction in patients with gastric cancer and cancer-related fatigue(CRF).Methods:Using the random number table method as a reference,68 cases of gastric CRF were randomly divided into two groups.One group served as the control group and received basic treatment,while the other was the observation group.The observation group,in addition to the control group’s treatment,received Jianpi Fuzheng Decoction.The clinical treatment effectiveness,fatigue scores,immune function indicators,and treatment safety were compared between the two groups.Results:The total clinical treatment effectiveness of the observation group and the improvement in immune function indicators after treatment were higher than those of the control group.The fatigue score after treatment was lower in the observation group than in the control group(P<0.05).No serious adverse reactions occurred during the treatment in either group.Conclusion:Jianpi Fuzheng Decoction can enhance the clinical treatment effectiveness for gastric cancer patients with CRF.It facilitates the acceleration of fatigue symptom improvement and immune function enhancement.The medication’s safety is guaranteed,making it worthy of promotion.

关键词： Jianpi Fuzheng Decoction Gastric cancer Cancer-related fatigue Clinical effect

Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2

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Acupuncture and Herbal Medicine 2024年第1期4卷 92-101页

作者： Li liu yanqing liu Shujie Zhang Junzhe Zhang Yuqing Meng Dandan liu Liwei Gu Ying Zhang Liting Xu Ziyue Zhang Minghong Zhao Yinkwan Wong Qixin Wang Yongping Zhu Jigang Wang College of Pharmacy Gannan Medical UniversityGanzhouChina State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijingChina Department of Pharmacological Sciences Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

Objective:Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicinal herb,Tripterygium wilfordii.This study aims to provide a scientific basis for the rational development and use of celastrol in breast cancer.Method:A quantitative chemical biology approach was used to investigate the protein targets and molecular mechanisms of celastrol in breast cancer cells.Results:Low-concentration celastrol exerted an anti-tumor effect by directly binding to hydroxysteroid dehydrogenase-like 2(HSDL2)and inhibiting its expression.Moreover,the expression of the pro-apoptotic protein,Bcl-2-associated X(BaX),increased,the level of the anti-apoptotic protein,B-cell lymphoma-2(Bcl-2),decreased,and the rate of apoptosis increased.After the transfection of cells with si-HSDL2,the apoptosis rate was similar to that observed after the administration of celastrol.However,apoptosis was reversed by the overexpression of HSDL2.Furthermore,our mass spectrometry(MS)data indicated a relationship between HSDL2 and the mitogen-activated protein kinase(MAPK)signaling pathway.We also found that the expression of HSDL2 was directly related to the degree of extracellular signal-regulated kinase(ERK)phosphorylation.Conclusion:Celastrol may promote apoptosis by suppressing the HSDL2/MAPK/ERK signaling pathway.

关键词： Activity-based protein profiling Apoptosis Celastrol HSDL2

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从“宝钗扑蝶”说唱本看宝钗形象的民间接受

红楼梦学刊 2024年第2期 177-197页

作者：刘衍青宁夏师范学院文学院 756000

“宝钗扑蝶”包含多个场景,暗含复杂的意蕴,从小说情节、脂砚斋评点及富察明义“题红诗”第四首即可见一斑。“宝钗扑蝶”说唱本以巧妙精悍的结构、雅俗交融的语言与富有趣味的画面,成功再创作了这一经典片断。这些说唱本主题多样、形... 详细信息

“宝钗扑蝶”包含多个场景,暗含复杂的意蕴,从小说情节、脂砚斋评点及富察明义“题红诗”第四首即可见一斑。“宝钗扑蝶”说唱本以巧妙精悍的结构、雅俗交融的语言与富有趣味的画面,成功再创作了这一经典片断。这些说唱本主题多样、形象生动,较好地传达了小说中这一意象的丰富内涵,反映出民间百姓对宝钗形象的接受与理解。

关键词：说唱宝钗扑蝶民间接受

Effect of allogeneic umbilical cord mesenchymal stem cell transplantation in a rat model of hepatic cirrhosis

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Journal of Traditional Chinese Medicine 2015年第1期35卷 63-68页

作者： Yang Lihua Wang Yun Wang Xiaohua liu yanqing Institution of Traditional Chinese Medicine and Western Medicine Nanjing University of Chinese Medicine Institute of Digestive Endoscopy & Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University

