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Effect of stromal cell-derived factor-1/CXCR4 axis in neural stem cell transplantation for Parkinson’s disease

Neural Regeneration Research 2020年第1期15卷 112-119页

作者： jiao-Tian xu yuan Qian wei Wang xiao-Xiang Chen yang li yu li Zhi-Yong yang xiao-Bin song Di Lu Xing-li deng department of Neurosurgery First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan ProvinceChina Diagnosis Prenatal Unit Department of ObstetricsFirst Affiliated Hospital of Kunming Medical UniversityKunmingYunnan ProvinceChina The People’s Hospital of Chuxiong yi Autonomous Prefecture ChuxiongYunnan ProvinceChina Rehabilitation Engineering Research Laboratory Biomedicine Engineering Research CenterKunming Medical UniversityKunmingYunnan ProvinceChina

Previous studies have shown that neural stem cell transplantation has the potential to treat Parkinson’s disease,but its specific mechanism of action is still *** cell-derived factor-1 and its receptor,chemokine receptor 4(CXCR4),are important regulators of cell *** speculated that the CXCR4/stromal cell-derived factor 1 axis may be involved in the therapeutic effect of neural stem cell transplantation in the treatment of Parkinson’s disease.A Parkinson’s disease rat model was injected with 6-hydroxydopamine via the right ascending nigrostriatal dopaminergic pathway,and then treated with 5μL of neural stem cell suspension(1.5×104/L)in the right substantia *** were intraperitoneally injected once daily for 3 days with 1.25 mL/kg of the CXCR4 antagonist AMD3100 to observe changes after neural stem cell ***-like behavior in rats was detected using apomorphine-induced *** staining was used to determine the immunoreactivity of tyrosine hydroxylase,CXCR4,and stromal cell-derived factor-1 in the *** quantitative real-time polymerase chain reaction,the mRNA expression of stromal cell-derived factor-1 and CXCR4 in the right substantia nigra were *** addition,western blot assays were performed to analyze the protein expression of stromal cell-derived factor-1 and *** results demonstrated that neural stem cell transplantation noticeably reduced apomorphine-induced rotation,increased the mRNA and protein expression of stromal cell-derived factor-1 and CXCR4 in the right substantia nigra,and enhanced the immunoreactivity of tyrosine hydroxylase,CXCR4,and stromal cell-derived factor-1 in the *** of AMD3100 inhibited the aforementioned *** findings suggest that the stromal cell-derived factor-1/CXCR4 axis may play a significant role in the therapeutic effect of neural stem cell transplantation in a rat model of Parkinson’s *** study was approved by the Ani

关键词： AMD3100 corpus striatum CXCR4 neural stem cells Parkinson’s disease stromal cell-derived factor-1 substantia nigra

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.dedovich A.denig I.denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.han L.han M.han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.ji J.J.jia S.jia Z.K.jia H.B.jiang J.jiang S.Z.jiang J.B.jiao Z.jiao H.J.jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.L.li J.M.li J.li L.li L.li L.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao L.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu L.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.L.liu Z.Q.liu Z.Y.liu Z.W.liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Genome-wide association and linkage mapping strategies reveal the genetic loci and candidate genes of important agronomic traits in Sichuan wheat

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Journal of Integrative Agriculture 2023年第11期22卷 3380-3393页

作者： ZhanG Zhi-peng li Zhen HE Fang Lü ji-juan XIE Bin yi xiao-yu li jia-min li jing song jing-han PU Zhi-en MA jian PENG yuan-ying CHEN Guo-yue wei yu-ming ZHENG You-liang li wei State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130P.R.China College of Agronomy Sichuan Agricultural UniversityChengdu 611130P.R.China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130P.R.China Sichuan Provincial Seed Station Chengdu 610044P.R.China Huaiyin Institute of Agricultural Sciences of xuhuai Area in jiangsu Huai'an 223001P.R.China Beijing Foreign Studies University Beijing 100081P.R.China

Increasing wheat yield is a long-term goal for wheat breeders around the *** elite genetic resources and dissecting the genetic basis of important agronomic traits in wheat are the necessary methods for high-yield wheat *** study evaluated nine crucial agronomic traits found in a natural population of 156 wheat varieties and77 landraces from Sichuan,China in seven environments over two *** results of this investigation of agronomic traits showed that the landraces had more tillers and higher kernel numbers per spike (KNS),while the breeding varieties had higher thousand-kernel weight (TKW) and kernel weight per spike (KWS).The generalized heritability (H2) values of the nine agronomic traits varied from 0.74 to *** analysis suggested that the natural population could be divided into three groups using 43 198 single nucleotide polymorphism (SNP) markers from the wheat 55K SNP chip.A total of 67 quantitative trait loci (QTLs) were identified by the genome-wide association study (GWAS) analysis based on the Q+K method of a mixed linear *** important QTLs were analyzed in this *** haplotypes of ***-7BL.1 for fertile tillers number (FTN),three haplotypes of ***-1AL.2 for KNS,and four haplotypes of ***-3BS.1 for TKW were ***-Hap2,KNS-Hap1,and TKW-Hap2 were excellent haplotypes for each QTL based on the yield performance of 42 varieties in regional trials from 2002 to *** varieties with all three haplotypes showed the highest yield compared to those with either two haplotypes or one *** addition,the KASP-AX-108866053 marker of QTL ***-1AL.2 was successfully distinguished between three haplotypes(or alleles) in 63 varieties based on the number of kernels per spike in regional trials between 2018 and *** genetic loci and reliable makers can be applied in marker-assisted selection or map-based gene cloning for the genetic improvement of wheat yield.