OBJECTIVE: To determine the effects of human umbilical cord mesenchymal stem cell(UCMSC) transplantation, alone or in combination with tanshinone IIA(Tan IIA) on hepatic cirrhosis in rats.METHODS: A rat model of cirrhosis was established. Rats were divided into control, UCMSC, and UCSMC plus Tan IIA groups. Rats in the UCMSC group were injected via the tail vein with 0.2 m L Di I-labeled UCMSC suspension. Intraperitoneal Tan IIA injections(20 mg/kg) were started on the day ofUCMSC transplantation in the UCMSC plus Tan IIA group, and continued for 7 consecutive days thereafter. Rats were sacrificed 1 day, 3 days, 1 month,and 3 months after transplantation and the numbers of Di I-labeled UCMSCs colonizing the liver were determined. Albumin(ALB) and alanine aminotransferase(ALT) levels were measured in venous blood, and m RNA and protein expression levels of human ALB and cytokeratin(CK)-18 in liver tissues were determined by reverse transcription-polymerase chain reaction and western blotting, respectively.RESULTS: Serum ALT levels were significantly lower and serum ALB levels significantly higher in rats in the UCMSC group compared with the control group(P < 0.05). Hepatic CK-18 and ALB m RNA and protein expression levels increased after transplantation, and were significantly higher in the UCMSC plus Tan IIA group compared with the UCMSC group(P < 0.05).CONCLUSION: Human UCMSCs transplanted into rats with liver cirrhosis can grow and differentiate into hepatocyte-like cells resulting in improved liver function in vivo. Tan IIA further influenced transplantation outcomes.

关键词：干细胞移植大鼠模型肝硬化脐带 Western印迹反转录聚合酶链反应间充质干细胞丙氨酸转氨酶

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“出奇”与归真——王子武的艺术探索道路

美术 2024年第2期 48-51,F0003页

作者：刘艳卿屈健西北大学西安美术学院

在20世纪中国美术史上,王子武将西方写实观念与传统中国画笔墨语言融会贯通,形成了一种厚重而不失灵动、严谨而充满生机、朴茂而意蕴深远的艺术风格。关中黄土大地厚重的文化根脉、“徐蒋体系”的造型观念和传统文人绘画的笔墨语言直接... 详细信息

在20世纪中国美术史上,王子武将西方写实观念与传统中国画笔墨语言融会贯通,形成了一种厚重而不失灵动、严谨而充满生机、朴茂而意蕴深远的艺术风格。关中黄土大地厚重的文化根脉、“徐蒋体系”的造型观念和传统文人绘画的笔墨语言直接影响了王子武的艺术探索和理想追求,使其艺术道路呈现出一种入手于写实、出奇于写意、回归于写心的发展轨迹。

关键词：王子武人物画徐蒋体系长安画派

Phase structure and hydrogen storage properties of REMg8.35Ni2.18Al0.21 （RE=La, Ce, Pr, and Nd） hydrogen storage alloys

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Journal of Rare Earths 2013年第8期31卷 784-789页

作者： liu yanqing HAN Shumin HU Lin liu Baozhong ZHAO Xin JIA Yanhong College of Environmental and Chemical Engineering Yanshan University Qinhuangdao 066004 China State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China School of Materials Science and Engineering Henan Polytechnic University Jiaozuo 454000 China

REMg8.35Ni2.18Al0.21 （RE=La, Ce, Pr, and Nd） alloys were prepared by induction melting and following annealing. X-ray diffraction （XRD） and scanning electron microscopy （SEM） results showed that the alloys were composed of Mg2Ni, （La, Pr, Nd）MgzNi, （La, Ce）2MgxT, （Ce, Pr, Nd）Mg12 and Ce2Ni7 phases. The above phases were disproportioned into Mg2NiH4, MgH2 and REHx （x=2.5 1 or 3） phases in hydriding. CEH2.51 phase transformed into CEH2.29 phase in dehydriding, whereas LaH3, PrH3 and NdH3 phases re- mained unchanged. The PrMg8.41Ni2.14Al0.20 alloy had the fastest hydriding kinetics and the highest dehydriding plateau pressure while the CeMg8.35Ni2.18Al0.21 alloy presented the best hydriding/dehydriding reversibility. The onset hydrogen desorption tempera- ture of the CeMg8.35Ni2.18Al0.21 hydride decreased remarkably owing to the phase transformation between the Cell2.51 and the CEH2.29.

关键词： rare earth hydrogen storage alloy Mg-based alloys phase structure hydriding kinetics