关键词： Sichuan wheat GWAS yield traits haplotype analysis KASP

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Modified FOLFIRINOX for unresectable locally advanced or metastatic gallbladder cancer,a comparison with GEMOX regimen

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 498-506页

作者： xu-Ya Cui xue-Chuan li jiu-jie Cui Xiang-song Wu Lu Zou xiao-ling song Tai ren yi-Di Zhu Huai-Feng li yang yang Ke liu xu-Sheng han Zi-Yao jia Wen-Guang Wu xu-An Wang wei Gong li-wei Wang Mao-Lan li ying-Bin liu department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Biliary Tract Disease Research ShanghaiChina State Key Laboratory of Oncogenes and Related Genes ShanghaiChina Shanghai Research Center of Biliary Tract Disease ShanghaiChina Shanghai Cancer Institute ShanghaiChina department of Medical Oncology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background:The first-line chemotherapy regimen for advanced gallbladder cancer(GBC)is gemcitabine plus platinum(GP),despite its efficacy is *** current investigation is a retrospective study to compare the safety and efficacy between the modified FOLFIRINOX(mFOLFIRINOX)and gemcitabine plus oxaliplatin(GEMOX)as the first-line chemotherapy for unresectable locally advanced or metastatic ***:The data of patients with unresectable locally advanced or metastatic GBC,who were treated with mFOLFIRINOX or GEMOX as the first-line therapy between April 2014 and April 2018 at Xinhua Hospital Affiliated to Shanghai jiaotong University School of Medicine,were *** retrospective study evaluated the clinical characteristics,survival outcomes and adverse ***:A total of 44 patients(n=25 in mFOLFIRINOX,n=19 in GEMOX)were *** were no significant differences between groups in baseline *** median progression free survival(mPFS)was 5.0 months in the mFOLFIRINOX group and 2.5 months in the GEMOX group[P=0.021;hazard ratio(HR),0.499;95%CI,0.266 to 0.937].The median overall survival(mOS)was 9.5 months in the mFOLFIRINOX group and 7.0 months in the GEMOX group(P=0.019;HR,0.471;95%CI,0.239 to 0.929).Disease control rate(DCR)was 76.0%in the mFOLFIRINOX group and 47.4%in the GEMOX group(P=0.051).The rate of grade 3-4 adverse events was 48%in the mFOLFIRINOX group and 36.8%in the GEMOX group(P=0.459).The incidence of grade 3-4 neutropenia and diarrhea were more common in the mFOLFIRINOX group,while the incidence of grade 3-4 thrombocytopenia and peripheral neuropathy were more common in the GEMOX ***:mFOLFIRINOX might improve the poor prognosis of unresectable locally advanced or metastatic GBC,and the results need to be further verified by prospective clinical studies.

关键词： Gallbladder cancer(GBC) modified FOLFIRINOX(mFOLFIRINOX) gemcitabine plus oxaliplatin(GEMOX) chemotherapy

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Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou ren yi-wei yang Yong-Hao Chen Rong liu Bang-jiao Ye jie Wen Hai-rui Guo Zi-jie han Qi-Ping Chen Zhong-wei Wen wei-li Sun han yi Xing-Yan liu Tao Ye jiang-Bo Bai Qi An jie Bao yu Bao Ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui rui-rui Fan Chang-Qing Feng Ke-Qing Gao xiao-Long Gao Min-Hao Gu Chang-Cai han Guo-Zhu He Yong-Cheng He yang hong yi-wei Hu han-Xiong Huang Xi-ru Huang Hao-yu jiang wei jiang Zhi-jie jiang han-Tao jing ling Kang Bo li Chao li jia-Wen li Qiang li xiao li yang li jie liu Shu-Bin liu Ze Long Guang-yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi jie ren Xi-Chao ruan Zhao-Hui song Kang Sun Zhi-jia Sun Zhi-Xin Tan jing-yu Tang Xin-yi Tang Bin-Bin Tian li-jiao Wang Peng-Cheng Wang Zhao-Hui Wang xiao-Guang Wu xuan Wu li-Kun Xie xiao-yun yang li yu Tao yu Yong-ji yu Guo-Hui Zhang lin-Hao Zhang Qi-wei Zhang Xian-Peng Zhang yu-liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

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3-to 24-month Follow-up on COVID-19 with Pulmonary Tuberculosis Survivors after Discharge:Results from a Prospective,Multicenter Study

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Biomedical and Environmental Sciences 2022年第12期35卷 1091-1099页

作者： WANG jing Ya ZONG Xing yu WU Gui Hui QI yuan lin li Hui Zhen ji Xin yu TONG lin ZhanG Lei yang Ming Bo yang Pu Ye li ji Ke xiao Fu Rong ZhanG lin song HU yun hong liu hong de xu Shou Fang SUN Sheng WU wei MAO Ya li Min Qing HOU Hao Hua GONG Zhao yuan GUO yang jiAO li Wen QIN jin WANG Ding yi WANG Fang GUAN li liN Gang MA Yan WANG Yan Ping SHI Nan Nan Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Public Health Clinical Center of Chengdu Chengdu 610066SichuanChina yiyuan TCM Hospital Zibo 256199ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Xi’an Eighth Hospital Xi’an 710000ShaanxiChina Harbin Infectious Disease Hospital Harbin 150000HeilongjiangChina Hospital(T.C.M)Affiliated to Southwest Medical University Luzhou 646000SichuanChina Xingtai Hospital of Chinese Medicine Xingtai 054000HebeiChina Shijiazhuang Fifth Hospital Shijiazhuang 050000HebeiChina jiamusi Infectious Disease Hospital Jiamusi 154000HeilongjiangChina Chengde Hospital of Traditional Chinese Medicine Chengde 067040HebeiChina hanzhong Central Hospital Hanzhong 723000ShaanxiChina Ankang Hospital of Traditional Chinese Medicine Ankang 725000ShaanxiChina department of Traditional Chinese medicine Dazhou Central HospitalDazhou 635000SichuanChina China National Medicines Corporation Ltd Beijing 100077China Beijing University of Chinese Medicine Beijing 101121China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChin

Objective Coronavirus disease 2019(COVID-19)and tuberculosis(TB)are major public health and social issues *** long-term follow-up of COVID-19 with pulmonary TB(PTB)survivors after discharge is *** study aimed to comprehensively describe clinical outcomes,including sequela and recurrence at 3,12,and 24 months after discharge,among COVID-19 with PTB *** From January 22,2020 to May 6,2022,with a follow-up by August 26,2022,a prospective,multicenter follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from four provinces in *** outcomes,including sequela,recurrence of COVID-19,and PTB survivors,were collected via telephone and face-to-face interviews at 3,12,and 24 months after *** Thirty-two COVID-19 with PTB survivors were *** median age was 52(45,59)years,and 23(71.9%)were *** them,nearly two-thirds(62.5%)of the survivors were moderate,three(9.4%)were severe,and more than half(59.4%)had at least one comorbidity(PTB excluded).The proportion of COVID-19 survivors with at least one sequela symptom decreased from 40.6%at 3 months to 15.8%at 24 months,with anxiety having a higher proportion over a *** and amnesia recovered at the 12-month follow-up,while anxiety,fatigue,and trouble sleeping remained after ***,one(3.1%)case presented two recurrences of PTB and no re-positive COVID-19during the follow-up *** The proportion of long symptoms in COVID-19 with PTB survivors decreased over time,while nearly one in six still experience persistent symptoms with a higher proportion of *** recurrence of PTB and the psychological support of COVID-19 with PTB after discharge require more attention.

关键词： COVID-19 Pulmonary tuberculosis Long-term Sequela Recurrence Re-positive

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多组分碳同位素录井在天然气勘探中的应用——以琼东南盆地BD21地区为例

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物探与化探 2024年第2期48卷 348-355页

作者：胡益涛张焕旭倪朋勃郝为瞿煜扬校韩立中法渤海地质服务有限公司湛江分公司广东湛江524057 苏州冠德能源科技有限公司江苏苏州215129 中法渤海地质服务有限公司天津300450

为了了解琼东南盆地深海油气田天然气的成藏特征,对琼东南盆地天然气井进行了连续多组分碳同位素测量。通过对一口重点井连续碳同位素剖面测量及与周边井重点层段碳同位素值对比分析,探讨了该井天然气的成因类型与气源。结果表明:研究... 详细信息

为了了解琼东南盆地深海油气田天然气的成藏特征,对琼东南盆地天然气井进行了连续多组分碳同位素测量。通过对一口重点井连续碳同位素剖面测量及与周边井重点层段碳同位素值对比分析,探讨了该井天然气的成因类型与气源。结果表明:研究区三亚组一段以上为干气,以生物气和亚生物气为主,三亚组二段之下为湿气,为热成因气,主要是伴生气;BD21-1区块天然气存在两种来源,即始新统高熟油型气和特殊成因的低熟崖城组来源气。研究表明,多组分碳同位素录井技术可用于研究天然气的成因类型、气源及成熟度。

关键词：琼东南盆地碳同位素录井成因类型崖城组

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Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： jing-yu Tang Qi An jiang-Bo Bai jie Bao yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui rui-rui Fan Chang-Qing Feng Ke-Qing Gao xiao-Long Gao Min-Hao Gu Chang-Cai han Zi-jie han Guo-Zhu He Yong-Cheng He yang hong yi-wei Hu han-Xiong Huang Xi-ru Huang Hao-yu jiang wei jiang Zhi-jie jiang han-Tao jing ling Kang Bo li Chao li jia-Wen li Qiang li xiao li yang li jie liu Rong liu Shu-Bin liu Xing-Yan liu Ze Long Guang-yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi jie ren Zhi-Zhou ren Xi-Chao ruan Zhao-Hui song Kang Sun Zhi-jia Sun Zhi-Xin Tan Xin-yi Tang Bin-Bin Tian li-jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-wei Wen xiao-Guang Wu xuan Wu li-Kun Xie xiao-yun yang yi-wei yang han yi li yu Tao yu Yong-ji yu Guo-Hui Zhang lin-Hao Zhang Qi-wei Zhang Xian-Peng Zhang yu-liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 State Key Laboratory of Particle detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications

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Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease

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Journal of Geriatric Cardiology 2018年第1期15卷 30-40页

作者： yun-Dai CHEN wei-yi FANG ji-Yan CHEN Zhan-Ming FAN Chuan-yu GAO Jun-Bo GE Zuo-Xiang HE Yong HUO Lang li Si-jin li Xi-lie LU Bin LV Ju-ying QIAN Ya-Jun SHI Zhu-Jun SHEN jing WANG yi-Ning WANG Lei xu li yang Bo yu Mei ZhanG Jun-jie yang Shu-yang ZhanG xiao-li ZhanG Shi-Hua ZHAO yang ZHENG yu-Chi han Guang ZHI Chinese PLA General Hospital Beijing China Shanghai Chest Hospital Shanghai Jiaotong University Shanghai China Guangdong General Hospital Guangzhou China Beijing Anzhen Hospital Capital Medical University Beijing China Henan Provincial People's Hospital Zhengzhou China Zhongshan Hospital Fudan University Shanghai China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China The First Hospital of Peking University Beijing China The First Affiliated Hospital of Guangxi Medical University Nanning China The First Affiliated Hospital of Shanxi Medical University Taiyuan China Peking Union Medical College Hospital Beijing China The 2^nd Affiliated Hospital of Harbin Medical University Harbin China Qilu Hospital of Shandong University Jinan China The First Bethune Hospital of jilin University Changchun China University of Pennsylvania United States

1 Introduction Early detection and diagnosis of stable coronary artery disease （SCAD） is essential for proactive secondary prevention of myocardial infarction （MI）, control of disease progress, and reduction of mortality. Clinical decision-making in modem medicine is increasingly dependent on cardiovascular imaging techniques. 2012 ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease has been issued by American Heart Association （AHA）. European Society of Cardiology （ESC） has issued 2013 ESC guidelines on the management of stable coronary artery disease.

关键词： Expert consensus Clinical pathway Coronary artery disease Non-invasive imaging examination Pre-test probabilities

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新型层状氟化磷酸铝[C_4H_(12)N_2][Al_2(PO_4)_2(H_2O)_2F_2]的水热合成与表征

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高等学校化学学报 2005年第6期26卷 1027-1029页

作者：王梅李激扬李乙宋晓伟于吉红徐如人吉林大学无机合成与制备化学国家重点实验室长春130012

A new layered fluoroaluminophosphate \\[Al2（PO4）2（H2O）2F2\]（compound Ⅰ） was synthesized hydrothermally. It crystallizes in the monoclinic space group P21/c with a=1.102 40（7） nm, （b=0.695 51（4） nm,） c=0.928 05（5） nm, β=111.027（3）°, Z=6, R1=0.037 9, wR2=0.079 2（all data）. Its structure contains \[Al2（PO4）2（H2O）2F2\]2- macroanonic sheets built up from PO3（O） tetrahedra and AlO3F2（H2O） octahedra to form three-, four-, six-membered ring-net stacked sheets in an AAAA sequence along \ direction. The sheets are held together by diprotonated piperazine cations decomposed from 1-methylpiperazine through extensive hydrogen bonds.

关键词：氟化磷酸铝水热合成层状结构主-客体作用

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